| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Rutten, P Harmon, D R Campbel. Insulin enhances epidermal growth factor- and transforming growth factor-alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells. Scandinavian journal of gastroenterology. vol 26. issue 9. 1991-12-04. PMID:1947790. |
the effect of insulin on epidermal growth factor (egf)- and transforming growth factor-alpha (tgf alpha)-induced cell proliferation was examined in primary cultures of gastric surface mucous epithelial cells by using changes in cell counts and dna as indices of cell growth. |
1991-12-04 |
2023-08-11 |
cattle |
| M J Rutten, P Harmon, D R Campbel. Insulin enhances epidermal growth factor- and transforming growth factor-alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells. Scandinavian journal of gastroenterology. vol 26. issue 9. 1991-12-04. PMID:1947790. |
in low-serum dmem with no insulin the lowest effective dose of egf or tgf alpha for stimulating cell growth was 10 nm and 5 nm, respectively. |
1991-12-04 |
2023-08-11 |
cattle |
| M J Rutten, P Harmon, D R Campbel. Insulin enhances epidermal growth factor- and transforming growth factor-alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells. Scandinavian journal of gastroenterology. vol 26. issue 9. 1991-12-04. PMID:1947790. |
in low-serum dmem containing 2.5 micrograms/ml insulin there was a dose-dependent increase in cell growth with egf and tfg alpha at concentrations of 0.5-10.0 nm. |
1991-12-04 |
2023-08-11 |
cattle |
| M J Rutten, P Harmon, D R Campbel. Insulin enhances epidermal growth factor- and transforming growth factor-alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells. Scandinavian journal of gastroenterology. vol 26. issue 9. 1991-12-04. PMID:1947790. |
the addition of insulin alone at 2.5 micrograms/ml, egf alone at 2 nm, or tgf alpha alone at 2 nm in serum-free dmem media had no effect on gastric surface mucous cell dna. |
1991-12-04 |
2023-08-11 |
cattle |
| M J Rutten, P Harmon, D R Campbel. Insulin enhances epidermal growth factor- and transforming growth factor-alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells. Scandinavian journal of gastroenterology. vol 26. issue 9. 1991-12-04. PMID:1947790. |
in serum-free dmem media with 2.5 micrograms/ml insulin, the addition of 2 nm egf or 2 nm tgf alpha caused an increase in both cell counts and dna of 1.80- and 3.50-fold, respectively. |
1991-12-04 |
2023-08-11 |
cattle |
| M J Rutten, P Harmon, D R Campbel. Insulin enhances epidermal growth factor- and transforming growth factor-alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells. Scandinavian journal of gastroenterology. vol 26. issue 9. 1991-12-04. PMID:1947790. |
the present study demonstrates that insulin, at concentrations that are not mitogenic, will enhance the proliferative effects of egf and tgf alpha on the growth of primary cultures of guinea pig gastric surface mucous epithelial cells. |
1991-12-04 |
2023-08-11 |
cattle |
| P G Mitchell, H S Cheun. Tumor necrosis factor alpha and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes. Journal of cellular physiology. vol 149. issue 1. 1991-12-02. PMID:1658009. |
the degree of c-fos and c-jun stimulation by tnf alpha or egf did not correlate with the levels of collagenase and stromelysin message stimulated by these factors. |
1991-12-02 |
2023-08-11 |
Not clear |
| P G Mitchell, H S Cheun. Tumor necrosis factor alpha and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes. Journal of cellular physiology. vol 149. issue 1. 1991-12-02. PMID:1658009. |
egf stimulated significant accumulation of both c-fos and c-jun mrnas while only very low amounts of these messages were stimulated by tnf alpha. |
1991-12-02 |
2023-08-11 |
Not clear |
| B K Gangrade, J S Davis, J V Ma. A novel mechanism for the induction of aromatase in ovarian cells in vitro: role of transforming growth factor alpha-induced protein tyrosine kinase. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1935810. |
previous studies have shown that egf and tgf alpha do not affect basal estrogen production but attenuate fsh-stimulated estrogen production in vitro in rat granulosa cells. |
1991-12-02 |
2023-08-11 |
rat |
| A Tarnawski, J Stachura, W J Krause, T G Douglass, H Gergel. Quality of gastric ulcer healing: a new, emerging concept. Journal of clinical gastroenterology. vol 13 Suppl 1. 1991-11-29. PMID:1719066. |
under influence of growth factors [predominantly epidermal growth factor (egf) and transforming growth factor (tgf alpha)], the epithelial cells at the ulcer margin dedifferentiate and proliferate, supplying cells for re-epithelialization of the mucosal scar surface and reconstruction of glandular structures. |
1991-11-29 |
2023-08-11 |
Not clear |
| A Tarnawski, J Stachura, T Durbin, H Gergel. Expression of epidermal growth factor receptor in rat gastric oxyntic mucosa. Journal of clinical gastroenterology. vol 13 Suppl 1. 1991-11-29. PMID:1940185. |
it is likely that these cells represent the major targets for the egf [and transforming growth factor alpha (tgf-alpha) which shares a common receptor with egf] actions, stimulating cell proliferation and inhibiting acid secretion. |
1991-11-29 |
2023-08-11 |
rat |
| K Morishige, H Kurachi, K Amemiya, H Adachi, M Inoue, A Miyake, O Tanizawa, Y Sakoyam. Involvement of transforming growth factor alpha/epidermal growth factor receptor autocrine growth mechanism in an ovarian cancer cell line in vitro. Cancer research. vol 51. issue 21. 1991-11-25. PMID:1718591. |
although transforming growth factor (tgf) alpha and epidermal growth factor (egf) receptor (egfr) autocrine mechanism is widely demonstrated in many kinds of cancers, its biological significances still remain circumstantial. |
1991-11-25 |
2023-08-11 |
human |
| K Morishige, H Kurachi, K Amemiya, H Adachi, M Inoue, A Miyake, O Tanizawa, Y Sakoyam. Involvement of transforming growth factor alpha/epidermal growth factor receptor autocrine growth mechanism in an ovarian cancer cell line in vitro. Cancer research. vol 51. issue 21. 1991-11-25. PMID:1718591. |
tgf alpha and egfr but not egf proteins were observed by immunocytochemical stainings, using monoclonal antibodies against human tgf alpha, egfr, and egf, respectively. |
1991-11-25 |
2023-08-11 |
human |
| K Morishige, H Kurachi, K Amemiya, H Adachi, M Inoue, A Miyake, O Tanizawa, Y Sakoyam. Involvement of transforming growth factor alpha/epidermal growth factor receptor autocrine growth mechanism in an ovarian cancer cell line in vitro. Cancer research. vol 51. issue 21. 1991-11-25. PMID:1718591. |
although 0.1, 1.0, and 10 nm concentrations of tgf alpha did not show significant growth promotion, monoclonal antibodies against tgf alpha and egfr but not egf significantly inhibited cell growth. |
1991-11-25 |
2023-08-11 |
human |
| J Nelson, R Stewart, M McGivern, J R Bailie, B Walker, R F Murphy, D J Wilso. Synthetic murine epidermal growth factor sequence 20-31 is mitogenic and angiogenic. Carcinogenesis. vol 12. issue 10. 1991-11-25. PMID:1718617. |
epidermal growth factor (egf) and its homologue, transforming growth factor alpha (tgf alpha), are mitogenic, angiogenic and tumour-promoting polypeptides. |
1991-11-25 |
2023-08-11 |
human |
| H Nogawa, Y Takahash. Substitution for mesenchyme by basement-membrane-like substratum and epidermal growth factor in inducing branching morphogenesis of mouse salivary epithelium. Development (Cambridge, England). vol 112. issue 3. 1991-11-25. PMID:1935691. |
transforming growth factor alpha had the same effect as egf. |
1991-11-25 |
2023-08-11 |
mouse |
| N R Lemoine, C M Hughes, W J Gullick, C L Brown, D Wynford-Thoma. Abnormalities of the EGF receptor system in human thyroid neoplasia. International journal of cancer. vol 49. issue 4. 1991-11-21. PMID:1917156. |
we have therefore examined an archival series of thyroid tumours and non-neoplastic pathologies for expression of the egf-r and 2 of its ligands, transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf), using immunohistochemistry. |
1991-11-21 |
2023-08-11 |
human |
| M J Dixon, J Garner, M W Ferguso. Immunolocalization of epidermal growth factor (EGF), EGF receptor and transforming growth factor alpha (TGF alpha) during murine palatogenesis in vivo and in vitro. Anatomy and embryology. vol 184. issue 1. 1991-11-05. PMID:1928747. |
immunolocalization of epidermal growth factor (egf), egf receptor and transforming growth factor alpha (tgf alpha) during murine palatogenesis in vivo and in vitro. |
1991-11-05 |
2023-08-11 |
Not clear |
| S K Roy, G S Greenwal. Mediation of follicle-stimulating hormone action on follicular deoxyribonucleic acid synthesis by epidermal growth factor. Endocrinology. vol 129. issue 4. 1991-10-30. PMID:1655388. |
to determine whether follicular egf is the intracellular transducer of fsh action on hamster preantral follicles, intact follicles at stages 1 to 7 (stages 1-4 = preantral follicles 1-4 layers of granulosa cells, respectively, and no theca; stages 5-6 = 5-6 and 7-8 layers granulosa cells, respectively, and developing theca; and stage 7 = follicles with incipient antrum) were cultured for 24 h in a serum-free culture medium in the absence or presence of 100 ng fsh, 50 ng egf, 50 ng transforming growth factor-alpha (tgf alpha), or 1 mumol 8-br-camp and challenged with 50 microliters polyclonal antimurine egf antiserum; the rate of dna synthesis was determined by [3h]thymidine incorporation. |
1991-10-30 |
2023-08-11 |
Not clear |
| S K Roy, G S Greenwal. Mediation of follicle-stimulating hormone action on follicular deoxyribonucleic acid synthesis by epidermal growth factor. Endocrinology. vol 129. issue 4. 1991-10-30. PMID:1655388. |
fsh, egf, and tgf alpha significantly (p less than 0.05) stimulated follicular dna synthesis; tgf alpha per se was less effective than either fsh or egf. |
1991-10-30 |
2023-08-11 |
Not clear |