| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N C Luetteke, D C Le. Transforming growth factor alpha: expression, regulation and biological action of its integral membrane precursor. Seminars in cancer biology. vol 1. issue 4. 1991-10-04. PMID:2103501. |
coincubation of these cells with a431 cells resulted in binding and autophosphorylation of egf receptors, and mobilization of intracellular calcium in a431 cells, demonstrating that the transmembrane protgf alpha can activate egf receptors on adjacent cells, leading to signal transduction. |
1991-10-04 |
2023-08-11 |
mouse |
| G T Merlin. Epidermal growth factor receptor regulation and function. Seminars in cancer biology. vol 1. issue 4. 1991-10-04. PMID:2103502. |
the epidermal growth factor (egf) receptor is a transmembrane, cell-surface glycoprotein that mediates the mitogenic action of a family of ligands, including egf and transforming growth factor alpha (tgf alpha). |
1991-10-04 |
2023-08-11 |
Not clear |
| J E Kudlow, J D Bjorg. TGF alpha in normal physiology. Seminars in cancer biology. vol 1. issue 4. 1991-10-04. PMID:2103504. |
the expression of the epidermal growth factor (egf) receptor, which is also the tgf alpha receptor, is also stimulated by phorbol esters. |
1991-10-04 |
2023-08-11 |
human |
| J E Kudlow, J D Bjorg. TGF alpha in normal physiology. Seminars in cancer biology. vol 1. issue 4. 1991-10-04. PMID:2103504. |
the ability of ligand to stimulate its own synthesis and that of its receptor suggests the presence of an autocrine positive feedback loop, however we were unable to break this loop in the breast cancer cells by antibodies that blocked the interaction of tgf alpha with the egf receptor. |
1991-10-04 |
2023-08-11 |
human |
| J E Kudlow, J D Bjorg. TGF alpha in normal physiology. Seminars in cancer biology. vol 1. issue 4. 1991-10-04. PMID:2103504. |
the ability of egf to stimulate egf receptor and tgf alpha expression appears to require protein kinase c, since inhibition of this enzyme blocked the ability of egf to stimulate these genes. |
1991-10-04 |
2023-08-11 |
human |
| J E Kudlow, J D Bjorg. TGF alpha in normal physiology. Seminars in cancer biology. vol 1. issue 4. 1991-10-04. PMID:2103504. |
these studies raise the possibility that hormones capable of activating protein kinase c could stimulate egf receptor and tgf alpha expression. |
1991-10-04 |
2023-08-11 |
human |
| F Ciardiello, N Kim, T Saeki, R Dono, M G Persico, G D Plowman, J Garrigues, S Radke, G J Todaro, D S Salomo. Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 17. 1991-10-03. PMID:1715580. |
amphiregulin (ar) and cripto are proteins that are structurally related to epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha). |
1991-10-03 |
2023-08-11 |
human |
| I Hatayama, Y Yamada, K Tanaka, A Ichihara, K Sat. Induction of glutathione S-transferase P-form in primary cultured rat hepatocytes by epidermal growth factor and insulin. Japanese journal of cancer research : Gann. vol 82. issue 7. 1991-10-01. PMID:1908848. |
western blot analysis of gsts revealed that gst-p, which is not present in freshly isolated hepatocytes, was markedly induced and that gst subunits 3 and 4 of the mu class also increased after addition of egf and/or insulin, while the subunits 1 and 2 of the alpha class disappeared. |
1991-10-01 |
2023-08-11 |
rat |
| I D Campbell, R M Cooke, M Baron, T S Harvey, M J Tappi. The solution structures of epidermal growth factor and transforming growth factor alpha. Progress in growth factor research. vol 1. issue 1. 1991-10-01. PMID:2491252. |
the structures of human epidermal growth factor (egf) and human transforming growth factor alpha (tgf alpha) have been determined in solution using nuclear magnetic resonance techniques. |
1991-10-01 |
2023-08-11 |
human |
| I D Campbell, R M Cooke, M Baron, T S Harvey, M J Tappi. The solution structures of epidermal growth factor and transforming growth factor alpha. Progress in growth factor research. vol 1. issue 1. 1991-10-01. PMID:2491252. |
the tgf alpha and egf structures also serve as models for homologous modules in other extracellular proteins. |
1991-10-01 |
2023-08-11 |
human |
| J J Hsuan, G Panayotou, M D Waterfiel. Structural basis for epidermal growth factor receptor function. Progress in growth factor research. vol 1. issue 1. 1991-10-01. PMID:2491253. |
in addition to egf, the related polypeptides transforming growth factor alpha (tgf alpha) and vaccinia virus growth factor are also ligands for the egf receptor. |
1991-10-01 |
2023-08-11 |
human |
| J J Hsuan, G Panayotou, M D Waterfiel. Structural basis for epidermal growth factor receptor function. Progress in growth factor research. vol 1. issue 1. 1991-10-01. PMID:2491253. |
expression of tgf alpha occurs during embryonal development and in specific adult tissues; it may also play a role in cellular transformation these important properties, as well as the potential roles of both tgf alpha and egf in wound repair, have emphasized the need to understand egf receptor structure, function and regulation. |
1991-10-01 |
2023-08-11 |
human |
| M Dodeur, A Mensier, E Alsat, D Bellet, J M Bidart, D Evain-Brio. Effect of human parathyroid hormone on the cAMP production and the endocrine functions of trophoblast cells from first trimester placenta. Reproduction, nutrition, development. vol 31. issue 3. 1991-09-27. PMID:1652259. |
egf and hpth added separately or together significantly stimulated (p less than 0.01) the secretion of free alpha subunit 2-fold from 35 ng/ml to 70 ng/ml. |
1991-09-27 |
2023-08-11 |
human |
| A M Sizeland, A W Burges. The proliferative and morphologic responses of a colon carcinoma cell line (LIM 1215) require the production of two autocrine factors. Molecular and cellular biology. vol 11. issue 8. 1991-08-21. PMID:2072905. |
in addition, the egf receptor was found to be phosphorylated on tyrosine in lim 1215 cells proliferating at high density, suggesting that the autocrine production of transforming growth factor alpha (tgf alpha) and subsequent ligation to the egf receptor was occurring. |
1991-08-21 |
2023-08-11 |
Not clear |
| A M Sizeland, A W Burges. The proliferative and morphologic responses of a colon carcinoma cell line (LIM 1215) require the production of two autocrine factors. Molecular and cellular biology. vol 11. issue 8. 1991-08-21. PMID:2072905. |
the antisense inhibition could be overcome by the addition of egf, indicating that the effect of the antisense tgf alpha oligonucleotide was on the production of autocrine tgf alpha. |
1991-08-21 |
2023-08-11 |
Not clear |
| C A Laschinger, C G Bellows, S Was. Modulation of plasminogen activators and plasminogen activator inhibitors by TGF-beta, IL-1 alpha and EGF in fetal rat calvaria cells at different times of culture. Bone and mineral. vol 13. issue 1. 1991-08-13. PMID:2065216. |
modulation of plasminogen activators and plasminogen activator inhibitors by tgf-beta, il-1 alpha and egf in fetal rat calvaria cells at different times of culture. |
1991-08-13 |
2023-08-11 |
rat |
| C A Laschinger, C G Bellows, S Was. Modulation of plasminogen activators and plasminogen activator inhibitors by TGF-beta, IL-1 alpha and EGF in fetal rat calvaria cells at different times of culture. Bone and mineral. vol 13. issue 1. 1991-08-13. PMID:2065216. |
since transforming growth factor beta (tgf-beta), interleukin 1-alpha (il-1 alpha) and epidermal growth factor (egf) affect both bone resorption and bone formation, we have studied the ability of these growth factors to affect plasminogen activators and plasminogen activator inhibitors release by rc cells at different times throughout this proliferation/differentiation sequence. |
1991-08-13 |
2023-08-11 |
rat |
| C A Laschinger, C G Bellows, S Was. Modulation of plasminogen activators and plasminogen activator inhibitors by TGF-beta, IL-1 alpha and EGF in fetal rat calvaria cells at different times of culture. Bone and mineral. vol 13. issue 1. 1991-08-13. PMID:2065216. |
tgf-beta significantly decreased bone nodule formation after both a 6 and 24 h serum-free exposure, whereas il-1 alpha and egf decreased nodule number only after the 24 h exposure. |
1991-08-13 |
2023-08-11 |
rat |
| C Bulletti, V M Jasonni, V Polli, F Cappuccini, A Galassi, C Flamign. Basement membrane in human endometrium: possible role of proteolytic enzymes in developing hyperplasia and carcinoma. Annals of the New York Academy of Sciences. vol 622. 1991-08-07. PMID:1648321. |
epidermal growth factor (egf), transforming growth factors alpha and beta (tgf-alpha, beta)] seem to be involved in the extracellular matrix formation and degradation. |
1991-08-07 |
2023-08-11 |
human |
| M B Zhang, D D Woo, B D Howar. Transforming growth factor alpha and a PC12-derived growth factor induce neurites in PC12 cells and enhance the survival of embryonic brain neurons. Cell regulation. vol 1. issue 7. 1991-08-01. PMID:2098114. |
the factor resembles transforming growth factor alpha (tgf alpha) and epidermal growth factor (egf) in that it induces anchorage-independent colony formation of normal rat kidney cells in soft agar and competes with egf for binding to the egf receptor. |
1991-08-01 |
2023-08-11 |
human |