| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T M Fynan, M Reis. Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis. Critical reviews in oncogenesis. vol 4. issue 5. 1993-12-23. PMID:8241322. |
transforming growth factor-beta (tgf beta) was first described as a soluble factor capable of transforming normal rat kidney cells in the presence of transforming growth factor-alpha (tgf alpha) or epidermal growth factor (egf). |
1993-12-23 |
2023-08-12 |
rat |
| H H Wu, H Kawamata, D D Wang, R Oyas. Immunohistochemical localization of transforming growth factor alpha in the major salivary glands of male and female rats. The Histochemical journal. vol 25. issue 9. 1993-12-21. PMID:8226101. |
the three major salivary glands of normal male and female fischer 344 rats of different ages were examined for the localization of epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) by immunohistochemical staining. |
1993-12-21 |
2023-08-12 |
rat |
| T Modéer, T Yucel-Lindberg, M Iinuma, U H Lerner, G Andersso. Epidermal growth factor potentiates interleukin 1 and tumor necrosis factor-induced prostaglandin biosynthesis in human gingival fibroblasts. Cytokine. vol 5. issue 3. 1993-12-15. PMID:8218931. |
the effects of and interactions between epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha) interleukin 1 (il-1) and tumour necrosis factor alpha (tnf-alpha) on arachidonic acid release and prostaglandin biosynthesis in human gingival fibroblasts were studied. |
1993-12-15 |
2023-08-12 |
human |
| I Appleton, A Tomlinson, P R Colville-Nash, D A Willoughb. Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes. Laboratory investigation; a journal of technical methods and pathology. vol 69. issue 4. 1993-11-29. PMID:8231109. |
this study investigated the temporal and spatial distribution of transforming growth factor-beta (tgf-beta), platelet-derived growth factor (pdgf), epidermal growth factor (egf), basic fibroblast growth factor (bfgf), tumor necrosis factor-alpha (tnf-alpha), interleukin-1 alpha (il-1) and il-1 beta in developing granulomatous tissue. |
1993-11-29 |
2023-08-12 |
Not clear |
| B G Nair, T B Pate. Regulation of cardiac adenylyl cyclase by epidermal growth factor (EGF). Role of EGF receptor protein tyrosine kinase activity. Biochemical pharmacology. vol 46. issue 7. 1993-11-23. PMID:8216375. |
we have shown previously that the alpha subunit of the stimulatory gtp binding regulatory component of adenylyl cyclase (gs alpha) mediates epidermal growth factor (egf)-elicited stimulation of rat cardiac adenylyl cyclase (nair et al., j biol chem 265: 21317-21322, 1990). |
1993-11-23 |
2023-08-12 |
rat |
| J S Sanfilippo, C V Rao, J J Guarnaschelli, P G Woost, V M Byrd, E Jones, G S Schult. Detection of epidermal growth factor and transforming growth factor alpha protein in meningiomas and other tumors of the central nervous system in human beings. Surgery, gynecology & obstetrics. vol 177. issue 5. 1993-11-18. PMID:8211601. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) are potent mitogens for normal cells of ectodermal and mesodermal origin. |
1993-11-18 |
2023-08-12 |
human |
| J S Sanfilippo, C V Rao, J J Guarnaschelli, P G Woost, V M Byrd, E Jones, G S Schult. Detection of epidermal growth factor and transforming growth factor alpha protein in meningiomas and other tumors of the central nervous system in human beings. Surgery, gynecology & obstetrics. vol 177. issue 5. 1993-11-18. PMID:8211601. |
evidence is accumulating that suggests that egf, tgf alpha and their common receptor (egf/tgf alpha-r) influence development and functioning of tissues of the central nervous system (cns). |
1993-11-18 |
2023-08-12 |
human |
| J S Sanfilippo, C V Rao, J J Guarnaschelli, P G Woost, V M Byrd, E Jones, G S Schult. Detection of epidermal growth factor and transforming growth factor alpha protein in meningiomas and other tumors of the central nervous system in human beings. Surgery, gynecology & obstetrics. vol 177. issue 5. 1993-11-18. PMID:8211601. |
to further investigate the possible roles of egf, tgf alpha and their receptor in autocrine/paracrine regulation of tumor growth in the cns, a series of tumors of the cns were analyzed for the presence of specific, high affinity egf/tgf alpha receptors and for the presence of immunoreactive tgf alpha protein. |
1993-11-18 |
2023-08-12 |
human |
| J S Sanfilippo, C V Rao, J J Guarnaschelli, P G Woost, V M Byrd, E Jones, G S Schult. Detection of epidermal growth factor and transforming growth factor alpha protein in meningiomas and other tumors of the central nervous system in human beings. Surgery, gynecology & obstetrics. vol 177. issue 5. 1993-11-18. PMID:8211601. |
binding of 125i-egf to crude membranes from a pool of meningiomas was competed for equally well by low concentrations of unlabeled egf or tgf alpha, but not by high concentrations of other protein hormones, demonstrating the high degree of specificity of the egf/tgf alpha receptor. |
1993-11-18 |
2023-08-12 |
human |
| J S Sanfilippo, C V Rao, J J Guarnaschelli, P G Woost, V M Byrd, E Jones, G S Schult. Detection of epidermal growth factor and transforming growth factor alpha protein in meningiomas and other tumors of the central nervous system in human beings. Surgery, gynecology & obstetrics. vol 177. issue 5. 1993-11-18. PMID:8211601. |
a series of 13 tumors of the cns were analyzed for egf alpha with use of a specific radioimmunoassay. |
1993-11-18 |
2023-08-12 |
human |
| U Renner, J Mojto, E Arzt, M Lange, J Stalla, O A Müller, G K Stall. Secretion of polypeptide growth factors by human nonfunctioning pituitary adenoma cells in culture. Neuroendocrinology. vol 57. issue 5. 1993-11-17. PMID:8413819. |
addition of neutralizing antibodies against transforming growth factor alpha (tgf-alpha), epidermal growth factor (egf), insulin-like growth factor i (igf-i) and basic fibroblast growth factor (bfgf), either alone or in different combinations, reduced the growth-promoting activity of tu-cm on rat pituitary cells (range: 96-71%; control = growth effect of tu-cm without antibodies = 100%), strongly indicating the presence of these growth factors in tu-cm. |
1993-11-17 |
2023-08-12 |
human |
| J Qu, K Thoma. Regulation of inhibin secretion in human placental cell culture by epidermal growth factor, transforming growth factors, and activin. The Journal of clinical endocrinology and metabolism. vol 77. issue 4. 1993-11-12. PMID:8408467. |
in this study, the effects of epidermal growth factor (egf), transforming growth factor-alpha (tgf alpha), tgf beta 1, and activin-a on inhibin secretion were investigated in primary culture of human placental cells. |
1993-11-12 |
2023-08-12 |
human |
| Z Li, A L Johnso. Regulation of P450 cholesterol side-chain cleavage messenger ribonucleic acid expression and progesterone production in hen granulosa cells. Biology of reproduction. vol 49. issue 3. 1993-11-08. PMID:8399837. |
the present studies were conducted to evaluate the actions of fsh and of the growth factors epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), and insulin-like growth factor i (igf-i) in regulating levels of p450scc mrna and initiating progesterone production in cultured granulosa cells from 6- to 8-mm follicles. |
1993-11-08 |
2023-08-12 |
human |
| Z Li, A L Johnso. Regulation of P450 cholesterol side-chain cleavage messenger ribonucleic acid expression and progesterone production in hen granulosa cells. Biology of reproduction. vol 49. issue 3. 1993-11-08. PMID:8399837. |
while both egf and tgf alpha blocked the ability of rhfsh to increase p450scc mrna levels and initiate progesterone production, igf-i failed to alter p450scc mrna levels or progesterone production in either the presence or absence of rhfsh. |
1993-11-08 |
2023-08-12 |
human |
| Z Li, A L Johnso. Regulation of P450 cholesterol side-chain cleavage messenger ribonucleic acid expression and progesterone production in hen granulosa cells. Biology of reproduction. vol 49. issue 3. 1993-11-08. PMID:8399837. |
furthermore, we propose that egf and tgf alpha are, at least in part, responsible for preventing premature differentiation of granulosa cells in ovarian follicles that have not yet been selected into the preovulatory hierarchy. |
1993-11-08 |
2023-08-12 |
human |
| M E Christensen, M H Therkildsen, S S Poulsen, P Bretla. Transforming growth factor alpha and epidermal growth factor in laryngeal carcinomas demonstrated by immunohistochemistry. Acta oto-laryngologica. vol 113. issue 4. 1993-10-21. PMID:7691024. |
fifteen laryngeal squamous cell carcinomas were investigated for the presence of transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf) using immunohistochemical methods. |
1993-10-21 |
2023-08-12 |
Not clear |
| M R Pittelkow, P W Cook, G D Shipley, R Derynck, R J Coffe. Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 4. issue 6. 1993-10-21. PMID:8373735. |
in the studies reported here, we demonstrate that transforming growth factor alpha (tgf-alpha) or epidermal growth factor (egf) is required for the establishment of small colonies of human keratinocytes at clonal densities, but once small (10-15 cells) colonies have formed, the continued growth of these colonies can proceed in the absence of exogenous tgf-alpha or egf. |
1993-10-21 |
2023-08-12 |
human |
| N J Reynolds, H S Talwar, J J Baldassare, P A Henderson, J T Elder, J J Voorhees, G J Fishe. Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes. The Biochemical journal. vol 294 ( Pt 2). 1993-10-13. PMID:7690546. |
we have investigated coupling between the epidermal growth factor (egf) receptor and the phospholipase c (plc)/protein kinase c (pkc) signal-transduction system in normal skin fibroblasts and keratinocytes, for which egf and transforming growth factor alpha (tgf-alpha) are mitogenic. |
1993-10-13 |
2023-08-12 |
human |
| N L Occleston, C Walke. Production of multiple growth factors by a human non-small cell lung carcinoma cell line. Cancer letters. vol 71. issue 1-3. 1993-10-06. PMID:8395975. |
the 1pt cell line, derived from an undifferentiated bronchial carcinoma, produced, in conditioned medium, immunoreactive basic fibroblast growth factor (bfgf), insulin-like growth factors i and ii (igf-i and igf-ii), epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), and transforming growth factor beta-2 (tgf beta 2) in its latent form, but not platelet-derived growth factor (pdgf), tumour necrosis factor alpha (tnf alpha), or transforming growth factor beta-1 (tgf beta 1). |
1993-10-06 |
2023-08-12 |
human |
| K Hasegawa, B I Car. Neurotensin-amplification of DNA synthesis stimulated by EGF or TGF alpha in primary cultures of adult rat hepatocytes. Cell structure and function. vol 18. issue 2. 1993-10-05. PMID:8364977. |
neurotensin-amplification of dna synthesis stimulated by egf or tgf alpha in primary cultures of adult rat hepatocytes. |
1993-10-05 |
2023-08-12 |
rat |