| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Tilly, A L Johnso. Modulation of hen granulosa cell steroidogenesis and plasminogen activator activity hy transforming growth factor alpha. Growth factors (Chur, Switzerland). vol 3. issue 3. 1991-01-08. PMID:2173938. |
progesterone production stimulated by a camp analogue (8-bromo-camp, 1 mm) was also attenuated by egf (id50 = 75.9 nm) and tgf alpha (id50 = 0.08 nm), suggesting a post-camp site of inhibition by these growth factors on steroidogenesis. |
1991-01-08 |
2023-08-11 |
human |
| J L Tilly, A L Johnso. Modulation of hen granulosa cell steroidogenesis and plasminogen activator activity hy transforming growth factor alpha. Growth factors (Chur, Switzerland). vol 3. issue 3. 1991-01-08. PMID:2173938. |
finally, a 260-fold to 330-fold difference in the efficacy of tgf alpha versus egf to half-maximally stimulate cell-associated and secreted pa activity was observed. |
1991-01-08 |
2023-08-11 |
human |
| E M Valverius, F Ciardiello, N E Heldin, B Blondel, G Merlo, G Smith, M R Stampfer, M E Lippman, R B Dickson, D S Salomo. Stromal influences on transformation of human mammary epithelial cells overexpressing c-myc and SV40T. Journal of cellular physiology. vol 145. issue 2. 1991-01-08. PMID:2174061. |
however, a1n4-t or a1n4-myc cells, but not the parental a1n4 cells, form colonies in soft agar in response to either epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), or basic fibroblast growth factor (bfgf). |
1991-01-08 |
2023-08-11 |
mouse |
| T Leizer, J Cebon, J E Layton, J A Hamilto. Cytokine regulation of colony-stimulating factor production in cultured human synovial fibroblasts: I. Induction of GM-CSF and G-CSF production by interleukin-1 and tumor necrosis factor. Blood. vol 76. issue 10. 1990-12-31. PMID:1700731. |
finally, other cytokines, il-3, interferon gamma (ifn gamma), il-2, platelet-derived growth factor (pdgf), epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha), failed to stimulate either gm-csf or g-csf production, whether alone or in the presence of il-1. |
1990-12-31 |
2023-08-11 |
human |
| A MacDonald, G D Chisholm, F K Habi. Production and response of a human prostatic cancer line to transforming growth factor-like molecules. British journal of cancer. vol 62. issue 4. 1990-12-26. PMID:2223575. |
serum-free media conditioned by the androgen insensitive human prostate cancer cell line du145 showed immunological transforming growth factor-alpha (tgf alpha) activity, as well as competing activity in epidermal growth factor (egf) radioreceptor assays (rra). |
1990-12-26 |
2023-08-11 |
human |
| A MacDonald, G D Chisholm, F K Habi. Production and response of a human prostatic cancer line to transforming growth factor-like molecules. British journal of cancer. vol 62. issue 4. 1990-12-26. PMID:2223575. |
although du145 cells express high levels of egf receptors, dna synthesis was only minimally affected by exogenous egf and tgf alpha. |
1990-12-26 |
2023-08-11 |
human |
| M Höhne, V Becker-Rabbenstein, G F Kahl, H Taniguch. Regulation of cytochrome P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes. FEBS letters. vol 273. issue 1-2. 1990-12-13. PMID:2121542. |
epidermal growth factor (egf), transforming growth factor alpha (tgf alpha) and insulin, only egf or tgf alpha completely blocked cypia1 expression in the presence of the cypia1 inducer 3-methylcholanthrene (3-mc). |
1990-12-13 |
2023-08-11 |
mouse |
| A Sjöholm, N Welsh, S Sandler, C Hellerströ. Role of polyamines in mitogenic and secretory responses of pancreatic beta-cells to growth factors. The American journal of physiology. vol 259. issue 5 Pt 1. 1990-12-11. PMID:2240196. |
we have investigated the effects of glucose and the polypeptide growth factor growth hormone (gh), platelet-derived growth factor (pdgf), insulin-like growth factor i (igf-i), epidermal growth factor (egf), and transforming growth factor alpha (tgf alpha) on the polyamine content, in relation to proliferation and insulin secretion and content, of pancreatic beta-cells. |
1990-12-11 |
2023-08-11 |
rat |
| A Sjöholm, N Welsh, S Sandler, C Hellerströ. Role of polyamines in mitogenic and secretory responses of pancreatic beta-cells to growth factors. The American journal of physiology. vol 259. issue 5 Pt 1. 1990-12-11. PMID:2240196. |
in contrast, neither egf nor tgf alpha influenced the islet dna synthesis rate, polyamine content, insulin content, or insulin accumulation in culture medium. |
1990-12-11 |
2023-08-11 |
rat |
| P W Cook, R J Coffey, B E Magun, M R Pittelkow, G D Shiple. Expression and regulation of mRNA coding for acidic and basic fibroblast growth factor and transforming growth factor alpha in cells derived from human skin. Molecular endocrinology (Baltimore, Md.). vol 4. issue 9. 1990-12-07. PMID:1700283. |
in contrast, keratinocytes rapidly growing in the presence of epidermal growth factor (egf) contained transcripts for tgf alpha that increased substantially when these cells were treated with serum. |
1990-12-07 |
2023-08-11 |
human |
| P W Cook, R J Coffey, B E Magun, M R Pittelkow, G D Shiple. Expression and regulation of mRNA coding for acidic and basic fibroblast growth factor and transforming growth factor alpha in cells derived from human skin. Molecular endocrinology (Baltimore, Md.). vol 4. issue 9. 1990-12-07. PMID:1700283. |
this observation suggests that factors present in serum can elevate the levels of tgf alpha mrna beyond the levels already present in keratinocyte cultures growing in the presence of egf. |
1990-12-07 |
2023-08-11 |
human |
| S J Federspiel, S J DiMari, M L Guerry-Force, M A Haralso. Extracellular matrix biosynthesis by cultured fetal rat lung epithelial cells. II. Effects of acute exposure to epidermal growth factor and retinoic acid on collagen biosynthesis. Laboratory investigation; a journal of technical methods and pathology. vol 63. issue 4. 1990-12-04. PMID:2232701. |
evaluation of the molecular forms of type i collagen (the type i-heterotrimer-molecular composition [alpha 1 (i)]2 alpha 2(i) and the type i-homotrimer-molecular composition [alpha 1 (i)]3) synthesized under each condition revealed that egf minimally affected the production of either molecular form of type i collagen. |
1990-12-04 |
2023-08-11 |
rat |
| M Tateishi, T Ishida, T Mitsudomi, S Kaneko, K Sugimach. Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung. Cancer research. vol 50. issue 21. 1990-11-21. PMID:2208175. |
transforming growth factor alpha (tgf alpha) and epidermal growth factor (egf) were considered growth factors with epidermal growth factor receptor (egfr) as the receptor. |
1990-11-21 |
2023-08-11 |
human |
| M Tateishi, T Ishida, T Mitsudomi, S Kaneko, K Sugimach. Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung. Cancer research. vol 50. issue 21. 1990-11-21. PMID:2208175. |
in contrast, in the egfr-negative cases, there was no statistical difference between the 5-year survival rates of patients with either high tgf alpha or egf and low tgf alpha or egf. |
1990-11-21 |
2023-08-11 |
human |
| L D Murphy, E M Valverius, M Tsokos, L A Mickley, N Rosen, S E Bate. Modulation of EGF receptor expression by differentiating agents in human colon carcinoma cell lines. Cancer communications. vol 2. issue 10. 1990-11-14. PMID:2206777. |
the existence of an autocrine loop for self-stimulation of growth in malignant cells has been proposed for transforming growth factor-alpha (tgf alpha) and its receptor, the epidermal growth factor (egf) receptor, in a variety of malignant cell types. |
1990-11-14 |
2023-08-11 |
human |
| L D Murphy, E M Valverius, M Tsokos, L A Mickley, N Rosen, S E Bate. Modulation of EGF receptor expression by differentiating agents in human colon carcinoma cell lines. Cancer communications. vol 2. issue 10. 1990-11-14. PMID:2206777. |
in order to investigate whether there is a correlation between tgf alpha and egf receptor mrna expression and differentiation, we studied the effects of differentiating agents on seven human colon carcinoma cell lines. |
1990-11-14 |
2023-08-11 |
human |
| J Ben-Ezra, K Sheibani, D L Hwang, A Lev-Ra. Megakaryocyte synthesis is the source of epidermal growth factor in human platelets. The American journal of pathology. vol 137. issue 4. 1990-11-14. PMID:2221009. |
epidermal growth factor (egf) is known to be present in the alpha granules of human platelets; however the source of this egf, ie, whether it is taken up by the platelets from the circulation, or whether it is packaged into the platelets from the megakaryocyte during thrombopoiesis, is unknown. |
1990-11-14 |
2023-08-11 |
human |
| E Finzi, T Fleming, J H Pierc. Retroviral expression of transforming growth factor-alpha does not transform fibroblasts or keratinocytes. The Journal of investigative dermatology. vol 95. issue 4. 1990-11-06. PMID:2170538. |
we also investigated the effect of tgf alpha expression on the growth of balb/mk mouse keratinocytes, which require epidermal growth factor (egf) for proliferation. |
1990-11-06 |
2023-08-11 |
mouse |
| E Finzi, T Fleming, J H Pierc. Retroviral expression of transforming growth factor-alpha does not transform fibroblasts or keratinocytes. The Journal of investigative dermatology. vol 95. issue 4. 1990-11-06. PMID:2170538. |
however, retroviral expression of tgf alpha in balb/mk cells failed to relieve dependence on exogenously added egf (or tgf alpha) for cell growth. |
1990-11-06 |
2023-08-11 |
mouse |
| J R Hepler, R A Jeffs, W R Huckle, H E Outlaw, S G Rhee, H S Earp, T K Harde. Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways. The Biochemical journal. vol 270. issue 2. 1990-10-12. PMID:1698055. |
in intact wb cells, the capacity of egf, but not angiotensin ii, to stimulate inositol phosphate accumulation was correlated with its capacity to stimulate tyrosine phosphorylation of the 148 kda isoenzyme of phospholipase c. taken together, these findings suggest that, whereas angiotensin ii, [arg8]vasopressin and alpha 1-adrenergic receptors are linked to activation of one or more phospholipase(s) c by an unidentified g-protein(s), the egf receptor stimulates phosphoinositide hydrolysis by a different pathway, perhaps as a result of its capacity to stimulate tyrosine phosphorylation of phospholipase c-gamma. |
1990-10-12 |
2023-08-11 |
rat |