| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A C Colige, C A Lambert, B V Nusgens, C M Lapièr. Effect of cell-cell and cell-matrix interactions on the response of fibroblasts to epidermal growth factor in vitro. Expression of collagen type I, collagenase, stromelysin and tissue inhibitor of metalloproteinases. The Biochemical journal. vol 285 ( Pt 1). 1992-08-21. PMID:1637302. |
addition of egf to subconfluent cultures for increasing periods of time up to 5 days induced an inhibition of procollagen alpha 1(i) mrna and a strong stimulation of collagenase (100-fold) and stromelysin (1000-fold) mrnas, whereas the mrna of timp was increased to a lesser extent (5-fold). |
1992-08-21 |
2023-08-11 |
Not clear |
| A C Colige, C A Lambert, B V Nusgens, C M Lapièr. Effect of cell-cell and cell-matrix interactions on the response of fibroblasts to epidermal growth factor in vitro. Expression of collagen type I, collagenase, stromelysin and tissue inhibitor of metalloproteinases. The Biochemical journal. vol 285 ( Pt 1). 1992-08-21. PMID:1637302. |
upon treatment of these cultures with egf for 48h, the steady-state level of collagenase, stromelysin and timp increased, whereas procollagen alpha 1(i) mrna was slightly reduced. |
1992-08-21 |
2023-08-11 |
Not clear |
| E McGlynn, M Becker, H Mett, S Reutener, R Cozens, N B Lydo. Large-scale purification and characterisation of a recombinant epidermal growth-factor receptor protein-tyrosine kinase. Modulation of activity by multiple factors. European journal of biochemistry. vol 207. issue 1. 1992-08-14. PMID:1321046. |
the human epidermal-growth-factor receptor (egf-r) is a 170-kda transmembrane glycoprotein that mediates the mitogenic response of cells to egf and transforming growth factor alpha. |
1992-08-14 |
2023-08-11 |
human |
| D A Vesey, A C Selden, A C Woodman, H J Hodgso. Effect of in vivo administration of an antibody to epidermal growth factor on the rapid increase in DNA synthesis induced by partial hepatectomy in the rat. Gut. vol 33. issue 6. 1992-08-11. PMID:1624168. |
recent reports indicate that transforming growth factor alpha (tgf-alpha) is produced within the liver and acts as the natural ligand of the epidermal growth factor (egf) receptor causing the egf receptor down regulation and the hepatocyte proliferation observed after partial hepatectomy. |
1992-08-11 |
2023-08-11 |
rat |
| R J Kreitman, V K Chaudhary, C B Siegall, D J FitzGerald, I Pasta. Rational design of a chimeric toxin: an intramolecular location for the insertion of transforming growth factor alpha within Pseudomonas exotoxin as a targeting ligand. Bioconjugate chemistry. vol 3. issue 1. 1992-08-05. PMID:1616950. |
the chimeric toxins with tgf alpha had the same binding affinity for the egf receptor whether the ligand occupied the amino or carboxyl position. |
1992-08-05 |
2023-08-11 |
mouse |
| D D Von Hoff, M H Marshall, D C Heimbrook, S M Stirdivant, J D Ahern, W K Herbert, R Z Maigetter, A Olif. Activity of a recombinant transforming growth factor-alpha-Pseudomonas exotoxin hybrid protein against primary human tumor colony-forming units. Investigational new drugs. vol 10. issue 1. 1992-07-23. PMID:1607249. |
tp40 is a bifunctional molecule that possesses the epidermal growth factor (egf) receptor binding properties of tgf alpha and the cell killing properties of pseudomonas exotoxin a. |
1992-07-23 |
2023-08-11 |
mouse |
| M J Dixon, M W Ferguso. The effects of epidermal growth factor, transforming growth factors alpha and beta and platelet-derived growth factor on murine palatal shelves in organ culture. Archives of oral biology. vol 37. issue 5. 1992-07-22. PMID:1610308. |
the medium was supplemented with either 10 ng/ml epidermal growth factor (egf), 10 ng/ml transforming growth factor alpha (tgf alpha), 1 ng/ml transforming growth factor beta (tgf beta 1) or 2 ng/ml platelet-derived growth factor (pdgf) all in the presence or absence of 2.5% donor calf serum (dcs). |
1992-07-22 |
2023-08-11 |
mouse |
| M J Dixon, M W Ferguso. The effects of epidermal growth factor, transforming growth factors alpha and beta and platelet-derived growth factor on murine palatal shelves in organ culture. Archives of oral biology. vol 37. issue 5. 1992-07-22. PMID:1610308. |
a similar pattern was obtained in serum-free medium supplemented with either egf or tgf alpha. |
1992-07-22 |
2023-08-11 |
mouse |
| M J Dixon, M W Ferguso. The effects of epidermal growth factor, transforming growth factors alpha and beta and platelet-derived growth factor on murine palatal shelves in organ culture. Archives of oral biology. vol 37. issue 5. 1992-07-22. PMID:1610308. |
however in cultures with either egf or tgf alpha plus 2.5% dcs present in the medium, medial-edge epithelial degeneration was inhibited and the oral epithelia were more heavily keratinized. |
1992-07-22 |
2023-08-11 |
mouse |
| F Basolo, C Serra, F Ciardiello, L Fiore, J Russo, D Campani, A Dolei, F Squartini, A Toniol. Regulation of surface-differentiation molecules by epidermal growth factor, transforming growth factor alpha, and hydrocortisone in human mammary epithelial cells transformed by an activated c-Ha-ras proto-oncogene. International journal of cancer. vol 51. issue 4. 1992-07-13. PMID:1601524. |
studies of 125i-2'-deoxyuridine incorporation in cultures given graded doses of hydrocortisone (hc), cholera toxin (ct), epidermal growth factor (egf), and transforming growth factor alpha (tgf-alpha) showed that though mcf-10t had become almost independent on exogenous egf and tgf-alpha, they continued to respond to the synergistic effect of hc and ct plus egf. |
1992-07-13 |
2023-08-11 |
human |
| Z Zhang, M Krause, D L Davi. Epidermal growth factor receptors in porcine endometrium: binding characteristics and the regulation of prostaglandin E and F2 alpha production. Biology of reproduction. vol 46. issue 5. 1992-06-26. PMID:1591349. |
egf increased pge (p less than 0.01) and pgf2 alpha (p less than 0.05) secretion by stromal cells. |
1992-06-26 |
2023-08-11 |
Not clear |
| Z Zhang, M Krause, D L Davi. Epidermal growth factor receptors in porcine endometrium: binding characteristics and the regulation of prostaglandin E and F2 alpha production. Biology of reproduction. vol 46. issue 5. 1992-06-26. PMID:1591349. |
the highest concentration (20 ng/ml) of egf increased secretion of pge and pgf2 alpha by 133% and 64%, respectively, over controls. |
1992-06-26 |
2023-08-11 |
Not clear |
| D Mischoulon, B Rana, N L Bucher, S R Farme. Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture. Molecular and cellular biology. vol 12. issue 6. 1992-06-24. PMID:1588957. |
c/ebp alpha mrna expression also decreases dramatically during the growth of freshly isolated normal hepatocytes cultured under conventional conditions (on dried rat tail collagen; stimulated to proliferate by epidermal growth factor [egf] and insulin). |
1992-06-24 |
2023-08-11 |
rat |
| D Mischoulon, B Rana, N L Bucher, S R Farme. Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture. Molecular and cellular biology. vol 12. issue 6. 1992-06-24. PMID:1588957. |
cultures of hepatocytes on rat tail collagen in the presence or absence of egf clearly show that within 3 h, egf depresses c/ebp alpha mrna expression and that this effect is substantially greater by 4 h. inhibition of protein synthesis in the liver by cycloheximide or in cultured hepatocytes by puromycin or cycloheximide effectively blocks the down-regulation of c/ebp alpha gene expression, apparently by stabilizing the normal rapid turnover of the c/ebp alpha mrna (half-life of <2 h). |
1992-06-24 |
2023-08-11 |
rat |
| S P Ethier, R Moorthy, C A Dilt. Secretion of an epidermal growth factor-like growth factor by epidermal growth factor-independent rat mammary carcinoma cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 2. issue 11. 1992-06-24. PMID:1726054. |
this growth factor is neither egf nor transforming growth factor alpha and does not compete with 125i-egf for binding to egf receptors. |
1992-06-24 |
2023-08-11 |
rat |
| M M Ip, S F Shoemaker, K M Darc. Regulation of rat mammary epithelial cell proliferation and differentiation by tumor necrosis factor-alpha. Endocrinology. vol 130. issue 5. 1992-06-03. PMID:1572296. |
tnf alpha (5-10,000 u/ml) stimulated mammary epithelial cell proliferation both under conditions previously considered optimal for their growth as well as in medium deficient in epidermal growth factor (egf). |
1992-06-03 |
2023-08-11 |
rat |
| M M Ip, S F Shoemaker, K M Darc. Regulation of rat mammary epithelial cell proliferation and differentiation by tumor necrosis factor-alpha. Endocrinology. vol 130. issue 5. 1992-06-03. PMID:1572296. |
moreover, tnf alpha could completely substitute for egf for cell proliferation. |
1992-06-03 |
2023-08-11 |
rat |
| M M Ip, S F Shoemaker, K M Darc. Regulation of rat mammary epithelial cell proliferation and differentiation by tumor necrosis factor-alpha. Endocrinology. vol 130. issue 5. 1992-06-03. PMID:1572296. |
under optimal conditions, tnf alpha had no effect on morphological differentiation, but in medium either lacking or deficient in egf or when suboptimal reconstituted basement membrane was used, tnf alpha (5-100 u/ml) had a marked stimulatory effect on lobular and ductal morphogenesis. |
1992-06-03 |
2023-08-11 |
rat |
| M M Ip, S F Shoemaker, K M Darc. Regulation of rat mammary epithelial cell proliferation and differentiation by tumor necrosis factor-alpha. Endocrinology. vol 130. issue 5. 1992-06-03. PMID:1572296. |
in the absence of egf, however, the effect of tnf alpha appeared to follow a bell-shaped curve. |
1992-06-03 |
2023-08-11 |
rat |
| M M Ip, S F Shoemaker, K M Darc. Regulation of rat mammary epithelial cell proliferation and differentiation by tumor necrosis factor-alpha. Endocrinology. vol 130. issue 5. 1992-06-03. PMID:1572296. |
at low concentrations (approximately 5 u/ml), tnf alpha stimulated casein production in parallel to its stimulation of morphological differentiation, although not to the same extent as in medium containing optimal levels of egf. |
1992-06-03 |
2023-08-11 |
rat |