| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S K Roy, G S Greenwal. Mediation of follicle-stimulating hormone action on follicular deoxyribonucleic acid synthesis by epidermal growth factor. Endocrinology. vol 129. issue 4. 1991-10-30. PMID:1655388. |
however, both fsh- and egf-induced dna synthesis was drastically attenuated by egf antiserum; tgf alpha effect remained undisturbed. |
1991-10-30 |
2023-08-11 |
Not clear |
| K Morishige, H Kurachi, K Amemiya, Y Fujita, T Yamamoto, A Miyake, O Tanizaw. Evidence for the involvement of transforming growth factor alpha and epidermal growth factor receptor autocrine growth mechanism in primary human ovarian cancers in vitro. Cancer research. vol 51. issue 19. 1991-10-29. PMID:1717146. |
immunocytochemical studies using monoclonal antibodies (mabs) against tgf alpha, egf, and egfr showed that tgf alpha and egfr but not egf proteins were present on ovarian cancer cells in all cases. |
1991-10-29 |
2023-08-11 |
human |
| K Morishige, H Kurachi, K Amemiya, Y Fujita, T Yamamoto, A Miyake, O Tanizaw. Evidence for the involvement of transforming growth factor alpha and epidermal growth factor receptor autocrine growth mechanism in primary human ovarian cancers in vitro. Cancer research. vol 51. issue 19. 1991-10-29. PMID:1717146. |
moreover, the addition of mabs against tgf alpha and egfr but not egf inhibited [3h]thymidine incorporation dose dependently in egfr(+) cancer cells. |
1991-10-29 |
2023-08-11 |
human |
| R H Raja, A J Paterson, T H Shin, J E Kudlo. Transcriptional regulation of the human transforming growth factor-alpha gene. Molecular endocrinology (Baltimore, Md.). vol 5. issue 4. 1991-10-29. PMID:1922084. |
we and others have previously reported that transforming growth factor-alpha (tgf alpha) expression is hormonally responsive and its expression is coregulated with that of its receptor [the epidermal growth factor (egf) receptor]. |
1991-10-29 |
2023-08-11 |
human |
| R H Raja, A J Paterson, T H Shin, J E Kudlo. Transcriptional regulation of the human transforming growth factor-alpha gene. Molecular endocrinology (Baltimore, Md.). vol 5. issue 4. 1991-10-29. PMID:1922084. |
we now report that a 313-basepair (bp) proximal element of the tgf alpha 5'-flanking region (-373 to -59 relative to the tgf alpha translation start codon) is capable of conferring responses to phorbol ester and egf. |
1991-10-29 |
2023-08-11 |
human |
| R H Raja, A J Paterson, T H Shin, J E Kudlo. Transcriptional regulation of the human transforming growth factor-alpha gene. Molecular endocrinology (Baltimore, Md.). vol 5. issue 4. 1991-10-29. PMID:1922084. |
this gene segment does not contain the egf receptor gene homolog or potential ap-2-binding sites, suggesting that these elements are not necessary for basal and egf- or phorbol ester-responsive tgf alpha gene expression. |
1991-10-29 |
2023-08-11 |
human |
| R H Raja, A J Paterson, T H Shin, J E Kudlo. Transcriptional regulation of the human transforming growth factor-alpha gene. Molecular endocrinology (Baltimore, Md.). vol 5. issue 4. 1991-10-29. PMID:1922084. |
these results indicate that the tgf alpha gene 5'-flanking sequence contains the elements responsible for hormonal responsiveness of this gene and that these elements are distinct from those that regulate the expression of the egf receptor gene. |
1991-10-29 |
2023-08-11 |
human |
| S E Wilson, S A Lloy. Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells. Investigative ophthalmology & visual science. vol 32. issue 10. 1991-10-24. PMID:1716619. |
the authors tried to determine whether human corneal endothelial cells in primary culture synthesize messenger rna (mrna) coding for epidermal growth factor (egf), egf receptor, basic fibroblast growth factor (fgfb), transforming growth factor beta-1 (tgfb1), and interleukin-1 alpha (il-1 alpha). |
1991-10-24 |
2023-08-11 |
human |
| S E Wilson, S A Lloy. Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells. Investigative ophthalmology & visual science. vol 32. issue 10. 1991-10-24. PMID:1716619. |
the polymerase chain reaction (pcr) was used to amplify the growth factors (egf, fgfb, tgfb1, and il-1 alpha), egf receptor, and beta actin sequences from each of the cdna samples. |
1991-10-24 |
2023-08-11 |
human |
| S E Wilson, S A Lloy. Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells. Investigative ophthalmology & visual science. vol 32. issue 10. 1991-10-24. PMID:1716619. |
the egf mrnas were detected by pcr alone in four of the samples from proliferative cultures, tgfb1 mrnas in three, and il-1 alpha mrnas in three. |
1991-10-24 |
2023-08-11 |
human |
| D Goldstein, M O'Leary, J Mitchen, E C Borden, G Wildin. Effects of interferon beta ser and transforming growth factor beta on prostatic cell lines. The Journal of urology. vol 146. issue 4. 1991-10-23. PMID:1895445. |
neither epidermal growth factor (egf) nor transforming growth factor alpha (tgf alpha) reduced the antiproliferative effect of ifn beta ser on these cells. |
1991-10-23 |
2023-08-11 |
Not clear |
| E Birecree, L E King, L B Nanne. Epidermal growth factor and its receptor in the developing human nervous system. Brain research. Developmental brain research. vol 60. issue 2. 1991-10-21. PMID:1893564. |
positive binding studies with 125i-egf confirmed that numerous egf receptors are unoccupied, assessable, and available for interactions with potential ligands such as egf and tgf alpha in developing rat brains. |
1991-10-21 |
2023-08-11 |
human |
| E Schmitt, C Hüls, B Nagel, E Rüd. Characterization of a T-cell-derived mast cell costimulatory activity (MCA) that acts synergistically with interleukin 3 and interleukin 4 on the growth of murine mast cells. Cytokine. vol 2. issue 6. 1991-10-18. PMID:2104234. |
control experiments demonstrated that mca is identical to neither the t-cell-derived lymphokines il 2 to il 6, il 9, interferon gamma, tumor necrosis factor alpha or beta, or granulocyte-macrophage colony-stimulating factor (csf), nor to il 7, granulocyte csf, macrophage csf, erythropoietin, leukemia inhibitory factor, or epidermal growth factor (egf). |
1991-10-18 |
2023-08-11 |
Not clear |
| C Bovolenta, M Tognon, E Libo. Epidermal growth factor induces, in the EL alpha 4-2 cell line, herpes simplex virus-1 alpha 4 gene transcription in the absence of the viral trans-activator VP16. Virus research. vol 19. issue 2-3. 1991-10-11. PMID:1654017. |
here we report that a rapid, transient induction of the alpha 4 gene occurs only when el alpha 4-2 fibroblasts are stimulated with purified epidermal growth factor (egf). |
1991-10-11 |
2023-08-11 |
Not clear |
| C Bovolenta, M Tognon, E Libo. Epidermal growth factor induces, in the EL alpha 4-2 cell line, herpes simplex virus-1 alpha 4 gene transcription in the absence of the viral trans-activator VP16. Virus research. vol 19. issue 2-3. 1991-10-11. PMID:1654017. |
the role of cellular factors on the egf-mediated induction of the alpha 4 gene has been analyzed by gel mobility shift assays using nuclear extracts from el alpha 4-2 cells stimulated or not with egf. |
1991-10-11 |
2023-08-11 |
Not clear |
| C Bovolenta, M Tognon, E Libo. Epidermal growth factor induces, in the EL alpha 4-2 cell line, herpes simplex virus-1 alpha 4 gene transcription in the absence of the viral trans-activator VP16. Virus research. vol 19. issue 2-3. 1991-10-11. PMID:1654017. |
we conclude that a mechanism, different from the one involving vp16, is responsible for alpha 4 gene activation in el alpha 4-2 cells and that the dna-protein architecture is maintained at the taatgarat regulatory site regardless of changes in the transcriptional state induced by egf. |
1991-10-11 |
2023-08-11 |
Not clear |
| I Tamm, I Cardinale, P B Sehga. Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells. Cytokine. vol 3. issue 3. 1991-10-10. PMID:1653054. |
transforming growth factors alpha and beta 1, acidic and basic fibroblast growth factors, epidermal growth factor, and insulin-like growth factor-1 (tgf-alpha, tgf-beta 1, afgf, bfgf, egf, and igf-1) have little or no effect on breast cancer cell morphology, which serves to exclude the possibility that the il-6-induced changes are a consequence of induction of these growth factors by il-6. |
1991-10-10 |
2023-08-11 |
human |
| R E Haining, J P Schofield, D S Jones, J Rajput-Williams, S K Smit. Identification of mRNA for epidermal growth factor and transforming growth factor-alpha present in low copy number in human endometrium and decidua using reverse transcriptase-polymerase chain reaction. Journal of molecular endocrinology. vol 6. issue 3. 1991-10-07. PMID:1715708. |
the presence of mrna for epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) was demonstrated in small fragments of human endometrium and decidua by use of the technique of reverse transcriptase-polymerase chain reaction with nested oligonucleotide primers. |
1991-10-07 |
2023-08-11 |
human |
| R E Haining, J P Schofield, D S Jones, J Rajput-Williams, S K Smit. Identification of mRNA for epidermal growth factor and transforming growth factor-alpha present in low copy number in human endometrium and decidua using reverse transcriptase-polymerase chain reaction. Journal of molecular endocrinology. vol 6. issue 3. 1991-10-07. PMID:1715708. |
the presence of mrna encoding egf and tgf alpha has not been shown in human endometrium previously. |
1991-10-07 |
2023-08-11 |
human |
| R E Haining, J P Schofield, D S Jones, J Rajput-Williams, S K Smit. Identification of mRNA for epidermal growth factor and transforming growth factor-alpha present in low copy number in human endometrium and decidua using reverse transcriptase-polymerase chain reaction. Journal of molecular endocrinology. vol 6. issue 3. 1991-10-07. PMID:1715708. |
other studies using conventional techniques, such as northern blot or in-situ hybridization, showed the presence in low copy number of egf but not tgf alpha in murine endometrium. |
1991-10-07 |
2023-08-11 |
human |