| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cecilia Mur, Mónica Arribas, Manuel Benito, Angela M Valverd. Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation. Endocrinology. vol 144. issue 2. 2003-02-13. PMID:12538620. |
retrovirus-mediated reexpression of peroxisomal proliferator-activated receptor gamma (ppargamma) in igf-ir(-/-) brown adipocytes could overcome fas mrna impairment, bypassing insulin signaling. |
2003-02-13 |
2023-08-12 |
mouse |
| Cecilia Mur, Mónica Arribas, Manuel Benito, Angela M Valverd. Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation. Endocrinology. vol 144. issue 2. 2003-02-13. PMID:12538620. |
however, insulin further increased fas mrna expression in c/ebpalpha-igf-ir(-/-) cells, but not in ppargamma-igf-ir(-/-) cells. |
2003-02-13 |
2023-08-12 |
mouse |
| Armando R Tovar, Fernanda Murguía, Cristino Cruz, Rogelio Hernández-Pando, Carlos A Aguilar-Salinas, José Pedraza-Chaverri, Ricardo Correa-Rotter, Nimbe Torre. A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome. The Journal of nutrition. vol 132. issue 9. 2003-02-06. PMID:12221209. |
however, ns rats fed either casein or soy protein diets had low insulin concentrations with reductions in srebp-1, fas and malic enzyme expression compared with control rats fed the casein diet. |
2003-02-06 |
2023-08-12 |
rat |
| Marek Szolkiewicz, Tomasz Nieweglowski, Justyna Korczynska, Elzbieta Sucajtys, Ewa Stelmanska, Elzbieta Goyke, Julian Swierczynski, Boleslaw Rutkowsk. Upregulation of fatty acid synthase gene expression in experimental chronic renal failure. Metabolism: clinical and experimental. vol 51. issue 12. 2003-01-13. PMID:12489075. |
it seems that elevated plasma insulin and cytokine concentration could play an important role in the mechanism responsible for the increased fas gene expression in crf. |
2003-01-13 |
2023-08-12 |
rat |
| Joost J F P Luiken, Debby P Y Koonen, Jodil Willems, Antonio Zorzano, Christoph Becker, Yvan Fischer, Narendra N Tandon, Ger J Van Der Vusse, Arend Bonen, Jan F C Glat. Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes. vol 51. issue 10. 2002-12-03. PMID:12351456. |
the existence of an intracellular pool of fatty acid translocase (fat/cd36), an 88-kda membrane transporter for long-chain fatty acids (fas), and the ability of insulin to induce translocation events prompted us to investigate the direct effects of insulin on cellular uptake of fa by the heart. |
2002-12-03 |
2023-08-12 |
rat |
| Soazig Le Lay, Isabelle Lefrère, Christian Trautwein, Isabelle Dugail, Stéphane Krie. Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target. The Journal of biological chemistry. vol 277. issue 38. 2002-10-24. PMID:12048207. |
as expected, insulin up-regulated, dominant positive stimulated, and dominant negative decreased previously characterized direct srebp targets (fas, scd-1, and low density lipoprotein receptor). |
2002-10-24 |
2023-08-12 |
Not clear |
| Andreas Barthel, Klaus-Dieter Krüger, Richard A Roth, Hans-Georg Joos. Concentration-dependent stimulatory and inhibitory effect of troglitazone on insulin-induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 4. 2002-09-18. PMID:11919653. |
in this cell line, a low concentration of troglitazone (250 nm) increased the effect of insulin on the fas promoter activity and the expression of fas protein about 1.5- to 2-fold. |
2002-09-18 |
2023-08-12 |
Not clear |
| Andreas Barthel, Klaus-Dieter Krüger, Richard A Roth, Hans-Georg Joos. Concentration-dependent stimulatory and inhibitory effect of troglitazone on insulin-induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 4. 2002-09-18. PMID:11919653. |
since the effect of insulin on the expression of fas is believed to be mediated by activation of protein kinase b (pkb), we investigated the effect of troglitazone on the regulation of pkb. |
2002-09-18 |
2023-08-12 |
Not clear |
| T M Mason, B Chan, B El-Bahrani, T Goh, N Gupta, J Gamble, Z Qing Shi, M Prentki, G Steiner, Adria Giacc. The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats. Atherosclerosis. vol 161. issue 2. 2002-05-14. PMID:11888517. |
thus, in streptozotocin-diabetic rats, chronic intraperitoneal or subcutaneous insulin treatment increases tgsr and fas activity from their low levels in insulin-deficient rats to levels equal to but not higher than those in normal rats. |
2002-05-14 |
2023-08-12 |
rat |
| b' D Gail Palmer, Guy A Rutter, Jeremy M Tavar\\xc3\\xa. Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes. Biochemical and biophysical research communications. vol 291. issue 3. 2002-04-01. PMID:11855808.' |
in this paper we have investigated the regulation of the srebp-1 and fas genes in adipocytes and find that while an overexpressed constitutively active srebp-1 mutant is capable of substantially stimulating the fas promoter, insulin appears to stimulate fas gene expression in primary adipocytes in the absence of any apparent effect on srebp-1 transcription. |
2002-04-01 |
2023-08-12 |
Not clear |
| b' D Gail Palmer, Guy A Rutter, Jeremy M Tavar\\xc3\\xa. Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes. Biochemical and biophysical research communications. vol 291. issue 3. 2002-04-01. PMID:11855808.' |
taken together, our data suggest that insulin does not stimulate fas gene expression through increasing srebp-1c transcription in adipose cells. |
2002-04-01 |
2023-08-12 |
Not clear |
| D Yin, S D Clarke, T D Etherto. Transcriptional regulation of fatty acid synthase gene by somatotropin in 3T3-F442A adipocytes. Journal of animal science. vol 79. issue 9. 2002-03-13. PMID:11583420. |
somatotropin (st) antagonizes insulin stimulation of fatty acid synthase (fas) enzyme activity and gene transcription in adipocytes. |
2002-03-13 |
2023-08-12 |
human |
| D Yin, S D Clarke, T D Etherto. Transcriptional regulation of fatty acid synthase gene by somatotropin in 3T3-F442A adipocytes. Journal of animal science. vol 79. issue 9. 2002-03-13. PMID:11583420. |
previous studies have shown that an insulin response element (ire) is located in the proximal region of the fas promoter (-71 to -50) and upstream stimulatory factor (usf) 1 binds to this ire. |
2002-03-13 |
2023-08-12 |
human |
| Margarita Teran-Garcia, Caterina Rufo, Manabu T Nakamura, Timothy F Osborne, Steven D Clark. NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription. Biochemical and biophysical research communications. vol 290. issue 4. 2002-03-12. PMID:11812004. |
when in fact the srebp-1/usf sites of the insulin response element of fas were mutated, only 25% of the pufa inhibition of fas promoter activity was lost. |
2002-03-12 |
2023-08-12 |
Not clear |
| H Wang, Y Li, Q Sun, G Yan. Oral administration of insulin to female nonobese diabetic mice inhibited diabetes and induced Fas ligand expression on islets of Langerhans. Chinese medical journal. vol 113. issue 5. 2002-01-14. PMID:11776099. |
oral administration of insulin to female nonobese diabetic mice inhibited diabetes and induced fas ligand expression on islets of langerhans. |
2002-01-14 |
2023-08-12 |
mouse |
| H Wang, Y Li, Q Sun, G Yan. Oral administration of insulin to female nonobese diabetic mice inhibited diabetes and induced Fas ligand expression on islets of Langerhans. Chinese medical journal. vol 113. issue 5. 2002-01-14. PMID:11776099. |
to detect oral administration of recombinant human insulin to nonobese diabetic (nod) mice for preventing them from diabetes and insulitis and to detect the effects of oral administration of insulin on fas and fas ligand expression on islet of langerhans. |
2002-01-14 |
2023-08-12 |
mouse |
| R G Fiebig, J M Hollander, L L J. Exercise down-regulates hepatic fatty acid synthase in streptozotocin-treated rats. The Journal of nutrition. vol 131. issue 9. 2001-10-18. PMID:11533263. |
the purpose of the current study was to examine the role of insulin in this exercise down-regulation of fas. |
2001-10-18 |
2023-08-12 |
rat |
| R G Fiebig, J M Hollander, L L J. Exercise down-regulates hepatic fatty acid synthase in streptozotocin-treated rats. The Journal of nutrition. vol 131. issue 9. 2001-10-18. PMID:11533263. |
we conclude that although insulin status had a great influence on fas gene expression, e-induced down-regulation of fas mrna was not mediated by altered insulin response sequence binding but primarily by increased inverted ccaat-box element binding to the fas promoter and/or decreased concentration of carbohydrate metabolites. |
2001-10-18 |
2023-08-12 |
rat |
| J M Abadie, G T Malcom, J R Porter, F Sve. Dehydroepiandrosterone alters Zucker rat soleus and cardiac muscle lipid profiles. Experimental biology and medicine (Maywood, N.J.). vol 226. issue 8. 2001-09-27. PMID:11520945. |
high levels of serum free fatty acids (ffa) and lower proportions of polyunsaturated (pu) fas, specifically arachidonic acid (aa), are common in obesity, insulin resistance (ir), and type 2 diabetes mellitus. |
2001-09-27 |
2023-08-12 |
human |
| S Kim, I Dugail, M Standridge, K Claycombe, J Chun, N Moustaïd-Mouss. Angiotensin II-responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene: role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c. The Biochemical journal. vol 357. issue Pt 3. 2001-08-30. PMID:11463364. |
in conclusion, this is the first report that ang ii regulates adipocyte fas gene transcription via insulin response sequences in a glucose-dependent manner and that this regulation is mediated at least in part via the add1 transcription factor. |
2001-08-30 |
2023-08-12 |
Not clear |