| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Nestor, S R Newman, B DeLustro, G J Todaro, A B Schreibe. A synthetic fragment of rat transforming growth factor alpha with receptor binding and antigenic properties. Biochemical and biophysical research communications. vol 129. issue 1. 1985-07-11. PMID:2408618. |
the blocked decapeptide had no mitogenic activity but prevented the mitogenic effect of egf and tgf alpha on fibroblasts. |
1985-07-11 |
2023-08-11 |
human |
| Y Ebina, L Ellis, K Jarnagin, M Edery, L Graf, E Clauser, J H Ou, F Masiarz, Y W Kan, I D Goldfin. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell. vol 40. issue 4. 1985-05-28. PMID:2859121. |
the overall structure is reminiscent of the egf receptor; the cross-linking domain of the alpha subunit and several regions of the beta subunit exhibit sequence homology with the egf receptor. |
1985-05-28 |
2023-08-11 |
human |
| b' R Davis, B Like, J Massagu\\xc3\\xa. Modulation of type alpha transforming growth factor receptors by a phorbol ester tumor promoter. Journal of cellular biochemistry. vol 27. issue 1. 1985-04-26. PMID:2984222.' |
we conclude that the tumor-promoting phorbol diester regulates both the affinity and phosphorylation state of the a431 cell receptor for the type alpha transforming growth factors, etgf and egf. |
1985-04-26 |
2023-08-11 |
Not clear |
| H Toh, H Hayashida, R Kikuno, T Yasunaga, T Miyat. Sequence similarity between EGF receptor and alpha 1-acid glycoprotein. Nature. vol 314. issue 6007. 1985-04-25. PMID:2983235. |
sequence similarity between egf receptor and alpha 1-acid glycoprotein. |
1985-04-25 |
2023-08-11 |
Not clear |
| M H Silver, J C Murray, R M Prat. Epidermal growth factor stimulates type-V collagen synthesis in cultured murine palatal shelves. Differentiation; research in biological diversity. vol 27. issue 3. 1985-01-09. PMID:6334002. |
under the influence of egf, there was a significant increase in synthesis of the alpha 1 (v) and alpha 2 (v) chains of type-v collagen. |
1985-01-09 |
2023-08-12 |
Not clear |
| F Ito, S Ito, N Shimiz. Transmembrane delivery of polypeptide growth factors bypassing the intrinsic cell surface receptors: synthesis and biological activity of a conjugate of epidermal growth factor with alpha 2-macroglobulin. Cell structure and function. vol 9. issue 2. 1985-01-03. PMID:6209020. |
epidermal growth factor (egf) was derivatized at the amino terminus with n-succinimidyl 3-(2-pyridyldithio)propionate and then cross-linked to the cysteinyl residues of alpha 2-macroglobulin (alpha 2m) via disulfide bonds. |
1985-01-03 |
2023-08-12 |
mouse |
| F Ito, S Ito, N Shimiz. Transmembrane delivery of polypeptide growth factors bypassing the intrinsic cell surface receptors: synthesis and biological activity of a conjugate of epidermal growth factor with alpha 2-macroglobulin. Cell structure and function. vol 9. issue 2. 1985-01-03. PMID:6209020. |
the egf-alpha 2m conjugate delivered egf into dense lysosomal fractions through binding to alpha 2m receptors in a variant of mouse swiss/3t3 fibroblasts, nr-6, which are deficient in egf receptors. |
1985-01-03 |
2023-08-12 |
mouse |
| F Ito, S Ito, N Shimiz. Transmembrane delivery of polypeptide growth factors bypassing the intrinsic cell surface receptors: synthesis and biological activity of a conjugate of epidermal growth factor with alpha 2-macroglobulin. Cell structure and function. vol 9. issue 2. 1985-01-03. PMID:6209020. |
this differential stimulation was due to the conjugate's binding to egf receptors since bacitracin, which completely inhibits [125i]alpha 2m binding to its receptors, inhibited conjugate binding by approximately 80%. |
1985-01-03 |
2023-08-12 |
mouse |
| F Ito, S Ito, N Shimiz. Transmembrane delivery of polypeptide growth factors bypassing the intrinsic cell surface receptors: synthesis and biological activity of a conjugate of epidermal growth factor with alpha 2-macroglobulin. Cell structure and function. vol 9. issue 2. 1985-01-03. PMID:6209020. |
thus, egf bound to and internalized through alpha 2m receptors does not function as a mediator for dna stimulation. |
1985-01-03 |
2023-08-12 |
mouse |
| K M Richmond, P N Riddle, R F Brook. Apparent desensitization of Swiss 3T3 cells to the mitogens FGF and vasopressin. Journal of cellular physiology. vol 121. issue 3. 1984-12-27. PMID:6334090. |
however, in our case, the loss of sensitivity was not selective for vasopressin but applied also to epidermal growth factor (egf) and to prostaglandin f2 alpha. |
1984-12-27 |
2023-08-12 |
Not clear |
| J Thyber. The microtubular cytoskeleton and the initiation of DNA synthesis. Experimental cell research. vol 155. issue 1. 1984-12-07. PMID:6489451. |
on the other hand, antimicrotubular drugs stimulate dna replication in serum-free cultures and enhance the stimulatory effect of insulin, epidermal growth factor (egf), fibroblast growth factor (fgf), and prostaglandin f2 alpha on entrance into s phase. |
1984-12-07 |
2023-08-12 |
Not clear |
| J E Kudlow, M J Khosravi, M S Kobrin, W W Ma. Inability of anti-epidermal growth factor receptor monoclonal antibody to block "autocrine" growth stimulation in transforming growth factor-secreting melanoma cells. The Journal of biological chemistry. vol 259. issue 19. 1984-11-14. PMID:6090450. |
no egf receptor could be detected by immunoprecipitation after fibroblasts were treated with egf or conditioned medium from the melanoma cells which secrete egf-like tgf (alpha tgf). |
1984-11-14 |
2023-08-12 |
mouse |
| J E Kudlow, M J Khosravi, M S Kobrin, W W Ma. Inability of anti-epidermal growth factor receptor monoclonal antibody to block "autocrine" growth stimulation in transforming growth factor-secreting melanoma cells. The Journal of biological chemistry. vol 259. issue 19. 1984-11-14. PMID:6090450. |
the antibody itself did not down-regulate the receptor but could block down-regulation caused by egf and alpha tgf. |
1984-11-14 |
2023-08-12 |
mouse |
| J E Kudlow, M J Khosravi, M S Kobrin, W W Ma. Inability of anti-epidermal growth factor receptor monoclonal antibody to block "autocrine" growth stimulation in transforming growth factor-secreting melanoma cells. The Journal of biological chemistry. vol 259. issue 19. 1984-11-14. PMID:6090450. |
despite its ability to block egf-stimulated growth and down-regulation in fibroblasts, the antibody was unable to block the growth and soft agar colony formation of alpha tgf-secreting melanoma cells, nor could the antibody detect egf receptor in these cells under the conditions developed to prevent down-regulation and lysosomal degradation of the egf receptor. |
1984-11-14 |
2023-08-12 |
mouse |
| J E Kudlow, M J Khosravi, M S Kobrin, W W Ma. Inability of anti-epidermal growth factor receptor monoclonal antibody to block "autocrine" growth stimulation in transforming growth factor-secreting melanoma cells. The Journal of biological chemistry. vol 259. issue 19. 1984-11-14. PMID:6090450. |
these studies suggest that these melanoma cells do not have the intact egf receptor and that the secretion of alpha tgf by these cells plays no role in their growth in culture. |
1984-11-14 |
2023-08-12 |
mouse |
| R Van Wijk, A M Otto, L Jimenez de Asu. Hyperthermia can enhance the initiation of DNA synthesis stimulated by growth factors in swiss mouse 3T3 cells. Experimental cell research. vol 153. issue 2. 1984-08-22. PMID:6376159. |
confluent quiescent swiss mouse 3t3 cells can be stimulated to initiate dna synthesis and to divide by epidermal growth factor (egf) and prostaglandin f2 alpha (pgf2 alpha), two mitogens of unrelated structure. |
1984-08-22 |
2023-08-12 |
mouse |
| R Van Wijk, A M Otto, L Jimenez de Asu. Hyperthermia can enhance the initiation of DNA synthesis stimulated by growth factors in swiss mouse 3T3 cells. Experimental cell research. vol 153. issue 2. 1984-08-22. PMID:6376159. |
heat treatment at 46 degrees c for up to 20 min of confluent quiescent cells, which has no mitogenic effect, can enhance the stimulatory effect of suboptimal concentrations of egf or pgf2 alpha on the initiation of dna synthesis. |
1984-08-22 |
2023-08-12 |
mouse |
| R Van Wijk, A M Otto, L Jimenez de Asu. Hyperthermia can enhance the initiation of DNA synthesis stimulated by growth factors in swiss mouse 3T3 cells. Experimental cell research. vol 153. issue 2. 1984-08-22. PMID:6376159. |
likewise the combination of egf and pgf2 alpha is synergistic on dna synthesis, and this effect is also not enhanced by the heat treatment. |
1984-08-22 |
2023-08-12 |
mouse |
| J D Morris, J C Metcalfe, G A Smith, T R Hesketh, M V Taylo. Some mitogens cause rapid increases in free calcium in fibroblasts. FEBS letters. vol 169. issue 2. 1984-06-13. PMID:6370723. |
stimulation with the mitogens vasopressin, epidermal growth factor (egf) or prostaglandin f2 alpha (pgf2 alpha) caused a very rapid increase in [ca2+]i to a maximum of 200-500 nm after 60-90 s. [ca2+]i declined thereafter to a level above that in quiescent cells which was maintained for at least 15 min. |
1984-06-13 |
2023-08-12 |
Not clear |
| R van Wijk, A M Otto, L Jimenez de Asu. Effect of serum and growth factors on heat sensitivity in Swiss mouse 3T3 cells. Journal of cellular physiology. vol 119. issue 2. 1984-06-05. PMID:6371027. |
stimulating quiescent cells with serum or with the specific growth factors epidermal growth factor (egf) and prostaglandin f2 alpha (pgf2 alpha) markedly increased the heat resistance to a 46 degrees c treatment, but only when the heat treatment, but only when the heat treatment was applied within 2-3 h after the addition. |
1984-06-05 |
2023-08-12 |
mouse |