| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melania Manco, Menotti Calvani, Geltrude Mingron. Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes, obesity & metabolism. vol 6. issue 6. 2005-02-02. PMID:15479216. |
in humans, acute and prolonged effects of fas on glucose-stimulated insulin secretion have been widely investigated as well as the effect of high-fat diets on insulin sensitivity and secretion and on the development of type 2 diabetes. |
2005-02-02 |
2023-08-12 |
rat |
| Caroline Améen, Daniel Lindén, Britt-Mari Larsson, Agneta Mode, Agneta Holmäng, Jan Oscarsso. Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver. American journal of physiology. Endocrinology and metabolism. vol 287. issue 6. 2004-12-16. PMID:15280151. |
feminization of the gh plasma pattern in male rats by administration of gh as a continuous infusion decreased insulin sensitivity and increased expression of fas and gpat mrna but had no effect on srebp-1c, acc1, scd-1, or lxralpha mrna. |
2004-12-16 |
2023-08-12 |
rat |
| Sandeep Sinha, German Perdomo, Nicholas F Brown, Robert M O'Dohert. Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. The Journal of biological chemistry. vol 279. issue 40. 2004-11-15. PMID:15252018. |
we conclude that fas induce insulin resistance and activates nfkappab in l6 cells. |
2004-11-15 |
2023-08-12 |
Not clear |
| Elke M Wagner, Dagmar Kratky, Guenter Haemmerle, Andelko Hrzenjak, Gert M Kostner, Ernst Steyrer, Rudolf Zechne. Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis. Journal of lipid research. vol 45. issue 2. 2004-09-27. PMID:14594997. |
these results suggest that in the absence of lpl in at, lipogenesis is activated through increased srebp-1 expression and processing triggered by decreased availability of nutrition-derived fas, elevated insulin, and low leptin levels. |
2004-09-27 |
2023-08-12 |
mouse |
| Miguel A Iglesias, Stuart M Furler, Gregory J Cooney, Edward W Kraegen, Ji-Ming Y. AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of insulin-resistant rats in vivo. Diabetes. vol 53. issue 7. 2004-09-16. PMID:15220186. |
aicar decreased plasma levels of glucose (approximately 25%), insulin (approximately 60%), and fas (approximately 30%) at various times over the next 46 min (p < 0.05 vs. controls). |
2004-09-16 |
2023-08-12 |
rat |
| Per Sjogren, Magdalena Rosell, Camilla Skoglund-Andersson, Slobodan Zdravkovic, Bengt Vessby, Ulf de Faire, Anders Hamsten, Mai-Lis Hellenius, Rachel M Fishe. Milk-derived fatty acids are associated with a more favorable LDL particle size distribution in healthy men. The Journal of nutrition. vol 134. issue 7. 2004-08-10. PMID:15226461. |
we investigated (cross-sectionally) the relations between ldl profile and dietary fatty acids (fas) in 291 healthy men (62-64 y old) with a range of insulin sensitivities. |
2004-08-10 |
2023-08-12 |
Not clear |
| Jeffrey W Chisholm, Jenny Hong, Scott A Mills, Richard M Law. The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Journal of lipid research. vol 44. issue 11. 2004-08-03. PMID:12923232. |
because insulin may also regulate lipogenesis through srebp1c and fatty acid synthase (fas), we investigated the effect of an lxr ligand in hyperinsulinemic mice. |
2004-08-03 |
2023-08-12 |
mouse |
| Yanxin Wang, Brynn Jones Voy, Sumithra Urs, Suyeon Kim, Morvarid Soltani-Bejnood, Neil Quigley, Young-Ran Heo, Melissa Standridge, Brett Andersen, Madhu Dhar, Rashika Joshi, Patrick Wortman, James W Taylor, Joseph Chun, Michael Leuze, Kate Claycombe, Arnold M Saxton, Naima Moustaid-Mouss. The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. The Journal of nutrition. vol 134. issue 5. 2004-06-10. PMID:15113941. |
we also showed that linoleic acid, a representative pufa, attenuated the actions of insulin and dex on fatty acid and lipid synthesis as well as fas activity and expression. |
2004-06-10 |
2023-08-12 |
human |
| Yanxin Wang, Brynn Jones Voy, Sumithra Urs, Suyeon Kim, Morvarid Soltani-Bejnood, Neil Quigley, Young-Ran Heo, Melissa Standridge, Brett Andersen, Madhu Dhar, Rashika Joshi, Patrick Wortman, James W Taylor, Joseph Chun, Michael Leuze, Kate Claycombe, Arnold M Saxton, Naima Moustaid-Mouss. The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. The Journal of nutrition. vol 134. issue 5. 2004-06-10. PMID:15113941. |
using reporter assays, we determined that the regions responsible for hormonal regulation of the fas gene lie in the proximal portion of the gene's 5'-flanking region, within which we identified an insulin response element similar to the e-box sequence we identified previously in the rat fas gene. |
2004-06-10 |
2023-08-12 |
human |
| Trevor J Biden, Darren Robinson, Damien Cordery, William E Hughes, Anna K Busc. Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics. Diabetes. vol 53 Suppl 1. 2004-03-23. PMID:14749282. |
in contrast to a modest decoupling of glucose-stimulated insulin secretion, fa pretreatment markedly enhanced the secretory response to an acute subsequent challenge with fas. |
2004-03-23 |
2023-08-12 |
Not clear |
| Trevor J Biden, Darren Robinson, Damien Cordery, William E Hughes, Anna K Busc. Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics. Diabetes. vol 53 Suppl 1. 2004-03-23. PMID:14749282. |
we propose that this apparent switch in sensitivity from glucose to fas would be an appropriate response to hyperlipidemia in vivo and thus plays a positive role in beta-cell compensation for insulin resistance. |
2004-03-23 |
2023-08-12 |
Not clear |
| José-Manuel Fernández-Real, Montserrat Broch, Joan Vendrell, Wifredo Ricar. Insulin resistance, inflammation, and serum fatty acid composition. Diabetes care. vol 26. issue 5. 2003-12-18. PMID:12716789. |
fatty acids (fas) have been involved in the development of chronic inflammatory conditions such as insulin resistance and obesity. |
2003-12-18 |
2023-08-12 |
human |
| José-Manuel Fernández-Real, Montserrat Broch, Joan Vendrell, Wifredo Ricar. Insulin resistance, inflammation, and serum fatty acid composition. Diabetes care. vol 26. issue 5. 2003-12-18. PMID:12716789. |
however, the relation among insulin resistance, obesity, inflammatory activity (circulating interleukin [il]-6) and dietary fas has been scarcely studied in otherwise healthy subjects. |
2003-12-18 |
2023-08-12 |
human |
| Sadhana Joshi, Shobha Rao, Ajit Golwilkar, Manisha Patwardhan, Ramesh Bhond. Fish oil supplementation of rats during pregnancy reduces adult disease risks in their offspring. The Journal of nutrition. vol 133. issue 10. 2003-12-01. PMID:14519805. |
serum insulin concentrations were higher (p < 0.05) in the fad group (males 1476 +/- 317, females 1441 +/- 220 pmol/l) but were lower in males from the fas group (483 +/- 165 pmol/l) compared with controls (males 917 +/- 373, females 981 +/- 264 pmol/l). |
2003-12-01 |
2023-08-12 |
rat |
| Irina Apostolou, Zhenyue Hao, Klaus Rajewsky, Harald von Boehme. Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes. The Journal of experimental medicine. vol 198. issue 7. 2003-11-12. PMID:14530378. |
to directly test this hypothesis, we have generated a beta cell-specific knockout of the fas gene in a transgenic model of type 1 autoimmune diabetes in which cd4+ t cells with a transgenic tcr specific for influenza hemagglutinin (ha) are causing diabetes in mice that express ha under control of the rat insulin promoter. |
2003-11-12 |
2023-08-12 |
mouse |
| John M Rumberger, Tong Wu, Michelle A Hering, Stephen Marshal. Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels: effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels. The Journal of biological chemistry. vol 278. issue 31. 2003-09-10. PMID:12759350. |
treatment with insulin and various concentrations of d-glucose increased mrna levels for fas (280%), acc (93%), and gpdh (633%) in a dose-dependent manner (ed50 8-16 mm). |
2003-09-10 |
2023-08-12 |
Not clear |
| Maria-Jesus Latasa, Michael J Griffin, Yang Soo Moon, Chulho Kang, Hei Sook Su. Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals. Molecular and cellular biology. vol 23. issue 16. 2003-08-29. PMID:12897158. |
upstream regulatory factor (usf) and sterol regulatory element binding protein (srebp) play key roles in the transcriptional regulation of the fatty acid synthase (fas) gene by feeding and insulin. |
2003-08-29 |
2023-08-12 |
mouse |
| Angela M Valverde, Monica Arribas, Cecilia Mur, Paloma Navarro, Sebastián Pons, Anne-Marie Cassard-Doulcier, C Ronald Kahn, Manuel Benit. Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. The Journal of biological chemistry. vol 278. issue 12. 2003-05-05. PMID:12525499. |
both c/ebpalpha and peroxisome proliferator-activated receptor gamma reconstituted fas mrna expression, but only c/ebpalpha restored insulin sensitivity in the absence of irs-1. |
2003-05-05 |
2023-08-12 |
Not clear |
| Cecilia Mur, Mónica Arribas, Manuel Benito, Angela M Valverd. Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation. Endocrinology. vol 144. issue 2. 2003-02-13. PMID:12538620. |
treatment of wild-type brown adipocytes with insulin for 12 h up-regulated fatty acid synthase (fas) and adipocyte determination and differentiation (add1/srebp) mrnas; this effect was impaired in the absence of igf-ir. |
2003-02-13 |
2023-08-12 |
mouse |
| Cecilia Mur, Mónica Arribas, Manuel Benito, Angela M Valverd. Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation. Endocrinology. vol 144. issue 2. 2003-02-13. PMID:12538620. |
at the protein level, insulin increased fas content and the amount of the mature form of adipocyte determination and differentiation (add1/srebp) in the nucleus in wild-type cells, but not in igf-ir(-/-) cells. |
2003-02-13 |
2023-08-12 |
mouse |