| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M B Zhang, D D Woo, B D Howar. Transforming growth factor alpha and a PC12-derived growth factor induce neurites in PC12 cells and enhance the survival of embryonic brain neurons. Cell regulation. vol 1. issue 7. 1991-08-01. PMID:2098114. |
the pc12 variant-derived factor can be distinguished from tgf alpha and egf immunologically and by migration rates on reversed-phase high-performance liquid chromatography. |
1991-08-01 |
2023-08-11 |
human |
| U Rodeck, K Melber, R Kath, H D Menssen, M Varello, B Atkinson, M Herly. Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes. The Journal of investigative dermatology. vol 97. issue 1. 1991-07-29. PMID:2056188. |
neither neutralizing antisera to pdgf or tgf- alpha nor a monoclonal antibody to the epidermal growth factor (egf)-receptor inhibited melanoma cell growth. |
1991-07-29 |
2023-08-11 |
Not clear |
| J H Kim, E R Sherwood, D M Sutkowski, C Lee, J M Kozlowsk. Inhibition of prostatic tumor cell proliferation by suramin: alterations in TGF alpha-mediated autocrine growth regulation and cell cycle distribution. The Journal of urology. vol 146. issue 1. 1991-07-26. PMID:2056586. |
our studies, and others, suggest that the androgen-independent human prostatic carcinoma cell lines pc3 and du145 proliferate via autocrine growth mechanisms mediated by transforming growth factor alpha (tgfa) and its receptor, the epidermal growth factor (egf) receptor. |
1991-07-26 |
2023-08-11 |
human |
| G Schultz, D S Rotatori, W Clar. EGF and TGF-alpha in wound healing and repair. Journal of cellular biochemistry. vol 45. issue 4. 1991-07-17. PMID:2045428. |
two peptide growth factors which may play important roles in normal wound healing in tissues such as skin, cornea, and gastrointestinal tract are the structurally related peptides epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha). |
1991-07-17 |
2023-08-11 |
rat |
| S Suemori, C Ciacci, D K Podolsk. Regulation of transforming growth factor expression in rat intestinal epithelial cell lines. The Journal of clinical investigation. vol 87. issue 6. 1991-07-10. PMID:2040702. |
addition of the transforming growth factor alpha (tgf alpha) homologue epidermal growth factor (egf) to media of subconfluent iec-6 cells led to autocrine stimulation of tgf alpha expression as well as increased expression of the transforming growth factor beta 1 (tgf beta 1). |
1991-07-10 |
2023-08-11 |
rat |
| S Suemori, C Ciacci, D K Podolsk. Regulation of transforming growth factor expression in rat intestinal epithelial cell lines. The Journal of clinical investigation. vol 87. issue 6. 1991-07-10. PMID:2040702. |
increased expression of tgf alpha was maximal between 3 and 6 h after addition of egf and subsequently declined coincident with increasing level of expression of tgf beta 1, which achieved maximal levels 6 h after addition of egf and was sustained for more than 12 h. addition of tgf beta 1 also led to autocrine induction of its own expression coincident with suppression of tgf alpha expression. |
1991-07-10 |
2023-08-11 |
rat |
| S Kurata, R Hat. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative. The Journal of biological chemistry. vol 266. issue 15. 1991-06-25. PMID:2033086. |
the accumulation of pro alpha 1(i) and pro alpha 2(i) mrnas and the transcriptional activity of these genes were determined in human skin fibroblasts in order to investigate site(s) of regulation of type i collagen production by human egf in the absence and presence of l-ascorbic acid 2-phosphate (asc 2-p), a long-acting vitamin c derivative. |
1991-06-25 |
2023-08-11 |
human |
| S Kurata, R Hat. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative. The Journal of biological chemistry. vol 266. issue 15. 1991-06-25. PMID:2033086. |
human egf (10 ng/ml) used alone reduced the steady state levels of mrnas for pro alpha 1(i) and pro alpha 2(i) chains and transcriptional activity of these genes in vitro by 45%. |
1991-06-25 |
2023-08-11 |
human |
| D R Hofer, E R Sherwood, W D Bromberg, J Mendelsohn, C Lee, J M Kozlowsk. Autonomous growth of androgen-independent human prostatic carcinoma cells: role of transforming growth factor alpha. Cancer research. vol 51. issue 11. 1991-06-21. PMID:2032218. |
the purpose of the present study was to investigate the role of transforming growth factor alpha (tgf-alpha) and its receptor, the epidermal growth factor (egf) receptor, in the regulation of pc3 cell proliferation. |
1991-06-21 |
2023-08-11 |
human |
| S M Rashed, T B Pate. Regulation of hepatic energy metabolism by epidermal growth factor. European journal of biochemistry. vol 197. issue 3. 1991-06-20. PMID:1903108. |
additionally, experiments involving pulsatile infusion of either egf or phenylephrine into livers demonstrated that, unlike the alpha 1-adrenergic receptor, homologous desensitization of the egf receptor occurs. |
1991-06-20 |
2023-08-11 |
rat |
| A Chakravarthy, L C Chen, D Mehta, A W Hamburge. Modulation of epidermal growth factor receptors by gamma interferon in a breast cancer cell line. Anticancer research. vol 11. issue 1. 1991-05-23. PMID:1902074. |
growth inhibition by gamma but not alpha interferon was associated with a decrease in the number of egf receptors (egfrs) after 5 days. |
1991-05-23 |
2023-08-11 |
human |
| A Chakravarthy, L C Chen, D Mehta, A W Hamburge. Modulation of epidermal growth factor receptors by gamma interferon in a breast cancer cell line. Anticancer research. vol 11. issue 1. 1991-05-23. PMID:1902074. |
scatchard analysis of receptor binding data revealed that gamma but not alpha interferon reduced the number of available egf receptor binding sites without any change in the affinity of the receptor. |
1991-05-23 |
2023-08-11 |
human |
| J L Merchant, B Demediuk, S J Bran. A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter. Molecular and cellular biology. vol 11. issue 5. 1991-05-21. PMID:2017173. |
epidermal growth factor (egf) and transforming growth factor alpha are important determinants of mucosal integrity in the gastrointestinal tract, and they act both directly and indirectly to prevent ulceration in the stomach. |
1991-05-21 |
2023-08-11 |
human |
| M Otsu, I Hiles, I Gout, M J Fry, F Ruiz-Larrea, G Panayotou, A Thompson, R Dhand, J Hsuan, N Tott. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell. vol 65. issue 1. 1991-05-13. PMID:1707345. |
the active pi3-kinase complex containing p85 alpha or p85 beta and the 110 kd protein binds to pdgf but not egf receptors. |
1991-05-13 |
2023-08-11 |
cattle |
| J L Barnes, K A Heve. Glomerular mesangial cell migration. Response to platelet secretory products. The American journal of pathology. vol 138. issue 4. 1991-05-06. PMID:2012174. |
examination of specific platelet alpha granule secretory proteins disclosed a potent mesangial cell migratory response to platelet-released fibronectin (fn), but not to transforming growth factor-alpha (tgf-alpha), -beta (tgf-beta), epidermal growth factor (egf), or platelet factor 4 (pf4). |
1991-05-06 |
2023-08-11 |
rat |
| M F Crouc. Growth factor-induced cell division is paralleled by translocation of Gi alpha to the nucleus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 5. issue 2. 1991-04-25. PMID:1900794. |
insulin and egf, particularly when added together or in combination with phorbol dibutyrate (pdbu), induced a rapid (1-4 h) redistribution of gi alpha from the plasma membrane to perinuclear sites in the cell. |
1991-04-25 |
2023-08-11 |
Not clear |
| S C Chen, C K Chou, F H Wong, C M Chang, C P H. Overexpression of epidermal growth factor and insulin-like growth factor-I receptors and autocrine stimulation in human esophageal carcinoma cells. Cancer research. vol 51. issue 7. 1991-04-23. PMID:2004373. |
the growth-stimulatory effects of epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha), and insulin-like growth factor-i (igf-i) on the human esophageal carcinoma cell line ce48t/vgh were evaluated. |
1991-04-23 |
2023-08-11 |
human |
| B D Gehm, M R Rosne. Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. Endocrinology. vol 128. issue 3. 1991-04-10. PMID:1847863. |
we have previously shown that ide can also degrade transforming growth factor-alpha (tgf alpha), but not epidermal growth factor (egf), in vitro. |
1991-04-10 |
2023-08-11 |
human |
| B D Gehm, M R Rosne. Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. Endocrinology. vol 128. issue 3. 1991-04-10. PMID:1847863. |
this selectivity was surprising, since tgf alpha and egf are structurally similar and bind to the same receptor with comparable affinities. |
1991-04-10 |
2023-08-11 |
human |
| B D Gehm, M R Rosne. Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. Endocrinology. vol 128. issue 3. 1991-04-10. PMID:1847863. |
the results suggest that bacitracin-sensitive metalloproteases are involved in the degradation of tgf alpha and egf as well as insulin, and that the degradation of tgf alpha, but not egf, is mediated in part by ide. |
1991-04-10 |
2023-08-11 |
human |