| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lulu Chen, Yongbo Wang, Min Zhou, Baoping Wan. Effects of insulin treatment on intracellular lipid metabolism in liver of diabetic rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 3. 2008-06-16. PMID:16961270. |
meanwhile, insulin treatment was companied by 20% decrease in the rate of fatty acid oxidation and 31% increase in hepatic fas activity compared to ut group. |
2008-06-16 |
2023-08-12 |
rat |
| Lulu Chen, Yongbo Wang, Min Zhou, Baoping Wan. Effects of insulin treatment on intracellular lipid metabolism in liver of diabetic rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 3. 2008-06-16. PMID:16961270. |
it was concluded that treatment with insulin on type 2 diabetic rat increases hepatic intracellular lipid accumulation by inhibiting hepatic fatty acid oxidation and activating fas. |
2008-06-16 |
2023-08-12 |
rat |
| A Brianne Thrush, George J Heigenhauser, Kerry L Mullen, David C Wright, David J Dyc. Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 294. issue 4. 2008-05-22. PMID:18305020. |
exposure to high fatty acids (fas) induces whole body and skeletal muscle insulin resistance. |
2008-05-22 |
2023-08-12 |
human |
| Abdel M Hebbachi, Brian L Knight, David Wiggins, Dilip D Patel, Geoffrey F Gibbon. Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha. The Journal of biological chemistry. vol 283. issue 8. 2008-04-10. PMID:18079124. |
rat hepatocytes transfected with an adenovirus encoding a dominant negative form of pparalpha were resistant to the stimulatory effects of insulin on fas and scd-1 mrna expression in vitro. |
2008-04-10 |
2023-08-12 |
mouse |
| Abdel M Hebbachi, Brian L Knight, David Wiggins, Dilip D Patel, Geoffrey F Gibbon. Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha. The Journal of biological chemistry. vol 283. issue 8. 2008-04-10. PMID:18079124. |
we conclude that intact pparalpha is required to mediate the response of scd-1 and fas gene expression to insulin and that this is normally achieved directly by activation of lxralpha. |
2008-04-10 |
2023-08-12 |
mouse |
| Sven O E Ebbesson, M Elizabeth Tejero, Elizabeth D Nobmann, Juan Carlos Lopez-Alvarenga, Lars Ebbesson, Terri Romenesko, Elizabeth A Carter, Helaine E Resnick, Richard B Devereux, Jean W MacCluer, Bennett Dyke, Sandra L Laston, Charlotte R Wenger, Richard R Fabsitz, Anthony G Comuzzie, Barbara V Howar. Fatty acid consumption and metabolic syndrome components: the GOCADAN study. Journal of the cardiometabolic syndrome. vol 2. issue 4. 2008-03-25. PMID:18059206. |
long-chain omega-3 fas, from fish and sea mammals, were associated with lower blood pressure, serum triglycerides, and 2-hour glucose and higher high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment. |
2008-03-25 |
2023-08-12 |
Not clear |
| Ji Young Kim, Yu Wu, Cynthia M Sma. Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes. Physiological genomics. vol 31. issue 2. 2007-12-13. PMID:17609412. |
scap-23 adipocytes contain abundant lipid droplets and express transcripts for ppar gamma, c/ebp family, and srebp-1c transcription factors, scd1, afabp, atgl, glut4, fas, ldl, and gpdh, and are insulin responsive. |
2007-12-13 |
2023-08-12 |
mouse |
| Eun-Kyoung Kim, Amy M Kleman, Gabriele V Ronnet. Fatty acid synthase gene regulation in primary hypothalamic neurons. Neuroscience letters. vol 423. issue 3. 2007-11-13. PMID:17709201. |
insulin, glucose and aicar (an activator of amp-activated protein kinase) affected changes in hypothalamic fas mrna, which may be regulated via the srebp1c dependent or independent pathway. |
2007-11-13 |
2023-08-12 |
Not clear |
| Zhibo An, Hong Wang, Ping Song, Miao Zhang, Xuemei Geng, Ming-Hui Zo. Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress. The Journal of biological chemistry. vol 282. issue 37. 2007-10-19. PMID:17635921. |
inhibition of ampk using either pharmacologic (insulin, compound c) or genetic means (overexpression of dominant negative ampk; ampk-dn) abolished fas inhibition induced by nicotine or onoo(-). |
2007-10-19 |
2023-08-12 |
Not clear |
| Ariel C Cohen, Ming Tong, Jack R Wands, Suzanne M de la Mont. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Alcoholism, clinical and experimental research. vol 31. issue 9. 2007-10-16. PMID:17645580. |
previous studies linked cerebellar hypoplasia, neuronal loss, and impaired acetylcholine homeostasis to ethanol inhibition of insulin and insulin-like growth factor signaling mechanisms in experimental models of fetal alcohol syndrome (fas). |
2007-10-16 |
2023-08-12 |
Not clear |
| Marcella Pedullà, Riccardo d'Aquino, Vincenzo Desiderio, Francesco de Francesco, Andrew Puca, Gianpaolo Papacci. MnSOD mimic compounds can counteract mechanical stress and islet beta cell apoptosis, although at appropriate concentration ranges. Journal of cellular physiology. vol 212. issue 2. 2007-08-16. PMID:17311287. |
we demonstrate that this mnsod mimic diminishes the negative effects of mechanical stress by blocking insulin impairment, production of non-specific islet beta-cell proteins, transcription of inos and fas, activation of caspase-3 and -9 and, ultimately, apoptosis. |
2007-08-16 |
2023-08-12 |
Not clear |
| Serenella Salinari, Alessandro Bertuzzi, Melania Manco, Geltrude Mingron. NEFA-glucose comodulation model of beta-cell insulin secretion in 24-h multiple-meal test. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17341546. |
there is experimental evidence that a source of fatty acids (fas) that is either exogenous or endogenous is necessary to support normal insulin secretion. |
2007-07-30 |
2023-08-12 |
human |
| Serenella Salinari, Alessandro Bertuzzi, Melania Manco, Geltrude Mingron. NEFA-glucose comodulation model of beta-cell insulin secretion in 24-h multiple-meal test. American journal of physiology. Endocrinology and metabolism. vol 292. issue 6. 2007-07-30. PMID:17341546. |
therefore, fas comodulate the glucose-induced pancreatic insulin secretion. |
2007-07-30 |
2023-08-12 |
human |
| Xiao-hong Zhang, Jin-zhong Hua, Shu-ran Wang, Chang-hao Q Su. Post-weaning isocaloric hyper-soybean oil versus a hyper-carbohydrate diet reduces obesity in adult rats induced by a high-fat diet. Asia Pacific journal of clinical nutrition. vol 16 Suppl 1. 2007-06-14. PMID:17392134. |
on 3,5,11 wk, the body weight, body fat content, blood glucose, blood lipid, serum insulin and leptin levels and obesity-related gene (cpt-1, fas, ucp2, ucp3) expression levels in rats were detected. |
2007-06-14 |
2023-08-12 |
rat |
| Christopher J Nolan, Murthy S R Madiraju, Viviane Delghingaro-Augusto, Marie-Line Peyot, Marc Prentk. Fatty acid signaling in the beta-cell and insulin secretion. Diabetes. vol 55 Suppl 2. 2007-05-25. PMID:17130640. |
for the pancreatic beta-cell, while the presence of some fas is essential for glucose-stimulated insulin secretion, fas have enormous capacity to amplify glucose-stimulated insulin secretion, which is particularly operative in situations of beta-cell compensation for insulin resistance. |
2007-05-25 |
2023-08-12 |
Not clear |
| Mark J Holness, Nicholas D Smith, Gemma K Greenwood, Mary C Sugde. PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy. American journal of physiology. Endocrinology and metabolism. vol 292. issue 4. 2007-05-21. PMID:17164438. |
we also assessed whether effects of dietary saturated fat are influenced by pparalpha activation or substitution of 7% of dietary fatty acids (fas) with long-chain omega-3 fa, manipulations that improve insulin action in the nonpregnant state. |
2007-05-21 |
2023-08-12 |
rat |
| Desiree M Schumann, Kathrin Maedler, Isobel Franklin, Daniel Konrad, Joachim Størling, Marianne Böni-Schnetzler, Asllan Gjinovci, Michael O Kurrer, Benoit R Gauthier, Domenico Bosco, Axel Andres, Thierry Berney, Melanie Greter, Burkhard Becher, Alexander V Chervonsky, Philippe A Halban, Thomas Mandrup-Poulsen, Claes B Wollheim, Marc Y Donat. The Fas pathway is involved in pancreatic beta cell secretory function. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 8. 2007-04-12. PMID:17299038. |
the results support a previously undescribed role for the fas pathway in regulating insulin production and release. |
2007-04-12 |
2023-08-12 |
mouse |
| Steen B Haugaard, Allan Vaag, Carl-Erik Høy, Sten Madsba. Desaturation of skeletal muscle structural and depot lipids in obese individuals during a very-low-calorie diet intervention. Obesity (Silver Spring, Md.). vol 15. issue 1. 2007-03-20. PMID:17228039. |
the working hypothesis proposed that a vlcd would decrease saturated fatty acids (fas) and increase long-chain polyunsaturated fas (lcpufas) in muscular structural lipids, as such changes have been associated with improved insulin sensitivity. |
2007-03-20 |
2023-08-12 |
human |
| Gouri Ranganathan, Resat Unal, Irina Pokrovskaya, Aiwei Yao-Borengasser, Bounleut Phanavanh, Beata Lecka-Czernik, Neda Rasouli, Philip A Ker. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. Journal of lipid research. vol 47. issue 11. 2007-01-17. PMID:16894240. |
the lipogenic enzymes dgat1, fas, and lpl in adipose tissue: effects of obesity, insulin resistance, and tzd treatment. |
2007-01-17 |
2023-08-12 |
mouse |
| Gouri Ranganathan, Resat Unal, Irina Pokrovskaya, Aiwei Yao-Borengasser, Bounleut Phanavanh, Beata Lecka-Czernik, Neda Rasouli, Philip A Ker. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. Journal of lipid research. vol 47. issue 11. 2007-01-17. PMID:16894240. |
to study the relationship of dgat1, fas, and lpl with insulin, we examined adipose mrna expression of these genes in subjects with a wide range of insulin sensitivity (si). |
2007-01-17 |
2023-08-12 |
mouse |