| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Tarnawski, S Y Lu, J Stachura, I J Sarfe. Adaptation of gastric mucosa to chronic alcohol administration is associated with increased mucosal expression of growth factors and their receptor. Scandinavian journal of gastroenterology. Supplement. vol 193. 1993-03-24. PMID:1290059. |
chronic administration of ethanol (1 ml, 50% ethanol, twice daily) significantly increased the extent of gastric mucosal mucous and proliferative cell zones, the number of proliferating (dna synthesizing) cells and mucosal expression of egf, tgf alpha and egfr by 13, 6, and 20-fold, respectively. |
1993-03-24 |
2023-08-11 |
rat |
| A Tarnawski, S Y Lu, J Stachura, I J Sarfe. Adaptation of gastric mucosa to chronic alcohol administration is associated with increased mucosal expression of growth factors and their receptor. Scandinavian journal of gastroenterology. Supplement. vol 193. 1993-03-24. PMID:1290059. |
thus, adaptation of gastric mucosa to chronic alcohol administration is associated with increased cell proliferation and increased expression of mucosal egf, tgf alpha and egfr. |
1993-03-24 |
2023-08-11 |
rat |
| R Serra, H C Iso. Stimulation of DNA synthesis and protooncogene expression in primary rat hepatocytes in long-term DMSO culture. Journal of cellular physiology. vol 154. issue 3. 1993-03-23. PMID:8436603. |
tgf beta inhibited dna synthesis stimulated by egf shiftup, tgf alpha shiftup, or egf shiftup in combination with removal of dex + dmso. |
1993-03-23 |
2023-08-12 |
rat |
| R Serra, H C Iso. Stimulation of DNA synthesis and protooncogene expression in primary rat hepatocytes in long-term DMSO culture. Journal of cellular physiology. vol 154. issue 3. 1993-03-23. PMID:8436603. |
stimulation of dna synthesis was accompanied by a specific, sequential induction of protooncogene mrna levels; c-fos mrna was induced 23-fold at 0.5 h after readdition of egf; c-myc mrna was induced three- to four-fold by 0.5 h; tgf alpha mrna was induced sevenfold by 8 h; k-ras mrna was induced fourfold by 26 h. changes in protooncogene expression paralleled changes seen in regenerating liver. |
1993-03-23 |
2023-08-12 |
rat |
| N Brünner, D Yee, F G Kern, M Spang-Thomsen, M E Lippman, K J Culle. Effect of endocrine therapy on growth of T61 human breast cancer xenografts is directly correlated to a specific down-regulation of insulin-like growth factor II (IGF-II). European journal of cancer (Oxford, England : 1990). vol 29A. issue 4. 1993-03-22. PMID:8435211. |
this down-regulation was found to be specific for igf-ii, since analyses of the effect of e2 on the expression of igf-i mrna, 36b4 mrna, transforming growth factor alpha(tgf-alpha) mrna, and epidermal growth factor (egf) receptor mrna in t61 tumours did not reveal any down-regulation. |
1993-03-22 |
2023-08-12 |
human |
| H Modjtahedi, S Eccles, G Box, J Styles, C Dea. Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction. British journal of cancer. vol 67. issue 2. 1993-03-17. PMID:7679281. |
athymic mice bearing xenografts of human tumours that overexpress the receptor (egfr) for egf and tgf alpha have been used to evaluate the therapeutic potential of three new rat monoclonal antibodies (mabs) directed against two distinct epitopes on the extracellular domain of the human egfr. |
1993-03-17 |
2023-08-12 |
mouse |
| H Modjtahedi, J M Styles, C J Dea. The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468. British journal of cancer. vol 67. issue 2. 1993-03-17. PMID:8094290. |
unlike egf and tgf alpha none of the mabs stimulated the growth of quiescent human foreskin fibroblasts but they inhibited the egf and tgf alpha induced growth stimulation of these cells in vitro. |
1993-03-17 |
2023-08-12 |
human |
| Y Yang, G D Chisholm, F K Habi. Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels. British journal of cancer. vol 67. issue 1. 1993-03-10. PMID:7678977. |
we measured immunoreactive egf and tgf alpha in prostate tissue extracts obtained from 19 patients with benign prostatic hyperplasia (bph) and 19 with cancer of the prostate (cap). |
1993-03-10 |
2023-08-12 |
Not clear |
| Y Yang, G D Chisholm, F K Habi. Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels. British journal of cancer. vol 67. issue 1. 1993-03-10. PMID:7678977. |
whilst both bph and cap expressed egf (bph = 195.61 +/- 19.94 ng g-1 protein; cap = 235.60 +/- 24.45 ng g-1 protein) and tgf alpha (bph = 92.57 +/- 7.60 ng g-1 protein; cap = 100.73 +/- 15.47 ng g-1 protein) in equal concentrations, the levels of egf in any tissue extract were on average twice those of tgf alpha. |
1993-03-10 |
2023-08-12 |
Not clear |
| Y Yang, G D Chisholm, F K Habi. Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels. British journal of cancer. vol 67. issue 1. 1993-03-10. PMID:7678977. |
furthermore analysis of the individual growth factor data revealed a direct correlation between egf and tgf alpha in both bph (r = 0.72, p < 0.001) and cap (r = 0.69, p < 0.001). |
1993-03-10 |
2023-08-12 |
Not clear |
| Y Yang, G D Chisholm, F K Habi. Epidermal growth factor and transforming growth factor alpha concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels. British journal of cancer. vol 67. issue 1. 1993-03-10. PMID:7678977. |
there was a small positive correlation only between testosterone and egf (r = 0.62, p < 0.05) and testosterone and tgf alpha (r = 0.61, p < 0.05) in cap. |
1993-03-10 |
2023-08-12 |
Not clear |
| L Yang, A M Camoratto, G Baffy, S Raj, D R Manning, J R Williamso. Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes. The Journal of biological chemistry. vol 268. issue 5. 1993-03-09. PMID:8429049. |
egf also caused a rapid, tyrosine kinase-dependent association of g(i) alpha with plc-gamma, which was maximal within 10 min. |
1993-03-09 |
2023-08-12 |
Not clear |
| L Yang, A M Camoratto, G Baffy, S Raj, D R Manning, J R Williamso. Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes. The Journal of biological chemistry. vol 268. issue 5. 1993-03-09. PMID:8429049. |
the role of g-proteins in egf signaling was investigated further by microinjection of g alpha antibodies into single fura-2-loaded hepatocytes. |
1993-03-09 |
2023-08-12 |
Not clear |
| J Stagsted, S Ziebe, S Satoh, G D Holman, S W Cushman, L Olsso. Insulinomimetic effect on glucose transport by epidermal growth factor when combined with a major histocompatibility complex class I-derived peptide. The Journal of biological chemistry. vol 268. issue 3. 1993-02-18. PMID:8420953. |
transforming growth factor alpha had an effect similar to egf on glucose uptake. |
1993-02-18 |
2023-08-12 |
rat |
| D Kohda, M Odaka, I Lax, H Kawasaki, K Suzuki, A Ullrich, J Schlessinger, F Inagak. A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor. The Journal of biological chemistry. vol 268. issue 3. 1993-02-18. PMID:8420971. |
this fragment is a monomeric structural domain consisting of 202 amino acid residues (cys302-arg503) and 18-kda sugar chains, and binds egf and transforming growth factor-alpha (tgf alpha). |
1993-02-18 |
2023-08-12 |
human |
| J L Tilly, H Billig, K I Kowalski, A J Hsue. Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Molecular endocrinology (Baltimore, Md.). vol 6. issue 11. 1993-02-10. PMID:1480180. |
treatment of granulosa cells with epidermal growth factor (egf), transforming growth factor-alpha (tgf alpha), or basic fibroblast growth factor (bfgf) inhibited the spontaneous onset of apoptotic dna cleavage found during culture by 40-60%. |
1993-02-10 |
2023-08-11 |
rat |
| I Teitelbau. Hormone signaling systems in inner medullary collecting ducts. The American journal of physiology. vol 263. issue 6 Pt 2. 1993-02-05. PMID:1362328. |
these include the following: adenylyl cyclase activity stimulated by vasopressin (avp), beta-adrenergic agonists, or prostanoids and inhibited by alpha 2-adrenergic agents or adenosine; guanylate cyclase activity in response to atrial natriuretic peptide (anp); phospholipase c activity stimulated by anp, avp, bradykinin, endothelin, epidermal growth factor (egf), and muscarinic cholinergic agents; and phospholipase a2 activity stimulated by avp, bradykinin, egf, and endothelin. |
1993-02-05 |
2023-08-11 |
Not clear |
| M Harbers, P Borowski, W Fanick, H Lengyel, F Buck, K D Hinsch, H Hil. Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro. Carcinogenesis. vol 13. issue 12. 1993-02-03. PMID:1473250. |
promotion of 'initiated' jb6 epidermal cells to the tumor phenotype can be effected by 12-o-tetradecanoylphorbol-13-acetate treatment, by stimulation of epidermal growth factor (egf) receptor activity with egf or transforming growth factor alpha and by exposure to the isoquinoline derivative h7. |
1993-02-03 |
2023-08-11 |
Not clear |
| A J Watso. The cell biology of blastocyst development. Molecular reproduction and development. vol 33. issue 4. 1993-01-29. PMID:1335276. |
several of these gene products have been identified and include the tight junction (zo-1), na/k-atpase (alpha and beta subunits), uvomorulin, gap junction (connexin43), and growth factors such as transforming growth factor-alpha (tgf-alpha) and epidermal growth factor (egf). |
1993-01-29 |
2023-08-11 |
Not clear |
| S R Ojeda, G A Dissen, M P Junie. Neurotrophic factors and female sexual development. Frontiers in neuroendocrinology. vol 13. issue 2. 1993-01-28. PMID:1468600. |
in glial cells it may interact with epidermal growth factor (egf) receptors to further enhance tgf alpha synthesis and to, perhaps, stimulate eicosanoid formation. |
1993-01-28 |
2023-08-11 |
rat |