| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvia H Trang, David E Joyner, Timothy A Damron, Albert J Aboulafia, R Lor Randal. Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis. Growth factors (Chur, Switzerland). vol 28. issue 1. 2010-04-02. PMID:20092031. |
in this cdna microarray study, using an agilent microarray platform and genesifter analysis software, we evaluated (1) the degree of downstream transcriptional redundancy and (2) the level of genetic uniqueness apparent in desmoid tumor cells stimulated in vitro for 3 h or for 24 h with 100 ng/ml of exogenous recombinant human egf (rhegf) or with recombinant human transforming growth factor alpha (rhtgfalpha). |
2010-04-02 |
2023-08-12 |
human |
| Adele Vivacqua, Rosamaria Lappano, Paola De Marco, Diego Sisci, Saveria Aquila, Francesca De Amicis, Suzanne A W Fuqua, Sebastiano Andò, Marcello Maggiolin. G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Molecular endocrinology (Baltimore, Md.). vol 23. issue 11. 2010-02-17. PMID:19749156. |
g protein-coupled receptor 30 expression is up-regulated by egf and tgf alpha in estrogen receptor alpha-positive cancer cells. |
2010-02-17 |
2023-08-12 |
Not clear |
| Adele Vivacqua, Rosamaria Lappano, Paola De Marco, Diego Sisci, Saveria Aquila, Francesca De Amicis, Suzanne A W Fuqua, Sebastiano Andò, Marcello Maggiolin. G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Molecular endocrinology (Baltimore, Md.). vol 23. issue 11. 2010-02-17. PMID:19749156. |
we demonstrate that epidermal growth factor (egf) and tgf alpha transactivate the gpr30 promoter and accordingly up-regulate gpr30 mrna and protein levels only in endometrial and tamoxifen-resistant breast cancer cells. |
2010-02-17 |
2023-08-12 |
Not clear |
| Adele Vivacqua, Rosamaria Lappano, Paola De Marco, Diego Sisci, Saveria Aquila, Francesca De Amicis, Suzanne A W Fuqua, Sebastiano Andò, Marcello Maggiolin. G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Molecular endocrinology (Baltimore, Md.). vol 23. issue 11. 2010-02-17. PMID:19749156. |
these effects exerted by egf and tgf alpha were dependent on egf receptor (egfr) expression and activation and involved phosphorylation of the tyr(1045) and tyr(1173) egfr sites. |
2010-02-17 |
2023-08-12 |
Not clear |
| Adele Vivacqua, Rosamaria Lappano, Paola De Marco, Diego Sisci, Saveria Aquila, Francesca De Amicis, Suzanne A W Fuqua, Sebastiano Andò, Marcello Maggiolin. G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Molecular endocrinology (Baltimore, Md.). vol 23. issue 11. 2010-02-17. PMID:19749156. |
using gene-silencing experiments and specific pharmacological inhibitors, we have ascertained that egf and tgf alpha induce gpr30 expression through the egfr/erk transduction pathway, and the recruitment of c-fos to the activator protein-1 site located within gpr30 promoter sequence. |
2010-02-17 |
2023-08-12 |
Not clear |
| Yasuo Matsuzawa, Yoshiaki Kiuchi, Kaori Toyomura, Ikiru Matsumoto, Hiroyuki Nakamura, Hiromichi Fujino, Toshihiko Murayama, Tatsuo Kawashim. Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf. Journal of pharmacological sciences. vol 111. issue 2. 2010-01-28. PMID:19783865. |
pharmacological experiments showed that the responses (erk phosphorylation and aa release) induced by egf and pma were mediated by a mitogen-activated protein kinase/erk kinase (mek)-erk-alpha-type cytosolic phospholipase a(2) (cpla(2)alpha) pathway and that egfr couples with the pathway in a manner insensitive to sorafenib, an inhibitor of b- and c-raf, enzymes upstream of mek. |
2010-01-28 |
2023-08-12 |
human |
| Ting Du, Baoman Li, Shufang Liu, Peizhuo Zang, Vincent Prevot, Leif Hertz, Liang Pen. ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19501623. |
erk phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of egf receptors. |
2009-11-17 |
2023-08-12 |
mouse |
| Ting Du, Baoman Li, Shufang Liu, Peizhuo Zang, Vincent Prevot, Leif Hertz, Liang Pen. ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19501623. |
our previous work demonstrated dexmedetomidine-activated phosphorylation of extracellular regulated kinases 1 and 2 (erk(1/2)) in primary cultures of mouse astrocytes and showed that it is evoked by alpha(2)-adrenoceptor-mediated transactivation of epidermal growth factor (egf) receptors, a known response to activation of g(i/o)- or g(q)-coupled receptors [li, b., du, t., li, h., gu, l., zhang, h., huang, j., hertz, l., peng, l., 2008a. |
2009-11-17 |
2023-08-12 |
mouse |
| Ting Du, Baoman Li, Shufang Liu, Peizhuo Zang, Vincent Prevot, Leif Hertz, Liang Pen. ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19501623. |
thus, in intact brain hb-egf, known to be expressed in brain, may be the major egf agonist released in response to stimulation of alpha(2)-adrenoceptors, the released agonist(s) activate(s) egf receptors, and erk(1/2) is phosphorylated as a conventional response to egf receptor activation. |
2009-11-17 |
2023-08-12 |
mouse |
| Ting Du, Baoman Li, Shufang Liu, Peizhuo Zang, Vincent Prevot, Leif Hertz, Liang Pen. ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19501623. |
the present findings therefore suggest that egf receptor transactivation in astrocytes in the mature brain in vivo is an important process in response to alpha(2)-adrenoceptor stimulation and may lead to phosphorylation of erk(1/2) both in astrocytes themselves and in adjacent neurons. |
2009-11-17 |
2023-08-12 |
mouse |
| Tedla D Dadi, Ming W Li, K C Kent Lloy. Decreased growth factor expression through RNA interference inhibits development of mouse preimplantation embryos. Comparative medicine. vol 59. issue 4. 2009-11-09. PMID:19712572. |
the purpose of this study was to assess the extent to which epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha) and their cognate receptor (egfr) are crucial for normal preimplantation embryo development. |
2009-11-09 |
2023-08-12 |
mouse |
| C Ekaterina Rodríguez-Pérez, Erika Calvo-Ochoa, Ekaterina V Kalashnikova, Guadalupe Reyes-Cruz, M Teresa Romero-Avila, J Adolfo García-Sáin. Receptor tyrosine kinases regulate alpha1D-adrenoceptor signaling properties: phosphorylation and desensitization. The international journal of biochemistry & cell biology. vol 41. issue 6. 2009-10-26. PMID:19038360. |
insulin, igf-i, egf and pdgf induced concentration-dependent increases in the phosphorylation state of alpha(1d)-adrenoceptors; phosphorylation took place on serine residues. |
2009-10-26 |
2023-08-12 |
human |
| C Ekaterina Rodríguez-Pérez, Erika Calvo-Ochoa, Ekaterina V Kalashnikova, Guadalupe Reyes-Cruz, M Teresa Romero-Avila, J Adolfo García-Sáin. Receptor tyrosine kinases regulate alpha1D-adrenoceptor signaling properties: phosphorylation and desensitization. The international journal of biochemistry & cell biology. vol 41. issue 6. 2009-10-26. PMID:19038360. |
insulin, igf-i and egf actions take place through the action of pi3k and pkc; additional pathway(s) seem to participate in pdgf-induced alpha(1d)-adrenoceptor desensitization and phosphorylation. |
2009-10-26 |
2023-08-12 |
human |
| Katriina Peltola, Maija Hollmen, Sanna-Mari Maula, Eeva Rainio, Raija Ristamäki, Marjaana Luukkaa, Jouko Sandholm, Maria Sundvall, Klaus Elenius, Päivi J Koskinen, Reidar Grenman, Sirpa Jalkane. Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor. Neoplasia (New York, N.Y.). vol 11. issue 7. 2009-09-09. PMID:19568408. |
when directly testing egfr dependence of pim-1 expression, up-regulation and nuclear translocation of pim-1 could be induced through stimulation of egfr with its ligands egf or transforming growth factor alpha. |
2009-09-09 |
2023-08-12 |
Not clear |
| Xin Lu, Qiongqing Wang, Guohong Hu, Catherine Van Poznak, Martin Fleisher, Michael Reiss, Joan Massagué, Yibin Kan. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes & development. vol 23. issue 16. 2009-08-28. PMID:19608765. |
proteolytic release of membrane-bound epidermal growth factor (egf)-like growth factors, including amphiregulin (areg), heparin-binding egf (hb-egf), and transforming growth factor alpha (tgfalpha) from tumor cells suppress the expression of osteoprotegerin (opg) in osteoblasts and subsequently potentiate osteoclast differentiation. |
2009-08-28 |
2023-08-12 |
Not clear |
| Anna Chung-Kwan Tse, Wei G. Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 153. issue 1. 2009-07-17. PMID:19000772. |
recently the roles of epidermal growth factor (egf) family ligands in vertebrate ovaries have received increasing attention, including betacellulin (btc), amphiregulin (ar), heparin-binding egf-like growth factor (hb-egf), transforming growth factor alpha (tgfalpha), epiregulin, and egf itself. |
2009-07-17 |
2023-08-12 |
zebrafish |
| Lian Liu, Billie Jeanne Duke, Bela Malik, Qiang Yue, Douglas C Eato. Biphasic regulation of ENaC by TGF-{alpha} and EGF in renal epithelial cells. American journal of physiology. Renal physiology. vol 296. issue 6. 2009-07-15. PMID:19297452. |
biphasic regulation of enac by tgf-{alpha} and egf in renal epithelial cells. |
2009-07-15 |
2023-08-12 |
xenopus_laevis |
| Marcus Franz, Karin Spiegel, Claudia Umbreit, Petra Richter, Carolina Codina-Canet, Angela Berndt, Annelore Altendorf-Hofmann, Sven Koscielny, Peter Hyckel, Hartwig Kosmehl, Ismo Virtanen, Alexander Bernd. Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma. Histochemistry and cell biology. vol 131. issue 5. 2009-06-19. PMID:19198871. |
additionally, the influence of tgf beta 1 and egf on snail, e-cadherin, vimentin, and alpha sma expression was analysed in two oscc cell lines. |
2009-06-19 |
2023-08-12 |
Not clear |
| R Alcántara-Hernández, J Adolfo García-Sáin. Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation. Autonomic & autacoid pharmacology. vol 29. issue 1-2. 2009-06-08. PMID:19302552. |
association of phospho-erk 1/2 to alpha(1b)-adrenoceptors increased not only in response to agonist but also in response to agents that increase alpha(1b)-adrenoceptor and erk1/2 phosphorylation [such as endothelin-1, phorbol 12-myristate-13-acetate (pma) and epidermal growth factor (egf)]; not surprisingly, pd98059 decreased this effect. |
2009-06-08 |
2023-08-12 |
Not clear |
| Marlon R Schneider, Bettina Mayer-Roenne, Maik Dahlhoff, Verena Proell, Karin Weber, Eckhard Wolf, Reinhold G Erbe. High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 24. issue 3. 2009-05-18. PMID:19049329. |
signaling through the epidermal growth factor receptor (egfr) by ligands such as epidermal growth factor (egf), transforming growth factor alpha (tgfa), and amphiregulin (areg) has been reported to have effects on skeletal growth. |
2009-05-18 |
2023-08-12 |
mouse |