| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B D Gehm, M R Rosne. Regulation of insulin, epidermal growth factor, and transforming growth factor-alpha levels by growth factor-degrading enzymes. Endocrinology. vol 128. issue 3. 1991-04-10. PMID:1847863. |
the existence of separate degradative pathways for egf and tgf alpha may explain how the two factors exert differential effects in some systems, and degradation of tgf alpha by ide would provide a possible mechanism for interaction between the insulin and tgf alpha/egf signalling systems. |
1991-04-10 |
2023-08-11 |
human |
| F Ciardiello, M L McGeady, N Kim, F Basolo, N Hynes, B C Langton, H Yokozaki, T Saeki, J W Elliott, H Masu. Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 1. issue 9. 1991-04-02. PMID:1981145. |
c-ha-ras-transfected mcf-10a cells grow as colonies in soft agar, exhibit a 3- to 4-fold increase in their growth rate in serum-free medium, and show a reduced mitogenic response to exogenous epidermal growth factor (egf) or transforming growth factor-alpha (tgf alpha) as compared to mcf-10a cells. |
1991-04-02 |
2023-08-11 |
human |
| F Ciardiello, M L McGeady, N Kim, F Basolo, N Hynes, B C Langton, H Yokozaki, T Saeki, J W Elliott, H Masu. Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 1. issue 9. 1991-04-02. PMID:1981145. |
however, c-neu-transformed mcf-10a cells show no increase in tgf alpha secretion and no change in their responsiveness to exogenous egf or tgf alpha. |
1991-04-02 |
2023-08-11 |
human |
| F Ciardiello, M L McGeady, N Kim, F Basolo, N Hynes, B C Langton, H Yokozaki, T Saeki, J W Elliott, H Masu. Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 1. issue 9. 1991-04-02. PMID:1981145. |
tgf alpha-infected mcf-10a cells secrete 15- to 20-fold more tgf alpha protein than mcf-10a cells, form colonies in soft agar, exhibit an enhanced growth rate in serum-free medium, and show a decreased mitogenic response to exogenous egf or tgf alpha at a level equivalent to ha-ras-transformed mcf-10a cells. |
1991-04-02 |
2023-08-11 |
human |
| F Ciardiello, M L McGeady, N Kim, F Basolo, N Hynes, B C Langton, H Yokozaki, T Saeki, J W Elliott, H Masu. Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary DNA leads to transformation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 1. issue 9. 1991-04-02. PMID:1981145. |
these results suggest that tgf alpha is an intermediary in the transformation of human mammary epithelial cells by an activated c-ha-ras gene, but not by the c-neu gene, and demonstrate that overexpression of this growth factor is able to transform immortalized human mammary epithelial cells which also express a sufficient complement of functional egf receptors. |
1991-04-02 |
2023-08-11 |
human |
| H J Guyd. Metabolic effects of growth factors and polycyclic aromatic hydrocarbons on cultured human placental cells of early and late gestation. The Journal of clinical endocrinology and metabolism. vol 72. issue 3. 1991-04-02. PMID:1997525. |
since benzo[alpha]pyrene (bp) inhibits egf binding and autophosphorylation in cultured human placental cells, particularly in early gestation, we also studied the effect of benzo[alpha]pyrene and other polycyclic aromatic hydrocarbons (pahs) on egf-mediated aib uptake. |
1991-04-02 |
2023-08-11 |
human |
| L A Wheeler, D D Goodrum, G Sach. Role of protein kinase C in the regulation of cytosolic Ca2+ in A431 cells: separation of growth factor and bradykinin pathways. The Journal of membrane biology. vol 118. issue 1. 1991-03-15. PMID:2283681. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) both stimulated ca2+ entry and release while bradykinin appeared only to release ca2+ from intracellular stores. |
1991-03-15 |
2023-08-11 |
Not clear |
| S E Singletary, N N Williams, U Rodeck, L Larry, S Tucker, G Spitzer, M Herly. Transforming growth factor-alpha secretion by epidermal growth factor-dependent human tumor cell lines. Anticancer research. vol 10. issue 6. 1991-03-15. PMID:2285223. |
egf-adapted cultures of melanoma and cervical adenocarcinoma origin secreted higher levels of bioactive transforming growth factor alpha (tgf-alpha) when compared to cultures maintained in the absence of egf. |
1991-03-15 |
2023-08-11 |
human |
| S Werner, P Viehweger, P H Hofschneider, W K Rot. Low mitogenic response to EGF and TGF-alpha: a characteristic feature of cultured Kaposi's sarcoma derived cells. Oncogene. vol 6. issue 1. 1991-03-08. PMID:1992446. |
we have investigated the mitogenicity of epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) for cultured kaposi's sarcoma derived cells (ks cells). |
1991-03-08 |
2023-08-11 |
Not clear |
| G K Wollenberg, J LaMarre, E Semple, E Farber, J Gauldie, M A Haye. Counteracting effects of dexamethasone and alpha 2-macroglobulin on inhibition of proliferation of normal and neoplastic rat hepatocytes by transforming growth factors-beta type 1 and type 2. International journal of cancer. vol 47. issue 2. 1991-02-25. PMID:1703130. |
primary cultures of hepatocytes isolated from normal f-344 rats or from f-344 rats with hepatocellular carcinomas generated by a 2-step model of chemical carcinogenesis were used to determine if dexamethasone (dex) or alpha 2-macroglobulin (alpha 2m) modify the ability of transforming growth factors-beta type i (tgf-beta i) and type 2 (tgf-beta 2) to inhibit labelling index of hepatocytes cultured continuously with or without epidermal growth factor (egf). |
1991-02-25 |
2023-08-11 |
rat |
| E D Adamso. EGF receptor activities in mammalian development. Molecular reproduction and development. vol 27. issue 1. 1991-02-25. PMID:2271181. |
the receptor for epidermal growth factor (egf) and its analog transforming growth factor alpha (tgf alpha) is ubiquitous, implying quite general roles for egf/tgf alpha in cell viability and tissue maintenance in adult tissues. |
1991-02-25 |
2023-08-11 |
Not clear |
| S M Snedeker, C F Brown, R P DiAugustin. Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 1. 1991-02-14. PMID:1986376. |
primer-directed enzyme amplification was used to examine epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) mrna transcripts in mammary glands of young virgin, mature virgin, midpregnant, and midlactating mice. |
1991-02-14 |
2023-08-11 |
mouse |
| T Okamoto, T Asano, S Harada, E Ogata, I Nishimot. Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21. The Journal of biological chemistry. vol 266. issue 2. 1991-02-12. PMID:1985936. |
these results suggest that the signaling pathway triggered by igf-ii is uncoupled between the igf-iir and gi-2 alpha in quiescent cells and that pdgf and egf restore the igf-iir-gi-2 coupling. |
1991-02-12 |
2023-08-11 |
Not clear |
| T Okamoto, T Asano, S Harada, E Ogata, I Nishimot. Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21. The Journal of biological chemistry. vol 266. issue 2. 1991-02-12. PMID:1985936. |
therefore, the igf-i signaling pathway may also be uncoupled between the igf-ir and gi-2 alpha in quiescent cells and restored by pdgf and egf. |
1991-02-12 |
2023-08-11 |
Not clear |
| B A Ruggeri, D M Klurfeld, D Kritchevsky, K K Fric. Steady-state mRNA expression for growth factors in DMBA-induced rat mammary tumors. Cancer letters. vol 55. issue 2. 1991-02-12. PMID:2124948. |
steady-state mrna levels were examined for insulin-like growth factors (igf) i and ii, transforming growth factor alpha (tgf alpha) and its receptor and the epidermal growth factor (egf) receptor in mammary tumors induced by dmba in rats. |
1991-02-12 |
2023-08-11 |
rat |
| S R Ojeda, H F Urbanski, M E Costa, D F Hill, M Moholt-Sieber. Involvement of transforming growth factor alpha in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 24. 1991-02-07. PMID:2263621. |
we have investigated the ability of epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) to affect the release of luteinizing hormone-releasing hormone (lhrh), the neuropeptide that controls reproductive development. |
1991-02-07 |
2023-08-11 |
rat |
| R M Cooke, M J Tappin, I D Campbell, D Kohda, T Miyake, T Fuwa, T Miyazawa, F Inagak. Nuclear-magnetic-resonance studies of human epidermal growth factor. European journal of biochemistry. vol 193. issue 3. 1991-01-11. PMID:2249695. |
comparison of the resonance shifts of human, rat and mouse egf and human transforming growth factor alpha (tgf alpha) enables shifts characteristic of the egf conformation to be identified, providing standards by which the structures of related proteins may be assessed. |
1991-01-11 |
2023-08-11 |
mouse |
| J L Tilly, A L Johnso. Modulation of hen granulosa cell steroidogenesis and plasminogen activator activity hy transforming growth factor alpha. Growth factors (Chur, Switzerland). vol 3. issue 3. 1991-01-08. PMID:2173938. |
studies were conducted with chicken granulosa cells to evaluate the relative efficacy of human recombinant transforming growth factor alpha (tgf alpha) versus murine epidermal growth factor (egf) to affect cyclic adenosine monophosphate (camp) accumulation and progesterone production stimulated by luteinizing hormone (lh) or steroid output induced by a camp analogue, and to modulate plasminogen activator (pa) activity. |
1991-01-08 |
2023-08-11 |
human |
| J L Tilly, A L Johnso. Modulation of hen granulosa cell steroidogenesis and plasminogen activator activity hy transforming growth factor alpha. Growth factors (Chur, Switzerland). vol 3. issue 3. 1991-01-08. PMID:2173938. |
increasing concentrations of egf (33-328 nm) and tgf alpha (0.04-18 nm) were found to inhibit camp formation stimulated by lh in a dose-dependent manner, with calculated half-maximal inhibitory doses (id50's) of 97.1 and 0.27 nm, respectively. |
1991-01-08 |
2023-08-11 |
human |
| J L Tilly, A L Johnso. Modulation of hen granulosa cell steroidogenesis and plasminogen activator activity hy transforming growth factor alpha. Growth factors (Chur, Switzerland). vol 3. issue 3. 1991-01-08. PMID:2173938. |
similarly, a 470-fold difference in the ability of tgf alpha (id50 = 0.13 nm) versus egf (id50 = 61.3 nm) to half-maximally suppress lh-induced progesterone production was observed in the same cells. |
1991-01-08 |
2023-08-11 |
human |