| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Grupcev, C Wallin, S Emås, E Theodorsson, P M Hellströ. Transforming growth factor-alpha and epidermal growth factor inhibit gastric acid secretion and stimulate release of somatostatin and neurotensin in the conscious rat. Regulatory peptides. vol 52. issue 2. 1994-12-28. PMID:7972934. |
at the highest doses, tgf alpha and egf caused 194% and 698% increase of somatostatin-like immunoreactivity (som-li) in plasma, respectively (each p < 0.05). |
1994-12-28 |
2023-08-12 |
rat |
| G Grupcev, C Wallin, S Emås, E Theodorsson, P M Hellströ. Transforming growth factor-alpha and epidermal growth factor inhibit gastric acid secretion and stimulate release of somatostatin and neurotensin in the conscious rat. Regulatory peptides. vol 52. issue 2. 1994-12-28. PMID:7972934. |
neurotensin-like immunoreactivity (nt-li) increased 438% by egf (p < 0.05), but the increase of 700% with tgf alpha did not reach statistical significance. |
1994-12-28 |
2023-08-12 |
rat |
| G Grupcev, C Wallin, S Emås, E Theodorsson, P M Hellströ. Transforming growth factor-alpha and epidermal growth factor inhibit gastric acid secretion and stimulate release of somatostatin and neurotensin in the conscious rat. Regulatory peptides. vol 52. issue 2. 1994-12-28. PMID:7972934. |
thus, tgf alpha and egf inhibit acid secretion, but also promote the release of som and nt into the circulation and may be involved in the acid inhibitory effects of these growth factors. |
1994-12-28 |
2023-08-12 |
rat |
| I A Mórocz, D Schmitter, B Lauber, R A Stahe. Autocrine stimulation of a human lung mesothelioma cell line is mediated through the transforming growth factor alpha/epidermal growth factor receptor mitogenic pathway. British journal of cancer. vol 70. issue 5. 1994-12-22. PMID:7947089. |
four well-characterised cell lines are analysed for their responsiveness to exogenous egf and transforming growth factor alpha (tgf-alpha) as well as for coexpression of egfr and egf/tgf-alpha. |
1994-12-22 |
2023-08-12 |
human |
| B Patel, P Hiscott, D Charteris, J Mather, D McLeod, M Boulto. Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy. The British journal of ophthalmology. vol 78. issue 9. 1994-12-22. PMID:7947554. |
the aim of this study was to determine the potential role of epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha), and their receptor (egf-r) in pdr development. |
1994-12-22 |
2023-08-12 |
Not clear |
| M Korc, H Friess, Y Yamanaka, M S Kobrin, M Buchler, H G Bege. Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma. Gut. vol 35. issue 10. 1994-12-20. PMID:7959207. |
the epidermal growth factor (egf) receptor is a transmembrane protein that binds egf and transforming growth factor alpha (tgf alpha), and that stimulates phospholipase c gamma 1 (plc gamma 1) activity. |
1994-12-20 |
2023-08-12 |
Not clear |
| M Korc, H Friess, Y Yamanaka, M S Kobrin, M Buchler, H G Bege. Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma. Gut. vol 35. issue 10. 1994-12-20. PMID:7959207. |
northern blot analysis showed that, by comparison with normal controls, 19 of 27 chronic pancreatitis tissues exhibited a 5.7-fold increase in egf receptor mrna concentrations, and 20 of 27 chronic pancreatitis tissues exhibited a sixfold increase in tgf alpha mrna concentrations. |
1994-12-20 |
2023-08-12 |
Not clear |
| M Korc, H Friess, Y Yamanaka, M S Kobrin, M Buchler, H G Bege. Chronic pancreatitis is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor alpha, and phospholipase C gamma. Gut. vol 35. issue 10. 1994-12-20. PMID:7959207. |
these findings suggest that tgf alpha may act through autocrine and paracrine mechanisms to excessively activate the overexpressed egf receptor in the two major cell types of the exocrine pancreas, thereby contributing to the pathobiology of this disorder. |
1994-12-20 |
2023-08-12 |
Not clear |
| L B Nanney, R J Coffey, D L Elli. Expression and distribution of transforming growth factor-alpha within melanocytic lesions. The Journal of investigative dermatology. vol 103. issue 5. 1994-12-20. PMID:7963661. |
stimulation of epidermal growth factor (egf) receptor by ligands such as transforming growth factor (tgf) alpha may be associated with cell proliferation or transformation in both nevocytes and keratinocytes. |
1994-12-20 |
2023-08-12 |
Not clear |
| L B Nanney, R J Coffey, D L Elli. Expression and distribution of transforming growth factor-alpha within melanocytic lesions. The Journal of investigative dermatology. vol 103. issue 5. 1994-12-20. PMID:7963661. |
previously, egf receptors have been identified within a variety of pigmented lesions, suggesting a possible responsiveness to ligands such as tgf alpha. |
1994-12-20 |
2023-08-12 |
Not clear |
| M Grau, C Rodríguez, M Soley, I Ramíre. Relationship between epidermal growth factor in mouse submandibular glands, plasma, and bile: effects of catecholamines and fasting. Endocrinology. vol 135. issue 5. 1994-12-16. PMID:7956907. |
acute administration of the alpha 1-adrenergic agonist phenylephrine (1.7 mg/kg, iv) to male mice produced a rapid increase in the egf concentration in bile. |
1994-12-16 |
2023-08-12 |
mouse |
| G Carruba, R E Leake, F Rinaldi, D Chalmers, L Comito, C Sorci, M Pavone-Macaluso, L A Castagnett. Steroid-growth factor interaction in human prostate cancer. 1. Short-term effects of transforming growth factors on growth of human prostate cancer cells. Steroids. vol 59. issue 7. 1994-12-02. PMID:7974525. |
furthermore, high levels of both egf-r and tgf alpha, and a fairly high amount of egf, were found in du145 cells and, to a lesser extent, in lncap cells; in contrast, pc3 cells exhibited low expression levels of both receptors (egf-r) and ligands (egf, tgf alpha), but displayed remarkable tgf beta binding and relatively high levels of endogenous tgf beta. |
1994-12-02 |
2023-08-12 |
human |
| R F Nicosia, S V Nicosia, M Smit. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. The American journal of pathology. vol 145. issue 5. 1994-11-29. PMID:7526691. |
rings of rat aorta were cultured in collagen gels under serum-free conditions in the presence or absence of vascular endothelial growth factor (vegf), natural platelet-derived growth factor (pdgf), pdgf-aa, pdgf-bb, insulin-like growth factor-1 (igf-1), transforming growth factor-alpha (tgf-alpha), transforming growth factor-beta 1 (tgf-beta 1), epidermal growth factor (egf), interleukin-1 alpha (il-1 alpha), or hepatocyte growth factor (hgf). |
1994-11-29 |
2023-08-12 |
rat |
| P M Brown, M T Debanne, S Grothe, D Bergsma, M Caron, C Kay, M D O'Connor-McCour. The extracellular domain of the epidermal growth factor receptor. Studies on the affinity and stoichiometry of binding, receptor dimerization and a binding-domain mutant. European journal of biochemistry. vol 225. issue 1. 1994-11-23. PMID:7925442. |
the apparent dissociation constant (kd) of the secreted egfr extracellular domain for egf and transforming growth factor alpha (tgf-alpha), as determined using an immobilized receptor binding assay, was approximately 200 nm. |
1994-11-23 |
2023-08-12 |
Not clear |
| M Andries, D Tilemans, C Dene. Modulation of epidermal growth factor receptor binding and action by N-acetyl-TGF alpha (34-43) methyl ester. Peptides. vol 15. issue 4. 1994-11-22. PMID:7937336. |
controversial data have been reported concerning the ability of n-acetyl-tgf alpha (34-43) methyl ester (tgf alpha a) to antagonize the mitogenic effect or the receptor binding of tgf alpha and egf. |
1994-11-22 |
2023-08-12 |
rat |
| M Andries, D Tilemans, C Dene. Modulation of epidermal growth factor receptor binding and action by N-acetyl-TGF alpha (34-43) methyl ester. Peptides. vol 15. issue 4. 1994-11-22. PMID:7937336. |
tgf alpha a (5 microm) completely blocked the effect of 0.1 nm egf on both lactotrophs and somatotrophs. |
1994-11-22 |
2023-08-12 |
rat |
| M Andries, D Tilemans, C Dene. Modulation of epidermal growth factor receptor binding and action by N-acetyl-TGF alpha (34-43) methyl ester. Peptides. vol 15. issue 4. 1994-11-22. PMID:7937336. |
however, depending on the batch of [125i]egf used, a dose of 5-10 microm tgf alpha a did not or only partially inhibited the binding of 3 x 10(-10) m [125i]egf to pituitary monolayer cell cultures. |
1994-11-22 |
2023-08-12 |
rat |
| M Andries, D Tilemans, C Dene. Modulation of epidermal growth factor receptor binding and action by N-acetyl-TGF alpha (34-43) methyl ester. Peptides. vol 15. issue 4. 1994-11-22. PMID:7937336. |
in the egf-sensitive cell lines a-431, bs-c-1, nrk-52e, and pituitary gh3 cells, none of the egf effects were antagonized by tgf alpha a. |
1994-11-22 |
2023-08-12 |
rat |
| M Andries, D Tilemans, C Dene. Modulation of epidermal growth factor receptor binding and action by N-acetyl-TGF alpha (34-43) methyl ester. Peptides. vol 15. issue 4. 1994-11-22. PMID:7937336. |
it is concluded that, although tgf alpha a negatively interacts with egf action and binding in normal pituitary, this is most likely not due to a direct competition with the binding of egf. |
1994-11-22 |
2023-08-12 |
rat |
| M Romano, E R Kraus, C R Boland, R J Coffe. Comparison between transforming growth factor alpha and epidermal growth factor in the protection of rat gastric mucosa against drug-induced injury. The Italian journal of gastroenterology. vol 26. issue 5. 1994-11-21. PMID:7522648. |
this study was designed to compare the protective effect of recombinant human tgf alpha or egf against drug-induced damage to the rat gastric mucosa. |
1994-11-21 |
2023-08-12 |
human |