| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Di Marco, J H Pierce, T P Fleming, M H Kraus, C J Molloy, S A Aaronson, P P Di Fior. Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype. Oncogene. vol 4. issue 7. 1989-09-07. PMID:2755700. |
alterations affecting the epidermal growth factor (egf)/transforming growth factor alpha (tgf alpha)-responsive mitogenic pathway are frequently detected in malignancies. |
1989-09-07 |
2023-08-11 |
human |
| M G Bachem, U Riess, A M Gressne. Liver fat storing cell proliferation is stimulated by epidermal growth factor/transforming growth factor alpha and inhibited by transforming growth factor beta. Biochemical and biophysical research communications. vol 162. issue 2. 1989-09-07. PMID:2787989. |
human epidermal growth factor (egf) and rat recombinant transforming growth factor alpha (tgfa) stimulated in a dose dependent manner the proliferation of rat liver fat storing cells (fsc) grown as primary culture in dulbecco's modification of eagles medium (dmem) with 0.5% fetal calf serum (fcs). |
1989-09-07 |
2023-08-11 |
human |
| K P Karey, D A Sirbask. Glutaraldehyde fixation increases retention of low molecular weight proteins (growth factors) transferred to nylon membranes for western blot analysis. Analytical biochemistry. vol 178. issue 2. 1989-08-25. PMID:2502042. |
radioiodinated epidermal growth factor (egf, mr 6045, pi 4.4), transforming growth factor type alpha (tgf alpha, mr 5623, pi 6.8), insulin-like growth factor (igf-i, mr 7649, pi 8.3), and basic fibroblast growth factor (bfgf, mr 15,000-17,000, pi 9.6) all transferred with high efficiency (74.1 +/- 12.6%) to a positively charged nylon membrane. |
1989-08-25 |
2023-08-11 |
Not clear |
| D Loo, C Rawson, A Helmrich, D Barne. Serum-free mouse embryo cells: growth responses in vitro. Journal of cellular physiology. vol 139. issue 3. 1989-08-10. PMID:2786879. |
insulin could be replaced by insulin-like growth factor i and egf could be replaced by transforming growth factor alpha in the same concentration range. |
1989-08-10 |
2023-08-11 |
mouse |
| J H Boal, S F Deamond, D E Callahan, S A Bruce, P O Ts'o, L S Ka. High-frequency 1H NMR studies of the effects of growth factors and phorbol esters on normal Syrian hamster diploid fibroblast cells. Cell biophysics. vol 14. issue 3. 1989-08-03. PMID:2472211. |
secondary culture sh fetal fibroblast cells were treated with epidermal growth factor (egf), fibroblast growth factor (fgf), phorbol-12,13-didecanoate (pdd) and 4-alpha-phorbol-12,13-didecanoate (4 alpha pdd). |
1989-08-03 |
2023-08-11 |
Not clear |
| M Chackal-Roy, C Niemeyer, M Moore, B R Zette. Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow. The Journal of clinical investigation. vol 84. issue 1. 1989-08-03. PMID:2786890. |
the proliferative activity found in bone marrow was not duplicated by any of a variety of purified growth factors including epidermal growth factor (egf), acidic or basic fibroblast growth factor (fgf), platelet-derived growth factor (pdgf), transforming growth factor (tgf) alpha or beta, interleukins 1, 2, 3, 4 or 6, granulocyte (g), macrophage (m) or granulocyte-macrophage (gm) colony stimulating factor (csf). |
1989-08-03 |
2023-08-11 |
human |
| A B Galway, M Oikawa, T Ny, A J Hsue. Epidermal growth factor stimulates tissue plasminogen activator activity and messenger ribonucleic acid levels in cultured rat granulosa cells: mediation by pathways independent of protein kinases-A and -C. Endocrinology. vol 125. issue 1. 1989-08-02. PMID:2544397. |
in this study, the effect of egf and its structural analog transforming growth factor-alpha (tgf alpha) on ovarian tpa mrna and activity was investigated. |
1989-08-02 |
2023-08-11 |
rat |
| A B Galway, M Oikawa, T Ny, A J Hsue. Epidermal growth factor stimulates tissue plasminogen activator activity and messenger ribonucleic acid levels in cultured rat granulosa cells: mediation by pathways independent of protein kinases-A and -C. Endocrinology. vol 125. issue 1. 1989-08-02. PMID:2544397. |
granulosa cells obtained from immature estrogen-treated rats were cultured with fsh or increasing doses of egf or tgf alpha before analysis of tpa activity using sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by a fibrin overlay technique. |
1989-08-02 |
2023-08-11 |
rat |
| A B Galway, M Oikawa, T Ny, A J Hsue. Epidermal growth factor stimulates tissue plasminogen activator activity and messenger ribonucleic acid levels in cultured rat granulosa cells: mediation by pathways independent of protein kinases-A and -C. Endocrinology. vol 125. issue 1. 1989-08-02. PMID:2544397. |
like fsh and gnrh, egf and tgf alpha stimulated the secretion of tpa activity in a dose- and time-dependent manner (onset, 12 h; maximum, 48 h). |
1989-08-02 |
2023-08-11 |
rat |
| A B Galway, M Oikawa, T Ny, A J Hsue. Epidermal growth factor stimulates tissue plasminogen activator activity and messenger ribonucleic acid levels in cultured rat granulosa cells: mediation by pathways independent of protein kinases-A and -C. Endocrinology. vol 125. issue 1. 1989-08-02. PMID:2544397. |
these results suggest that egf and tgf alpha induce tpa mrna and activity in granulosa cells through a pathway independent of protein kinases-a (fsh) and -c (gnrh and phorbol ester), providing an interesting model for future elucidation of the molecular mechanism involved in tpa gene expression. |
1989-08-02 |
2023-08-11 |
rat |
| N A Abdullah, B A Torres, M Basu, H M Johnso. Differential effects of epidermal growth factor, transforming growth factor-alpha, and vaccinia virus growth factor in the positive regulation of IFN-gamma production. Journal of immunology (Baltimore, Md. : 1950). vol 143. issue 1. 1989-07-21. PMID:2499624. |
in contrast to the positive signal of purified murine egf and recombinant human egf (both at 1 nm), neither synthetic tgf alpha nor recombinant vgf were capable of restoring competence for ifn-gamma production by th cell-depleted spleen cell cultures. |
1989-07-21 |
2023-08-11 |
human |
| A Ristimäk. Transforming growth factor alpha stimulates prostacyclin production by cultured human vascular endothelial cells more potently than epidermal growth factor. Biochemical and biophysical research communications. vol 160. issue 3. 1989-07-10. PMID:2658990. |
tgf alpha induced pgi2 production at 10-100 times lower concentrations than did epidermal growth factor (egf), although in stimulating endothelial cell growth the two factors were equipotent. |
1989-07-10 |
2023-08-11 |
human |
| H Lehväslaiho, L Lehtola, L Sistonen, K Alital. A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. The EMBO journal. vol 8. issue 1. 1989-06-22. PMID:2565807. |
egf or tgf alpha induced tyrosine phosphorylation of the chimeric receptor protein, stimulated dna synthesis of egf-r-neu expressing cells and led to a transformed cell morphology and growth in soft agar. |
1989-06-22 |
2023-08-11 |
mouse |
| J Lee, T J Dull, I Lax, J Schlessinger, A Ullric. HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor. The EMBO journal. vol 8. issue 1. 1989-06-22. PMID:2565808. |
this her1-2 receptor is targetted to the cell surface of transfected nih 3t3 cells, forms high and low affinity binding sites, and generates normal mitogenic and cell transforming signals upon interaction with egf or tgf alpha. |
1989-06-22 |
2023-08-11 |
human |
| T Bauknecht, M Kohler, I Janz, A Pfleidere. The occurrence of epidermal growth factor receptors and the characterization of EGF-like factors in human ovarian, endometrial, cervical and breast cancer. EGF receptors and factors in gynecological carcinomas. Journal of cancer research and clinical oncology. vol 115. issue 2. 1989-06-20. PMID:2785520. |
the egf-f of tissue extracts consists of egf and transforming growth factor tgf alpha) as shown by the results of egf and tgf alpha radioimmunoassays. |
1989-06-20 |
2023-08-11 |
human |
| D Evain-Brio. [Growth factors and embryonic development]. Reproduction, nutrition, developpement. vol 28. issue 6B. 1989-06-19. PMID:3073453. |
the best characterized group of growth factors includes the epidermal growth factor (egf), platelet-derived growth factor (pdgf), insulin and insulin-like growth factors (igf) and the transforming growth factors tgf alpha and tgf beta. |
1989-06-19 |
2023-08-11 |
mouse |
| T J Velu, L Beguinot, W C Vass, K Zhang, I Pastan, D R Low. Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay. Journal of cellular biochemistry. vol 39. issue 2. 1989-06-15. PMID:2565908. |
the dose-dependent growth response to egf of infected nr6 cells grown in serum-free medium can be used as a highly sensitive bioassay for the quantitative assessment of egf and transforming growth factor type alpha (tgf alpha). |
1989-06-15 |
2023-08-11 |
human |
| S Y Koyama, D K Podolsk. Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells. The Journal of clinical investigation. vol 83. issue 5. 1989-06-05. PMID:2708531. |
no egf transcripts were detected in any intestinal cell population, suggesting that the true ligand of the egf receptor was tgf alpha. |
1989-06-05 |
2023-08-11 |
rat |
| V Samuels, J M Barrett, S Bockman, C G Pantazis, M B Alle. Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas. The American journal of pathology. vol 134. issue 4. 1989-05-24. PMID:2705509. |
immunocytochemical studies using polyclonal antibodies to epidermal growth factor (egf) and transforming growth factor (tgf) alpha and beta were performed on 20 cases of human gliomas. |
1989-05-24 |
2023-08-11 |
human |
| A Macias, R Perez, T Hägerström, L Skoo. Transforming growth factor alpha in human mammary carcinomas and their metastases. Anticancer research. vol 9. issue 1. 1989-05-23. PMID:2705746. |
thirty one percent of the primary and 50 percent of the metastases expressed the transforming growth factor alpha with values ranging between 1.6 to 278 egf equivalent ng/mg tumour extract protein. |
1989-05-23 |
2023-08-11 |
human |