| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L E King, R E Gates, C M Stoscheck, L B Nanne. The EGF/TGF alpha receptor in skin. The Journal of investigative dermatology. vol 94. issue 6 Suppl. 1990-07-19. PMID:2191051. |
the egf/tgf alpha receptor is a single-chain glycoprotein (1186 amino acids) containing three functional domains: 1) an extracellular, glycosylated portion that binds egf; 2) a small transmembrane portion; and 3) a cytoplasmic portion that has the intrinsic tyrosine kinase activity and multiple sites that can be phosphorylated. |
1990-07-19 |
2023-08-11 |
human |
| B C Paria, S K De. Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 12. 1990-07-19. PMID:2352946. |
the inferior development of singly cultured embryos was markedly improved by addition of epidermal growth factor (egf) or transforming growth factor alpha or beta 1 (tgf-alpha or tgf-beta 1) to the culture medium. |
1990-07-19 |
2023-08-11 |
mouse |
| M Motomura, I Ozaki, N Fujio, Y Setoguchi, K Yamamoto, T Kariya, T Saka. Increment of pro alpha 1 (I) and pro alpha 1 (IV) collagen mRNA steady-state levels by EGF stimulated hepatocytes in primary culture. Gastroenterologia Japonica. vol 25. issue 2. 1990-07-12. PMID:2347480. |
increment of pro alpha 1 (i) and pro alpha 1 (iv) collagen mrna steady-state levels by egf stimulated hepatocytes in primary culture. |
1990-07-12 |
2023-08-11 |
Not clear |
| S Massoglia, A Gray, T J Dull, S Munemitsu, H J Kun, J Schlessinger, A Ullric. Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation. Molecular and cellular biology. vol 10. issue 6. 1990-06-25. PMID:1971419. |
however, the mitogenic and transforming signaling activities of an egf receptor carrying v-erbb-es4 (but not v-erbb-h) cytoplasmic sequences remained ligand independent, whereas those of a receptor with a v-erbb-h cytoplasmic domain were regulated by egf or transforming growth factor alpha. |
1990-06-25 |
2023-08-11 |
Not clear |
| G L'Allemain, K Seuwen, T Velu, J Pouyssegu. Signal transduction in hamster fibroblasts overexpressing the human EGF receptor. Growth factors (Chur, Switzerland). vol 1. issue 4. 1990-06-06. PMID:2699431. |
unlike nih 3t3 cells, ccl39 fibroblasts overexpressing hers are not transformed nor can a transformed phenotype be observed in response to egf or tgf alpha. |
1990-06-06 |
2023-08-11 |
human |
| E Tahar. Growth factors and oncogenes in human gastrointestinal carcinomas. Journal of cancer research and clinical oncology. vol 116. issue 2. 1990-05-24. PMID:2157713. |
multi-autocrine loops of the epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), platelet-derived growth factor (pdgf) and tgf beta system are expressed in human gastrointestinal carcinomas. |
1990-05-24 |
2023-08-11 |
human |
| E Tahar. Growth factors and oncogenes in human gastrointestinal carcinomas. Journal of cancer research and clinical oncology. vol 116. issue 2. 1990-05-24. PMID:2157713. |
tgf alpha and egf are the ligands of the tumor cells that overexpress egf receptor in esophageal carcinomas. |
1990-05-24 |
2023-08-11 |
human |
| E Tahar. Growth factors and oncogenes in human gastrointestinal carcinomas. Journal of cancer research and clinical oncology. vol 116. issue 2. 1990-05-24. PMID:2157713. |
the synchronous expression of egf and its receptor, as well as tgf alpha and ras p21, is evidently correlated with the depth of tumor invasion, metastasis and prognosis of gastric carcinomas. |
1990-05-24 |
2023-08-11 |
human |
| E Tahar. Growth factors and oncogenes in human gastrointestinal carcinomas. Journal of cancer research and clinical oncology. vol 116. issue 2. 1990-05-24. PMID:2157713. |
in addition to tgf alpha and egf, tgf beta and pdgf a chain produced by tumor cells may stimulate collagen synthesis not only by fibroblasts but also by tumor cells themselves, resulting in extensive progression and diffuse fibrosis of scirrhous gastric carcinomas. |
1990-05-24 |
2023-08-11 |
human |
| E Tahar. Growth factors and oncogenes in human gastrointestinal carcinomas. Journal of cancer research and clinical oncology. vol 116. issue 2. 1990-05-24. PMID:2157713. |
moreover, tgf alpha or egf and estrogen may also play a cooperative role in the development of scirrhous gastric carcinoma. |
1990-05-24 |
2023-08-11 |
human |
| G D Plowman, J M Green, V L McDonald, M G Neubauer, C M Disteche, G J Todaro, M Shoya. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. Molecular and cellular biology. vol 10. issue 5. 1990-05-21. PMID:2325643. |
we have isolated the gene for a novel growth regulator, amphiregulin (ar), that is evolutionarily related to epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha). |
1990-05-21 |
2023-08-11 |
human |
| Q R Wang, Z J Yan, N S Wol. Dissecting the hematopoietic microenvironment. VI. The effects of several growth factors on the in vitro growth of murine bone marrow CFU-F. Experimental hematology. vol 18. issue 4. 1990-05-17. PMID:2323369. |
growth factors, including interleukin 3 (il-3), interleukin 1 alpha (il-1 alpha), epidermal growth factor (egf), fibroblast growth factor (fgf), platelet-derived growth factor (pdgf), macrophage colony-stimulating factor (m-csf), granulocyte-macrophage colony-stimulating factor (gm-csf), and buffalo rat liver cell-conditioned medium (brl-cm) were tested for stimulation of the proliferation of cfu-f in a standard culture in both 2% and 15% serum. |
1990-05-17 |
2023-08-11 |
rat |
| G J Pepe, E D Albrech. Regulation of the primate fetal adrenal cortex. Endocrine reviews. vol 11. issue 1. 1990-05-04. PMID:2180686. |
these studies, coupled with the observation that activation of protein kinase c by egf or bfgf can block acth and/or other camp-induced increases in the activity of p-450(17 alpha), provide new insight into the subcellular mechanisms that underlie the regulation of fetal adrenal function. |
1990-05-04 |
2023-08-11 |
Not clear |
| R C Harris, K A Munger, K F Badr, K Takahash. Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 4. issue 6. 1990-05-01. PMID:2138579. |
intrarenal egf infusion increased urinary ipgf2 alpha by 300%, and in isolated glomeruli egf stimulated ipgf2 alpha by 38%, but did not affect thromboxane b2 production. |
1990-05-01 |
2023-08-11 |
rat |
| J M Sorvillo, E S McCormack, L Yanez, D Valenzuela, F H Reynold. Preparation and characterization of monoclonal antibodies specific for human transforming growth factor alpha. Oncogene. vol 5. issue 3. 1990-04-23. PMID:1690379. |
one mab 189-2130.1, which reacted with the carboxyl terminal seventeen amino acids, was able to block tgf alpha binding to the egf receptor. |
1990-04-23 |
2023-08-11 |
human |
| I Todd, L J Hammond, R F James, M Feldmann, G F Bottazz. Epidermal growth factor and transforming growth factor-alpha suppress HLA class II induction in human thyroid epithelial cells. Immunology. vol 69. issue 1. 1990-04-16. PMID:2107145. |
transforming growth factor-alpha (tgf alpha), which is structurally related to egf and interacts with the same cell surface receptor, has a similar inhibitory activity on the induction of thyrocyte hla class ii expression. |
1990-04-16 |
2023-08-11 |
human |
| J A Handler, R M Danilowicz, T E Elin. Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins. The Journal of biological chemistry. vol 265. issue 7. 1990-03-28. PMID:2105952. |
when pgf2 alpha (10(-8) to 10(-5) m) was added in the presence of egf, c-myc rna levels and thymidine incorporation were elevated up to 5-6-fold above levels observed with egf alone. |
1990-03-28 |
2023-08-11 |
Not clear |
| J A Fernandez-Pol, D J Klos, P D Hamilto. Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. Journal of cellular biochemistry. vol 41. issue 3. 1990-03-05. PMID:2613750. |
we have investigated the actions of transforming growth factor (tgf) type alpha on epidermal growth factor (egf) receptor mrna expression in mda-468 human mammary carcinoma cells in serum-free media. |
1990-03-05 |
2023-08-11 |
human |
| J A Fernandez-Pol, D J Klos, P D Hamilto. Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. Journal of cellular biochemistry. vol 41. issue 3. 1990-03-05. PMID:2613750. |
we found that exposure of mda-468 cells to tgf alpha results in elevated levels of egf receptor mrna. |
1990-03-05 |
2023-08-11 |
human |
| J A Fernandez-Pol, D J Klos, P D Hamilto. Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. Journal of cellular biochemistry. vol 41. issue 3. 1990-03-05. PMID:2613750. |
addition of tgf beta 1 enhanced the accumulation of egf receptor mrna induced by tgf alpha in a time- and dose-dependent manner. |
1990-03-05 |
2023-08-11 |
human |