| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Salomon, I Perroteau, W R Kidwell, J Tam, R Derync. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. Journal of cellular physiology. vol 130. issue 3. 1987-05-08. PMID:3494020. |
the higher levels of biologically active tgfs found in the cm from the transformed cells relative to the nmumg cells is paralleled by a corresponding increase in the cm from these cells in the amount of immunoreactive alpha tgf, by an increase in the amount of egf receptor-competing activity, and by an increase in the levels of alpha tgf mrna in the nmumg/rash cells. |
1987-05-08 |
2023-08-11 |
mouse |
| D S Salomon, I Perroteau, W R Kidwell, J Tam, R Derync. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. Journal of cellular physiology. vol 130. issue 3. 1987-05-08. PMID:3494020. |
these results demonstrate that mammary epithelial cells which have been transformed by an activated ras proto-oncogene, but not by the polyoma middle t-transforming gene, become unresponsive to exogenous egf or alpha tgf. |
1987-05-08 |
2023-08-11 |
mouse |
| T Maruo, H Matsuo, T Oishi, M Hayashi, R Nishino, M Mochizuk. Induction of differentiated trophoblast function by epidermal growth factor: relation of immunohistochemically detected cellular epidermal growth factor receptor levels. The Journal of clinical endocrinology and metabolism. vol 64. issue 4. 1987-04-16. PMID:2434521. |
the time course of egf effects indicated that the egf-stimulated increase in hcg alpha secretion required a lag period of approximately 1 day, whereas significant increases in hcg and hpl secretion became apparent only after 3 days of egf treatment. |
1987-04-16 |
2023-08-11 |
mouse |
| T Maruo, H Matsuo, T Oishi, M Hayashi, R Nishino, M Mochizuk. Induction of differentiated trophoblast function by epidermal growth factor: relation of immunohistochemically detected cellular epidermal growth factor receptor levels. The Journal of clinical endocrinology and metabolism. vol 64. issue 4. 1987-04-16. PMID:2434521. |
by contrast, in term placental tissues egf stimulated only hcg alpha and hpl release, with a lag period of approximately 3 days. |
1987-04-16 |
2023-08-11 |
mouse |
| E Y Adashi, C E Resnick, D R Twardzi. Transforming growth factor-alpha attenuates the acquisition of aromatase activity by cultured rat granulosa cells. Journal of cellular biochemistry. vol 33. issue 1. 1987-04-15. PMID:3029149. |
relative potency comparison revealed epidermal growth factor (egf; ec50 = 0.24 +/- 0.03 ng/ml) and tgf alpha to be virtually equipotent as regards the attenuation of fsh-stimulated estrogen biosynthesis. |
1987-04-15 |
2023-08-11 |
rat |
| E Y Adashi, C E Resnick, D R Twardzi. Transforming growth factor-alpha attenuates the acquisition of aromatase activity by cultured rat granulosa cells. Journal of cellular biochemistry. vol 33. issue 1. 1987-04-15. PMID:3029149. |
as such, these findings provide yet another example of the remarkable qualitative and quantitative similarities between egf and tgf alpha, thereby reaffirming the prospect that ligands of the egf/tgf alpha receptor may play a modulatory role in the course of granulosa cell ontogeny. |
1987-04-15 |
2023-08-11 |
rat |
| M Popliker, A Shatz, A Avivi, A Ullrich, J Schlessinger, C G Web. Onset of endogenous synthesis of epidermal growth factor in neonatal mice. Developmental biology. vol 119. issue 1. 1987-02-19. PMID:3539666. |
previously demonstrated egf receptors in mouse embryonic cell types may be activated by either alpha type transforming growth factor or maternal egf transported via the placenta. |
1987-02-19 |
2023-08-11 |
mouse |
| J A García-Sáinz, M I Tussié-Luna, S M Hernăndez-Sotomayo. Insulin-like effect of epidermal growth factor in isolated rat hepatocytes. Modulation of the alpha-1-adrenergic stimulation of ureagenesis. Biochimica et biophysica acta. vol 889. issue 2. 1987-01-07. PMID:3022828. |
insulin and epidermal growth factor (egf) inhibit the stimulation of ureagenesis induced by adrenaline (alpha 1-adrenergic effect) in hepatocytes from control rats incubated in medium without calcium and in cells from hypothyroid rats. |
1987-01-07 |
2023-08-11 |
rat |
| J A García-Sáinz, M I Tussié-Luna, S M Hernăndez-Sotomayo. Insulin-like effect of epidermal growth factor in isolated rat hepatocytes. Modulation of the alpha-1-adrenergic stimulation of ureagenesis. Biochimica et biophysica acta. vol 889. issue 2. 1987-01-07. PMID:3022828. |
in hepatocytes from euthyroid rats incubated in normal buffer neither insulin or egf diminished the alpha 1-adrenergic stimulation of ureagenesis. |
1987-01-07 |
2023-08-11 |
rat |
| J A García-Sáinz, M I Tussié-Luna, S M Hernăndez-Sotomayo. Insulin-like effect of epidermal growth factor in isolated rat hepatocytes. Modulation of the alpha-1-adrenergic stimulation of ureagenesis. Biochimica et biophysica acta. vol 889. issue 2. 1987-01-07. PMID:3022828. |
no effect of egf or insulin on the alpha 1-adrenergic stimulation of phosphatidylinositol labeling was observed under any conditions. |
1987-01-07 |
2023-08-11 |
rat |
| J A García-Sáinz, M I Tussié-Luna, S M Hernăndez-Sotomayo. Insulin-like effect of epidermal growth factor in isolated rat hepatocytes. Modulation of the alpha-1-adrenergic stimulation of ureagenesis. Biochimica et biophysica acta. vol 889. issue 2. 1987-01-07. PMID:3022828. |
it is suggested that egf mimics the action of insulin on one of the pathways of the alpha 1-adrenergic action: the calcium-independent, insulin-sensitive pathway which predominates in hepatocytes from hypothyroid rats. |
1987-01-07 |
2023-08-11 |
rat |
| I Perroteau, D Salomon, M DeBortoli, W Kidwell, P Hazarika, R Pardue, J Dedman, J Ta. Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells. Breast cancer research and treatment. vol 7. issue 3. 1987-01-06. PMID:3465381. |
immunoreactive alpha tgfs were quantitated by a competitive radioimmunoassay (ria) using affinity-purified polyclonal sheep anti-rat alpha tgf antibodies which react with human alpha tgf but not with human epidermal growth factor (egf). |
1987-01-06 |
2023-08-11 |
human |
| H Riedel, T J Dull, J Schlessinger, A Ullric. A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor. Nature. vol 324. issue 6092. 1986-12-30. PMID:3024008. |
the egf receptor is a single polypeptide chain but the insulin receptor consists of distinct alpha and beta subunits that function as an alpha 2 beta 2 heterotetrameric receptor complex. |
1986-12-30 |
2023-08-11 |
Not clear |
| A Gebhardt, J C Bell, J G Foulke. Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice. The EMBO journal. vol 5. issue 9. 1986-12-19. PMID:3023060. |
alpha tgf is homologous to the epidermal growth factor (egf) and stimulates cell growth via the egf receptor pathway. |
1986-12-19 |
2023-08-11 |
mouse |
| A Gebhardt, J C Bell, J G Foulke. Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice. The EMBO journal. vol 5. issue 9. 1986-12-19. PMID:3023060. |
to separate metabolic events in the v-abl-transformed cells mediated by alpha tgf as opposed to the v-abl-encoded protein-tyrosine kinase, we have employed the swiss 3t3 variant cell line nr6 which lacks a functional egf receptor. |
1986-12-19 |
2023-08-11 |
mouse |
| A Gebhardt, J C Bell, J G Foulke. Abelson transformed fibroblasts lacking the EGF receptor are not tumourigenic in nude mice. The EMBO journal. vol 5. issue 9. 1986-12-19. PMID:3023060. |
these results imply an important function for alpha tgf and the egf receptor in the establishment of the v-abl-induced fibrosarcomas. |
1986-12-19 |
2023-08-11 |
mouse |
| M S Kobrin, J Samsoondar, J E Kudlo. Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. II. Identification using a sequence-specific monoclonal antibody. The Journal of biological chemistry. vol 261. issue 31. 1986-11-26. PMID:3464598. |
untransformed bovine anterior pituitary cells cultured in serum-free defined medium secrete an epidermal growth factor (egf)-like peptide with an amino acid composition similar to rat or human alpha-transforming growth factor (alpha tgf). |
1986-11-26 |
2023-08-11 |
mouse |
| M S Kobrin, J Samsoondar, J E Kudlo. Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. II. Identification using a sequence-specific monoclonal antibody. The Journal of biological chemistry. vol 261. issue 31. 1986-11-26. PMID:3464598. |
the binding of 125i-peptide to mf9 was displaced by human alpha tgf but not by egf. |
1986-11-26 |
2023-08-11 |
mouse |
| T Akiyama, T Kadowaki, E Nishida, T Kadooka, H Ogawara, Y Fukami, H Sakai, F Takaku, M Kasug. Substrate specificities of tyrosine-specific protein kinases toward cytoskeletal proteins in vitro. The Journal of biological chemistry. vol 261. issue 31. 1986-11-26. PMID:3771552. |
among microfilament-related proteins examined, the purified egf receptor kinase phosphorylated the beta subunit, but not the alpha subunit, of fodrin on tyrosine residues with a km below the micromolar range. |
1986-11-26 |
2023-08-11 |
Not clear |
| T Akiyama, T Kadowaki, E Nishida, T Kadooka, H Ogawara, Y Fukami, H Sakai, F Takaku, M Kasug. Substrate specificities of tyrosine-specific protein kinases toward cytoskeletal proteins in vitro. The Journal of biological chemistry. vol 261. issue 31. 1986-11-26. PMID:3771552. |
when the phosphorylation of the tubulin subunits was examined, the egf receptor kinase preferred beta subunit to alpha subunit, but the src kinase phosphorylated both alpha and beta subunits to a similar extent. |
1986-11-26 |
2023-08-11 |
Not clear |