| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Fan, H Masui, I Altas, J Mendelsoh. Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer research. vol 53. issue 18. 1993-10-01. PMID:8364927. |
we have previously described anti-epidermal growth factor (egf) receptor monoclonal antibodies (mabs) which can block binding of transforming growth factor alpha (tgf-alpha) and egf to receptors and inhibit activation of receptor tyrosine kinase. |
1993-10-01 |
2023-08-12 |
mouse |
| M R Stampfer, C H Pan, J Hosoda, J Bartholomew, J Mendelsohn, P Yaswe. Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous reentry into the cell cycle. Experimental cell research. vol 208. issue 1. 1993-09-30. PMID:7689475. |
for normal hmec, the significant level of endogenous production of tgf alpha requires utilization of blocking antibodies to the egf receptor to achieve cessation of growth in mass culture, whereas removal of egf is sufficient to arrest the immortal cell lines. |
1993-09-30 |
2023-08-12 |
human |
| M R Stampfer, C H Pan, J Hosoda, J Bartholomew, J Mendelsohn, P Yaswe. Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous reentry into the cell cycle. Experimental cell research. vol 208. issue 1. 1993-09-30. PMID:7689475. |
inhibition of dna synthesis is not detectable until approximately 12 h after removal of egf/tgf alpha and is pronounced by 24 h. reexposure to egf produces high levels of synthesis of the early response genes, c-myc, c-fos, c-jun, and mgsa, within 1 h. dna synthesis increases only after 10 h, with a sharp peak after 15-20 h. reexposure of the growth-arrested normal hmec for 1 h with egf allows a majority of the cells capable of cycling to subsequently enter the s phase. |
1993-09-30 |
2023-08-12 |
human |
| J Schmidtler, K Dehne, V Schusdziarra, M Classen, W Schep. Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8394819. |
epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) are known to inhibit histamine-stimulated parietal cell function by reducing camp production in a pertussis toxin-sensitive manner. |
1993-09-17 |
2023-08-12 |
rat |
| J Schmidtler, K Dehne, V Schusdziarra, M Classen, W Schep. Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8394819. |
therefore, we used pertussis toxin as a tool to determine whether egf and tgf alpha inhibit glp-1-stimulated parietal cell function via gi alpha. |
1993-09-17 |
2023-08-12 |
rat |
| J Schmidtler, K Dehne, V Schusdziarra, M Classen, W Schep. Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8394819. |
egf and tgf alpha (10(-13)-10(-7) m) caused concentration-dependent inhibition of glp-1-stimulated parietal cell function. |
1993-09-17 |
2023-08-12 |
rat |
| J Schmidtler, K Dehne, V Schusdziarra, M Classen, W Schep. Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8394819. |
there was a close correlation (r = 0.83; p < 0.05; n = 7) between the inhibition by egf and tgf alpha of [14c]aminopyrine accumulation and the fall in camp production in glp-1-stimulated parietal cells. |
1993-09-17 |
2023-08-12 |
rat |
| P G Gettins, B C Crew. Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry. vol 32. issue 31. 1993-09-16. PMID:7688570. |
we have examined the binding of 125i-labeled human and mouse epidermal growth factors (egf) to human alpha 2-macroglobulin (alpha 2m). |
1993-09-16 |
2023-08-12 |
mouse |
| P G Gettins, B C Crew. Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry. vol 32. issue 31. 1993-09-16. PMID:7688570. |
in the presence of human neutrophil elastase, both mouse and human egf bound to alpha 2m, whereas little binding was found to native alpha 2m. |
1993-09-16 |
2023-08-12 |
mouse |
| P G Gettins, B C Crew. Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry. vol 32. issue 31. 1993-09-16. PMID:7688570. |
pretreatment of native alpha 2m with either proteinase or methylamine greatly reduced binding of egf. |
1993-09-16 |
2023-08-12 |
mouse |
| P G Gettins, B C Crew. Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry. vol 32. issue 31. 1993-09-16. PMID:7688570. |
titration of human 125i-egf into native alpha 2m, in the presence of 2 equiv of proteinase, gave a gradual increase in egf binding as a function of egf concentration. |
1993-09-16 |
2023-08-12 |
mouse |
| P G Gettins, B C Crew. Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry. vol 32. issue 31. 1993-09-16. PMID:7688570. |
between 0.8 and 1.0 equiv of hegf were bound per alpha 2m tetramer when 30 equiv of egf were used. |
1993-09-16 |
2023-08-12 |
mouse |
| P G Gettins, B C Crew. Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry. vol 32. issue 31. 1993-09-16. PMID:7688570. |
the ph dependence of binding of both mouse and human egf to alpha 2m was examined and showed more egf bound at ph 6 than at ph 9. |
1993-09-16 |
2023-08-12 |
mouse |
| P G Gettins, B C Crew. Epidermal growth factor binding to human alpha 2-macroglobulin. Implications for alpha 2-macroglobulin-growth factor interactions. Biochemistry. vol 32. issue 31. 1993-09-16. PMID:7688570. |
these results suggest that egf can react with the reactive thiol ester of proteinase-activated alpha 2m by nucleophilic attack of the alpha-amino group and to a lesser extent by sulfide-disulfide exchange with the free sh of the cleaved thiol ester. |
1993-09-16 |
2023-08-12 |
mouse |
| J Qu, K Thoma. Prostaglandins stimulate the secretion of inhibin from human placental cells. The Journal of clinical endocrinology and metabolism. vol 77. issue 2. 1993-09-09. PMID:8345062. |
treatment with egf (100 ng/ml) increased inhibin in the medium by 83.3% (ed50) in the presence of pge2 or by 70.3% (ed50) in the presence of pgf2 alpha compared to the control values. |
1993-09-09 |
2023-08-12 |
human |
| J Qu, K Thoma. Prostaglandins stimulate the secretion of inhibin from human placental cells. The Journal of clinical endocrinology and metabolism. vol 77. issue 2. 1993-09-09. PMID:8345062. |
morphological studies showed that pge2 alpha (1 microm), alone or combined with egf (100 ng/ml), significantly accelerated the process of differentiation from cytotrophoblasts to syncytiotrophoblasts, indicating that the actions of pgs may be related to their effects on syncytial transformation, rather than cellular proliferation. |
1993-09-09 |
2023-08-12 |
human |
| H H Wu, H Kawamata, K Kawai, C Lee, R Oyas. Immunohistochemical localization of epidermal growth factor and transforming growth factor alpha in the male rat accessory sex organs. The Journal of urology. vol 150. issue 3. 1993-09-09. PMID:8345628. |
we examined the presence of epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) in the prostate (ventral, lateral, dorsal lobes), coagulating gland and seminal vesicle of fisher 344 adult male rats by immunohistochemical and radioimmunoassay methods. |
1993-09-09 |
2023-08-12 |
rat |
| H H Wu, H Kawamata, K Kawai, C Lee, R Oyas. Immunohistochemical localization of epidermal growth factor and transforming growth factor alpha in the male rat accessory sex organs. The Journal of urology. vol 150. issue 3. 1993-09-09. PMID:8345628. |
this is the first report describing the presence of immunoreactive tgf alpha and egf in the male accessory sex organs. |
1993-09-09 |
2023-08-12 |
rat |
| J H Mydlo, J Zajac, R J Macchi. Conditioned media from a renal cell carcinoma cell line demonstrates the presence of basic fibroblast growth factor. The Journal of urology. vol 150. issue 3. 1993-09-09. PMID:8345629. |
in this report, we demonstrate that the growth of the renal cell carcinoma cell line rc29 is stimulated by the addition of exogenous fibroblast growth factor (fgf), epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha). |
1993-09-09 |
2023-08-12 |
human |
| C Chudaska, W Schlege. The influence of growth factors on the prostaglandin synthesis in cultured rabbit luteal cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 25. issue 6. 1993-09-03. PMID:8344644. |
tnf-alpha, il-2, igf-i, igf-ii, and egf alone were not able to change significantly the production of either progesterone or pge2 and pgf2 alpha when compared with the controls. |
1993-09-03 |
2023-08-12 |
rabbit |