| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V K Han, A J D'Ercole, D C Le. Expression of transforming growth factor alpha during development. Canadian journal of physiology and pharmacology. vol 66. issue 8. 1988-12-22. PMID:3052745. |
one of these growth-regulating molecules, transforming growth factor alpha (tgf-alpha), is a 50 amino acid polypeptide that is related to epidermal growth factor (egf) and binds to the egf receptor. |
1988-12-22 |
2023-08-11 |
Not clear |
| S C Jacobs, M T Stor. Exocrine secretion of epidermal growth factor by the rat prostate: effect of adrenergic agents, cholinergic agents, and vasoactive intestinal peptide. The Prostate. vol 13. issue 1. 1988-10-26. PMID:3262216. |
egf secretion into rat prostatic fluid is under both alpha 1-adrenergic and cholinergic control. |
1988-10-26 |
2023-08-11 |
rat |
| L Sankaran, Y J Toppe. Progesterone and prolactin are both required for suppression of the induction of rat alpha-lactalbumin activity. Biochemical and biophysical research communications. vol 155. issue 2. 1988-10-25. PMID:3048255. |
alpha lactalbumin activity can be induced to some extent in pregnant rat mammary explants by insulin and hydrocortisone alone, and to a greater extent with prolactin in addition, or with egf in addition. |
1988-10-25 |
2023-08-11 |
rat |
| G G Skouteris, M G Ord, L A Stocke. Regulation of the proliferation of primary rat hepatocytes by eicosanoids. Journal of cellular physiology. vol 135. issue 3. 1988-09-02. PMID:3260899. |
dna synthesis in primary adult rat hepatocyte cultures was promoted by epidermal growth factor (egf), arachidonic acid, and prostaglandins e2 and f2 alpha (pge2 and pgf2 alpha). |
1988-09-02 |
2023-08-11 |
rat |
| G G Skouteris, M G Ord, L A Stocke. Regulation of the proliferation of primary rat hepatocytes by eicosanoids. Journal of cellular physiology. vol 135. issue 3. 1988-09-02. PMID:3260899. |
hepatocytes stimulated by egf or arachidonic acid released pge2 and pgf2 alpha into the culture medium. |
1988-09-02 |
2023-08-11 |
rat |
| C L Eaton, P Davies, M E Phillip. Growth factor involvement and oncogene expression in prostatic tumours. Journal of steroid biochemistry. vol 30. issue 1-6. 1988-08-11. PMID:3260310. |
the effects of egf, tgf alpha and 5 alpha-dihydrotestosterone on the growth of a prostatic epithelial cell line have been evaluated in clonal growth assays. |
1988-08-11 |
2023-08-11 |
human |
| D Kohda, C Kodama, R Kase, H Nomoto, K Hayashi, F Inagak. A comparative 1H NMR study of mouse alpha(1-53) and beta(2-53) epidermal growth factors. Biochemistry international. vol 16. issue 4. 1988-08-03. PMID:3260496. |
the three-dimensional structure of the mouse epidermal growth factor (egf) in solution was studied by comparison of the 1h nmr spectra of alpha egf (1-53) and beta egf (2-53, des-asparaginyl 1 form). |
1988-08-03 |
2023-08-11 |
mouse |
| I Lax, A Johnson, R Howk, J Sap, F Bellot, M Winkler, A Ullrich, B Vennstrom, J Schlessinger, D Givo. Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha. Molecular and cellular biology. vol 8. issue 5. 1988-07-29. PMID:3260329. |
chicken epidermal growth factor (egf) receptor: cdna cloning, expression in mouse cells, and differential binding of egf and transforming growth factor alpha. |
1988-07-29 |
2023-08-11 |
mouse |
| I Lax, A Johnson, R Howk, J Sap, F Bellot, M Winkler, A Ullrich, B Vennstrom, J Schlessinger, D Givo. Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha. Molecular and cellular biology. vol 8. issue 5. 1988-07-29. PMID:3260329. |
surprisingly, human transforming growth factor alpha (tgf-alpha) bound equally well or even better to the chicken egf receptor than to the human egf receptor. |
1988-07-29 |
2023-08-11 |
mouse |
| E Tahara, H Yokozak. [Growth factors as biological markers of malignancy]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 15. issue 4 Pt 2-1. 1988-07-29. PMID:3260465. |
the expressions of epidermal growth factor (egf), egf receptor, transforming growth factor (tgf) alpha and c-ha-ras p21 in human gastric carcinomas were studied immunohistochemically. |
1988-07-29 |
2023-08-11 |
human |
| E Tahara, H Yokozak. [Growth factors as biological markers of malignancy]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 15. issue 4 Pt 2-1. 1988-07-29. PMID:3260465. |
the incidences of cases with egf or synchronous expression of tgf alpha and c-ha-ras in metastatic tumors were significantly higher than those in primary tumors (p less than 0.05 or p less than 0.01). |
1988-07-29 |
2023-08-11 |
human |
| E Tahara, H Yokozak. [Growth factors as biological markers of malignancy]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 15. issue 4 Pt 2-1. 1988-07-29. PMID:3260465. |
patients with synchronous expression of egf and its receptor or tgf alpha and ras p21 had a far poorer prognosis than those without such synchronous expression. |
1988-07-29 |
2023-08-11 |
human |
| A Ristimäki, O Ylikorkala, J Perheentupa, L Viinikk. Epidermal growth factor stimulates prostacyclin production by cultured human vascular endothelial cells. Thrombosis and haemostasis. vol 59. issue 2. 1988-07-29. PMID:3291183. |
epidermal growth factor (egf) stimulated prostacyclin (pgi2) production by cultured human umbilical vein endothelial cells, as measured by radioimmunoassay of its stable metabolite 6-keto-prostaglandin f1 alpha. |
1988-07-29 |
2023-08-11 |
human |
| H Kurod. [Effects of phorbol esters and various growth factors on prostaglandin E2 synthesis by cultured porcine thyroid cells]. Nihon Naibunpi Gakkai zasshi. vol 64. issue 2. 1988-06-24. PMID:3259516. |
finally, other growth factors such as insulin (0.1-10 micrograms/ml), insulin like growth factor i (igf-1) (10(-9)-10(-7) m) and interleukin 1 alpha (1-100 ng/ml) also stimulated pge2 production by thyroid cells in the presence or absence of egf (10(-10)-10(-9) m). |
1988-06-24 |
2023-08-11 |
cattle |
| E Lazar, S Watanabe, S Dalton, M B Spor. Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities. Molecular and cellular biology. vol 8. issue 3. 1988-06-14. PMID:3285178. |
to study the relationship between the primary structure of transforming growth factor alpha (tgf-alpha) and some of its functional properties (competition with epidermal growth factor (egf) for binding to the egf receptor and induction of anchorage-independent growth), we introduced single amino acid mutations into the sequence for the fully processed, 50-amino-acid human tgf-alpha. |
1988-06-14 |
2023-08-11 |
human |
| E S Kimball, M C Fisher, F J Persic. Potentiation of Balb/3T3 fibroblast proliferative response by interleukin-1 and epidermal growth factor. Cellular immunology. vol 113. issue 2. 1988-06-01. PMID:3282679. |
unexpectedly, the response to recombinant il-1 alpha was only additive with egf. |
1988-06-01 |
2023-08-11 |
Not clear |
| A F Cutry, A J Kinniburgh, D R Twardzik, C E Wenne. Transforming growth factor alpha (TGF alpha) induction of C-FOS and C-MYC expression in C3H 10T1/2 cells. Biochemical and biophysical research communications. vol 152. issue 1. 1988-05-24. PMID:3258745. |
we find that egf and tgf alpha, which both utilize the egf receptor for signal generation, are able to stimulate dna synthesis in these cells with nearly superimposable kinetics; however, the stimulation by tgf alpha was slightly greater at nearly all time points assayed. |
1988-05-24 |
2023-08-11 |
Not clear |
| A F Cutry, A J Kinniburgh, D R Twardzik, C E Wenne. Transforming growth factor alpha (TGF alpha) induction of C-FOS and C-MYC expression in C3H 10T1/2 cells. Biochemical and biophysical research communications. vol 152. issue 1. 1988-05-24. PMID:3258745. |
a significant stimulation of c-myc and c-fos mrna levels is observed with both tgf alpha and egf; c-myc mrna levels show an 8-fold induction with both mitogens, while c-fos inductions were on the order of 12 to 14-fold at maximum. |
1988-05-24 |
2023-08-11 |
Not clear |
| A F Cutry, A J Kinniburgh, D R Twardzik, C E Wenne. Transforming growth factor alpha (TGF alpha) induction of C-FOS and C-MYC expression in C3H 10T1/2 cells. Biochemical and biophysical research communications. vol 152. issue 1. 1988-05-24. PMID:3258745. |
however, the induction of c-myc mrna by tgf alpha has slower kinetics than by egf. |
1988-05-24 |
2023-08-11 |
Not clear |
| R J Davis, N Gironès, M Fauche. Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor. The Journal of biological chemistry. vol 263. issue 11. 1988-05-23. PMID:3258597. |
epidermal growth factor (egf) and transforming growth factor alpha bind to a common receptor at the cell surface. |
1988-05-23 |
2023-08-11 |
human |