| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Chudaska, W Schlege. The influence of growth factors on the prostaglandin synthesis in cultured rabbit luteal cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 25. issue 6. 1993-09-03. PMID:8344644. |
aa together with egf increased the level of pg more pronounced when compared with aa alone (1.5-fold for pge2, 5-fold for pgf2 alpha; p < 0.05 and p < 0.005). |
1993-09-03 |
2023-08-12 |
rabbit |
| J Baselga, L Norton, H Masui, A Pandiella, K Coplan, W H Miller, J Mendelsoh. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. Journal of the National Cancer Institute. vol 85. issue 16. 1993-08-31. PMID:8340945. |
a variety of human tumors frequently express high levels of epidermal growth factor (egf) receptor and its ligand, transforming growth factor alpha (tgf-alpha), which in some tumors is associated with poor prognosis. |
1993-08-31 |
2023-08-12 |
human |
| C K Jiang, T Magnaldo, M Ohtsuki, I M Freedberg, F Bernerd, M Blumenber. Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 14. 1993-08-30. PMID:7688128. |
we have analyzed the effects of egfr activation on keratin gene transcription by transfecting dnas containing keratin promoters linked to a reporter gene into primary cultures of human epidermal keratinocytes in the presence or absence of egf or transforming growth factor alpha (tgf alpha), two growth factors that activate egfr. |
1993-08-30 |
2023-08-12 |
human |
| P D Mier, C A van Hooijdonk, R F Freund, G J de Jongh, P E van Erp, P C van de Kerkho. EGF induces ornithine decarboxylase transcription in Balb/MK keratinocytes: a proposed mechanism for the TGF alpha autocrine loop. Archives of dermatological research. vol 285. issue 4. 1993-08-30. PMID:8342967. |
egf induces ornithine decarboxylase transcription in balb/mk keratinocytes: a proposed mechanism for the tgf alpha autocrine loop. |
1993-08-30 |
2023-08-12 |
Not clear |
| M E Harper, L Goddard, E Glynne-Jones, D W Wilson, M Price-Thomas, W B Peeling, K Griffith. An immunocytochemical analysis of TGF alpha expression in benign and malignant prostatic tumors. The Prostate. vol 23. issue 1. 1993-08-24. PMID:7687782. |
as in the prostatic carcinomas, the immunostaining was eliminated by prior absorption of the antibody with pure tgf alpha and not with human or mouse egf. |
1993-08-24 |
2023-08-12 |
mouse |
| M E Harper, L Goddard, E Glynne-Jones, D W Wilson, M Price-Thomas, W B Peeling, K Griffith. An immunocytochemical analysis of TGF alpha expression in benign and malignant prostatic tumors. The Prostate. vol 23. issue 1. 1993-08-24. PMID:7687782. |
no crossreactivity of the tgf alpha antibody with salivary egf was demonstrated. |
1993-08-24 |
2023-08-12 |
mouse |
| F Ciardiello, C Bianco, N Normanno, G Baldassarre, S Pepe, G Tortora, A R Bianco, D S Salomo. Infection with a transforming growth factor alpha anti-sense retroviral expression vector reduces the in vitro growth and transformation of a human colon cancer cell line. International journal of cancer. vol 54. issue 6. 1993-08-24. PMID:8335403. |
geo cells, from a human colon carcinoma cell line that expresses tgf alpha and functional epidermal growth factor (egf) receptors, were infected with a replication-defective, recombinant amphotropic retroviral expression vector containing the neomycin-resistance gene and a 435-bp apai-ecori coding fragment of the human tgf alpha cdna oriented in the 3' to 5' direction under the transcriptional control of the heavy-metal-inducible mouse metallothionein i promoter. |
1993-08-24 |
2023-08-12 |
mouse |
| K J Fowler, G B Mann, A R Dun. Linkage of the murine transforming growth factor alpha gene with Igk, Ly-2, and Fabp1 on chromosome 6. Genomics. vol 16. issue 3. 1993-08-12. PMID:8100806. |
although its physiological role in normal tissues is uncertain, the autocrine action of tgf alpha on the egf receptor is postulated to play a role in tumorigenesis. |
1993-08-12 |
2023-08-12 |
mouse |
| K Morishige, H Kurachi, K Amemiya, H Adachi, K Adachi, Y Sakoyama, A Miyake, O Tanizaw. Menstrual stage-specific expression of epidermal growth factor and transforming growth factor-alpha in human oviduct epithelium and their role in early embryogenesis. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8319567. |
quantitative reverse transcription and polymerase chain reaction, using beta-actin messenger rna as an internal standard, revealed the menstrual stage-specific expression of egf and tgf alpha gene transcripts: relative amounts of egf and tgf alpha messenger rna to those of beta-actin were 1.5 +/- 1.9% (mean +/- sd) and 1.4 +/- 0.6% (n = 3) at early follicular, 16.5 +/- 4.9% and 12.6 +/- 2.6% (n = 3) at late follicular, and 18.9 +/- 2.2% and 13.8 +/- 3.2% (n = 3) at luteal stages, respectively. |
1993-08-03 |
2023-08-12 |
mouse |
| K Morishige, H Kurachi, K Amemiya, H Adachi, K Adachi, Y Sakoyama, A Miyake, O Tanizaw. Menstrual stage-specific expression of epidermal growth factor and transforming growth factor-alpha in human oviduct epithelium and their role in early embryogenesis. Endocrinology. vol 133. issue 1. 1993-08-03. PMID:8319567. |
all these results showed that egf and tgf alpha were synthesized and expressed in human oviduct epithelium specifically to menstrual stages, and that these growth factors may be involved in early embryonic development. |
1993-08-03 |
2023-08-12 |
mouse |
| S Suzuk. [Effects of growth factors on the gene expression of extracellular matrix components in cultured rat mesangial cells]. Nihon Jinzo Gakkai shi. vol 35. issue 2. 1993-07-29. PMID:8315884. |
mcs showed little increase in the gene expression for alpha 1 (iv) collagen and fibronectin by the addition of pdgf, egf, and et, and no change was noted in the igf-treated mcs. |
1993-07-29 |
2023-08-12 |
rat |
| S A Halter, A R Winnier, C L Arteag. Pretreatment with vitamin A inhibits transforming growth factor alpha stimulation of human mammary carcinoma cells. Journal of cellular physiology. vol 156. issue 1. 1993-07-27. PMID:7686167. |
in the t47d cell line the mechanism was not related to an effect on the cellular content of tgf alpha, epidermal growth factor (egf) receptor protein, egf receptor mrna, or on the binding of tgf alpha to the egf receptor. |
1993-07-27 |
2023-08-12 |
human |
| S A Halter, A R Winnier, C L Arteag. Pretreatment with vitamin A inhibits transforming growth factor alpha stimulation of human mammary carcinoma cells. Journal of cellular physiology. vol 156. issue 1. 1993-07-27. PMID:7686167. |
these results suggest that pretreatment with retinol decreases cellular proliferation seen with tgf alpha treatment by altering phospholipase c-gamma 1 response and/or egf receptor tyrosine kinase activity. |
1993-07-27 |
2023-08-12 |
human |
| D Wölfle, E Becker, C Schmutt. Growth stimulation of primary rat hepatocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cell biology and toxicology. vol 9. issue 1. 1993-07-27. PMID:8100183. |
under culture conditions allowing high rates of dna synthesis, e.g., at low concentrations of dexamethasone, in the presence of egf plus alpha 1-adrenergic agonists or rat serum, no significant effect of tcdd on cellular growth was observed. |
1993-07-27 |
2023-08-12 |
rat |
| D L Cadena, G N Gil. Expression and purification of the epidermal growth factor receptor extracellular domain utilizing a polycistronic expression system. Protein expression and purification. vol 4. issue 3. 1993-07-27. PMID:8518559. |
glutaraldehyde crosslinking was used to show that egfr-ed specifically binds egf and tgf alpha and that the affinity for egf is 5.5 x 10(-7) m. |
1993-07-27 |
2023-08-12 |
Not clear |
| M S Filla, C X Zhang, K L Kau. A potential transforming growth factor alpha/epidermal growth factor receptor autocrine circuit in placental cytotrophoblasts. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 4. issue 5. 1993-07-26. PMID:8518231. |
a potential autocrine loop involving transforming growth factor alpha (tgf-alpha) and the epidermal growth factor (egf) receptor (egfr) in benign placental cytotrophoblasts was examined. |
1993-07-26 |
2023-08-12 |
Not clear |
| C Garcìa Castro, M Ravina, V Castro, E C Salid. Expression of epidermal growth factor receptor (proto-oncogene c-erbB-1) and estrogen receptor in human breast carcinoma. An immunocytochemical study of 70 cases. Archives of gynecology and obstetrics. vol 252. issue 4. 1993-07-15. PMID:8512345. |
we found an inverse relationship between the expression of egf-r and er (kendall's tau b = -0.1997, p < 0.03), which prompts us to conclude that er(-) breast carcinomas may grow in a hormone-independent manner through the over-expression of the proto-oncogene c-erbb-1, which is the receptor for epidermal (egf) and alpha transforming (tgfalfa) growth factors. |
1993-07-15 |
2023-08-12 |
human |
| L L Chen, R Narayanan, M S Hibbs, P A Benn, M L Clawson, G Lu, J S Rhim, B Greenberg, J Mendelsoh. Altered epidermal growth factor signal transduction in activated Ha-ras-transformed human keratinocytes. Biochemical and biophysical research communications. vol 193. issue 1. 1993-07-01. PMID:8503904. |
the karyotype, the expression of egf receptor (egfr) and transforming growth factor (tgf) alpha at the mrna level remained unchanged. |
1993-07-01 |
2023-08-12 |
human |
| K Yoshida, H Kuniyasu, W Yasui, Y Kitadai, T Toge, E Tahar. Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. Journal of cancer research and clinical oncology. vol 119. issue 7. 1993-06-17. PMID:8491760. |
the expression of mrnas for epidermal growth factor (egf), transforming growth factor alpha(tgf alpha), egfr, platelet-derived growth factor (pdgf) a and b chain, pdgf receptor (pdgfr), transforming growth factor beta (tgf beta), erbb-2 and estrogen receptor (er) genes was first examined in 6 human esophageal carcinoma cell lines, 6 xenoplanted and 15 surgically resected esophageal carcinomas. |
1993-06-17 |
2023-08-12 |
human |
| K Yoshida, H Kuniyasu, W Yasui, Y Kitadai, T Toge, E Tahar. Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. Journal of cancer research and clinical oncology. vol 119. issue 7. 1993-06-17. PMID:8491760. |
secondly, the effect of egf and tgf alpha on the expression of these genes by the te-1 esophageal carcinoma cell line was investigated. |
1993-06-17 |
2023-08-12 |
human |