| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Pisano, R M Green. Epidermal growth factor potentiates the induction of ornithine decarboxylase activity by prostaglandins in embryonic palate mesenchymal cells: effects on cell proliferation and glycosaminoglycan synthesis. Developmental biology. vol 122. issue 2. 1987-08-25. PMID:3109985. |
treatment of confluent cultures of mepm cells with egf (1-50 ng/ml) resulted in a dose-related increase in odc activity, while similar treatment with either pge2 or pgf2 alpha (at concentrations up to 1 microm) did not elicit a dose-dependent increase in enzyme activity. |
1987-08-25 |
2023-08-11 |
Not clear |
| M M Pisano, R M Green. Epidermal growth factor potentiates the induction of ornithine decarboxylase activity by prostaglandins in embryonic palate mesenchymal cells: effects on cell proliferation and glycosaminoglycan synthesis. Developmental biology. vol 122. issue 2. 1987-08-25. PMID:3109985. |
concurrent treatment of mepm cells with egf (20 ng/ml) and either pge2 or pgf2 alpha (0.1-10000 nm) resulted in a marked prostaglandin dose-dependent induction of odc activity, suggesting a strong cooperative interaction between these factors. |
1987-08-25 |
2023-08-11 |
Not clear |
| T L Riss, D A Sirbask. Growth and continuous passage of COMMA-D mouse mammary epithelial cells in hormonally defined serum-free medium. Cancer research. vol 47. issue 14. 1987-08-20. PMID:3297308. |
the growth-promoting characteristics of egf and transforming growth factor alpha were compared in sfm and were not distinguishable, showing identical dose-response curves. |
1987-08-20 |
2023-08-11 |
mouse |
| J P Ta. Synthesis of biologically active transforming growth factor alpha. International journal of peptide and protein research. vol 29. issue 3. 1987-08-12. PMID:3474216. |
synthetic and natural tgf alpha were indistinguishable from each other in hplc and in different assays, including the assay for anchorage-independent growth of normal rat kidney fibroblasts in soft agar, binding, and stimulating to epidermal growth factor (egf)-receptor protein kinase. |
1987-08-12 |
2023-08-11 |
rat |
| J P Ta. Synthesis of biologically active transforming growth factor alpha. International journal of peptide and protein research. vol 29. issue 3. 1987-08-12. PMID:3474216. |
furthermore, synthetic tgf alpha showed similar biological activities when compared with egf in these assays. |
1987-08-12 |
2023-08-11 |
rat |
| J P Ta. Synthesis of biologically active transforming growth factor alpha. International journal of peptide and protein research. vol 29. issue 3. 1987-08-12. PMID:3474216. |
thus, the chemical synthesis of tgf alpha provided convincing evidence that tgf alpha is functionally related to egf and is one of the active principles required for cellular transformation. |
1987-08-12 |
2023-08-11 |
rat |
| J M Siegfrie. Detection of human lung epithelial cell growth factors produced by a lung carcinoma cell line: use in culture of primary solid lung tumors. Cancer research. vol 47. issue 11. 1987-06-25. PMID:3032416. |
cm was superior to both egf and tgf alpha in stimulating growth of normal and neoplastic lung cells. |
1987-06-25 |
2023-08-11 |
human |
| J M Siegfrie. Detection of human lung epithelial cell growth factors produced by a lung carcinoma cell line: use in culture of primary solid lung tumors. Cancer research. vol 47. issue 11. 1987-06-25. PMID:3032416. |
egf also was inhibitory to tumor cells while tgf alpha stimulated both normal and tumor cell growth. |
1987-06-25 |
2023-08-11 |
human |
| J M Siegfrie. Detection of human lung epithelial cell growth factors produced by a lung carcinoma cell line: use in culture of primary solid lung tumors. Cancer research. vol 47. issue 11. 1987-06-25. PMID:3032416. |
the results suggest that autocrine factors may be important in non-small cell lung tumor cell growth and that differences in response to egf and tgf alpha may provide the basis for selective culturing of normal and neoplastic lung epithelial cells. |
1987-06-25 |
2023-08-11 |
human |
| I Novak-Hofer, W Küng, D Fabbro, U Eppenberge. Estrogen stimulates growth of mammary tumor cells ZR-75 without activation of S6 kinase and S6 phosphorylation. Difference from epidermal growth factor and alpha-transforming growth-factor-induced proliferation. European journal of biochemistry. vol 164. issue 2. 1987-06-05. PMID:3494604. |
growth of the human mammary tumor cell line zr-75-1 is stimulated by epidermal growth factor (egf) and alpha-type transforming growth factor (alpha tgf), as well as by estradiol (e2). |
1987-06-05 |
2023-08-11 |
human |
| I Novak-Hofer, W Küng, D Fabbro, U Eppenberge. Estrogen stimulates growth of mammary tumor cells ZR-75 without activation of S6 kinase and S6 phosphorylation. Difference from epidermal growth factor and alpha-transforming growth-factor-induced proliferation. European journal of biochemistry. vol 164. issue 2. 1987-06-05. PMID:3494604. |
the role of activation of s6 kinase and s6 phosphorylation in the egf(alpha tgf)-induced and e2-induced growth was investigated. |
1987-06-05 |
2023-08-11 |
human |
| I Novak-Hofer, W Küng, D Fabbro, U Eppenberge. Estrogen stimulates growth of mammary tumor cells ZR-75 without activation of S6 kinase and S6 phosphorylation. Difference from epidermal growth factor and alpha-transforming growth-factor-induced proliferation. European journal of biochemistry. vol 164. issue 2. 1987-06-05. PMID:3494604. |
maximal effects on growth are observed at 10 nm egf or alpha tgf. |
1987-06-05 |
2023-08-11 |
human |
| I Novak-Hofer, W Küng, D Fabbro, U Eppenberge. Estrogen stimulates growth of mammary tumor cells ZR-75 without activation of S6 kinase and S6 phosphorylation. Difference from epidermal growth factor and alpha-transforming growth-factor-induced proliferation. European journal of biochemistry. vol 164. issue 2. 1987-06-05. PMID:3494604. |
egf as well as alpha tgf treatment of serum-starved cells leads to rapid activation of s6 kinase; the activity is increased about tenfold after 30 min of egf treatment and declines with the time reaching about 25% of the maximal activity after 2 h of egf treatment. |
1987-06-05 |
2023-08-11 |
human |
| I Novak-Hofer, W Küng, D Fabbro, U Eppenberge. Estrogen stimulates growth of mammary tumor cells ZR-75 without activation of S6 kinase and S6 phosphorylation. Difference from epidermal growth factor and alpha-transforming growth-factor-induced proliferation. European journal of biochemistry. vol 164. issue 2. 1987-06-05. PMID:3494604. |
similar to the growth response, s6 kinase is activated at lower doses of egf than alpha tgf and shows a maximal response at 10 nm for both growth factors. |
1987-06-05 |
2023-08-11 |
human |
| I Novak-Hofer, W Küng, D Fabbro, U Eppenberge. Estrogen stimulates growth of mammary tumor cells ZR-75 without activation of S6 kinase and S6 phosphorylation. Difference from epidermal growth factor and alpha-transforming growth-factor-induced proliferation. European journal of biochemistry. vol 164. issue 2. 1987-06-05. PMID:3494604. |
the results suggest that different pathway are involved in e2-induced and egf(alpha tgf)-induced proliferation. |
1987-06-05 |
2023-08-11 |
human |
| J Keski-Oja, E B Leof, R M Lyons, R J Coffey, H L Mose. Transforming growth factors and control of neoplastic cell growth. Journal of cellular biochemistry. vol 33. issue 2. 1987-06-01. PMID:3553215. |
one of these, tgf alpha, is related to epidermal growth factor (egf) and binds to the egf receptor, whereas the other, tgf beta, is not structurally or functionally related to tgf alpha or egf and mediates its effects via distinct receptors. |
1987-06-01 |
2023-08-11 |
Not clear |
| N Takasu, S Sato, T Yamada, Y Shimiz. Epidermal growth factor (EGF) and tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulate PG synthesis and thymidine incorporation in cultured porcine thyroid cells. Biochemical and biophysical research communications. vol 143. issue 3. 1987-05-18. PMID:3494448. |
in cultured porcine thyroid cells, egf and tpa stimulate pge2 and 6-keto pgf1 alpha production; the maximum pg levels were obtained after 3-4 h incubation with egf or tpa; the addition of as little as 10(-11) m egf or 5 x 10(-11) m tpa resulted in increases in pge2 and 6-keto pgf1 alpha, and the maximum levels were obtained with 10(-8)-10(-7) m egf or tpa. |
1987-05-18 |
2023-08-11 |
Not clear |
| D S Salomon, I Perroteau, W R Kidwell, J Tam, R Derync. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. Journal of cellular physiology. vol 130. issue 3. 1987-05-08. PMID:3494020. |
human epidermal growth factor (egf) or human alpha-transforming growth factor (alpha tgf) can stimulate, in a dose-dependent fashion, the anchorage-independent growth of nmumg and nmumg/pyt cells in soft agar but fail to enhance the anchorage-independent growth of the nmumgrash cells. |
1987-05-08 |
2023-08-11 |
mouse |
| D S Salomon, I Perroteau, W R Kidwell, J Tam, R Derync. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. Journal of cellular physiology. vol 130. issue 3. 1987-05-08. PMID:3494020. |
likewise, human egf or human alpha tgf is also able to stimulate the anchorage-dependent growth of normal nmumg cells and nmumg/pyt cells in a serum-free medium supplemented with insulin, transferrin, fetuin, and laminin, or in medium containing low concentrations of serum, whereas these same growth factors under comparable culture conditions have little or no effect upon the anchorage-dependent growth of the ras-transformed nmumg-rash cells. |
1987-05-08 |
2023-08-11 |
mouse |
| D S Salomon, I Perroteau, W R Kidwell, J Tam, R Derync. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. Journal of cellular physiology. vol 130. issue 3. 1987-05-08. PMID:3494020. |
the biological refractoriness of the nmumg/rash cells to human egf or human alpha tgf is reflected by a reduction in the total number of cell surface receptors for egf and by an absence of a high-affinity population of binding sites for mouse [125l]egf on these cells as compared to the nmumg or nmumg/pyt cells. |
1987-05-08 |
2023-08-11 |
mouse |