| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R van Wijk, A M Otto, L Jimenez de Asu. Effect of serum and growth factors on heat sensitivity in Swiss mouse 3T3 cells. Journal of cellular physiology. vol 119. issue 2. 1984-06-05. PMID:6371027. |
when insulin (which is not mitogenic, but synergistic with egf and pgf2 alpha in these cells) was added alone or in combination with either egf or pgf2 alpha, it has no effect on the development of heat resistance. |
1984-06-05 |
2023-08-12 |
mouse |
| C H Macphee, A H Drummond, A M Otto, L Jimenez de Asu. Prostaglandin F2 alpha stimulates phosphatidylinositol turnover and increases the cellular content of 1,2-diacylglycerol in confluent resting Swiss 3T3 cells. Journal of cellular physiology. vol 119. issue 1. 1984-05-03. PMID:6584431. |
stimulation of phosphatidylinositol metabolism resulting in an increase in the cellular content of 1,2-diacylglycerol may thus constitute an event in the pathway leading to the initiation of dna synthesis in which pgf2 alpha differs in its action from egf. |
1984-05-03 |
2023-08-12 |
Not clear |
| J Martin-Pérez, M Siegmann, G Thoma. EGF, PGF2 alpha and insulin induce the phosphorylation of identical S6 peptides in swiss mouse 3T3 cells: effect of cAMP on early sites of phosphorylation. Cell. vol 36. issue 2. 1984-03-21. PMID:6319014. |
egf, pgf2 alpha and insulin induce the phosphorylation of identical s6 peptides in swiss mouse 3t3 cells: effect of camp on early sites of phosphorylation. |
1984-03-21 |
2023-08-12 |
mouse |
| M DiPaola, C H Keith, D Feldman, B Tycko, F R Maxfiel. Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides. Journal of cellular physiology. vol 118. issue 2. 1984-03-06. PMID:6319437. |
we have found that certain naphthalenesulfonamides [e.g., n-6(-aminohexyl)-5-chloro-1-naphthalenesulfonamide (w-7)] and phenothiazines [e.g., trifluoperazine (tfp)] induce a loss of cell-surface receptors for alpha 2-macroglobulin, and epidermal growth factor (egf) in fibroblasts. |
1984-03-06 |
2023-08-12 |
Not clear |
| M DiPaola, C H Keith, D Feldman, B Tycko, F R Maxfiel. Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides. Journal of cellular physiology. vol 118. issue 2. 1984-03-06. PMID:6319437. |
the extent of egf receptor loss is less than for alpha 2-macroglobulin, and the egf receptors do not reappear at the surface when w-7 is removed. |
1984-03-06 |
2023-08-12 |
Not clear |
| M DiPaola, C H Keith, D Feldman, B Tycko, F R Maxfiel. Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides. Journal of cellular physiology. vol 118. issue 2. 1984-03-06. PMID:6319437. |
the loss of alpha 2-macroglobulin and egf receptors occurs at concentrations which do not cause an increase in the ph of endocytic vesicles or the cytoplasm, indicating that these agents act by a mechanism distinct from the effect of other weak bases. |
1984-03-06 |
2023-08-12 |
Not clear |
| A W Burgess, C J Lloyd, E C Nic. Murine epidermal growth factor: heterogeneity on high resolution ion-exchange chromatography. The EMBO journal. vol 2. issue 11. 1984-01-27. PMID:6315413. |
techniques can be resolved into two species, egf alpha and egf beta. |
1984-01-27 |
2023-08-12 |
Not clear |
| A W Burgess, C J Lloyd, E C Nic. Murine epidermal growth factor: heterogeneity on high resolution ion-exchange chromatography. The EMBO journal. vol 2. issue 11. 1984-01-27. PMID:6315413. |
analysis by isoelectric focusing on agarose gels followed by transfer to nitrocellulose and silver staining showed that egf alpha could be further resolved into three sub-species which focused at ph 4.6, 4.3 and 4.1. |
1984-01-27 |
2023-08-12 |
Not clear |
| A W Burgess, C J Lloyd, E C Nic. Murine epidermal growth factor: heterogeneity on high resolution ion-exchange chromatography. The EMBO journal. vol 2. issue 11. 1984-01-27. PMID:6315413. |
egf beta (which also focused at ph 4.6) contained very small amounts of the species with isoelectric points of 4.1 and 4.3, probably due to slight contamination of this preparation by egf alpha. |
1984-01-27 |
2023-08-12 |
Not clear |
| A W Burgess, C J Lloyd, E C Nic. Murine epidermal growth factor: heterogeneity on high resolution ion-exchange chromatography. The EMBO journal. vol 2. issue 11. 1984-01-27. PMID:6315413. |
preparative separation of the sub-species of egf alpha was achieved by high performance anion-exchange chromatography at ph 6.5 on a pharmacia mono q column. |
1984-01-27 |
2023-08-12 |
Not clear |
| A W Burgess, C J Lloyd, E C Nic. Murine epidermal growth factor: heterogeneity on high resolution ion-exchange chromatography. The EMBO journal. vol 2. issue 11. 1984-01-27. PMID:6315413. |
however, two slightly different forms of [125i]egf alpha 1 (ph 4.6 species) were separable by anion-exchange chromatography on the mono q column. |
1984-01-27 |
2023-08-12 |
Not clear |
| M A Anzano, A B Roberts, J M Smith, M B Sporn, J E De Larc. Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors. Proceedings of the National Academy of Sciences of the United States of America. vol 80. issue 20. 1983-11-23. PMID:6604914. |
type alpha tgf (tgf-alpha), but not type beta tgf (tgf-beta), competes for binding to the egf receptor and induces the formation of small colonies (1,000-2,000 micron2) of normal rat kidney cells in soft agar. |
1983-11-23 |
2023-08-12 |
rat |
| M C Willingham, H T Haigler, D J Fitzgerald, M G Gallo, A V Rutherford, I H Pasta. The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells. Studies on A431, KB, and 3T3 cells, using multiple methods of labelling. Experimental cell research. vol 146. issue 1. 1983-08-26. PMID:6190668. |
double label experiments showed that egf is internalized together with alpha 2-macroglobulin and adenovirus particles. |
1983-08-26 |
2023-08-12 |
Not clear |
| A B Roberts, C A Frolik, M A Anzano, M B Spor. Transforming growth factors from neoplastic and nonneoplastic tissues. Federation proceedings. vol 42. issue 9. 1983-07-29. PMID:6303865. |
tgfs have been classified as type alpha or type beta based on their interactions with the receptor for epidermal growth factor (egf) and their requirement for egf (or an egf-like polypeptide) for functional activity. |
1983-07-29 |
2023-08-12 |
rat |
| R B Dickson, R Schlegel, M C Willingham, I H Pasta. Involvement of Na+ and HCO-3 in receptor-mediated endocytosis of alpha 2-macroglobulin, epidermal growth factor, and vesicular stomatitis virus. Journal of cellular physiology. vol 113. issue 3. 1983-02-25. PMID:6184377. |
alpha 2-macroglobulin (alpha 2m), epidermal growth factor (egf), and vesicular stomatitis virus (vsv) each enter cultured fibroblasts by receptor-mediated endocytosis. |
1983-02-25 |
2023-08-12 |
Not clear |
| E Canali. Effect of hormones and growth factors on alkaline phosphatase activity and collagen synthesis in cultured rat calvariae. Metabolism: clinical and experimental. vol 32. issue 1. 1983-02-25. PMID:6217395. |
insulin, pth, 1,25(oh)2d3, epidermal and fibroblast growth factors (egf, fgf) were examined for their effects on alkaline phosphatase activity and type i, [alpha 1 (i)]2 alpha 2, collagen synthesis in cultures of 21-day fetal rat calvariae. |
1983-02-25 |
2023-08-12 |
rat |
| G Thomas, J Martin-Pérez, M Siegmann, A M Ott. The effect of serum, EGF, PGF2 alpha and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis. Cell. vol 30. issue 1. 1982-12-18. PMID:6751557. |
the effect of serum, egf, pgf2 alpha and insulin on s6 phosphorylation and the initiation of protein and dna synthesis. |
1982-12-18 |
2023-08-12 |
Not clear |
| G Thomas, J Martin-Pérez, M Siegmann, A M Ott. The effect of serum, EGF, PGF2 alpha and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis. Cell. vol 30. issue 1. 1982-12-18. PMID:6751557. |
to test the connection between s6 phosphorylation and the activation of protein and dna synthesis, we compared the effects of serum, epidermal growth factor (egf), prostaglandin f2 alpha (pgf2 alpha) and insulin (which is not mitogenic in these cells). |
1982-12-18 |
2023-08-12 |
Not clear |
| G Thomas, J Martin-Pérez, M Siegmann, A M Ott. The effect of serum, EGF, PGF2 alpha and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis. Cell. vol 30. issue 1. 1982-12-18. PMID:6751557. |
pgf2 alpha (8.5 x 10(-7) m) alone acted similarly to egf (10(-9) m) and with egf produced a synergistic effect on all three processes. |
1982-12-18 |
2023-08-12 |
Not clear |
| M A Anzano, A B Roberts, C A Meyers, A Komoriya, L C Lamb, J M Smith, M B Spor. Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer research. vol 42. issue 11. 1982-12-16. PMID:6290046. |
tgb beta, purified by high-pressure liquid chromatography, will not induce formation of large colonies of cells in soft agar in the absence of tgf alpha or egf. |
1982-12-16 |
2023-08-12 |
Not clear |