| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Jimenez de Asua, M Goi. Prostaglandin F2 alpha decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation. FEBS letters. vol 299. issue 3. 1992-04-16. PMID:1312042. |
scatchard analysis reveals that pgf2 alpha decreases the number of high-affinity egf binding sites without changing the total number of receptors. |
1992-04-16 |
2023-08-11 |
mouse |
| L Jimenez de Asua, M Goi. Prostaglandin F2 alpha decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation. FEBS letters. vol 299. issue 3. 1992-04-16. PMID:1312042. |
prostaglandins e1 (pge1), e2 (pge2) or f2 beta (pgf2 beta) do not alter the egf binding to these cells and do not enhance the pgf2 alpha effect. |
1992-04-16 |
2023-08-11 |
mouse |
| L Jimenez de Asua, M Goi. Prostaglandin F2 alpha decreases the affinity of epidermal growth factor receptors in Swiss mouse 3T3 cells via protein kinase C activation. FEBS letters. vol 299. issue 3. 1992-04-16. PMID:1312042. |
these results indicate that pgf2 alpha decreases egf binding in swiss 3t3 cells via pkc activation. |
1992-04-16 |
2023-08-11 |
mouse |
| L Lehtola, J Partanen, L Sistonen, J Korhonen, A Wärri, P Härkönen, R Clarke, K Alital. Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells. International journal of cancer. vol 50. issue 4. 1992-03-30. PMID:1311287. |
these studies have indicated that the growth stimulation of the mcf-7 cells by estrogens may be effected by an autocrine mechanism involving several growth factors, such as egf, tgf alpha and igf-i and their receptors. |
1992-03-30 |
2023-08-11 |
human |
| Y Yu, B G Nair, T B Pate. Epidermal growth factor stimulates cAMP accumulation in cultured rat cardiac myocytes. Journal of cellular physiology. vol 150. issue 3. 1992-03-30. PMID:1311331. |
more recently, employing an antibody against the carboxy-terminus decapeptide of gs alpha, we have demonstrated that gs alpha mediates the effects of egf on cardiac adenylyl cyclase (nair et al., 1990). |
1992-03-30 |
2023-08-11 |
rat |
| S M Sagar, R H Edwards, F R Shar. Epidermal growth factor and transforming growth factor alpha induce c-fos gene expression in retinal Muller cells in vivo. Journal of neuroscience research. vol 29. issue 4. 1992-03-30. PMID:1791642. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) are peptides that act at a common receptor and are mitogenic for immature astrocytes and trophic for developing brain neurons in vitro. |
1992-03-30 |
2023-08-11 |
Not clear |
| S M Sagar, R H Edwards, F R Shar. Epidermal growth factor and transforming growth factor alpha induce c-fos gene expression in retinal Muller cells in vivo. Journal of neuroscience research. vol 29. issue 4. 1992-03-30. PMID:1791642. |
to investigate the actions of egf and tgf alpha in the adult central nervous system (cns) in vivo, the growth factors were injected into the vitreous cavity of adult male rabbits. |
1992-03-30 |
2023-08-11 |
Not clear |
| S M Sagar, R H Edwards, F R Shar. Epidermal growth factor and transforming growth factor alpha induce c-fos gene expression in retinal Muller cells in vivo. Journal of neuroscience research. vol 29. issue 4. 1992-03-30. PMID:1791642. |
fos nuclear immunostaining is induced selectively in nuclei of muller cells by both egf and tgf alpha. |
1992-03-30 |
2023-08-11 |
Not clear |
| S M Sagar, R H Edwards, F R Shar. Epidermal growth factor and transforming growth factor alpha induce c-fos gene expression in retinal Muller cells in vivo. Journal of neuroscience research. vol 29. issue 4. 1992-03-30. PMID:1791642. |
these observations demonstrate that mature retinal muller cells respond to exogenously applied egf and tgf alpha in vivo, although the effect of the growth factors is not necessarily direct. |
1992-03-30 |
2023-08-11 |
Not clear |
| G G Skouteris, M McMenami. Transforming growth factor-alpha-induced DNA synthesis and c-myc expression in primary rat hepatocyte cultures is modulated by indomethacin. The Biochemical journal. vol 281 ( Pt 3). 1992-03-24. PMID:1531590. |
transforming growth factor-alpha (tgf alpha), a potent hepatocyte mitogen, shares the same receptor with egf, and its expression is increased after partial hepatectomy. |
1992-03-24 |
2023-08-11 |
rat |
| G G Skouteris, M McMenami. Transforming growth factor-alpha-induced DNA synthesis and c-myc expression in primary rat hepatocyte cultures is modulated by indomethacin. The Biochemical journal. vol 281 ( Pt 3). 1992-03-24. PMID:1531590. |
tgf alpha increased the expression of the egf receptor gene, and this was prevented by the presence of an antibody against tgf alpha in the culture medium. |
1992-03-24 |
2023-08-11 |
rat |
| A Chalazonitis, J A Kessler, D R Twardzik, R S Morriso. Transforming growth factor alpha, but not epidermal growth factor, promotes the survival of sensory neurons in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 2. 1992-03-20. PMID:1740693. |
transforming growth factor alpha (tgf alpha) is a mitogenic polypeptide that is structurally homologous to epidermal growth factor (egf) and appears to bind to the same receptor in all systems tested previously. |
1992-03-20 |
2023-08-11 |
rat |
| A Chalazonitis, J A Kessler, D R Twardzik, R S Morriso. Transforming growth factor alpha, but not epidermal growth factor, promotes the survival of sensory neurons in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 2. 1992-03-20. PMID:1740693. |
moreover, egf did not antagonize the tgf alpha survival-promoting effect unless present in large excess (500-fold the concentration for which tgf alpha is effective); even in this case, only partial antagonism was achieved. |
1992-03-20 |
2023-08-11 |
rat |
| A Chalazonitis, J A Kessler, D R Twardzik, R S Morriso. Transforming growth factor alpha, but not epidermal growth factor, promotes the survival of sensory neurons in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 2. 1992-03-20. PMID:1740693. |
this binding was inhibited by excess unlabeled tgf alpha but not egf. |
1992-03-20 |
2023-08-11 |
rat |
| J Watanabe, H Hata, K Masuda, H Kuramot. [The physiological function of human endometrium]. Human cell. vol 4. issue 3. 1992-03-18. PMID:1782183. |
growth factors (igf- i, egf, tgf- alpha etc.) |
1992-03-18 |
2023-08-11 |
human |
| S G Mueller, J E Kudlo. Transforming growth factor-beta (TGF beta) inhibits TGF alpha expression in bovine anterior pituitary-derived cells. Molecular endocrinology (Baltimore, Md.). vol 5. issue 10. 1992-03-05. PMID:1723143. |
we have previously demonstrated that these cells express both tgf alpha and its receptor [the epidermal growth factor (egf) receptor] and that expression can be stimulated by phorbol ester (tpa) and egf. |
1992-03-05 |
2023-08-11 |
cattle |
| S G Mueller, J E Kudlo. Transforming growth factor-beta (TGF beta) inhibits TGF alpha expression in bovine anterior pituitary-derived cells. Molecular endocrinology (Baltimore, Md.). vol 5. issue 10. 1992-03-05. PMID:1723143. |
treatment of the tgf beta 1 down-regulated cells with egf resulted in the stimulation of tgf alpha mrna levels; thus, the tgf beta 1-treated cells remained responsive to egf. |
1992-03-05 |
2023-08-11 |
cattle |
| W E Hopkins, D R Westerhausen, S Fujii, J J Billadello, B E Sobe. Mediators of induction of augmented expression of plasminogen activator inhibitor type-1 in Hep G2 cells by platelets. Thrombosis and haemostasis. vol 66. issue 2. 1992-02-25. PMID:1663280. |
antibodies to transforming growth factor-beta (tgf-beta) and to the epidermal growth factor (egf)/transforming growth factor alpha (tgf-alpha) receptor inhibited the platelet lysate-mediated increase in pai-1 protein by 77%. |
1992-02-25 |
2023-08-11 |
Not clear |
| W E Karnes, J H Walsh, S V Wu, R S Kim, M G Martin, H C Wong, J Mendelsohn, J G Park, F Cuttitt. Autonomous proliferation of colon cancer cells that coexpress transforming growth factor alpha and its receptor. Variable effects of receptor-blocking antibody. Gastroenterology. vol 102. issue 2. 1992-02-25. PMID:1732118. |
all four cell lines show epidermal growth factor (egf) receptors (egfrs), express transforming growth factor alpha (tgf-alpha) messenger rna, and release anti-tgf-alpha-immunoreactive molecules. |
1992-02-25 |
2023-08-11 |
human |
| S J Prestrelski, T Arakawa, C S Wu, K D O'Neal, K R Westcott, L O Narh. Solution structure and dynamics of epidermal growth factor and transforming growth factor alpha. The Journal of biological chemistry. vol 267. issue 1. 1992-02-18. PMID:1730598. |
circular dichroism (cd) and fourier transform infrared spectroscopic studies have shown that the secondary structure of transforming growth factor alpha (tgf-alpha) is very similar to that of epidermal growth factor (egf). |
1992-02-18 |
2023-08-11 |
Not clear |