| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fátima Pérez de Heredia, Elvira Larqué, Salvador Zamora, Marta Garaule. Dehydroepiandrosterone modifies rat fatty acid composition of serum and different adipose tissue depots and lowers serum insulin levels. The Journal of endocrinology. vol 201. issue 1. 2009-07-23. PMID:19144736. |
fas are involved in the development of insulin resistance; thus, there might be a relationship between dhea, fa, and insulin. |
2009-07-23 |
2023-08-12 |
rat |
| A I Martín, E Castillero, M Granado, M López-Menduiña, M A Villanúa, A López-Calderó. Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis. The Journal of endocrinology. vol 197. issue 1. 2009-07-07. PMID:18372237. |
serum concentrations of insulin, leptin, adiponectin, glycerol and nitrites, as well as gene expression of leptin, adiponectin, hormone-sensitive lipase (hsl), fatty acid synthase (fas), tumour necrosis factor alpha and zinc-alpha(2)-glycoprotein (zag) were determined. |
2009-07-07 |
2023-08-12 |
rat |
| Miriam Granado, Ana Isabel Martín, Estíbaliz Castillero, Asunción López-Calderón, M A Angeles Villanú. Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation. European journal of pharmacology. vol 608. issue 1-3. 2009-06-24. PMID:19239908. |
arthritis was induced in rats by freund's adjuvant injection, and the effect of the cox-2 inhibitor meloxicam on serum concentrations of leptin, adiponectin, insulin and glycerol, as well as on gene expression of leptin, adiponectin, hormone-sensitive lipase (hsl), fatty acid synthase (fas), tumour necrosis factor alpha (tnf) and insulin-like growth factor i (igf-i) in white adipose tissue were determined. |
2009-06-24 |
2023-08-12 |
rat |
| Miriam Granado, Ana Isabel Martín, Estíbaliz Castillero, Asunción López-Calderón, M A Angeles Villanú. Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation. European journal of pharmacology. vol 608. issue 1-3. 2009-06-24. PMID:19239908. |
arthritis decreased serum insulin and fas and igf-i gene expression in adipose tissue. |
2009-06-24 |
2023-08-12 |
rat |
| Nimbe Torres, Lilia Noriega, Armando R Tova. Nutrient modulation of insulin secretion. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251040. |
fas in the absence of glucose induce fa oxidation and insulin secretion in a lesser extent. |
2009-06-23 |
2023-08-12 |
Not clear |
| Nimbe Torres, Lilia Noriega, Armando R Tova. Nutrient modulation of insulin secretion. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251040. |
however, fas in the presence of glucose produce high concentration of malonyl-coa that repress fa oxidation and increase the formation of lc-coa amplifying the insulin release. |
2009-06-23 |
2023-08-12 |
Not clear |
| Manu V Chakravarthy, Yimin Zhu, Li Yin, Trey Coleman, Kirk L Pappan, Connie A Marshall, Michael L McDaniel, Clay F Semenkovic. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. Journal of lipid research. vol 50. issue 4. 2009-06-22. PMID:19029118. |
thus, inducing central fas deficiency may be a valuable integrative strategy for treating several components of the metabolic syndrome, in part by correcting hepatic insulin resistance and suppressing inflammation. |
2009-06-22 |
2023-08-12 |
mouse |
| A Mori, P Lee, H Takemitsu, T Sako, T Ara. Comparison of insulin signaling gene expression in insulin sensitive tissues between cats and dogs. Veterinary research communications. vol 33. issue 3. 2009-04-23. PMID:19043794. |
moreover, differences in glucose and lipid metabolism related gene expression (mdh, g6dph, and fas) demonstrate that felines have an overall lower metabolic rate in various tissues which may be attributed to overall lower insulin signaling gene expression and a lack of physical activity as compared to canines. |
2009-04-23 |
2023-08-12 |
Not clear |
| Roger H F Wong, Inhwan Chang, Carolyn S S Hudak, Suzanne Hyun, Hiu-Yee Kwan, Hei Sook Su. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell. vol 136. issue 6. 2009-04-06. PMID:19303849. |
fatty acid synthase (fas) is a central enzyme in lipogenesis and transcriptionally activated in response to feeding and insulin signaling. |
2009-04-06 |
2023-08-12 |
mouse |
| Pascal P H Hommelberg, Jogchum Plat, Ramon C J Langen, Annemie M W J Schols, Ronald P Mensin. Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. American journal of physiology. Endocrinology and metabolism. vol 296. issue 1. 2009-02-19. PMID:18957619. |
incubation of l6 cells with the long-chain fas c16:0 and c18:0 reduced insulin-stimulated glut4 translocation and deoxyglucose uptake, whereas l6 cells incubated with the medium-chain fas c8:0 and c12:0 remained insulin sensitive. |
2009-02-19 |
2023-08-12 |
Not clear |
| John O Hollosz. Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance. The American journal of clinical nutrition. vol 89. issue 1. 2009-02-05. PMID:19056574. |
it has been hypothesized that this "deficiency" of mitochondria mediates insulin resistance by impairing the ability of muscle to oxidize fatty acids (fas). |
2009-02-05 |
2023-08-12 |
Not clear |
| Fátima Pérez de Heredia, Elvira Larque, Maria Del Puy Portillo, Manuel Canteras, Salvador Zamora, Marta Garaule. Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin. Nutrition (Burbank, Los Angeles County, Calif.). vol 24. issue 10. 2009-02-04. PMID:18562171. |
we studied age-related changes in fatty acids (fas) from serum and adipose tissue in rats by comparing different adipose regions and analyzed their relations to adiposity and insulin function. |
2009-02-04 |
2023-08-12 |
rat |
| Raúl A Bastarrachea, Julio C Montero, Ictor Saavedra-Gajardo, Ricardo Cerda-Flores, Anselmo Machado-Domínguez, Anthony G Comuzzi. [Molecular targets for new drug discovery to treat type 2 diabetes and obesity]. Revista medica de Chile. vol 136. issue 1. 2008-11-24. PMID:18483661. |
promising biological targets are rapidly emerging such as the role of lipotoxicity as a cause of glucometabolic insulin resistance, leading to a host of new molecular drug targets such as amp-activated protein kinase (ampk) activators, recombinant adiponectin derivatives, and fatty acid synthase (fas) inhibitors. |
2008-11-24 |
2023-08-12 |
Not clear |
| Anne Radenne, Murielle Akpa, Caroline Martel, Sabine Sawadogo, Daniel Mauvoisin, Catherine Mounie. Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and nongenomic actions. American journal of physiology. Endocrinology and metabolism. vol 295. issue 4. 2008-11-17. PMID:18682535. |
in particular, glucose, insulin, and t(3) increase fas activity, whereas glucagon and saturated and polyunsaturated fatty acids decrease it. |
2008-11-17 |
2023-08-12 |
Not clear |
| Anne Radenne, Murielle Akpa, Caroline Martel, Sabine Sawadogo, Daniel Mauvoisin, Catherine Mounie. Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and nongenomic actions. American journal of physiology. Endocrinology and metabolism. vol 295. issue 4. 2008-11-17. PMID:18682535. |
in the present study we show that, in liver, t(3) and insulin were able to activate fas enzymatic activity, mrna expression, and gene transcription. |
2008-11-17 |
2023-08-12 |
Not clear |
| Anne Radenne, Murielle Akpa, Caroline Martel, Sabine Sawadogo, Daniel Mauvoisin, Catherine Mounie. Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and nongenomic actions. American journal of physiology. Endocrinology and metabolism. vol 295. issue 4. 2008-11-17. PMID:18682535. |
we show that both t(3) and insulin regulate fas transcription via this sequence. |
2008-11-17 |
2023-08-12 |
Not clear |
| Ana C A Malipa, Roy A Meintjes, Marianne Haa. Arachidonic acid and glucose uptake by freshly isolated human adipocytes. Cell biochemistry and function. vol 26. issue 2. 2008-10-10. PMID:17708582. |
studies done on the effects of fas on glucose uptake, and the influence of insulin on fa uptake by adipocytes, have yielded contradictory results. |
2008-10-10 |
2023-08-12 |
human |
| A A F B V José, M A S Gama, D D P Lann. Effects of trans-10, cis-12 conjugated linoleic acid on gene expression and lipid metabolism of adipose tissue of growing pigs. Genetics and molecular research : GMR. vol 7. issue 2. 2008-10-06. PMID:18551394. |
the objective of the present study was to determine the effects of trans-10, cis-12 conjugated linoleic acid (cla) in adipose tissue explant cultures of growing pigs on the following responses: lipogenesis (measured as rate of (14)c-labeled glucose incorporation over a subsequent 2-h incubation in the presence or absence of insulin), lipolysis (release of non-esterified fatty acid over a 2-h incubation in the presence or absence of isoproterenol), activities of lipogenic enzymes, and mrna abundance of fatty acid synthase (fas). |
2008-10-06 |
2023-08-12 |
Not clear |
| Elisabeth Plagnes-Juan, Marine Lansard, Iban Seiliez, Françoise Médale, Geneviève Corraze, Sadasivam Kaushik, Stéphane Panserat, Sandrine Skiba-Cass. Insulin regulates the expression of several metabolism-related genes in the liver and primary hepatocytes of rainbow trout (Oncorhynchus mykiss). The Journal of experimental biology. vol 211. issue Pt 15. 2008-10-03. PMID:18626086. |
in vitro studies revealed that, as in mammals, glucose is an important regulator of some insulin target genes such as the glycolytic enzyme pyruvate kinase (pk) and the lipogenic enzyme fatty acid synthase (fas). |
2008-10-03 |
2023-08-12 |
cattle |
| V Leray, S Serisier, S Khosniat, L Martin, H Dumon, P Nguye. Adipose tissue gene expression in obese dogs after weight loss. Journal of animal physiology and animal nutrition. vol 92. issue 3. 2008-07-25. PMID:18477322. |
gene expression of irs-2, srebp, intracellular insulin effectors, acc, fas, fabp, adrp, pepck, lipogenesis key proteins, perilipin and hsl, lipolysis key proteins were quantified using real-time rt-pcr in subcutaneous and visceral fat. |
2008-07-25 |
2023-08-12 |
Not clear |