| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Han Hou, Feng-Ling Lin, Kai-Biao Tong, Sheng-Mon Hou, Ju-Fang Li. Transforming growth factor alpha promotes osteosarcoma metastasis by ICAM-1 and PI3K/Akt signaling pathway. Biochemical pharmacology. vol 89. issue 4. 2014-07-29. PMID:24685520. |
transforming growth factor alpha (tgf-α) is classified as the egf (epidermal growth factor)-like family, which is involved in cancer cellular activities such as proliferation, motility, migration, adhesion and invasion abilities. |
2014-07-29 |
2023-08-12 |
human |
| Chandrani Mukhopadhyay, Xiangshan Zhao, Dulce Maroni, Vimla Band, Mayumi Naramur. Distinct effects of EGFR ligands on human mammary epithelial cell differentiation. PloS one. vol 8. issue 10. 2014-07-11. PMID:24124521. |
k5(+)k19(-) hmecs acquired distinct cell fates in response to egfr ligands epidermal growth factor (egf), amphiregulin (areg) and transforming growth factor alpha (tgfα) in differentiation-promoting megm medium. |
2014-07-11 |
2023-08-12 |
human |
| Haiquan Lu, Xinqun Li, Zhongguang Luo, Jie Liu, Zhen Fa. Cetuximab reverses the Warburg effect by inhibiting HIF-1-regulated LDH-A. Molecular cancer therapeutics. vol 12. issue 10. 2014-05-19. PMID:23920275. |
previous studies have shown that cetuximab, an egf receptor-blocking monoclonal antibody, downregulates the alpha subunit of hif-1 (hif-1α) through the inhibition of egf receptor downstream cell signaling and that downregulation of hif-1α is required for cetuximab-induced antiproliferative effects. |
2014-05-19 |
2023-08-12 |
Not clear |
| Meng Zhang, Man-Him Chan, Wen-Jian Tu, Li-Ran He, Chak-Man Lee, Miao H. Using the theory of coevolution to predict protein-protein interactions in non-small cell lung cancer. Chinese journal of cancer. vol 32. issue 2. 2013-11-14. PMID:23237220. |
fifteen key proteins were identified and categorized into a special protein family f(k), which included cyclin d1 (ccnd1), e-cadherin (cdh1), cyclin-dependent kinase inhibitor 2a (cdkn2a), chemokine (c-x-c motif) ligand 12 (cxcl12), epidermal growth factor (egf), epidermal growth factor receptor (egfr), tnf receptor superfamily, member 6(fas), fk506 binding protein 12-rapamycin associated protein 1 (frap1), o-6-methylguanine-dna methyltransferase (mgmt), parkinson protein 2, e3 ubiquitin protein ligase (park2), phosphatase and tensin homolog (pten), calcium channel voltage-dependent alpha 2/delta subunit 2 (cacna2d2), tubulin beta class i (tubb), swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2 (smarca2), and wingless-type mmtv integration site family, member 7a (wnt7a). |
2013-11-14 |
2023-08-12 |
Not clear |
| H Modjtahedi, B Cohen, C Dea. Monoclonal antibodies directed against the EGF receptor show differential bindings of amphiregulin and EGF to the EGF receptor. International journal of oncology. vol 10. issue 2. 2013-07-04. PMID:21533382. |
like egf, tgf alpha and hb-egf, ar could inhibit the growth in culture of egfr overexpressing tumour cell lines, namely hn5, hsc-1 and mda-mb468 cells, and again compared to other ligands ar was moderately effective at low concentration. |
2013-07-04 |
2023-08-12 |
human |
| S Scarpa, G Mincione, M Raganocaracciolo, A Modesti, G Collett. Transforming growth-factor-alpha modulates replication and differentiation markers on a human neuroblastoma cell-line. International journal of oncology. vol 5. issue 3. 2012-12-20. PMID:21559611. |
the effects of tgf alpha and egf on a human neuroblastoma cell line expressing egf receptor were studied. |
2012-12-20 |
2023-08-12 |
human |
| S Scarpa, G Mincione, M Raganocaracciolo, A Modesti, G Collett. Transforming growth-factor-alpha modulates replication and differentiation markers on a human neuroblastoma cell-line. International journal of oncology. vol 5. issue 3. 2012-12-20. PMID:21559611. |
these data suggest a possible involvement of egf and tgf alpha in a paracrine and autocrine control of neuroblastoma, possibly each accomplishing similar but complementary functions. |
2012-12-20 |
2023-08-12 |
human |
| Su Jin Cho, Moon Jung Chae, Bong Kyung Shin, Han Kyeom Kim, Aeree Ki. Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment. Molecular medicine reports. vol 1. issue 1. 2012-10-02. PMID:21479382. |
several peptides, such as epidermal growth factor (egf), heregulin (hrg) and transforming growth factor alpha (tgfα), are ligands for egfr family. |
2012-10-02 |
2023-08-12 |
human |
| R Ito, W Yasui, H Yokozaki, U Yamashita, T Takata, H Nikai, E Tahar. Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines. International journal of oncology. vol 11. issue 4. 2012-10-02. PMID:21528278. |
the expression of il-1 alpha mrna by these cell lines was induced by either il-1 alpha, epidermal growth factor (egf) or transforming growth factor alpha (tgf-alpha). |
2012-10-02 |
2023-08-12 |
human |
| R Ito, W Yasui, H Yokozaki, U Yamashita, T Takata, H Nikai, E Tahar. Growth stimulatory effect of interleukin (IL)-1 alpha produced by oral squamous carcinoma cell lines. International journal of oncology. vol 11. issue 4. 2012-10-02. PMID:21528278. |
on the other hand, il-1 alpha promoted the mrna expression of tgf-alpha and egf receptor. |
2012-10-02 |
2023-08-12 |
human |
| M Maxwell, T Galanopoulos, H Antoniade. Coexpression of EGF receptor and TGF alpha mRNA and protein occurs in primary meningiomas. International journal of oncology. vol 9. issue 5. 2012-10-02. PMID:21541596. |
coexpression of egf receptor and tgf alpha mrna and protein occurs in primary meningiomas. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Kruczynski, P Yeaton, F Darro, I Camby, C Deprez, J Martinez, J Pasteels, R Kis. Characterization by means of Delaunay triangulation and Voronoi paving of the influence of anti-hormone and/or anti-growth factor antibodies on the in vitro cell growth of human colorectal neoplastic cell lines. International journal of oncology. vol 8. issue 3. 2012-10-02. PMID:21544386. |
this technique enabled us to characterize the influence on the proliferation and the differentiation of the hct-15 and lovo colorectal cell lines of anti-gastrin (g), anti-estradiol (e(2)), anti-epidermal growth factor (egf), anti-luteinizing hormone-releasing hormone (lhrh), and anti-transforming growth factor alpha (tgf alpha) and beta (tgf beta) antibodies. |
2012-10-02 |
2023-08-12 |
human |
| H Modjtahedi, C Dea. Antibody-induced inhibition of growth of egfr overexpressing tumors occurs in the absence of receptor down-regulation. International journal of oncology. vol 7. issue 4. 2012-10-02. PMID:21552904. |
it (a) blocks the binding of egf, tgf alpha and hb-egf to the egfr, (b) prevents the egf, tgf alpha and hb-egf induced tyrosine phosphorylation of the egfr, and (c) inhibits the growth in vitro of the head and neck tumour (hn5) cell line overexpressing the egf receptor. |
2012-10-02 |
2023-08-12 |
human |
| K Kitahara, W Yasui, H Kuniyasu, H Yokozaki, K Fujii, T Hisatsugu, E Tahar. The expression of stat91, ras-independent signal transducer and activator, in human gastric carcinomas. International journal of oncology. vol 7. issue 4. 2012-10-02. PMID:21552922. |
upon binding of interferon (ifn) and epidermal growth factor (egf) to their cell surface receptors, tyrosine phosphorylation of latent cytoplasmic stat91 (ras-independent signal transducer and activator of transcription, stat1 alpha) protein is promptly induced and translocate from the cytoplasm to the nucleus to transduce the signal. |
2012-10-02 |
2023-08-12 |
human |
| H Modjtahedi, C Dea. The receptor for EGF and its ligands - expression, prognostic value and target for therapy in cancer (review). International journal of oncology. vol 4. issue 2. 2012-10-02. PMID:21566922. |
the egf receptor which transmits the growth promoting or inhibitory effects of epidermal growth factor (egf), transforming growth factor alpha (tgfalpha) and amphiregulin is a member of the type i family of growth factor receptors which possess tyrosine kinase activity. |
2012-10-02 |
2023-08-12 |
human |
| Y Yonemura, K Sugiyama, I Ninomiya, S Fushida, K Tsugawa, Y Hirono, A Yamaguchi, I Miyazaki, Y Endou, M Tanaka, T Sasak. Evidence of autocrine mechanism in poorly differentiated adenocarcinoma of the stomach. International journal of oncology. vol 2. issue 4. 2012-10-02. PMID:21573605. |
to evaluate a potential role of an autocrine mechanism in gastric cancer, we carried out an immunohistochemical study of epidermal growth factor (egf), transforming growth factor alpha (tgfalpha), and epidermal growth factor receptor (egfr) in 167 primary gastric cancer tissues. |
2012-10-02 |
2023-08-12 |
Not clear |
| N Normanno, C Qi, W Gullick, G Persico, Y Yarden, D Wen, G Plowman, N Kenney, G Johnson, N Kim, R Brandt, I Martinezlacaci, R Dickson, D Salomo. Expression of amphiregulin, cripto-1, and heregulin-alpha in human breast-cancer cells. International journal of oncology. vol 2. issue 6. 2012-10-02. PMID:21573645. |
cripto-1 (cr-1), amphiregulin (ar), and heregulin alpha (hrgalpha) are three recently discovered epidermal growth factor (egf)-related peptides. |
2012-10-02 |
2023-08-12 |
human |
| O Owens, R Leak. Growth-factor content of benign and malignant ovaries - a comparison. International journal of oncology. vol 1. issue 3. 2012-10-02. PMID:21584555. |
epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha) were estimated in extracts of 193 malignant ovarian samples, 42 benign ovarian samples and 71 normal ovaries. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Lakshmikesari, R Radhakrishna, A Bhanumathi, D Ravi, G Srinivas, M Nair, M Pilla. Expression of epidermal and transforming growth factors in pancreatic cancer. Oncology reports. vol 3. issue 5. 2012-10-02. PMID:21594491. |
we have examined by immunocytochemistry, the expression of epidermal growth factor (egf), its receptor (egfr) and the transforming growth factors alpha and beta (tgf alpha and beta) in various grades of pancreatic adenocarcinoma. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Lakshmikesari, R Radhakrishna, A Bhanumathi, D Ravi, G Srinivas, M Nair, M Pilla. Expression of epidermal and transforming growth factors in pancreatic cancer. Oncology reports. vol 3. issue 5. 2012-10-02. PMID:21594491. |
egf, tgf alpha and tgf beta was expressed in normal pancreatic tissue while the expression of egfr was slight and restricted. |
2012-10-02 |
2023-08-12 |
Not clear |