| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Stromberg, W R Hudgin. Urinary transforming growth factors in neoplasia: separation of 125I-labeled transforming growth factor-alpha from epidermal growth factor in human urine. Cancer research. vol 46. issue 11. 1986-11-20. PMID:3019543. |
transforming growth factors of the alpha type (tgf-alpha), potentially present in normal human urine or urine from tumor-bearing patients, also promote anchorage-independent cell growth and compete with egf for membrane receptor binding. |
1986-11-20 |
2023-08-11 |
mouse |
| M E Winkler, T Bringman, B J Mark. The purification of fully active recombinant transforming growth factor alpha produced in Escherichia coli. The Journal of biological chemistry. vol 261. issue 29. 1986-11-17. PMID:3531211. |
recombinant human transforming growth factor alpha (tgf alpha), which is active as assessed by competition with epidermal growth factor (egf) for binding to the egf receptor, has been produced in escherichia coli and separated from misfolded and inactive forms of recombinant tgf alpha using reverse-phase high performance liquid chromatography. |
1986-11-17 |
2023-08-11 |
human |
| M E Winkler, T Bringman, B J Mark. The purification of fully active recombinant transforming growth factor alpha produced in Escherichia coli. The Journal of biological chemistry. vol 261. issue 29. 1986-11-17. PMID:3531211. |
the egf receptor binding activity of antibody affinity purified tgf alpha is comparable to that of high performance liquid chromatography-purified active tgf alpha, and is 0.55 mg of egf eq/mg of tgf alpha. |
1986-11-17 |
2023-08-11 |
human |
| M E Winkler, T Bringman, B J Mark. The purification of fully active recombinant transforming growth factor alpha produced in Escherichia coli. The Journal of biological chemistry. vol 261. issue 29. 1986-11-17. PMID:3531211. |
the disulfide arrangement of the active tgf alpha was determined after digestion with thermolysin, and found to be analogous to the disulfide arrangement previously determined for egf (savage, c. r., hash, j. h., and cohen, s. (1973) j. biol. |
1986-11-17 |
2023-08-11 |
human |
| A H Neufeld, M M Jumblatt, E D Matkin, G M Raymon. Maintenance of corneal endothelial cell shape by prostaglandin E2: effects of EGF and indomethacin. Investigative ophthalmology & visual science. vol 27. issue 10. 1986-11-13. PMID:3489692. |
corneal endothelial cells cultured in the presence of egf, indomethacin, and pge2 (0.5 microgram/ml) maintain their polygonal shape; pgf2 alpha is not effective at reversing the drugs' effects. |
1986-11-13 |
2023-08-11 |
rabbit |
| K M Bel. The preliminary characterization of mitogens secreted by embryonic chick wing bud tissues in vitro. Journal of embryology and experimental morphology. vol 93. 1986-09-17. PMID:3525735. |
furthermore, the effects of chick-derived mitogens were synergistically enhanced by insulin and pgf 2 alpha but remained unaffected by ecdgf, egf, fgf and msa. |
1986-09-17 |
2023-08-11 |
rat |
| J A Rhodes, J P Tam, U Finke, M Saunders, J Bernanke, W Silen, R A Murph. Transforming growth factor alpha inhibits secretion of gastric acid. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 11. 1986-07-09. PMID:3487083. |
transforming growth factor alpha (tgf-alpha), a protein secreted by transformed cells and related to epidermal growth factor (egf), was tested for its effects on gastric acid secretion. |
1986-07-09 |
2023-08-11 |
Not clear |
| J M McNeill, M J Reed, P A Beranek, C J Newton, M W Ghilchik, V H Jame. The effect of epidermal growth factor, transforming growth factor and breast tumour homogenates on the activity of oestradiol 17 beta hydroxysteroid dehydrogenase in cultured adipose tissue. Cancer letters. vol 31. issue 2. 1986-06-24. PMID:3486035. |
the effect of epidermal growth factor (egf), transforming growth factor (tgf alpha) and breast tumour homogenates on oestradiol 17 beta hydroxysteroid dehydrogenase (e2dh) activity has been examined using cultured human breast adipose tissue. |
1986-06-24 |
2023-08-11 |
human |
| K J Ibbotson, J Harrod, M Gowen, S D'Souza, D D Smith, M E Winkler, R Derynck, G R Mund. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 7. 1986-05-08. PMID:3485799. |
human recombinant transforming growth factor alpha (tgf alpha), which binds to the epidermal growth factor (egf) receptor and causes several biological effects similar to those caused by egf, was compared with murine egf for its effects on a number of parameters of bone cell metabolism. |
1986-05-08 |
2023-08-11 |
mouse |
| K J Ibbotson, J Harrod, M Gowen, S D'Souza, D D Smith, M E Winkler, R Derynck, G R Mund. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 7. 1986-05-08. PMID:3485799. |
tgf alpha effects on bone resorption in mouse calvariae were inhibited by indomethacin, suggesting that, like egf, its effects were mediated by prostaglandin synthesis. |
1986-05-08 |
2023-08-11 |
mouse |
| K J Ibbotson, J Harrod, M Gowen, S D'Souza, D D Smith, M E Winkler, R Derynck, G R Mund. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 7. 1986-05-08. PMID:3485799. |
tgf alpha had a different time course of action on bone resorption from that of egf, causing more rapid release of previously incorporated 45ca from bone cultures, suggesting that tgf alpha does not function on bone as a simple egf analogue. |
1986-05-08 |
2023-08-11 |
mouse |
| K J Ibbotson, J Harrod, M Gowen, S D'Souza, D D Smith, M E Winkler, R Derynck, G R Mund. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 7. 1986-05-08. PMID:3485799. |
tgf alpha also caused effects on osteoblast function resembling those of egf. |
1986-05-08 |
2023-08-11 |
mouse |
| K J Ibbotson, J Harrod, M Gowen, S D'Souza, D D Smith, M E Winkler, R Derynck, G R Mund. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 83. issue 7. 1986-05-08. PMID:3485799. |
the lowest concentration of tgf alpha (expressed as nanogram equivalents of egf per ml) required to produce a response in all of the systems tested was about 1/10th of that needed for egf to produce a similar effect. |
1986-05-08 |
2023-08-11 |
mouse |
| S D Holmes, G Spotts, R G Smit. Rat Sertoli cells secrete a growth factor that blocks epidermal growth factor (EGF) binding to its receptor. The Journal of biological chemistry. vol 261. issue 9. 1986-04-18. PMID:3005317. |
thus, the sertoli cells secrete a potent mitogen that is distinct from egf and alpha tgf. |
1986-04-18 |
2023-08-11 |
rat |
| R J Coffey, G D Shipley, H L Mose. Production of transforming growth factors by human colon cancer lines. Cancer research. vol 46. issue 3. 1986-03-21. PMID:3002610. |
production of both tgf alpha-like and tgf beta-like activity was quantitated, as were cellular receptors for these molecules, and growth response in soft agar to exogenous epidermal growth factor (egf) (as a substitute for tgf alpha) and tgf beta. |
1986-03-21 |
2023-08-11 |
human |
| M Centrella, E Canali. Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae. Proceedings of the National Academy of Sciences of the United States of America. vol 82. issue 21. 1985-12-05. PMID:2997787. |
bdgf did not displace 125i-labeled epidermal growth factor (egf) in a radioligand-receptor assay, indicating the absence of egf and transforming growth factor alpha (tgf-alpha). |
1985-12-05 |
2023-08-11 |
rat |
| R M Greene, M R Lloy. Effect of epidermal growth factor on synthesis of prostaglandins and cyclic AMP by embryonic palate mesenchymal cells. Biochemical and biophysical research communications. vol 130. issue 3. 1985-09-25. PMID:2992494. |
preincubation of mepm cells with egf enhanced, in a dose-dependent fashion, (1) the responsiveness of mepm cells to prostaglandin e1-induced elevation of intracellular levels of camp, and (2) the responsiveness of cells to calcium ionophore (a23187) and melittin-induced synthesis of prostaglandins e2 and f2 alpha. |
1985-09-25 |
2023-08-11 |
Not clear |
| P Stroobant, A P Rice, W J Gullick, D J Cheng, I M Kerr, M D Waterfiel. Purification and characterization of vaccinia virus growth factor. Cell. vol 42. issue 1. 1985-09-04. PMID:2410141. |
sequence analysis shows it to be a processed form of a polypeptide encoded in the vaccinia virus genome which is related to epidermal growth factor (egf) and alpha-transforming growth factor (alpha tgf). |
1985-09-04 |
2023-08-11 |
Not clear |
| P Stroobant, A P Rice, W J Gullick, D J Cheng, I M Kerr, M D Waterfiel. Purification and characterization of vaccinia virus growth factor. Cell. vol 42. issue 1. 1985-09-04. PMID:2410141. |
vvgf, unlike egf or alpha tgf, is glycosylated. |
1985-09-04 |
2023-08-11 |
Not clear |
| J J Nestor, S R Newman, B DeLustro, G J Todaro, A B Schreibe. A synthetic fragment of rat transforming growth factor alpha with receptor binding and antigenic properties. Biochemical and biophysical research communications. vol 129. issue 1. 1985-07-11. PMID:2408618. |
affinity was increased 100x to 0.2% of egf or tgf alpha binding by blocking the peptide ends. |
1985-07-11 |
2023-08-11 |
human |