| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Winkler, L O'Connor, M Winget, B Fendl. Epidermal growth factor and transforming growth factor alpha bind differently to the epidermal growth factor receptor. Biochemistry. vol 28. issue 15. 1989-11-22. PMID:2790004. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) compete with each other for binding to the egf receptor. |
1989-11-22 |
2023-08-11 |
Not clear |
| M E Winkler, L O'Connor, M Winget, B Fendl. Epidermal growth factor and transforming growth factor alpha bind differently to the epidermal growth factor receptor. Biochemistry. vol 28. issue 15. 1989-11-22. PMID:2790004. |
a monoclonal antibody to the egf receptor (13a9) has been identified which has only small effects on the binding of egf to the egf receptor, but which has very large effects on the binding of tgf alpha to the egf receptor; 5 micrograms/ml antibody has been shown to totally block 0.87 microm tgf alpha from binding to purified egf receptor and to lower both the high- and low-affinity binding constants of tgf alpha binding to egf receptor on a431 cells by about 10-fold. |
1989-11-22 |
2023-08-11 |
Not clear |
| M E Winkler, L O'Connor, M Winget, B Fendl. Epidermal growth factor and transforming growth factor alpha bind differently to the epidermal growth factor receptor. Biochemistry. vol 28. issue 15. 1989-11-22. PMID:2790004. |
the data suggest either that the antibody stabilizes a conformation of the egf receptor which is not favorable for tgf alpha binding or that it blocks a part of the surface of the receptor which is necessary for tgf alpha binding but not egf binding. |
1989-11-22 |
2023-08-11 |
Not clear |
| G Wilding, E Valverius, C Knabbe, E P Gelman. Role of transforming growth factor-alpha in human prostate cancer cell growth. The Prostate. vol 15. issue 1. 1989-11-09. PMID:2798227. |
conditioned media contained tgf alpha by radioimmunoassay (ria), transforming activity by rat kidney fibroblast (nrk) colony formation, and epidermal growth factor (egf) receptor competable activity by radioreceptor assay. |
1989-11-09 |
2023-08-11 |
human |
| T M Stevens, J E Chin, M McGowan, J Giannaras, J S Ker. Phospholipase A2 (PLA2) activity in rabbit chondrocytes. Agents and actions. vol 27. issue 3-4. 1989-11-09. PMID:2801329. |
the effects of recombinant interleukin-1 beta (ril-1 beta), recombinant tumor necrosis factor (rtnf alpha) and two growth factors, basic fibroblast growth factor (bfgf) and epidermal growth factor (egf) on pla2 activity and prostaglandin e2 (pge2) release were investigated using rabbit chondrocytes. |
1989-11-09 |
2023-08-11 |
rabbit |
| T M Stevens, J E Chin, M McGowan, J Giannaras, J S Ker. Phospholipase A2 (PLA2) activity in rabbit chondrocytes. Agents and actions. vol 27. issue 3-4. 1989-11-09. PMID:2801329. |
pge2 release significantly increased (p less than 0.05) when the chondrocytes were incubated with ril-1 beta, bfgf and egf alone, but not with rtnf alpha above. |
1989-11-09 |
2023-08-11 |
rabbit |
| P E Rippetoe, J W Olson, R J Altiere, T H Pauly, M N Gillespi. Epidermal growth factor augments reactivity to angiotensin II in the rat pulmonary circulation. The American review of respiratory disease. vol 140. issue 3. 1989-10-19. PMID:2789491. |
elevation of baseline tone with either prostaglandin (pg)f2 alpha or angiotensin ii also failed to unmask an effect of egf on pulmonary vascular resistance. |
1989-10-19 |
2023-08-11 |
rat |
| P E Rippetoe, J W Olson, R J Altiere, T H Pauly, M N Gillespi. Epidermal growth factor augments reactivity to angiotensin II in the rat pulmonary circulation. The American review of respiratory disease. vol 140. issue 3. 1989-10-19. PMID:2789491. |
constrictor responses to potassium chloride and to pgf2 alpha were unaffected by egf pretreatment. |
1989-10-19 |
2023-08-11 |
rat |
| M Laato, J Heino, V M Kähäri, J Niinikoski, B Gerdi. Epidermal growth factor (EGF) prevents methylprednisolone-induced inhibition of wound healing. The Journal of surgical research. vol 47. issue 4. 1989-10-10. PMID:2475671. |
methylprednisolone treatment resulted in a dose-dependent reduction in pro alpha 1(i) collagen mrna levels, which was partially inhibited by low egf concentrations (1 and 10 ng/ml). |
1989-10-10 |
2023-08-11 |
rat |
| P J Miettinen, J Perheentupa, T Otonkoski, A Lähteenmäki, P Panul. EGF- and TGF-alpha-like peptides in human fetal gut. Pediatric research. vol 26. issue 1. 1989-10-06. PMID:2788859. |
the presence of epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) immunoreactivities in fetal human tissues was studied immunohistochemically at different gestational ages. |
1989-10-06 |
2023-08-11 |
human |
| P J Miettinen, J Perheentupa, T Otonkoski, A Lähteenmäki, P Panul. EGF- and TGF-alpha-like peptides in human fetal gut. Pediatric research. vol 26. issue 1. 1989-10-06. PMID:2788859. |
egf and tgf alpha immunoreactivities were detected from the 20th gestational wk. |
1989-10-06 |
2023-08-11 |
human |
| P J Miettinen, J Perheentupa, T Otonkoski, A Lähteenmäki, P Panul. EGF- and TGF-alpha-like peptides in human fetal gut. Pediatric research. vol 26. issue 1. 1989-10-06. PMID:2788859. |
egf immunoreactivity was limited to the small intestine, but tgf alpha immunoreactive cells were present in the colon also. |
1989-10-06 |
2023-08-11 |
human |
| M Ascoli, D L Segalof. Regulation of the differentiated functions of Leydig tumor cells by epidermal growth factor. Annals of the New York Academy of Sciences. vol 564. 1989-10-05. PMID:2549837. |
there is increasing evidence for the production of egf (or related peptides such as transforming growth factor alpha) in several tissues, including the testes and ovaries. |
1989-10-05 |
2023-08-11 |
Not clear |
| H Z Sheng, A Turnley, M Murphy, C C Bernard, P F Bartlet. Epidermal growth factor inhibits the expression of myelin basic protein in oligodendrocytes. Journal of neuroscience research. vol 23. issue 4. 1989-10-03. PMID:2475642. |
the action of egf in these cultures could be mimicked by transforming growth factor-alpha (tgf alpha). |
1989-10-03 |
2023-08-11 |
mouse |
| R D Beauchamp, J A Barnard, C M McCutchen, J A Cherner, R J Coffe. Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. The Journal of clinical investigation. vol 84. issue 3. 1989-09-21. PMID:2760208. |
transforming growth factor alpha (tgf alpha) shares with epidermal growth factor (egf) structural homology (35%), a common cell-surface membrane receptor (tgf alpha/egf receptor), and a nearly identical spectrum of biological activity, including inhibition of gastric acid secretion. |
1989-09-21 |
2023-08-11 |
rat |
| R D Beauchamp, J A Barnard, C M McCutchen, J A Cherner, R J Coffe. Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. The Journal of clinical investigation. vol 84. issue 3. 1989-09-21. PMID:2760208. |
these findings, when interpreted in light of described actions of tgf alpha and egf, provide evidence that local production of tgf alpha could play an important role in the regulation of acid secretion and mucosal renewal in the stomach. |
1989-09-21 |
2023-08-11 |
rat |
| C B Siegall, V K Chaudhary, D J FitzGerald, I Pasta. Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin. The Journal of biological chemistry. vol 264. issue 24. 1989-09-13. PMID:2503515. |
the substitution of the cell recognition domain (domain ia) with a growth factor such as transforming growth factor alpha (tgf alpha), creates a cell-specific cytotoxic agent, tgf alpha-pe40, which kills cells bearing epidermal growth factor (egf) receptors. |
1989-09-13 |
2023-08-11 |
Not clear |
| S E Lynch, R B Colvin, H N Antoniade. Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds. The Journal of clinical investigation. vol 84. issue 2. 1989-09-08. PMID:2788174. |
six well-characterized human growth factors were chosen for detailed investigation by topical application to standardized skin wounds in swine: epidermal growth factor (egf), transforming growth factors alpha and beta (tgf-alpha and tgf-beta), fibroblast growth factor (fgf), insulin-like growth factor-i (igf-i), and platelet-derived growth factor (pdgf). |
1989-09-08 |
2023-08-11 |
human |
| F Ciardiello, N Hynes, N Kim, E M Valverius, M E Lippman, D S Salomo. Transformation of mouse mammary epithelial cells with the Ha-ras but not with the neu oncogene results in a gene dosage-dependent increase in transforming growth factor-alpha production. FEBS letters. vol 250. issue 2. 1989-09-07. PMID:2568949. |
there was also a decrease in the number of epidermal growth factor (egf) receptors on the nog-8 sr1 and nog-8 sr2 cells that is proportional to the amount of tgf alpha secreted. |
1989-09-07 |
2023-08-11 |
mouse |
| F Ciardiello, N Hynes, N Kim, E M Valverius, M E Lippman, D S Salomo. Transformation of mouse mammary epithelial cells with the Ha-ras but not with the neu oncogene results in a gene dosage-dependent increase in transforming growth factor-alpha production. FEBS letters. vol 250. issue 2. 1989-09-07. PMID:2568949. |
these effects were specific for ras because neu-transformed nog-8 cells grew in soft agar at a comparable level to nog-8 sr2 cells yet did not show any increase in tgf alpha production or change in egf receptor expression. |
1989-09-07 |
2023-08-11 |
mouse |