| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael J MacDonald, Noaman M Hasan, Agnieszka Dobrzyn, Scott W Stoker, James M Ntambi, Xueqing Liu, Harini Sampat. Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. Archives of biochemistry and biophysics. vol 532. issue 1. 2013-04-29. PMID:23357280. |
we now show that knockdown of fatty acid synthase (fas) mrna and protein also inhibits glucose-stimulated insulin release in this cell line. |
2013-04-29 |
2023-08-12 |
Not clear |
| Madeleen Bosma, Matthijs K C Hesselink, Lauren M Sparks, Silvie Timmers, Maria João Ferraz, Frits Mattijssen, Denis van Beurden, Gert Schaart, Marc H de Baets, Fons K Verheyen, Sander Kersten, Patrick Schrauwe. Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels. Diabetes. vol 61. issue 11. 2013-01-14. PMID:22807032. |
we conclude that plin2 is essential for lipid storage in skeletal muscle by enhancing the partitioning of excess fas toward tag storage in lds, thereby blunting lipotoxicity-associated insulin resistance. |
2013-01-14 |
2023-08-12 |
Not clear |
| Thomas Scherer, Claudia Lindtner, Elizabeth Zielinski, James O'Hare, Nika Filatova, Christoph Buettne. Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis. The Journal of biological chemistry. vol 287. issue 39. 2012-12-07. PMID:22810223. |
short term hfd feeding led to a 37% increase in caloric intake and elevated base-line free fas and insulin levels compared with rats fed regular chow. |
2012-12-07 |
2023-08-12 |
human |
| Jan A Mennigen, Stéphane Panserat, Mélanie Larquier, Elisabeth Plagnes-Juan, Françoise Medale, Iban Seiliez, Sandrine Skiba-Cass. Postprandial regulation of hepatic microRNAs predicted to target the insulin pathway in rainbow trout. PloS one. vol 7. issue 6. 2012-11-08. PMID:22701681. |
a concurrent increase in the activity of the hepatic insulin signaling pathway and the expression of lipogenic genes (srebp1c, fas, acly) was equally observed, while lipolytic gene expression (cpt1a and cpt1b) decreased significantly 4 h after the meal. |
2012-11-08 |
2023-08-12 |
Not clear |
| C Montoro, I R Ipharraguerre, A Bac. Blocking opioid receptors alters short-term feed intake and oro-sensorial preferences in weaned calves. Journal of dairy science. vol 95. issue 5. 2012-09-04. PMID:22541480. |
plasma glucose, insulin, and cholecystokinin concentrations were greater in fed than in fas calves. |
2012-09-04 |
2023-08-12 |
Not clear |
| Cheng-De Li, Jing-Jing Li, Lin Wang, Jin-Hong Wang, Gong Dai, Bai Kang, Shu-Mei Ma. [Inhibitory effect of Astragalus polysaccharides on apoptosis of pancreatic beta-cells mediated by Fas in diabetes mellitus rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. vol 34. issue 10. 2012-07-30. PMID:22372150. |
to observe the effects of astragalus polysaccharides (aps) on the bg, insulin and c-peptide in serum, ultrastructure and fas expression of pancreatic beta-cells in diabetes mellitus (dm) rats. |
2012-07-30 |
2023-08-12 |
rat |
| Xiaochao Wei, Zhen Yang, Federico E Rey, Vanessa K Ridaura, Nicholas O Davidson, Jeffrey I Gordon, Clay F Semenkovic. Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2. Cell host & microbe. vol 11. issue 2. 2012-06-06. PMID:22341463. |
furthermore, a diabetic mouse model exhibited lower fas levels and a decreased mucus layer, which could be restored with insulin treatment. |
2012-06-06 |
2023-08-12 |
mouse |
| Samer W El-Kadi, Agus Suryawan, Maria C Gazzaneo, Neeraj Srivastava, Renán A Orellana, Hanh V Nguyen, Gerald E Lobley, Teresa A Davi. Anabolic signaling and protein deposition are enhanced by intermittent compared with continuous feeding in skeletal muscle of neonates. American journal of physiology. Endocrinology and metabolism. vol 302. issue 6. 2012-05-01. PMID:22215651. |
insulin, branched-chain aa, phenylalanine, and tyrosine arterial concentrations and whole body phenylalanine and tyrosine fluxes were greater for int after the meal than for con or fas. |
2012-05-01 |
2023-08-12 |
Not clear |
| Sangbin Lim, Md Abdur Rashid, Miran Jang, Yeonghwan Kim, Hyeran Won, Jeonghoon Lee, Jeong-taek Woo, Young Seol Kim, Michael P Murphy, Liaquat Ali, Joohun Ha, Sung Soo Ki. Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 28. issue 5. 2012-04-20. PMID:22178940. |
when β-cells were incubated under these conditions, the expression levels of mitochondrial electron transport chain complex subunits, mitochondrial antioxidant enzymes (such as mnsod and prx3), β-cell apoptosis, lipogenic enzymes (such as acc, fas and abca1), intracellular lipid accumulation, oxidative stress, er stress, mitochondrial membrane depolarization, nuclear nf- κb and sterol regulatory element binding protein 1c (srebp1c) were all increased, in parallel with decreases in intracellular atp content, citrate synthase enzymatic activity and glucose-stimulated insulin secretion. |
2012-04-20 |
2023-08-12 |
Not clear |
| K M Schoenberg, K L Perfield, J K Farney, B J Bradford, Y R Boisclair, T R Overto. Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-α and leptin, and adipose tissue gene expression. Journal of dairy science. vol 94. issue 11. 2012-02-16. PMID:22032375. |
the objective of this work was to elucidate mechanisms of tzd action in transition dairy cattle by investigating changes in plasma leptin, tumor necrosis factor-α (tnfα), the revised quantitative insulin sensitivity check index (rquicki), and adipose tissue gene expression of leptin, pparγ, lipoprotein lipase (lpl), and fatty acid synthase (fas). |
2012-02-16 |
2023-08-12 |
cattle |
| Yuanli Cai, Zhigang Song, Xiaojuan Wang, Hongchao Jiao, Hai Li. Dexamethasone-induced hepatic lipogenesis is insulin dependent in chickens (Gallus gallus domesticus). Stress (Amsterdam, Netherlands). vol 14. issue 3. 2011-08-05. PMID:21294661. |
in cultured primary hepatocytes, combined dex and insulin significantly upregulated the transcription of the genes for fas (1.34-fold) and malic enzyme (1.72-fold). |
2011-08-05 |
2023-08-12 |
Not clear |
| Suman Dasgupta, Sushmita Bhattacharya, Sudipta Maitra, Durba Pal, Subeer S Majumdar, Asis Datta, Samir Bhattachary. Mechanism of lipid induced insulin resistance: activated PKCε is a key regulator. Biochimica et biophysica acta. vol 1812. issue 4. 2011-04-18. PMID:21236337. |
fatty acids (fas) are known to impair insulin signaling in target cells. |
2011-04-18 |
2023-08-12 |
mouse |
| Daozhong Jin, Hong Guo, So Young Bu, Yuanyuan Zhang, Jennifer Hannaford, Douglas G Mashek, Xiaoli Che. Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 2. 2011-04-04. PMID:20974668. |
we found that rosiglitazone (rosi) significantly improved insulin sensitivity in lcn2(-/-) mice as effectively as in wild-type (wt) mice; unfed-state levels of blood glucose, free fas, and triglycerides (tgs) were significantly reduced after a 25-d treatment of rosi in lcn2(-/-) mice. |
2011-04-04 |
2023-08-12 |
mouse |
| Ayman Hyder, Marwa Zenhom, Maja Klapper, Julia Herrmann, Jürgen Schrezenmei. Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose. Islets. vol 2. issue 3. 2011-03-31. PMID:21099311. |
although fas are known to stimulate insulin secretion from pancreatic islets when transiently elevated, while contributing to islet loss of function, lipotoxicity and apoptosis when chronically elevated, almost nothing is known regarding the fabps in this tissue. |
2011-03-31 |
2023-08-12 |
rat |
| Ayman Hyder, Marwa Zenhom, Maja Klapper, Julia Herrmann, Jürgen Schrezenmei. Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose. Islets. vol 2. issue 3. 2011-03-31. PMID:21099311. |
these data show a complex interrelationship between glucose and fas in the control of fabp gene expression and that fabp3 and 5 may play a role in insulin secretion. |
2011-03-31 |
2023-08-12 |
rat |
| Xiaochao Wei, Jochen G Schneider, Sherene M Shenouda, Ada Lee, Dwight A Towler, Manu V Chakravarthy, Joseph A Vita, Clay F Semenkovic. De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation. The Journal of biological chemistry. vol 286. issue 4. 2011-03-04. PMID:21098489. |
insulin induced fas in endothelial cells freshly isolated from humans, and enos palmitoylation was decreased in mice with insulin-deficient or insulin-resistant diabetes. |
2011-03-04 |
2023-08-12 |
mouse |
| M A Rashid, Seonmin Lee, Eunyoung Tak, Jisun Lee, Tae Gyu Choi, Joo-Won Lee, Jae Bum Kim, Jang H Youn, Insug Kang, Joohun Ha, Sung Soo Ki. Carbonyl reductase 1 protects pancreatic β-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free radical biology & medicine. vol 49. issue 10. 2011-02-17. PMID:20728534. |
under both conditions, knockdown of cbr1 by specific sirna increased β-cell apoptosis, expression of lipogenic enzymes (such as acc, fas, and abca1), intracellular lipid accumulation, oxidative stress, er stress, and nuclear srebp1c, but decreased glucose-stimulated insulin secretion. |
2011-02-17 |
2023-08-12 |
mouse |
| Murielle M Akpa, Floriane Point, Sabine Sawadogo, Anne Radenne, Catherine Mounie. Inhibition of insulin and T3-induced fatty acid synthase by hexanoate. Lipids. vol 45. issue 11. 2011-02-07. PMID:20811782. |
in this study, we show that insulin and t(3) have an inducing effect on fas enzymatic activity, which is synergetic when both hormones are present. |
2011-02-07 |
2023-08-12 |
Not clear |
| Murielle M Akpa, Floriane Point, Sabine Sawadogo, Anne Radenne, Catherine Mounie. Inhibition of insulin and T3-induced fatty acid synthase by hexanoate. Lipids. vol 45. issue 11. 2011-02-07. PMID:20811782. |
our results suggest that in hepatic cells, hexanoate needs to be activated into a coa derivative in order to inhibit the insulin and t(3)-induced fas expression. |
2011-02-07 |
2023-08-12 |
Not clear |
| Marine Lansard, Stéphane Panserat, Elisabeth Plagnes-Juan, Karine Dias, Iban Seiliez, Sandrine Skiba-Cass. L-leucine, L-methionine, and L-lysine are involved in the regulation of intermediary metabolism-related gene expression in rainbow trout hepatocytes. The Journal of nutrition. vol 141. issue 1. 2011-01-20. PMID:21106925. |
using rainbow trout hepatocytes stimulated with l-leucine, l-methionine, or l-lysine in the presence or absence of bovine insulin, we investigated the ability of these amino acids to mimic the effects of a pool of amino acids on protein kinase b (akt)/target of rapamycin (tor) signaling pathways and expression of 6 genes known to be subjected to insulin and/or amino acid regulation [glucose-6-phosphatase (g6pase), phosphoenolpyruvate carboxykinase (pepck), glucokinase (gk), pyruvate kinase (pk), fatty acid synthase (fas), and serine dehydratase (sdh)]. |
2011-01-20 |
2023-08-12 |
cattle |