| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D R Twardzik, J E Ranchalis, B Moss, G J Todar. Vaccinia growth factor: newest member of the family of growth modulators which utilize the membrane receptor for EGF. Acta neurochirurgica. Supplementum. vol 41. 1988-05-12. PMID:3502224. |
a computer-aided search for structural homology between epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha) and sequences of proteins contained in the dayhoff data base reveals a statistically significant homology with a peptide predicted to be encoded by an early gene of vaccinia virus (vv), a member of the poxvirus family. |
1988-05-12 |
2023-08-11 |
monkey |
| R J Coffey, N J Sipes, C C Bascom, R Graves-Deal, C Y Pennington, B E Weissman, H L Mose. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer research. vol 48. issue 6. 1988-04-14. PMID:2449957. |
tgf alpha supplanted the epidermal growth factor (egf) requirement in these cells. |
1988-04-14 |
2023-08-11 |
mouse |
| R J Coffey, N J Sipes, C C Bascom, R Graves-Deal, C Y Pennington, B E Weissman, H L Mose. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer research. vol 48. issue 6. 1988-04-14. PMID:2449957. |
in contrast, tgf beta reversibly inhibited the growth of balb/mk cells by abrogating the stimulatory actions of egf or tgf alpha. |
1988-04-14 |
2023-08-11 |
mouse |
| R J Coffey, N J Sipes, C C Bascom, R Graves-Deal, C Y Pennington, B E Weissman, H L Mose. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer research. vol 48. issue 6. 1988-04-14. PMID:2449957. |
in addition, tgf alpha, as well as egf, enhanced tgf alpha gene expression. |
1988-04-14 |
2023-08-11 |
mouse |
| R J Coffey, N J Sipes, C C Bascom, R Graves-Deal, C Y Pennington, B E Weissman, H L Mose. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer research. vol 48. issue 6. 1988-04-14. PMID:2449957. |
tgf alpha provides a positive growth signal, while tgf beta is a potent inhibitor of growth even in the presence of such positive modulators as tgf alpha and egf. |
1988-04-14 |
2023-08-11 |
mouse |
| W R Hudgins, D N Orth, K Stromber. Variant forms of rat epidermal growth factor present in the urine of nude rats bearing human tumors. Cancer research. vol 48. issue 6. 1988-04-14. PMID:3257897. |
rats bearing a large cell lung cancer excreted unusually hydrophilic mr 6000 peptides that were chromatographically similar to transforming growth factor alpha on reverse phase high performance liquid chromatography but proved to be rat egf by radioimmunoassay (ria). |
1988-04-14 |
2023-08-11 |
human |
| W R Hudgins, D N Orth, K Stromber. Variant forms of rat epidermal growth factor present in the urine of nude rats bearing human tumors. Cancer research. vol 48. issue 6. 1988-04-14. PMID:3257897. |
all reacted fully in the rat egf ria and were negative for human egf and transforming growth factor alpha by ria. |
1988-04-14 |
2023-08-11 |
human |
| W R Hudgins, D N Orth, K Stromber. Variant forms of rat epidermal growth factor present in the urine of nude rats bearing human tumors. Cancer research. vol 48. issue 6. 1988-04-14. PMID:3257897. |
no human egf or transforming growth factor alpha was detected by ria in any of the active fractions from tumor-bearing rat urine. |
1988-04-14 |
2023-08-11 |
human |
| A B Gottlieb, C K Chang, D N Posnett, B Fanelli, J P Ta. Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes. The Journal of experimental medicine. vol 167. issue 2. 1988-04-13. PMID:3279155. |
transforming growth factor alpha (tgf-alpha) is a 50-amino acid peptide, previously demonstrated only in transformed cell lines and human tumors, which is structurally homologous to epidermal growth factor (egf). |
1988-04-13 |
2023-08-11 |
human |
| E G Bade, S Feindle. Liver epithelial cell migration induced by epidermal growth factor or transforming growth factor alpha is associated with changes in the gene expression of secreted proteins. In vitro cellular & developmental biology : journal of the Tissue Culture Association. vol 24. issue 2. 1988-04-04. PMID:3277938. |
rat liver epithelial cells are induced to migrate by epidermal growth factor (egf) or transforming growth factor alpha (tgf-alpha) in serum-free medium supplemented with insulin. |
1988-04-04 |
2023-08-11 |
rat |
| R M Buller, S Chakrabarti, J A Cooper, D R Twardzik, B Mos. Deletion of the vaccinia virus growth factor gene reduces virus virulence. Journal of virology. vol 62. issue 3. 1988-03-18. PMID:3339716. |
the vaccinia virus growth factor (vgf) gene encodes a polypeptide with amino acid sequence homology to epidermal growth factor (egf) and transforming growth factor alpha and is present twice, once at each end of the virus genome within the inverted terminal repetition. |
1988-03-18 |
2023-08-11 |
mouse |
| N Takasu, T Yamada, Y Shimiz. Epidermal growth factor (EGF), tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) and calcium ionophore A23187 increase cytoplasmic free calcium and stimulate arachidonic acid release and PGE2/6-keto PGF1 alpha production in cultured porcine thyroid cells. FEBS letters. vol 225. issue 1-2. 1988-01-26. PMID:3121392. |
epidermal growth factor (egf), tumor promoter 12-o-tetradecanoylphorbol 13-acetate (tpa) and calcium ionophore a23187 increase cytoplasmic free calcium and stimulate arachidonic acid release and pge2/6-keto pgf1 alpha production in cultured porcine thyroid cells. |
1988-01-26 |
2023-08-11 |
Not clear |
| N Takasu, T Yamada, Y Shimiz. Epidermal growth factor (EGF), tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) and calcium ionophore A23187 increase cytoplasmic free calcium and stimulate arachidonic acid release and PGE2/6-keto PGF1 alpha production in cultured porcine thyroid cells. FEBS letters. vol 225. issue 1-2. 1988-01-26. PMID:3121392. |
egf, tpa and a23187 stimulate arachidonic acid release and pge2 and 6-keto pgf1 alpha production; the maximum effects are obtained after 2-4 h incubation. |
1988-01-26 |
2023-08-11 |
Not clear |
| H L Moses, R J Coffey, E B Leof, R M Lyons, J Keski-Oj. Transforming growth factor beta regulation of cell proliferation. Journal of cellular physiology. Supplement. vol Suppl 5. 1988-01-21. PMID:3316252. |
tgf alpha is a 5.6 kd single chain molecule that shows sequence homology to epidermal growth factor (egf), binds to the egf receptor, and has biological effects very similar to those of egf. |
1988-01-21 |
2023-08-11 |
Not clear |
| G E Gutierrez, G R Mundy, R Derynck, E L Hewlett, M S Kat. Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor. The Journal of biological chemistry. vol 262. issue 33. 1987-12-29. PMID:3500168. |
the effects of transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf) on parathyroid hormone (pth)-responsive adenylate cyclase were examined in clonal rat osteosarcoma cells (umr-106) with the osteoblast phenotype. |
1987-12-29 |
2023-08-11 |
rat |
| J M Culouscou, M Remacle-Bonnet, F Garrouste, J Marvaldi, G Pommie. Simultaneous production of IGF-I and EGF competing growth factors by HT-29 human colon cancer line. International journal of cancer. vol 40. issue 5. 1987-12-21. PMID:3500134. |
although more active in radioreceptor assay than in radioimmunoassay, the egf-competing factor is distinct from tgf alpha or beta since it is unable to induce anchorage-independent growth of nrk or fr3t3 target cells in the presence or absence of exogenous egf. |
1987-12-21 |
2023-08-11 |
human |
| M Centrella, T L McCarthy, E Canali. Mitogenesis in fetal rat bone cells simultaneously exposed to type beta transforming growth factor and other growth regulators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 1. issue 4. 1987-11-16. PMID:3498658. |
in contrast, other factors such as epidermal growth factor (egf), basic fibroblast growth factor (bfgf), and type alpha tumor necrosis factor (tnf-alpha) limit the response of osteoblastic bone cells to tgf-beta. |
1987-11-16 |
2023-08-11 |
rat |
| N Hanai, G Nores, C R Torres-Méndez, S Hakomor. Modified ganglioside as a possible modulator of transmembrane signaling mechanism through growth factor receptors: a preliminary note. Biochemical and biophysical research communications. vol 147. issue 1. 1987-10-08. PMID:3498483. |
two types of modified gm3 strongly alter egf-dependent phosphorylation of the egf receptor in opposite directions, i.e., de-n-acetyl-gm3 (amino-gm3; neunh2 alpha 2----3gal beta 1----4glc beta 1----1 ceramide) strongly promotes tyrosine phosphorylation of the egf receptor of a431 cells, while lyso-gm3 (neunac alpha 2----3gal beta 1----4 glc beta----1 sphingosine) as well as gm3 inhibit tyrosine phosphorylation of the egf receptor in the same cells under the same conditions. |
1987-10-08 |
2023-08-11 |
Not clear |
| R J Coffey, A S Goustin, A M Soderquist, G D Shipley, J Wolfshohl, G Carpenter, H L Mose. Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model. Cancer research. vol 47. issue 17. 1987-09-30. PMID:2887281. |
three human colon cancer lines (sw480, sw620, widr) secrete different levels of transforming growth factor beta (tgf beta)-like and transforming growth factor alpha (tgf alpha)/epidermal growth factor (egf)-like molecules into serum-free conditioned media as measured by competing activity in tgf beta and egf radioreceptor assays. |
1987-09-30 |
2023-08-11 |
human |
| R B Kent, D A Fallows, E Geissler, T Glaser, J R Emanuel, P A Lalley, R Levenson, D E Housma. Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse. Proceedings of the National Academy of Sciences of the United States of America. vol 84. issue 15. 1987-08-26. PMID:2885848. |
dna probes for three distinct isoforms of the na,k-atpase alpha subunit mapped to three different mouse chromosomes: the alpha 1 gene (atpa-1) cosegregated with the egf gene on chromosome 3; alpha 2 (atpa-2) with the cytochrome p-450pb gene family/coumarin hydroxylase locus on chromosome 7; alpha 3 (atpa-3) with the alpha-spectrin gene on chromosome 1. |
1987-08-26 |
2023-08-11 |
mouse |