| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Lakshmikesari, R Radhakrishna, A Bhanumathi, D Ravi, G Srinivas, M Nair, M Pilla. Expression of epidermal and transforming growth factors in pancreatic cancer. Oncology reports. vol 3. issue 5. 2012-10-02. PMID:21594491. |
expression of egf, tgf alpha and tgf beta was similar to that seen in normal pancreas. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Lakshmikesari, R Radhakrishna, A Bhanumathi, D Ravi, G Srinivas, M Nair, M Pilla. Expression of epidermal and transforming growth factors in pancreatic cancer. Oncology reports. vol 3. issue 5. 2012-10-02. PMID:21594491. |
moderate to intense expression of egf and tgf alpha was evident in all grades of pancreatic cancer. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Lakshmikesari, R Radhakrishna, A Bhanumathi, D Ravi, G Srinivas, M Nair, M Pilla. Expression of epidermal and transforming growth factors in pancreatic cancer. Oncology reports. vol 3. issue 5. 2012-10-02. PMID:21594491. |
egf and tgf alpha are growth promoters influencing the expression of egfr. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Lakshmikesari, R Radhakrishna, A Bhanumathi, D Ravi, G Srinivas, M Nair, M Pilla. Expression of epidermal and transforming growth factors in pancreatic cancer. Oncology reports. vol 3. issue 5. 2012-10-02. PMID:21594491. |
it therefore appears that the balance between egf and tgf alpha on the one hand and tgf beta on the other may be critical in the process of tumor progression, especially if one considers chronic pancreatitis as a pre-malignant condition and the growth factor expression associated with it. |
2012-10-02 |
2023-08-12 |
Not clear |
| C Farmer, M F Palin, G S Gilani, H Weiler, M Vignola, R K Choudhary, A V Capuc. Dietary genistein stimulates mammary hyperplasia in gilts. Animal : an international journal of animal bioscience. vol 4. issue 3. 2012-10-02. PMID:22443950. |
transcript levels for erα, erβ, igf1, epidermal growth factor (egf), epidermal growth factor receptor and transforming growth factor alpha were not altered by treatments. |
2012-10-02 |
2023-08-12 |
Not clear |
| Kristy J Wilson, Christopher Mill, Sydney Lambert, Jennifer Buchman, Timothy R Wilson, Victor Hernandez-Gordillo, Richard M Gallo, Laura M C Ades, Jeffrey Settleman, David J Ries. EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. Growth factors (Chur, Switzerland). vol 30. issue 2. 2012-07-23. PMID:22260327. |
in 32d/egfr myeloid and mcf10a breast cells, soluble amphiregulin (ar), transforming growth factor alpha (tgfα), neuregulin 2 beta, and epigen stimulate greater egfr coupling to cell proliferation and dna synthesis than do egf, betacellulin, heparin-binding egf-like growth factor, and epiregulin. |
2012-07-23 |
2023-08-12 |
Not clear |
| T Brzozowski, A Ptak-Belowska, S Kwiecien, G Krzysiek-Maczka, M Strzalka, D Drozdowicz, R Pajdo, R Olszanecki, R Korbut, S J Konturek, W W Pawli. Novel concept in the mechanism of injury and protection of gastric mucosa: role of renin-angiotensin system and active metabolites of angiotensin. Current medicinal chemistry. vol 19. issue 1. 2012-07-02. PMID:22300076. |
since that time many factors were implicated to possess gastroprotective properties such as growth factors including epidermal growth factor (egf) and transforming factor alpha (tgfα), vasodilatory mediators such as nitric oxide (no) and calcitonin gene related peptide (cgrp) as well as appetite gut hormones including gastrin and cholecystokinin (cck), leptin and recently ghrelin. |
2012-07-02 |
2023-08-12 |
Not clear |
| Juliana Jales H Celestino, Jamily B Bruno, Márcia Viviane A Saraiva, Rebeca M P Rocha, Ivina R Brito, Ana Beatriz G Duarte, Valdevane R Araújo, Cleidson M G Silva, Maria Helena T Matos, Claudio C Campello, José Roberto V Silva, José Ricardo Figueired. Steady-state level of epidermal growth factor (EGF) mRNA and effect of EGF on in vitro culture of caprine preantral follicles. Cell and tissue research. vol 344. issue 3. 2011-11-07. PMID:21503599. |
during culture, egf in the presence or absence of fsh increased the follicular daily growth rate of secondary follicles when compared with that in enriched alpha minimal essential medium. |
2011-11-07 |
2023-08-12 |
Not clear |
| George A Alexiou, Sofia Markoula, Pinelopi Gogou, Athanasios P Kyritsi. Genetic and molecular alterations in meningiomas. Clinical neurology and neurosurgery. vol 113. issue 4. 2011-07-29. PMID:21227570. |
meningiomas express various hormonal and growth factor receptors, such as progesterone, estrogen, somatostatin, transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf) receptors, which may be related to their biological behavior and response to treatment. |
2011-07-29 |
2023-08-12 |
Not clear |
| Vivian E Fernand, Jack N Losso, Robert E Truax, Emily E Villar, David K Bwambok, Sayo O Fakayode, Mark Lowry, Isiah M Warne. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chemico-biological interactions. vol 192. issue 3. 2011-07-25. PMID:21457705. |
rhein also inhibited the expression of hypoxia-inducible factor-1 alpha (hif-1α), vascular endothelial growth factor (vegf(165)), epidermal growth factor (egf), and the phosphorylation of inhibitor of nf-κb (i-κb) under normoxic or hypoxic conditions. |
2011-07-25 |
2023-08-12 |
human |
| Guo-Yang Wu, Qingjun Lu, Till Hasenberg, Marco Niedergethmann, Stefan Post, Jörg W Sturm, Michael Kees. Association between EGF, TGF-{beta}1, TNF-{alpha} gene polymorphisms and cancer of the pancreatic head. Anticancer research. vol 30. issue 12. 2011-02-04. PMID:21187523. |
association between egf, tgf-{beta}1, tnf-{alpha} gene polymorphisms and cancer of the pancreatic head. |
2011-02-04 |
2023-08-12 |
Not clear |
| Zhanxia Xue, Baoman Li, Li Gu, Xiaoling Hu, Min Li, Roger F Butterworth, Liang Pen. Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo. Neurochemistry international. vol 57. issue 4. 2010-12-22. PMID:20447429. |
in the present study we have investigated (i) effects of ammonia on mrna and protein expression of alpha(1) and alpha(2) isoforms in primary cultures of mouse astrocytes; (ii) effects of hyperammonia obtained by urease injection on mrna and protein expression of alpha(1) and alpha(2) isoforms in the brain in vivo; and (iii) effect on observed upregulation of gene expression of ag1478, an inhibitor of the egf receptor-tyrosine kinase, pp1, an inhibitor of src, and gm6001, an inhibitor of zn(2+)-dependent metalloproteinases in the cultured cells. |
2010-12-22 |
2023-08-12 |
mouse |
| Zhanxia Xue, Baoman Li, Li Gu, Xiaoling Hu, Min Li, Roger F Butterworth, Liang Pen. Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo. Neurochemistry international. vol 57. issue 4. 2010-12-22. PMID:20447429. |
based on the effects of the inhibitors and literature data it is concluded that ammonia activates formation of an endogenous ouabain-like compound, which binds to the na, k-atpase, activating src, which in turn stimulates the receptor-tyrosine kinase of the egf receptor, leading to activation of the ras, raf, mek pathway and phosphorylation of erk(1/2), which eventually causes upregulation of alpha(2) gene expression. |
2010-12-22 |
2023-08-12 |
mouse |
| Liang Peng, Baoman Li, Ting Du, Ebenezer K C Kong, Xiaoling Hu, Shiquen Zhang, Xiaolei Shan, Meixia Zhan. Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling. Neurochemistry international. vol 57. issue 4. 2010-12-22. PMID:20450946. |
using primary cell cultures we have found that dexmedetomidine, a specific alpha(2)-adrenergic receptor, induced shedding of hb-egf from astrocytes, which in turn transactivated egf receptors and stimulated astrocytic c-fos and fosb expression. |
2010-12-22 |
2023-08-12 |
Not clear |
| Elena Tamborini, Emanuela Virdis, Tiziana Negri, Marta Orsenigo, Silvia Brich, Elena Conca, Alessandro Gronchi, Silvia Stacchiotti, Giacomo Manenti, Paolo G Casali, Marco A Pierotti, Silvana Pilott. Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomas. Neuro-oncology. vol 12. issue 8. 2010-11-12. PMID:20164240. |
the presence of activated egfr was paralleled by the finding of high levels of epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha) and pdgfb co-expression and pdgfrb co-immunoprecipitation. |
2010-11-12 |
2023-08-12 |
human |
| Terry W Moody, Marc J Berna, Samuel Mantey, Veronica Sancho, Lisa Ridnour, David A Wink, Daniel Chan, Giuseppe Giaccone, Robert T Jense. Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20388507. |
the transactivation of the egf receptor caused by nmb-like peptides was inhibited by gm6001 (matrix metalloprotease inhibitor), pp2 (src inhibitor), or transforming growth factor (tgf)alpha antibody. |
2010-09-07 |
2023-08-12 |
human |
| Yi Luo, Huajia Diao, Suhua Xia, Lei Dong, Jiangning Chen, Junfeng Zhan. A physiologically active polysaccharide hydrogel promotes wound healing. Journal of biomedical materials research. Part A. vol 94. issue 1. 2010-08-17. PMID:20128009. |
the quantification of the infiltrating inflammatory cells and the level of tumor necrosis factor alpha (tnf-alpha) in the bsp group are attenuated, whereas the secretion of the epidermal growth factor (egf) is highly elevated. |
2010-08-17 |
2023-08-12 |
mouse |
| Rosemary Bass, Dylan R Edward. ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding? The Biochemical journal. vol 428. issue 3. 2010-07-23. PMID:20504280. |
the archetypal family member is adam17 {also known as tace [tnfalpha (tumour necrosis factor alpha)-converting enzyme]}, which is involved in processing pro-tnfalpha and in the activation of ligands for the egfr [egf (epidermal growth factor) receptor], as well as cleavage of diverse cell-surface receptors and adhesion molecules. |
2010-07-23 |
2023-08-12 |
Not clear |
| Yuhui Wang, Ling Zhao, Cynthia Smas, Hei Sook Su. Pref-1 interacts with fibronectin to inhibit adipocyte differentiation. Molecular and cellular biology. vol 30. issue 14. 2010-07-14. PMID:20457810. |
pref-1/dlk1 is made as an epidermal growth factor (egf) repeat-containing transmembrane protein but is cleaved by tumor necrosis factor alpha converting enzyme (tace) to generate a biologically active soluble form. |
2010-07-14 |
2023-08-12 |
Not clear |
| Yosuke Ohtake, Tomonori Kobayashi, Akiko Maruko, Nao Oh-Ishi, Fumihiko Yamamoto, Shinsuke Katoh, Yasuhito Ohkub. Norepinephrine modulates the zonally different hepatocyte proliferation through the regulation of transglutaminase activity. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 1. 2010-07-12. PMID:20448147. |
a neurotransmitter, norepinephrine (ne), amplifies the mitogenic effect of epidermal growth factor (egf) in the liver by acting on the alpha(1)-adrenergic receptor coupled with g protein, galpha(h). |
2010-07-12 |
2023-08-12 |
Not clear |