| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Anzano, A B Roberts, C A Meyers, A Komoriya, L C Lamb, J M Smith, M B Spor. Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer research. vol 42. issue 11. 1982-12-16. PMID:6290046. |
however, the combined action of either tgf alpha or egf (which by themselves are relatively ineffective in promoting growth of cells in soft agar) together with tgf beta results in a potent synergistic effect, with formation of large colonies. |
1982-12-16 |
2023-08-12 |
Not clear |
| M A Anzano, A B Roberts, C A Meyers, A Komoriya, L C Lamb, J M Smith, M B Spor. Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer research. vol 42. issue 11. 1982-12-16. PMID:6290046. |
it is suggested that tgf beta may be an important mediator of the known effects of both tgf alpha and egf on neoplastic transformation. |
1982-12-16 |
2023-08-12 |
Not clear |
| M Hiramatsu, K Hatakeyama, M Kumegawa, N Minam. Plasminogen activator activity in the subunits of mouse submandibular gland nerve-growth factor and epidermal growth factor. Archives of oral biology. vol 27. issue 6. 1982-10-29. PMID:6981400. |
the alpha subunit, beta subunit and low molecular weight egf showed no activity. |
1982-10-29 |
2023-08-12 |
mouse |
| Y Komeda, M Mochizuki, S Toj. [Studies on the secretion of human placental lactogen from human trophoblastic tissues (author's transl)]. Nihon Naibunpi Gakkai zasshi. vol 58. issue 5. 1982-10-21. PMID:6125418. |
these substances were (1), metal ions([ca2+], [k+], [mg2+], [na+]); (2) growth hormone and prolactin releasing or inhibiting factors (arginine, trh, somatostatin, dopamine); (3) lh-rh, dibutyryl cyclic-amp which stimulates hcg secretion; (4) prostaglandins f2 alpha and e2, bradykinin; (5) egf and insulin which have the receptors in the placenta; (6) glucose. |
1982-10-21 |
2023-08-12 |
human |
| A M Otto, M O Ulrich, L Jimenez de Asu. Epidermal growth factor initiates DNA synthesis after a time-dependent sequence of regulatory events in Swiss 3T3 cells--interactions with hormones and growth factors. Journal of cellular physiology. vol 108. issue 2. 1981-10-25. PMID:7021565. |
in contrast, both hydrocortisone and prostaglandin e1 (pge1) inhibit the stimulation of dna synthesis by egf only during the first 8 hours of the prereplicative period of decreasing the value of k. prostaglandin f2 alpha), which stimulates dna synthesis in a similar mode as egf, when added with egf has a synergistic effect on dna synthesis. |
1981-10-25 |
2023-08-12 |
Not clear |
| Y Yarden, M Gabbay, J Schlessinge. Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts. Biochimica et biophysica acta. vol 674. issue 2. 1981-08-20. PMID:6263349. |
however, studies based on fluorescence microscopy demonstrate that amines block the internalization of alpha 2-macroglobulin and egf by preventing it from clustering in clathrin coated pits. |
1981-08-20 |
2023-08-12 |
Not clear |
| Y Yarden, M Gabbay, J Schlessinge. Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts. Biochimica et biophysica acta. vol 674. issue 2. 1981-08-20. PMID:6263349. |
primary amines prevent the formation of visible patches of fluorescent egf and alpha 2-macroglobulin on the cell surface at least for 15 min, thus increasing the diffusion coefficients and the mobile fraction of egf-receptor complexes on the cell surface. |
1981-08-20 |
2023-08-12 |
Not clear |
| Y Yarden, M Gabbay, J Schlessinge. Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts. Biochimica et biophysica acta. vol 674. issue 2. 1981-08-20. PMID:6263349. |
amines do not block the endocytosis of egf and alpha 2-macroglobulin. |
1981-08-20 |
2023-08-12 |
Not clear |
| Y Yarden, M Gabbay, J Schlessinge. Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts. Biochimica et biophysica acta. vol 674. issue 2. 1981-08-20. PMID:6263349. |
on most cells fluorescent egf and alpha 2-macroglobulin are clustered and endocytosed within 30-45 min at 37 degrees c. 3. |
1981-08-20 |
2023-08-12 |
Not clear |
| L Jimenez de Asua, K M Richmond, A M Ott. Two growth factors and two hormones regulate initiation of DNA synthesis in cultured mouse cells through different pathways of events. Proceedings of the National Academy of Sciences of the United States of America. vol 78. issue 2. 1981-07-09. PMID:7015326. |
epidermal growth factor (egf) as well as prostaglandin f2 alpha (pgf2 alpha), when added to quiescent, confluent swiss 3t3 cells, stimulate the initiation of dna synthesis, which occurs with apparent first-order kinetics after a lag phase of 14-15 hr. |
1981-07-09 |
2023-08-12 |
mouse |
| L Jimenez de Asua, K M Richmond, A M Ott. Two growth factors and two hormones regulate initiation of DNA synthesis in cultured mouse cells through different pathways of events. Proceedings of the National Academy of Sciences of the United States of America. vol 78. issue 2. 1981-07-09. PMID:7015326. |
here we show that the addition of egf and pgf2 alpha together, however, results in a synergistic effect seen at the end of the lag phase, but only when egf and pgf2 alpha are added within 6 hr of each other. |
1981-07-09 |
2023-08-12 |
mouse |
| L Jimenez de Asua, K M Richmond, A M Ott. Two growth factors and two hormones regulate initiation of DNA synthesis in cultured mouse cells through different pathways of events. Proceedings of the National Academy of Sciences of the United States of America. vol 78. issue 2. 1981-07-09. PMID:7015326. |
insulin further increased the rate of entry into the s phage stimulated by egf and pgf2 alpha together, whereas hydrocortisone inhibited the stimulatory effect observed with either egf or pgf2 alpha alone. |
1981-07-09 |
2023-08-12 |
mouse |
| L Jimenez de Asua, K M Richmond, A M Ott. Two growth factors and two hormones regulate initiation of DNA synthesis in cultured mouse cells through different pathways of events. Proceedings of the National Academy of Sciences of the United States of America. vol 78. issue 2. 1981-07-09. PMID:7015326. |
these results suggest that, in spite of the common events responsible for the interactions with the two hormones, egf and pgf2 alpha must have differences in their sequences of events that initiate dna synthesis. |
1981-07-09 |
2023-08-12 |
mouse |
| L A Holladay, C R Savage, S Cohen, D Puet. Conformation and unfolding thermodynamics of epidermal growth factor and derivatives. Biochemistry. vol 15. issue 12. 1976-09-25. PMID:938633. |
from a comparison of the rotational strength of the 213-nm resolved cd band in native egf with that of standard proteins, egf is estimated to contain about 22% beta structure and no alpha helicity. |
1976-09-25 |
2023-08-11 |
mouse |