| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R Plymate, R C Hoop, R E Jones, L A Mate. Regulation of sex hormone-binding globulin production by growth factors. Metabolism: clinical and experimental. vol 39. issue 9. 1990-10-04. PMID:2168012. |
hep g2 cell cultures were incubated with insulin-like growth factor i (igf-i), epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha), or dehydroepiandrosterone (dhea). |
1990-10-04 |
2023-08-11 |
human |
| A J Blasband, D M Gilligan, L F Winchell, S T Wong, N C Luetteke, K T Rogers, D C Le. Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells. Oncogene. vol 5. issue 8. 1990-10-01. PMID:2392325. |
we have previously established that, in the absence of processing, membrane-anchored protgf alpha is biologically active and can interact with the egf receptor on adjacent cells, thereby inducing the receptor's intrinsic tyrosine kinase activity. |
1990-10-01 |
2023-08-11 |
mouse |
| A J Blasband, D M Gilligan, L F Winchell, S T Wong, N C Luetteke, K T Rogers, D C Le. Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells. Oncogene. vol 5. issue 8. 1990-10-01. PMID:2392325. |
nrk cells harboring these mutant constructs do not secrete mature growth factor, but do express biologically active protgf alpha on the cell surface as shown by their ability to induce the autophosphorylation of egf receptor on neighboring a431 cells in co-culture. |
1990-10-01 |
2023-08-11 |
mouse |
| A J Blasband, D M Gilligan, L F Winchell, S T Wong, N C Luetteke, K T Rogers, D C Le. Expression of the TGF alpha integral membrane precursor induces transformation of NRK cells. Oncogene. vol 5. issue 8. 1990-10-01. PMID:2392325. |
these results demonstrate that an interaction between egf receptor and the integral membrane precursor to tgf alpha can provide a mitogenic stimulus that leads to transformation. |
1990-10-01 |
2023-08-11 |
mouse |
| M A Heidaran, T P Fleming, D P Bottaro, G I Bell, P P Di Fiore, S A Aaronso. Transformation of NIH3T3 fibroblasts by an expression vector for the human epidermal growth factor precursor. Oncogene. vol 5. issue 8. 1990-10-01. PMID:2392327. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) bind to a common cell surface receptor that mediates their diverse biological activities. |
1990-10-01 |
2023-08-11 |
human |
| M A Heidaran, T P Fleming, D P Bottaro, G I Bell, P P Di Fiore, S A Aaronso. Transformation of NIH3T3 fibroblasts by an expression vector for the human epidermal growth factor precursor. Oncogene. vol 5. issue 8. 1990-10-01. PMID:2392327. |
nih3t3 fibroblasts transfected with either full-length egf precursor (preproegf) or protgf alpha cdna displayed distinct patterns of growth in culture. |
1990-10-01 |
2023-08-11 |
human |
| M A Heidaran, T P Fleming, D P Bottaro, G I Bell, P P Di Fiore, S A Aaronso. Transformation of NIH3T3 fibroblasts by an expression vector for the human epidermal growth factor precursor. Oncogene. vol 5. issue 8. 1990-10-01. PMID:2392327. |
at high cell density, where paracrine as well as autocrine effects of these growth factors would be evident, tgf alpha transfectants displayed at least as high or higher levels of egf receptor (egfr) tyrosine phosphorylation than preproegf transfectants. |
1990-10-01 |
2023-08-11 |
human |
| M A Heidaran, T P Fleming, D P Bottaro, G I Bell, P P Di Fiore, S A Aaronso. Transformation of NIH3T3 fibroblasts by an expression vector for the human epidermal growth factor precursor. Oncogene. vol 5. issue 8. 1990-10-01. PMID:2392327. |
since quantitative levels of ligand expression did not account for differences in their transforming properties, preproegf must be more efficient than protgf alpha in binding and/or activating egf receptors in an autocrine manner. |
1990-10-01 |
2023-08-11 |
human |
| R D Beauchamp, R M Lyons, E Y Yang, R J Coffey, H L Mose. Expression of and response to growth regulatory peptides by two human pancreatic carcinoma cell lines. Pancreas. vol 5. issue 4. 1990-09-12. PMID:2199964. |
tgf alpha and egf caused concentration-dependent stimulation of soft agar colony growth of the mia paca 2 cells, while only tgf alpha caused a significant but less dramatic stimulation of soft agar growth of the panc 1 cells. |
1990-09-12 |
2023-08-11 |
human |
| E Ohmura, T Tsushima, Y Kamiya, M Okada, N Onoda, K Shizume, H Demur. Epidermal growth factor and transforming growth factor alpha induce ascitic fluid in mice. Cancer research. vol 50. issue 16. 1990-09-12. PMID:2379155. |
peritoneal administration of epidermal growth factor (egf, 10 to 40 micrograms/mouse/wk) or transforming growth factor alpha (tgf-alpha, 10 to 40 micrograms/mouse/wk) via osmotic minipumps resulted in formation of bloody ascites. |
1990-09-12 |
2023-08-11 |
mouse |
| Y Miyachi, T Terazono, N Nagao, T Shoji, M Iri. Epidermal growth factor (EGF) receptors in human chorionic gonadotropin-producing tumor: transplantation in nude mice and the effect of EGF on tumor growth. The Journal of clinical endocrinology and metabolism. vol 71. issue 2. 1990-09-12. PMID:2380332. |
egf and transforming growth factor-alpha (tgf alpha) competed for [125i]egf binding, with 50% of the bound [125i]egf displaced by approximately 0.52 nm egf and 3.10 nm tgf alpha. |
1990-09-12 |
2023-08-11 |
mouse |
| H Eldar, Y Zisman, A Ullrich, E Livne. Overexpression of protein kinase C alpha-subtype in Swiss/3T3 fibroblasts causes loss of both high and low affinity receptor numbers for epidermal growth factor. The Journal of biological chemistry. vol 265. issue 22. 1990-09-04. PMID:1695906. |
hence, our studies imply that pkc alpha is involved in a cellular mechanism regulating the expression of egf receptor molecules in swiss/3t3 cells. |
1990-09-04 |
2023-08-11 |
Not clear |
| G Brooks, M W Goss, I R Har. Inhibition of [125I]epidermal growth factor binding to murine fibroblasts and keratinocytes by irradiation with UV-B light. Evidence for a protein kinase C-independent mechanism. Carcinogenesis. vol 11. issue 7. 1990-08-29. PMID:2372880. |
transfer of culture medium from irradiated cells to untreated control cells showed this effect was not induced as a result of transforming growth factor alpha release and subsequent binding to the egf receptor in these cells. |
1990-08-29 |
2023-08-11 |
Not clear |
| B L Lehman, R Smith, K D Leichty, C L Kauffman, R J Mille. Effects of epidermal growth factor and androgen influences on accessory sex glands in prepubertal Swiss-Webster mice. The Prostate. vol 16. issue 4. 1990-08-20. PMID:1695367. |
however, when a combined egf&5 alpha dht treatment was compared with 5 alpha dht treatment alone, the 5 alpha dht treatment effects on epithelial and lumen volumes and polyamine content were antagonized by the action of egf. |
1990-08-20 |
2023-08-11 |
mouse |
| K Grön, P Aula, L Peltone. Linkage of aspartylglucosaminuria (AGU) to marker loci on the long arm of chromosome 4. Human genetics. vol 85. issue 2. 1990-08-17. PMID:1973404. |
restriction fragment length polymorphism alleles for the adh2, adh3, egf, fg alpha and fg beta loci and blood group antigens for the mns locus were determined in a panel of 12 finnish agu families. |
1990-08-17 |
2023-08-11 |
Not clear |
| E Di Marco, J H Pierce, S A Aaronson, P P Di Fior. Mechanisms by which EGF receptor and TGF alpha contribute to malignant transformation. Natural immunity and cell growth regulation. vol 9. issue 3. 1990-08-17. PMID:2196461. |
mechanisms by which egf receptor and tgf alpha contribute to malignant transformation. |
1990-08-17 |
2023-08-11 |
human |
| G D Plowman, G S Whitney, M G Neubauer, J M Green, V L McDonald, G J Todaro, M Shoya. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 13. 1990-08-15. PMID:2164210. |
epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha), and amphiregulin are structurally and functionally related growth regulatory proteins. |
1990-08-15 |
2023-08-11 |
human |
| A Namiki, N Akatsuk. Vascular smooth muscle relaxation induced by epidermal growth factor is endothelium-dependent. European journal of pharmacology. vol 180. issue 2-3. 1990-08-13. PMID:2365006. |
in the presence of endothelium, egf relaxed vascular smooth muscle precontracted with 40 mm k+, 10(-5) m prostaglandin f2 alpha or 10(-6) m norepinephrine. |
1990-08-13 |
2023-08-11 |
rat |
| P E Petrides, S Bock, J Bovens, R Hofmann, G Jaks. Modulation of pro-epidermal growth factor, pro-transforming growth factor alpha and epidermal growth factor receptor gene expression in human renal carcinomas. Cancer research. vol 50. issue 13. 1990-07-23. PMID:2354442. |
we have analyzed the expression of the genes for the precursors of epidermal growth factor (pro-egf) and transforming growth factor alpha (protgf-alpha) as well as for the egf receptor in tissue specimens of a large number of adult patients with renal cell carcinoma. |
1990-07-23 |
2023-08-11 |
human |
| L E King, R E Gates, C M Stoscheck, L B Nanne. The EGF/TGF alpha receptor in skin. The Journal of investigative dermatology. vol 94. issue 6 Suppl. 1990-07-19. PMID:2191051. |
in responsive cells, all known effects of epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), and related proteins are mediated through binding to a specific membrane receptor. |
1990-07-19 |
2023-08-11 |
human |