| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Refsnes, G H Thoresen, O F Dajani, T Christofferse. Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: additivity with the effect of norepinephrine, and synergism with epidermal growth factor. Journal of cellular physiology. vol 159. issue 1. 1994-04-22. PMID:8138589. |
previous data obtained in vivo and in vitro suggest that both prostaglandins (pgs) and catecholamines may have a role in promoting hepatocyte proliferation, and pge2 and pgf2 alpha have also been implicated as mediators of the mitogenic actions of epidermal growth factor (egf) (and transforming growth factor alpha [tgf alpha]). |
1994-04-22 |
2023-08-12 |
rat |
| M Refsnes, G H Thoresen, O F Dajani, T Christofferse. Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: additivity with the effect of norepinephrine, and synergism with epidermal growth factor. Journal of cellular physiology. vol 159. issue 1. 1994-04-22. PMID:8138589. |
a more quantitative analysis of the effects of pge2 and pgf2 alpha on the dna synthesis, in the presence and absence of egf, indicated that these pgs interacted in an essentially multiplicative manner with the effect of egf. |
1994-04-22 |
2023-08-12 |
rat |
| M Refsnes, G H Thoresen, O F Dajani, T Christofferse. Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: additivity with the effect of norepinephrine, and synergism with epidermal growth factor. Journal of cellular physiology. vol 159. issue 1. 1994-04-22. PMID:8138589. |
the data suggest a) that pge2 and pgf2 alpha facilitate and synergize with, rather than mediate, the actions of egf in hepatocytes, and b) that this effect of the pgs occurs by mechanisms that are at least partly distinct from those of norepinephrine. |
1994-04-22 |
2023-08-12 |
rat |
| E A Musgrove, R L Sutherlan. Acute effects of growth factors on T-47D breast cancer cell cycle progression. European journal of cancer (Oxford, England : 1990). vol 29A. issue 16. 1994-03-31. PMID:8110499. |
t-47d cells, growth-inhibited by serum deprivation, were induced to re-enter the cell cycle in a concentration- and time-dependent manner by addition of insulin, insulin-like growth factor (igf)-i, epidermal growth factor (egf), transforming growth factor alpha (tgf alpha) or basic fibroblast growth factor (bfgf). |
1994-03-31 |
2023-08-12 |
human |
| E A Musgrove, R L Sutherlan. Acute effects of growth factors on T-47D breast cancer cell cycle progression. European journal of cancer (Oxford, England : 1990). vol 29A. issue 16. 1994-03-31. PMID:8110499. |
the relative potencies of maximal concentrations of growth factors were in the order: insulin approximately igf-i approximately bfgf > tgf alpha > egf, identifying bfgf as among the most potent mitogens for these cells. |
1994-03-31 |
2023-08-12 |
human |
| C Missale, F Boroni, S Sigala, L Castelletti, P Falardeau, R Dal Toso, M G Caron, P Span. Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells. Journal of neurochemistry. vol 62. issue 3. 1994-03-28. PMID:8113812. |
the gh-3 pituitary tumor cell line, which lacks functional d2 receptors, responds to epidermal growth factor (egf) by expressing a d2 receptor that, paradoxically, couples to potassium channel activation but poorly inhibits adenylyl cyclase; this was correlated with a pronounced increase in alpha subunit of the g protein gi3. |
1994-03-28 |
2023-08-12 |
rat |
| B A Thorne, G D Plowma. The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion. Molecular and cellular biology. vol 14. issue 3. 1994-03-25. PMID:8114701. |
the five members of the human epidermal growth factor (egf) family (egf, transforming growth factor alpha [tgf-alpha], heparin-binding egf-like growth factor [hb-egf], betacellulin, and amphiregulin [ar]) are synthesized as transmembrane proteins whose extracellular domains are proteolytically processed to release the biologically active mature growth factors. |
1994-03-25 |
2023-08-12 |
human |
| J K Pollard, D Thai, M D Mitchel. Evidence for a common mechanism of action of interleukin-1 beta, tumor necrosis factor-alpha, and epidermal growth factor on prostaglandin production in human chorion cells. American journal of reproductive immunology (New York, N.Y. : 1989). vol 30. issue 2-3. 1994-03-24. PMID:8311923. |
although chorion produces prostaglandins in response to interleukin-1 beta (il-1 beta), tumor necrosis factor alpha (tnf alpha), and epidermal growth factor (egf), little attention has been given to the mechanisms of action of prostaglandin biosynthesis in this tissue. |
1994-03-24 |
2023-08-12 |
human |
| H Friess, Y Yamanaka, M Büchler, M S Kobrin, E Tahara, M Kor. Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis. International journal of cancer. vol 56. issue 5. 1994-03-23. PMID:8314343. |
cripto is a 188 amino-acid protein containing a central segment that shares amino-acid sequence homology with epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha). |
1994-03-23 |
2023-08-12 |
human |
| C B Kienhuis, P G Koenders, H Klominska, T J Benraa. Endogenous ligands for the epidermal growth factor receptor in human breast tumors do not interfere in an epidermal growth factor receptor radioligand binding assay. Breast cancer research and treatment. vol 27. issue 3. 1994-03-22. PMID:8312585. |
egf and transforming growth factor alpha, tgf alpha) may be included in membrane preparations from human breast tumors, either complexed or not to egfr. |
1994-03-22 |
2023-08-12 |
human |
| C B Kienhuis, P G Koenders, H Klominska, T J Benraa. Endogenous ligands for the epidermal growth factor receptor in human breast tumors do not interfere in an epidermal growth factor receptor radioligand binding assay. Breast cancer research and treatment. vol 27. issue 3. 1994-03-22. PMID:8312585. |
assessment of egfr in human placental membranes (hpm) after preincubation with human egf (hegf) or human tgf alpha (htgf alpha) indicated that the presence of these ligands in a membrane preparations did not affect the apparent number of binding sites, but only resulted in an increased apparent dissociation constant (kd). |
1994-03-22 |
2023-08-12 |
human |
| J Sedlak, P Speiser, L Hunakova, J Duraj, B Chorvat. Modulation of EGF receptor and CD15 (Lewisx) antigen on the cell surface of breast carcinoma cell lines induced by cytokines, retinoic acid, 12-O-tetradecanoylphorbol 13-acetate and 1,25(OH)2-vitamin D3. Chemotherapy. vol 40. issue 1. 1994-03-17. PMID:7905817. |
interleukin (il) 1 alpha induced the up-regulation of cell-surfac-expressed epidermal growth factor (egf) receptor on both mda-mb-468 and bt-20 breast cancer cell lines. |
1994-03-17 |
2023-08-12 |
Not clear |
| J Sedlak, P Speiser, L Hunakova, J Duraj, B Chorvat. Modulation of EGF receptor and CD15 (Lewisx) antigen on the cell surface of breast carcinoma cell lines induced by cytokines, retinoic acid, 12-O-tetradecanoylphorbol 13-acetate and 1,25(OH)2-vitamin D3. Chemotherapy. vol 40. issue 1. 1994-03-17. PMID:7905817. |
il-1 beta and tumor necrosis factor alpha (tnf-alpha) increased the egf receptor surface expression only on bt-20 breast carcinoma cells. |
1994-03-17 |
2023-08-12 |
Not clear |
| M A Matthay, J P Thiery, F Lafont, F Stampfer, B Boye. Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. Journal of cell science. vol 106 ( Pt 3). 1994-03-11. PMID:8308069. |
the effect of egf was abolished by inhibiting alpha 2 integrins with specific antibodies, indicating that part of the mechanism for the increase in cell motility and accelerated wound closure depends on alpha 2 integrin functional expression. |
1994-03-11 |
2023-08-12 |
human |
| K Z Ching, E Ramsey, N Pettigrew, R D'Cunha, M Jason, J G Dod. Expression of mRNA for epidermal growth factor, transforming growth factor-alpha and their receptor in human prostate tissue and cell lines. Molecular and cellular biochemistry. vol 126. issue 2. 1994-03-09. PMID:7508078. |
enhanced expression of the epidermal growth factor receptor (egfr) or its ligands, epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) can increase signalling via receptor-mediated pathways which may lead to excessive proliferation and cellular transformation. |
1994-03-09 |
2023-08-12 |
human |
| C L Brunet, P M Sharpe, M W Ferguso. The distribution of epidermal growth factor binding sites in the developing mouse palate. The International journal of developmental biology. vol 37. issue 3. 1994-03-03. PMID:8292539. |
using submerged culture the mechanism of this down-regulation was investigated by treating with various growth factors such as egf, basic fibroblast growth factor (bfgf), insulin-like growth factor-ii (igf-ii) and transforming growth factors alpha and beta (tgf-alpha, tgf-beta). |
1994-03-03 |
2023-08-12 |
mouse |
| Z Li, A L Johnso. Expression and regulation of cytochrome P450 17 alpha-hydroxylase messenger ribonucleic acid levels and androstenedione production in hen granulosa cells. Biology of reproduction. vol 49. issue 6. 1994-02-24. PMID:8286611. |
by contrast, addition of the growth factors transforming growth factor alpha (tgf alpha), epidermal growth factor (egf), and basic fibroblast growth factor (bfgf) completely suppressed the stimulatory effects of fsh on both mrna levels and androstenedione production, while insulin-like growth factor i (igf-i) inhibited only androstenedione production. |
1994-02-24 |
2023-08-12 |
Not clear |
| M Müller, C Flössel, M Haase, T Luther, S Albrecht, P P Nawroth, Y Zhan. Cellular localization of tissue factor in human breast cancer cell lines. Virchows Archiv. B, Cell pathology including molecular pathology. vol 64. issue 5. 1994-02-24. PMID:8287123. |
the present study deals with the immunocytochemically detectable cellular distribution of tf in human breast cancer cell lines mcf-7 and matu stimulated by egf and tgf alpha. |
1994-02-24 |
2023-08-12 |
human |
| Y M Fu, E A Mesri, Z X Yu, R J Kreitman, I Pastan, S E Epstei. Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin. Cardiovascular research. vol 27. issue 9. 1994-02-22. PMID:8287449. |
a chimeric toxin created by genetically fusing the gene encoding tgf alpha (targets the egf receptor) to the gene encoding pseudomonas exotoxin (pe) preferentially kills rapidly proliferating smooth muscle cells. |
1994-02-22 |
2023-08-12 |
Not clear |
| S S Prime, S M Game, J B Matthews, A Stone, M J Donnelly, W A Yeudall, V Patel, R Sposto, A Silverthorne, C Scull. Epidermal growth factor and transforming growth factor alpha characteristics of human oral carcinoma cell lines. British journal of cancer. vol 69. issue 1. 1994-02-18. PMID:8286215. |
this study examined the expression of epidermal growth factor (egf) cell-surface receptors, the response to exogenous ligand and the autocrine production of transforming growth factor alpha (tgf-alpha) in normal and carcinoma-derived human oral keratinocytes. |
1994-02-18 |
2023-08-12 |
human |