| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Yoshida, H Kuniyasu, W Yasui, Y Kitadai, T Toge, E Tahar. Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. Journal of cancer research and clinical oncology. vol 119. issue 7. 1993-06-17. PMID:8491760. |
the expression of egf mrna was detected in 8 (29.6%) of 27 tumors including the cell lines, whereas the tgf alpha and egfr genes were expressed in 21 (77.8%) and 24 (88.9%) tumors respectively. |
1993-06-17 |
2023-08-12 |
human |
| K Yoshida, H Kuniyasu, W Yasui, Y Kitadai, T Toge, E Tahar. Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. Journal of cancer research and clinical oncology. vol 119. issue 7. 1993-06-17. PMID:8491760. |
on the other hand, exogenous egf and tgf alpha stimulated the expressions of fos and myc genes by te-1 cells. |
1993-06-17 |
2023-08-12 |
human |
| K Yoshida, H Kuniyasu, W Yasui, Y Kitadai, T Toge, E Tahar. Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. Journal of cancer research and clinical oncology. vol 119. issue 7. 1993-06-17. PMID:8491760. |
tgf alpha increased the accumulation of mrnas for egf, tgf alpha, egfr, pdgf a and b chain and the erbb-2 gene. |
1993-06-17 |
2023-08-12 |
human |
| K Yoshida, H Kuniyasu, W Yasui, Y Kitadai, T Toge, E Tahar. Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. Journal of cancer research and clinical oncology. vol 119. issue 7. 1993-06-17. PMID:8491760. |
moreover, the expression of mrnas for interstitial collagenase, stromelysin and type iv collagenase was increased after egf or tgf alpha treatment. |
1993-06-17 |
2023-08-12 |
human |
| K Yoshida, H Kuniyasu, W Yasui, Y Kitadai, T Toge, E Tahar. Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. Journal of cancer research and clinical oncology. vol 119. issue 7. 1993-06-17. PMID:8491760. |
these results indicate that egf and tgf alpha may regulate the multi-growth-factor receptor expression and may play a central role for tumor invasion and metastasis as autocrine modulators for human esophageal carcinoma. |
1993-06-17 |
2023-08-12 |
human |
| M E Christensen, M H Therkildsen, S S Poulsen, P Bretla. Immunoreactive transforming growth factor alpha and epidermal growth factor in oral squamous cell carcinomas. The Journal of pathology. vol 169. issue 3. 1993-06-15. PMID:8492225. |
forty oral squamous cell carcinomas have been investigated immunohistochemically for the presence of transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf). |
1993-06-15 |
2023-08-12 |
mouse |
| J Yeh, G Y Lee, E Anderso. Presence of transforming growth factor-alpha messenger ribonucleic acid (mRNA) and absence of epidermal growth factor mRNA in rat ovarian granulosa cells, and the effects of these factors on steroidogenesis in vitro. Biology of reproduction. vol 48. issue 5. 1993-06-01. PMID:8481471. |
granulosa cell steroidogenesis has been reported to be modulated by transforming growth factor-alpha (tgf alpha) and its biochemical and physiological analog, epidermal growth factor (egf). |
1993-06-01 |
2023-08-12 |
rat |
| J Yeh, G Y Lee, E Anderso. Presence of transforming growth factor-alpha messenger ribonucleic acid (mRNA) and absence of epidermal growth factor mRNA in rat ovarian granulosa cells, and the effects of these factors on steroidogenesis in vitro. Biology of reproduction. vol 48. issue 5. 1993-06-01. PMID:8481471. |
in this report, we studied whether tgf alpha or egf mrna is produced by granulosa cells, examined the morphological effects of tgf alpha or egf on granulosa cell cultures, and measured the changes in granulosa cell progesterone production in cells cultured with tgf alpha or egf. |
1993-06-01 |
2023-08-12 |
rat |
| J Yeh, G Y Lee, E Anderso. Presence of transforming growth factor-alpha messenger ribonucleic acid (mRNA) and absence of epidermal growth factor mRNA in rat ovarian granulosa cells, and the effects of these factors on steroidogenesis in vitro. Biology of reproduction. vol 48. issue 5. 1993-06-01. PMID:8481471. |
rna from fresh granulosa cells and from those incubated overnight and for 4, 7, and 10 days with fsh was studied with reverse transcription-polymerase chain reaction for tgf alpha and for egf. |
1993-06-01 |
2023-08-12 |
rat |
| J Yeh, G Y Lee, E Anderso. Presence of transforming growth factor-alpha messenger ribonucleic acid (mRNA) and absence of epidermal growth factor mRNA in rat ovarian granulosa cells, and the effects of these factors on steroidogenesis in vitro. Biology of reproduction. vol 48. issue 5. 1993-06-01. PMID:8481471. |
phase-contrast microscopy revealed that the combination of fsh plus tgf alpha or egf resulted in cell shape changes and an increase in lipid droplets in the granulosa cells. |
1993-06-01 |
2023-08-12 |
rat |
| J Yeh, G Y Lee, E Anderso. Presence of transforming growth factor-alpha messenger ribonucleic acid (mRNA) and absence of epidermal growth factor mRNA in rat ovarian granulosa cells, and the effects of these factors on steroidogenesis in vitro. Biology of reproduction. vol 48. issue 5. 1993-06-01. PMID:8481471. |
culture of the granulosa cells with fsh plus tgf alpha or with fsh plus egf resulted in significantly elevated progesterone and 20 alpha-hydroxyprogesterone levels. |
1993-06-01 |
2023-08-12 |
rat |
| P Battista, G Pizzicannella, P Vitullo, R Palmirotta, R Mariani-Costantin. The epidermal growth factor family in pulmonary carcinoids: immunohistochemical evidence of growth-promoting circuits. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 6. issue 2. 1993-05-28. PMID:8097879. |
we analyzed by immunohistochemistry 19 typical lung carcinoids for the expression of the epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), egf receptor (egfr), and egfr-related c-erbb-2 protein (p185). |
1993-05-28 |
2023-08-12 |
Not clear |
| P Battista, G Pizzicannella, P Vitullo, R Palmirotta, R Mariani-Costantin. The epidermal growth factor family in pulmonary carcinoids: immunohistochemical evidence of growth-promoting circuits. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 6. issue 2. 1993-05-28. PMID:8097879. |
the following patterns of coexpression could be documented: tgf alpha, egfr, egf, and p185: two cases (11%); tgf alpha, egfr, and egf: one case (5%); tgf alpha, egfr, and p185: two cases (11%); tgf alpha and egfr: six cases (32%); tgf alpha by itself: two cases (11%). |
1993-05-28 |
2023-08-12 |
Not clear |
| P Battista, G Pizzicannella, P Vitullo, R Palmirotta, R Mariani-Costantin. The epidermal growth factor family in pulmonary carcinoids: immunohistochemical evidence of growth-promoting circuits. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 6. issue 2. 1993-05-28. PMID:8097879. |
thus, egfr was coexpressed with its ligands, tgf alpha and egf, and the receptor encoded by c-erbb-2 was detected in carcinoids positive for egfr and tgf alpha. |
1993-05-28 |
2023-08-12 |
Not clear |
| M A Zorbas, L C Yeoma. Growth control in a human colon carcinoma cell line mediated by cell-associated transforming growth factor-alpha (TGF alpha). Experimental cell research. vol 206. issue 1. 1993-05-28. PMID:8482359. |
transforming growth factor-alpha (tgf alpha) is able to elicit growth in many target cells expressing a functional epidermal growth factor (egf) receptor. |
1993-05-28 |
2023-08-12 |
human |
| M A Zorbas, L C Yeoma. Growth control in a human colon carcinoma cell line mediated by cell-associated transforming growth factor-alpha (TGF alpha). Experimental cell research. vol 206. issue 1. 1993-05-28. PMID:8482359. |
phosphotyrosine content was restored to basal levels if elastase treatment was followed by addition of exogenous tgf alpha or egf. |
1993-05-28 |
2023-08-12 |
human |
| M A Zorbas, L C Yeoma. Growth control in a human colon carcinoma cell line mediated by cell-associated transforming growth factor-alpha (TGF alpha). Experimental cell research. vol 206. issue 1. 1993-05-28. PMID:8482359. |
these results suggest that hct116 cells use a "closed" autocrine loop between cell-associated tgf alpha species and their egf receptor to stimulate their cell growth. |
1993-05-28 |
2023-08-12 |
human |
| A Nakao, T Watanabe, S Taniguchi, M Nakamura, Z Honda, T Shimizu, K Kurokaw. Characterization of prostaglandin F2 alpha receptor of mouse 3T3 fibroblasts and its functional expression in Xenopus laevis oocytes. Journal of cellular physiology. vol 155. issue 2. 1993-05-28. PMID:8482718. |
the increase in [3h]thymidine incorporation with pgf2 alpha was additive with that seen with epidermal growth factor (egf) or insulin. |
1993-05-28 |
2023-08-12 |
mouse |
| J E Kronmiller, W B Upholt, E J Kolla. Effects of retinol on the temporal expression of transforming growth factor-alpha mRNA in the embryonic mouse mandible. Archives of oral biology. vol 38. issue 2. 1993-05-17. PMID:8476349. |
this suggests that retinoids may act to control the proliferative pattern of the dental lamina through egf expression and not tgf alpha expression, although mrnas for both mitogens are present at the same time. |
1993-05-17 |
2023-08-12 |
mouse |
| D B Alexander, L Goya, M K Webster, T Haraguchi, G L Fireston. Glucocorticoids coordinately disrupt a transforming growth factor alpha autocrine loop and suppress the growth of 13762NF-derived Con8 rat mammary adenocarcinoma cells. Cancer research. vol 53. issue 8. 1993-05-11. PMID:8467499. |
the smaller mitogen was identified as transforming growth factor alpha (tgf-alpha) since this activity competed with 125i-epidermal growth factor (egf) for egf receptor binding and was selectively immunodepleted with monoclonal tgf-alpha antibodies but not with egf antibodies. |
1993-05-11 |
2023-08-12 |
human |