| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Popi. Separation of transforming growth factors TGF alpha and TGF beta during chromatographic purification of extracts from mouse C-234 tumors. Archivum immunologiae et therapiae experimentalis. vol 35. issue 6. 1989-05-22. PMID:3508041. |
tgf alpha stimulated mouse balb/c-3t3, rat nrk-49f and human a549 cells to form colonies in soft agar, and competed with 125i-labeled epidermal growth factor (egf) for binding to human placenta membrane receptors. |
1989-05-22 |
2023-08-11 |
mouse |
| G T Montelione, M E Winkler, L E Burton, E Rinderknecht, M B Sporn, G Wagne. Sequence-specific 1H-NMR assignments and identification of two small antiparallel beta-sheets in the solution structure of recombinant human transforming growth factor alpha. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 5. 1989-04-13. PMID:2646637. |
transforming growth factor alpha (tgf alpha) is a small mitogenic protein with about 35% sequence identity with epidermal growth factor (egf). |
1989-04-13 |
2023-08-11 |
mouse |
| G T Montelione, M E Winkler, L E Burton, E Rinderknecht, M B Sporn, G Wagne. Sequence-specific 1H-NMR assignments and identification of two small antiparallel beta-sheets in the solution structure of recombinant human transforming growth factor alpha. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 5. 1989-04-13. PMID:2646637. |
human tgf alpha and mouse egf, however, differ with respect to their structural dynamics, since amide proton/deuteron exchange is much faster for htgf alpha than for mouse egf at ph 3.5. |
1989-04-13 |
2023-08-11 |
mouse |
| T L Riss, D A Sirbask. Identification of a 15,000-molecular-weight form of immunoreactive transforming growth factor alpha in extracts of porcine pituitary. Journal of cellular physiology. vol 138. issue 2. 1989-03-29. PMID:2918041. |
the data suggest that in addition to the well-documented presence of bfgf, normal adult porcine pituitaries contain a 15-kda form of immunoreactive tgf alpha that binds to egf receptors and is mitogenic for mammary epithelial cells. |
1989-03-29 |
2023-08-11 |
mouse |
| J L Cruise, K A Houck, G Michalopoulo. Early events in the regulation of hepatocyte DNA synthesis: the role of alpha-adrenergic stimulation. Scandinavian journal of gastroenterology. Supplement. vol 151. 1989-03-24. PMID:2852400. |
in liver regeneration the administration of an alpha 1 blocking agent interfered with the first wave of regenerative dna synthesis, and this effect was preceded by an elevation in egf receptor number. |
1989-03-24 |
2023-08-11 |
Not clear |
| J L Cruise, K A Houck, G Michalopoulo. Early events in the regulation of hepatocyte DNA synthesis: the role of alpha-adrenergic stimulation. Scandinavian journal of gastroenterology. Supplement. vol 151. 1989-03-24. PMID:2852400. |
these data suggest that stimulation at the alpha 1-adrenergic receptor is among the early signals for liver regeneration and that heterologous regulation of egf receptors, similar to that observed in vitro, may be a part of the regenerative response. |
1989-03-24 |
2023-08-11 |
Not clear |
| J Ková. Hybridoma cultivation in defined serum-free media: growth-supporting substances. II. Insulin, other hormones, and growth factors. Folia biologica. vol 32. issue 5. 1989-03-24. PMID:3333488. |
hormones testosterone, triiodothyronine, and prostaglandin f2 alpha as well as growth factors egf and fgf had no growth-supporting effect. |
1989-03-24 |
2023-08-11 |
Not clear |
| C L Arteaga, E Coronado, C K Osborn. Blockade of the epidermal growth factor receptor inhibits transforming growth factor alpha-induced but not estrogen-induced growth of hormone-dependent human breast cancer. Molecular endocrinology (Baltimore, Md.). vol 2. issue 11. 1989-03-23. PMID:3221874. |
transforming growth factor alpha (tgf alpha), a polypeptide that binds to the epidermal growth factor (egf) receptor, is expressed and secreted by human breast cancer cells and has been proposed as an autocrine growth factor and as a mediator of the mitogenic effect of estrogen. |
1989-03-23 |
2023-08-11 |
human |
| C L Arteaga, E Coronado, C K Osborn. Blockade of the epidermal growth factor receptor inhibits transforming growth factor alpha-induced but not estrogen-induced growth of hormone-dependent human breast cancer. Molecular endocrinology (Baltimore, Md.). vol 2. issue 11. 1989-03-23. PMID:3221874. |
confirming other studies, these mcf-7 cells expressed tgf alpha with mrna transcripts of 4.8 kilobases identified by northern analysis, and they secreted tgf alpha activity measured by normal rat kidney colony-forming assay and an egf rra of conditioned medium. |
1989-03-23 |
2023-08-11 |
human |
| C L Arteaga, E Coronado, C K Osborn. Blockade of the epidermal growth factor receptor inhibits transforming growth factor alpha-induced but not estrogen-induced growth of hormone-dependent human breast cancer. Molecular endocrinology (Baltimore, Md.). vol 2. issue 11. 1989-03-23. PMID:3221874. |
528ab and 225ab bound to egf receptors in mcf-7 cells with high affinity [dissociation constant (kd) 0.1-0.5 nm] and blocked the binding of egf/tgf alpha. |
1989-03-23 |
2023-08-11 |
human |
| A Pandiella, J Meldoles. Reinforcement of signal generation at B2 bradykinin receptors by insulin, epidermal growth factors, and other growth factors. The Journal of biological chemistry. vol 264. issue 6. 1989-03-21. PMID:2536735. |
insulin and various growth factors (epidermal growth factor (egf), insulin-like growth factor, fibroblast growth factor, and transforming growth factor alpha), which fail to modify the resting [ca2+]i in pc12 rat pheochromocytoma and sknbe human neuroblastoma cells when administered alone, became capable of inducing [ca2+]i increases when administered a few (4-20) min after another agent, bradykinin. |
1989-03-21 |
2023-08-11 |
human |
| B J Silver, F E Jaffer, H E Abbou. Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 3. 1989-03-16. PMID:2536931. |
other growth factors, such as epidermal growth factor (egf), transforming growth factor type alpha, basic fibroblast growth factor (bfgf), and tumor necrosis factor type alpha (tnf-alpha) also are mitogenic for human mesangial cells and induce expression of the pdgf mrnas. |
1989-03-16 |
2023-08-11 |
human |
| L C Murphy, H Dotzla. Endogenous growth factor expression in T-47D, human breast cancer cells, associated with reduced sensitivity to antiproliferative effects of progestins and antiestrogens. Cancer research. vol 49. issue 3. 1989-02-23. PMID:2783382. |
in t-47d cells the two antiestrogens did not affect the accumulation of egf mrna and decreased the accumulation of tgf alpha mrna. |
1989-02-23 |
2023-08-11 |
human |
| L C Murphy, H Dotzla. Endogenous growth factor expression in T-47D, human breast cancer cells, associated with reduced sensitivity to antiproliferative effects of progestins and antiestrogens. Cancer research. vol 49. issue 3. 1989-02-23. PMID:2783382. |
as we have shown before, the progestin, medroxyprogesterone acetate, increased the level of both egf mrna and tgf alpha mrna in this cell line. |
1989-02-23 |
2023-08-11 |
human |
| L C Murphy, H Dotzla. Endogenous growth factor expression in T-47D, human breast cancer cells, associated with reduced sensitivity to antiproliferative effects of progestins and antiestrogens. Cancer research. vol 49. issue 3. 1989-02-23. PMID:2783382. |
the variant cell line, t-47d-5, had no detectable egf mrna and contained about 1/10th the level of tgf alpha mrna expressed by "wild type" t-47d cells. |
1989-02-23 |
2023-08-11 |
human |
| T A Bird, J Saklatval. IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 142. issue 1. 1989-02-01. PMID:2783320. |
the effect of the human ril-1 alpha and rtnf-alpha on the binding of 125i-labeled epidermal growth factor ([125i]egf) to its receptor (egf-r) has been studied in human gingival fibroblasts (hugi). |
1989-02-01 |
2023-08-11 |
human |
| J R Given. Familial polycystic ovarian disease. Endocrinology and metabolism clinics of North America. vol 17. issue 4. 1989-01-26. PMID:3058473. |
the theoretic means by which similar male and female gonadal abnormalities may be coupled in families through growth factors egf and alpha tgf are presented. |
1989-01-26 |
2023-08-11 |
human |
| M K Skinner, R J Coffe. Regulation of ovarian cell growth through the local production of transforming growth factor-alpha by theca cells. Endocrinology. vol 123. issue 6. 1989-01-17. PMID:3264238. |
transforming growth factor-alpha (tgf alpha) is a protein that is structurally and functionally related to egf and binds to the egf receptor. |
1989-01-17 |
2023-08-11 |
cattle |
| R H Charollais, J Meste. Resumption of cell cycle in BALB/c-3T3 fibroblasts arrested by polyamine depletion: relation with "competence" gene expression. Journal of cellular physiology. vol 137. issue 3. 1989-01-12. PMID:3142887. |
in this case, the levels of "competence" mrnas become low or undetectable within 3 h, egf (10 nm) plus insulin had only slightly greater effect than insulin alone on the progression of alpha dfmo-arrested cells. |
1989-01-12 |
2023-08-11 |
Not clear |
| Y Z Lin, G Caporaso, P Y Chang, X H Ke, J P Ta. Synthesis of a biological active tumor growth factor from the predicted DNA sequence of Shope fibroma virus. Biochemistry. vol 27. issue 15. 1988-12-22. PMID:2846046. |
the disulfide pairings were established by enzymatic digestion and mass spectrometry and were found to be similar to those of egf and tgf alpha. |
1988-12-22 |
2023-08-11 |
Not clear |