| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Fernandez-Pol, D J Klos, P D Hamilto. Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. Journal of cellular biochemistry. vol 41. issue 3. 1990-03-05. PMID:2613750. |
we also found that triiodothyronine at physiological concentrations exerts synergistic control on the action of tgf alpha alone, or in association with tgf beta 1, on egf receptor mrna expression. |
1990-03-05 |
2023-08-11 |
human |
| J A Fernandez-Pol, D J Klos, P D Hamilto. Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. Journal of cellular biochemistry. vol 41. issue 3. 1990-03-05. PMID:2613750. |
the results described here suggest that optimum regulation of egf receptor gene expression by tgf alpha is a complex process involving synergistic interactions with heterologous growth factors and hormones. |
1990-03-05 |
2023-08-11 |
human |
| S Nishibe, M I Wahl, P B Wedegaertner, J W Kim, S G Rhee, G Carpenter, J J Ki. Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 1. 1990-02-09. PMID:2153302. |
we examined the relative phosphorylation of plc-gamma and plc-beta-1 by the 170-kda native egf receptor molecule, the 66-kda cytoplasmic kinase domain of the egf receptor (arg647-ala1186), the alpha 2 beta 2 native insulin receptor, and the 48-kda cytoplasmic kinase domain of the insulin receptor beta subunit (gly947-ser1343). |
1990-02-09 |
2023-08-11 |
human |
| P S Tong, N N Horowitz, L A Wheele. Trans retinoic acid enhances the growth response of epidermal keratinocytes to epidermal growth factor and transforming growth factor beta. The Journal of investigative dermatology. vol 94. issue 1. 1990-02-09. PMID:2295827. |
we have observed that in serum and growth factor free medium (basal medium), epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) stimulated dna synthesis in mouse epidermal keratinocyte cultures (mkc) in a time- and dose-dependent manner. |
1990-02-09 |
2023-08-11 |
mouse |
| A W Burges. Epidermal growth factor and transforming growth factor alpha. British medical bulletin. vol 45. issue 2. 1990-02-08. PMID:2688814. |
the review concludes with a discussion of the relationship between the production of the egf or tgf alpha to cancer induction and/or metastasis. |
1990-02-08 |
2023-08-11 |
Not clear |
| S E Bates, E M Valverius, B W Ennis, D A Bronzert, J P Sheridan, M R Stampfer, J Mendelsohn, M E Lippman, R B Dickso. Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial cells. Endocrinology. vol 126. issue 1. 1990-02-07. PMID:2294006. |
to better understand the possible roles and interactions of transforming growth factor-alpha (tgf alpha) and its receptor, the epidermal growth factor (egf) receptor in human breast epithelium, we have studied the expression of tgf alpha and the egf receptor in a series of normal human mammary epithelial cells derived from reduction mammoplasty before in vitro propagation, during short term proliferation in vitro, and after immortalization. |
1990-02-07 |
2023-08-11 |
human |
| S E Bates, E M Valverius, B W Ennis, D A Bronzert, J P Sheridan, M R Stampfer, J Mendelsohn, M E Lippman, R B Dickso. Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial cells. Endocrinology. vol 126. issue 1. 1990-02-07. PMID:2294006. |
after establishment, propagation, and proliferation in vitro, the cells expressed high levels of both tgf alpha and egf receptor mrnas. |
1990-02-07 |
2023-08-11 |
human |
| S E Bates, E M Valverius, B W Ennis, D A Bronzert, J P Sheridan, M R Stampfer, J Mendelsohn, M E Lippman, R B Dickso. Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial cells. Endocrinology. vol 126. issue 1. 1990-02-07. PMID:2294006. |
184) failed to reduce the expression of either tgf alpha or the egf receptor. |
1990-02-07 |
2023-08-11 |
human |
| S E Bates, E M Valverius, B W Ennis, D A Bronzert, J P Sheridan, M R Stampfer, J Mendelsohn, M E Lippman, R B Dickso. Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial cells. Endocrinology. vol 126. issue 1. 1990-02-07. PMID:2294006. |
however, regulation of tgf alpha mrna could be demonstrated by withdrawal of egf from the medium or by antibody-mediated blockade of the egf receptor in 184 cells. |
1990-02-07 |
2023-08-11 |
human |
| S E Bates, E M Valverius, B W Ennis, D A Bronzert, J P Sheridan, M R Stampfer, J Mendelsohn, M E Lippman, R B Dickso. Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial cells. Endocrinology. vol 126. issue 1. 1990-02-07. PMID:2294006. |
both growth and levels of tgf alpha mrna expression are controlled by binding of ligand to the egf receptor. |
1990-02-07 |
2023-08-11 |
human |
| B D Price, J D Morris, A Hal. Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells. The Biochemical journal. vol 264. issue 2. 1990-02-06. PMID:2690829. |
insulin and prostaglandin f2 alpha (pgf2 alpha) stimulated ptdcho synthesis, but not its breakdown, whereas epidermal growth factor (egf) and bradykinin were without effect. |
1990-02-06 |
2023-08-11 |
Not clear |
| T A Bird, J Saklatval. Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. The Journal of biological chemistry. vol 265. issue 1. 1990-02-02. PMID:1688428. |
interleukin 1 or tumor necrosis factor alpha can cause a transient down-modulation of epidermal growth factor (egf) binding to quiescent fibroblast monolayers; the effect results from a reduction in egf receptor (egf-r) affinity and appears to be mediated by a protein kinase c (pkc)-independent mechanism. |
1990-02-02 |
2023-08-11 |
Not clear |
| K A Houck, G K Michalopoulo. Altered responses of regenerating hepatocytes to norepinephrine and transforming growth factor type beta. Journal of cellular physiology. vol 141. issue 3. 1990-01-24. PMID:2574179. |
norepinephrine (ne), acting through the alpha 1-adrenergic receptor, modules the response of rat hepatocytes in primary culture to transforming growth factor type beta 1 (tgf beta) by increasing the amount of tgf beta required for a given degree of inhibition of epidermal growth factor (egf)-induced dna synthesis (houck et al., j. |
1990-01-24 |
2023-08-11 |
rat |
| H Kanno, M Shinonaga, T Kuwabara, M Umed. [Growth factors produced by rat glioma cells: activities of transforming growth factors]. No to shinkei = Brain and nerve. vol 41. issue 9. 1990-01-24. PMID:2590559. |
the activity of alpha-type tgfs was examined by soft agar colony formation of nrk49f cells and inhibition of egf-binding to a 431 cells since tgf alpha has sequence homology with egf and binds to egf receptors on the cell membrane, while the activity of beta-type tgfs was examined by soft agar colony formation of 3t3 cells and nrk 49 f cells with the addition of egf. |
1990-01-24 |
2023-08-11 |
rat |
| H Kanno, M Shinonaga, T Kuwabara, M Umed. [Growth factors produced by rat glioma cells: activities of transforming growth factors]. No to shinkei = Brain and nerve. vol 41. issue 9. 1990-01-24. PMID:2590559. |
since amplification of egf receptor gene has been demonstrated in glioma, tgf alpha released by glioma may provide autocrine stimulation through the binding to the amplified egf receptors. |
1990-01-24 |
2023-08-11 |
rat |
| C B Siegall, Y H Xu, V K Chaudhary, S Adhya, D Fitzgerald, I Pasta. Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 3. issue 14. 1990-01-19. PMID:2556314. |
comparison with a similar molecule in which tgf alpha was placed at the carboxyl end of pe40 demonstrated the importance of the position of the cell recognition element; tgf alpha-pe40 was found to be about 30-fold more cytotoxic to cells bearing egf receptors than pe40-tgf alpha. |
1990-01-19 |
2023-08-11 |
Not clear |
| P A Gruppus. Expression of hepatic transforming growth factor receptors during late gestation in the fetal rat. Endocrinology. vol 125. issue 6. 1990-01-09. PMID:2555136. |
since a regulatory role for tgf alpha and tgf beta in fetal hepatic growth requires the presence of high affinity receptors, the receptors for these hormones were studied in membranes from normal fetuses at 17-21 days gestational age and growth-retarded fetuses of mothers fasted for 48 h. fetal liver membranes bound [125i]epidermal growth factor ([125i]egf) with high affinity (kd = 1-2 nm). |
1990-01-09 |
2023-08-11 |
rat |
| P A Gruppus. Expression of hepatic transforming growth factor receptors during late gestation in the fetal rat. Endocrinology. vol 125. issue 6. 1990-01-09. PMID:2555136. |
tgf alpha could compete with egf for the same binding site, albeit at 4-fold lower affinity. |
1990-01-09 |
2023-08-11 |
rat |
| P A Gruppus. Expression of hepatic transforming growth factor receptors during late gestation in the fetal rat. Endocrinology. vol 125. issue 6. 1990-01-09. PMID:2555136. |
affinity labeling of fetal liver membranes with [125i]tgf alpha identified the 170,000 mol wt (mr) egf receptor. |
1990-01-09 |
2023-08-11 |
rat |
| A Berchuck, P C MacDonald, L Milewich, M L Case. Transforming growth factor-beta inhibits prostaglandin production in amnion and A431 cells. Prostaglandins. vol 38. issue 4. 1989-12-13. PMID:2813812. |
inhibition of pg production by treatment of amnion or a431 cells with mefenamic acid did not alter thymidine incorporation into dna in response to egf; similarly, the addition of pge2 or pgf2 alpha to culture media of amnion or a431 cells had no effect on mitogenesis (in the absence or presence of egf). |
1989-12-13 |
2023-08-11 |
mouse |