| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Brzozowsk. Experimental production of peptic ulcer, gastric damage and cancer models and their use in pathophysiological studies and pharmacological treatment--Polish achievements. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 54 Suppl 3. 2008-01-08. PMID:15075467. |
the experimental studies on healing of gastric ulcers that become supportive for the clinical trial in humans, performed also by polish pioneers and the effect of numerous growth factors (egf, tgf alpha), no inhibitors, cyclooxygenase- (cox)-1 and cox-2 inhibitors and new safer derivatives of nsaid releasing no in protection and ulcer healing are discussed. |
2008-01-08 |
2023-08-12 |
Not clear |
| Chika Funaki, Robin R Hodges, Darlene A Dart. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland. American journal of physiology. Cell physiology. vol 293. issue 5. 2007-12-27. PMID:17687004. |
freshly prepared rat lacrimal gland acinar cells were incubated with dibutyryl camp (dbcamp), carbachol (a cholinergic agonist), phenylephrine (an alpha(1)-adrenergic agonist), or epidermal growth factor (egf). |
2007-12-27 |
2023-08-12 |
rat |
| A Migliaccio, L Varricchio, A De Falco, G Castoria, C Arra, H Yamaguchi, A Ciociola, M Lombardi, R Di Stasio, A Barbieri, A Baldi, M V Barone, E Appella, F Auricchi. Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth. Oncogene. vol 26. issue 46. 2007-12-11. PMID:17486077. |
in human mammary and prostate cancer cells, steroid hormones or epidermal growth factor (egf) trigger association of the androgen receptor (ar)-estradiol receptor (er) (alpha or beta) complex with src. |
2007-12-11 |
2023-08-12 |
mouse |
| Dori C Woods, A L Johnso. Protein kinase C activity mediates LH-induced ErbB/Erk signaling in differentiated hen granulosa cells. Reproduction (Cambridge, England). vol 133. issue 4. 2007-09-26. PMID:17504917. |
inhibition of pkc activity with gf109203x attenuates lh- and 8-bromo-camp (8-br-camp)-induced p-erk, but not p-erk promoted by an epidermal growth factor (egf) family ligand (e.g., transforming growth factor alpha). |
2007-09-26 |
2023-08-12 |
Not clear |
| Garen S Wolff, Po Jen Chiang, Susan M Smith, Roberto Romero, D Randall Arman. Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells. Biology of reproduction. vol 77. issue 1. 2007-09-25. PMID:17392498. |
exposure to 25-50 mm ethanol significantly increased transforming growth factor alpha (tgfa) and heparin-binding egf-like growth factor (hbegf), but not egf or amphiregulin (areg). |
2007-09-25 |
2023-08-12 |
human |
| S A Teteris, S A Menahem, G Perry, J A Maguire, J P Dowling, R G Langham, N M Thomson, A N Stei. Dysregulated growth factor gene expression is associated with tubulointerstitial apoptosis and renal dysfunction. Kidney international. vol 71. issue 10. 2007-09-07. PMID:17361117. |
tubulointerstitial injury was correlated with increased tgfbeta(1) and tumour necrosis factor alpha (tnfalpha) mrna (p<0.005) and decreased egf mrna (p<0.05). |
2007-09-07 |
2023-08-12 |
Not clear |
| Augustin Baulig, Sophie Blanchet, Melina Rumelhard, Ghislaine Lacroix, Francelyne Marano, Armelle Baeza-Squiba. Fine urban atmospheric particulate matter modulates inflammatory gene and protein expression in human bronchial epithelial cells. Frontiers in bioscience : a journal and virtual library. vol 12. 2007-08-23. PMID:17127337. |
the gene profiling study performed using a 375 cdna cytokine expression array highlighted the differential expression of certain genes, three of which were selected as genes of interest: the il-1 alpha cytokine, the gro-alpha chemokine, and amphiregulin, a ligand of the egf receptor. |
2007-08-23 |
2023-08-12 |
human |
| Kelly Schultz, Vanishree Murthy, Jeffrey B Tatro, Debbie Beasle. Endogenous interleukin-1 alpha promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells. American journal of physiology. Heart and circulatory physiology. vol 292. issue 6. 2007-08-02. PMID:17293495. |
serum, pdgf, fgf-2, and egf each increased cellular il-1 alpha concentrations, and il-1 alpha knockdown inhibited serum- and pdgf-induced dna synthesis, further indicating that endogenous il-1 alpha also contributed to vsmc responses to growth factors. |
2007-08-02 |
2023-08-12 |
human |
| Dina Villanueva-García, Karen T Wang, Heber C Nielsen, Sujatha M Ramadura. Expression of specific protein kinase C (PKC) isoforms and ligand-specific activation of PKCalpha in late gestation fetal lung. Experimental lung research. vol 33. issue 3-4. 2007-08-02. PMID:17558679. |
the authors hypothesized that specific protein kinase c (pkc) isoforms are expressed and activated by epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha) (egf receptor [egfr] ligands) in fetal lung fibroblasts. |
2007-08-02 |
2023-08-12 |
rat |
| Kirsten Ejskjaer, Boe Sandahl Sørensen, Steen Seier Poulsen, Axel Forman, Ebba Nexø, Ole Mogense. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Gynecologic oncology. vol 104. issue 1. 2007-02-15. PMID:16962163. |
we describe the expression of the four receptors, her1, her2, her3, her4 and the six ligands amphiregulin, transforming growth factor alpha (tgf-alpha), heparin binding egf like growth factor (hb-egf), betacellulin, epiregulin and egf in endometrioid endometrial cancer. |
2007-02-15 |
2023-08-12 |
Not clear |
| Tzindilú Molina-Muñoz, María Teresa Romero-Avila, J Adolfo García-Sáin. Insulin-like growth factor-I induces alpha(1B)-adrenergic receptor phosphorylation through G beta gamma and epidermal growth factor receptor transactivation. Molecular endocrinology (Baltimore, Md.). vol 20. issue 11. 2007-02-12. PMID:16803866. |
the data clearly show that igf-i triggers a complex signaling pathway, which leads to the phosphorylation and desensitization of a serpentine g protein-coupled receptor, suggesting the following hypothetical model: 1) stimulation of igf-i receptors activate pertussis toxin-sensitive g proteins; 2) the growth factor action activates metalloproteinases, which catalyze heparin binding-egf shedding, and transactivation of egf receptors, and 3) dissociated gbetagamma subunits and phosphotyrosine residues seem to trigger pi3k activity, which leads to activation of protein kinase c, resulting in alpha(1b)-ar phosphorylation and desensitization. |
2007-02-12 |
2023-08-12 |
Not clear |
| LiLi Chen, Robin R Hodges, Chika Funaki, Driss Zoukhri, Robert J Gaivin, Dianne M Perez, Darlene A Dart. Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells. American journal of physiology. Cell physiology. vol 291. issue 5. 2006-11-24. PMID:16760267. |
we conclude that in freshly isolated lacrimal gland acini, alpha(1)-adrenergic agonists activate the alpha(1d)-ar to stimulate protein secretion and the ectodomain shedding of egf to transactivate the egf receptor, potentially via adam17, which activates p42/p44 mapk to negatively modulate protein secretion. |
2006-11-24 |
2023-08-12 |
Not clear |
| Hisaaki Namba, Tadasato Nagano, Yuriko Iwakura, Huabao Xiong, Hussam Jourdi, Nobuyuki Takei, Hiroyuki Naw. Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons. Molecular and cellular neurosciences. vol 31. issue 4. 2006-11-22. PMID:16443372. |
subchronic stimulation of erbb1 with transforming growth factor alpha (tgfalpha), egf, or heparin-binding egf (hb-egf) down-regulated protein expression of the glur1 ampa receptor subunit in cultured neocortical neurons. |
2006-11-22 |
2023-08-12 |
Not clear |
| Robin R Hodges, Jose D Rios, Joanna Vrouvlianis, Isao Ota, Driss Zoukhri, Darlene A Dart. Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK. Investigative ophthalmology & visual science. vol 47. issue 8. 2006-08-31. PMID:16877402. |
although p42/p44 mitogen-activated protein kinase (mapk) negatively modulates protein secretion stimulated by cholinergic and alpha(1d)-adrenergic agonists, it does not play a role in epidermal growth factor (egf)-stimulated protein secretion. |
2006-08-31 |
2023-08-12 |
rat |
| Deepti Chaturvedi, Francis Edwin, Hui Sun, Tarun B Pate. Analysis of EGF receptor interactions with the alpha subunit of the stimulatory GTP binding protein of adenylyl cyclase, Gs. Methods in molecular biology (Clifton, N.J.). vol 327. 2006-07-19. PMID:16780212. |
analysis of egf receptor interactions with the alpha subunit of the stimulatory gtp binding protein of adenylyl cyclase, gs. |
2006-07-19 |
2023-08-12 |
Not clear |
| Deepti Chaturvedi, Francis Edwin, Hui Sun, Tarun B Pate. Analysis of EGF receptor interactions with the alpha subunit of the stimulatory GTP binding protein of adenylyl cyclase, Gs. Methods in molecular biology (Clifton, N.J.). vol 327. 2006-07-19. PMID:16780212. |
moreover, we have also described how the stoichiometry of egf receptor association with the alpha subunit of gs can be monitored in vitro. |
2006-07-19 |
2023-08-12 |
Not clear |
| Tedla D Dadi, Ming-Wen Li, K C Kent Lloy. Development of mouse embryos after immunoneutralization of mitogenic growth factors mimics that of cloned embryos. Comparative medicine. vol 56. issue 3. 2006-07-18. PMID:16774127. |
we sought to determine the effect of epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha) on naturally fertilized (in vivo-derived) and in vitro-fertilized mouse embryos, compared with that on cloned (intracytoplasmic nuclear injection-derived) mouse embryos, in which egf and tgfalpha expression is markedly reduced. |
2006-07-18 |
2023-08-12 |
mouse |
| Inés López-Torrejón, Enrique Querol, Francesc X Avilés, Masaharu Seno, Rafael de Llorens, Baldomero Oliv. Human betacellulin structure modeled from other members of EGF family. Journal of molecular modeling. vol 8. issue 4. 2006-06-02. PMID:12111392. |
btc has been modeled with the program modeller, using human egf, human transforming growth factor alpha (htgfalpha), human hb-egf and human heregulin one alpha (hhrg-1alpha) as templates. |
2006-06-02 |
2023-08-12 |
human |
| Alexander Ivanov, Volodymyr Gerzanich, Svetlana Ivanova, Ryan Denhaese, Orest Tsymbalyuk, J Marc Simar. Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. The Journal of physiology. vol 570. issue Pt 1. 2006-05-08. PMID:16284070. |
the egfr ligands egf (100 ng ml(-1)), transforming growth factor alpha (0.4 ng ml(-1)) and heparin-binding egf (100 ng ml(-1)) all caused a 20% increase in maxi-k(ca) channel current that was blocked by ag-1478 or by knock-down of egfr expression using cisterna magna infusion of antisense oligodeoxynucleotide (as-odn). |
2006-05-08 |
2023-08-12 |
rat |
| N Maruotti, F P Cantatore, E Crivellato, A Vacca, D Ribatt. Angiogenesis in rheumatoid arthritis. Histology and histopathology. vol 21. issue 5. 2006-04-13. PMID:16493585. |
moreover, other angiogenic mediators such as platelet-derived growth factor (pdgf), fibroblast growth factor-2 (fgf-2), epidermal growth factor (egf), insulin-like growth factor (igf), hepatocyte growth factor (hgf), transforming growth factor beta (tgf-beta), tumor necrosis factor alpha (tnf-alpha), interleukin-1 (il-1), il-6, il-8, il-13, il-15, il-18, angiogenin, platelet activating factor (paf), angiopoietin, soluble adhesion molecules, endothelial mediator (endoglin) play an important role in angiogenesis in rheumatoid arthritis. |
2006-04-13 |
2023-08-12 |
Not clear |