| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Modjtahedi, S A Eccles, G Box, J Styles, C J Dea. Antitumor activity of combinations of antibodies directed against different epitopes on the extracellular domain of the human EGF receptor. Cell biophysics. vol 22. issue 1-3. 1995-04-20. PMID:7534211. |
egf and tgf alpha have also been correlated with poor prognosis in many patients. |
1995-04-20 |
2023-08-12 |
human |
| P Nugent, R M Green. Interactions between the transforming growth factor beta (TGF beta) and retinoic acid signal transduction pathways in murine embryonic palatal cells. Differentiation; research in biological diversity. vol 58. issue 2. 1995-04-18. PMID:7890140. |
tgf-beta 1, beta 2 and beta 3 also down-regulated the expression of crabp-i mrna, while epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) were without effect. |
1995-04-18 |
2023-08-12 |
Not clear |
| J Oberstrass, G U Ring, K T Vogeley, C M Kramm, J M Cobbers, J Wirths, T Bilzer, W Wechsle. [Alleles in chromosome 10p21-26 in malignant gliomas]. Verhandlungen der Deutschen Gesellschaft fur Pathologie. vol 78. 1995-04-13. PMID:7534011. |
the combined immunohistochemical analysis of overexpression of egfr, egf and tgf alpha with loh on chromosome 10 showed that chromosome 10 deletions are not exclusively bound to egfr overexpression. |
1995-04-13 |
2023-08-12 |
Not clear |
| D I Wilkinson, M J Theeuwes, E M Farbe. Nerve growth factor increases the mitogenicity of certain growth factors for cultured human keratinocytes: a comparison with epidermal growth factor. Experimental dermatology. vol 3. issue 5. 1995-04-11. PMID:7881770. |
newborn foreskin and adult skin keratinocytes (kts) were cultured in 24-well plates using keratinocyte basal medium (kbm) either alone or supplemented with epidermal growth factor (egf) or nerve growth factor (ngf), plus one of the following: insulin (ins), insulin-like growth factors (igf)-1 or -2, transforming growth factor alpha (tgf alpha), basic fibroblast growth factor (bfgf). |
1995-04-11 |
2023-08-12 |
human |
| D I Wilkinson, M J Theeuwes, E M Farbe. Nerve growth factor increases the mitogenicity of certain growth factors for cultured human keratinocytes: a comparison with epidermal growth factor. Experimental dermatology. vol 3. issue 5. 1995-04-11. PMID:7881770. |
in kbm alone, egf, igf-1, igf-2 and tgf alpha were mitogenic to newborn kts. |
1995-04-11 |
2023-08-12 |
human |
| C V Rao, X Li, P Toth, Z M Le. Expression of epidermal growth factor, transforming growth factor-alpha, and their common receptor genes in human umbilical cords. The Journal of clinical endocrinology and metabolism. vol 80. issue 3. 1995-04-11. PMID:7883816. |
epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha), present in amniotic fluid and/or in fetal blood, could potentially regulate cord functions. |
1995-04-11 |
2023-08-12 |
human |
| C V Rao, X Li, P Toth, Z M Le. Expression of epidermal growth factor, transforming growth factor-alpha, and their common receptor genes in human umbilical cords. The Journal of clinical endocrinology and metabolism. vol 80. issue 3. 1995-04-11. PMID:7883816. |
the present study investigated the possible presence of functional receptors and egf and tgf alpha themselves in umbilical cord. |
1995-04-11 |
2023-08-12 |
human |
| C V Rao, X Li, P Toth, Z M Le. Expression of epidermal growth factor, transforming growth factor-alpha, and their common receptor genes in human umbilical cords. The Journal of clinical endocrinology and metabolism. vol 80. issue 3. 1995-04-11. PMID:7883816. |
the reverse transcription-polymerase chain reaction followed by southern blotting demonstrated that human umbilical cords contain egf, tgf alpha, and egf/tgf alpha messenger ribonucleic acid (mrna) transcripts. |
1995-04-11 |
2023-08-12 |
human |
| C V Rao, X Li, P Toth, Z M Le. Expression of epidermal growth factor, transforming growth factor-alpha, and their common receptor genes in human umbilical cords. The Journal of clinical endocrinology and metabolism. vol 80. issue 3. 1995-04-11. PMID:7883816. |
the cord egf/tgf alpha receptors are functional in terms of binding of egf, activation of receptor autophosphorylation, and increasing the formation of vasoconstrictive eicosanoid. |
1995-04-11 |
2023-08-12 |
human |
| A R French, D K Tadaki, S K Niyogi, D A Lauffenburge. Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. The Journal of biological chemistry. vol 270. issue 9. 1995-04-05. PMID:7876195. |
mouse egf (megf), human egf (hegf), and transforming growth factor alpha (tgf alpha) bind to the human egf receptor (egfr) with similar affinities at ph 7.4. |
1995-04-05 |
2023-08-12 |
mouse |
| Y C Li, G T Montelion. Human type-alpha transforming growth factor undergoes slow conformational exchange between multiple backbone conformations as characterized by nitrogen-15 relaxation measurements. Biochemistry. vol 34. issue 8. 1995-04-04. PMID:7873520. |
these results demonstrate that, under conditions of ph and temperature at which it is tightly bound by the egf receptor, htgf alpha is a highly dynamic molecule. |
1995-04-04 |
2023-08-12 |
human |
| A Kihara, I Pasta. Analysis of sequences required for the cytotoxic action of a chimeric toxin composed of Pseudomonas exotoxin and transforming growth factor alpha. Bioconjugate chemistry. vol 5. issue 6. 1995-04-04. PMID:7873657. |
chimeric toxins composed of transforming growth factor alpha fused to mutant forms of pseudomonas exotoxin bind to the egf receptor and kill cells bearing these receptors. |
1995-04-04 |
2023-08-12 |
Not clear |
| E J Yeo, J H Exto. Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells. The Journal of biological chemistry. vol 270. issue 8. 1995-03-31. PMID:7876145. |
egf and bombesin induced biphasic translocations of pkc delta and epsilon to the membrane that were detectable at 15 s. in the presence of ro-31-8220, translocation of pkc alpha became evident, and membrane association of the delta- and epsilon-isozymes was enhanced and/or sustained in response to the two agonists. |
1995-03-31 |
2023-08-12 |
Not clear |
| D Evain-Brio. Hormonal regulation of fetal growth. Hormone research. vol 42. issue 4-5. 1995-03-30. PMID:7868075. |
tgf alpha and egf might play major roles as suggested by the modulation of their receptors with placental development, and by the specific alterations of egf receptors in intrauterine growth retardation. |
1995-03-30 |
2023-08-12 |
human |
| X Fan, G T Nagle, T J Collins, G V Child. Differential regulation of epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acid in the rat anterior pituitary and hypothalamus induced by stresses. Endocrinology. vol 136. issue 3. 1995-03-29. PMID:7867595. |
evidence has shown that epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) are present in the anterior pituitary as well as the hypothalamus, and that egf can influence the function of pituitary cells, particularly corticotropes in vivo and in vitro. |
1995-03-29 |
2023-08-12 |
rat |
| X Fan, G T Nagle, T J Collins, G V Child. Differential regulation of epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acid in the rat anterior pituitary and hypothalamus induced by stresses. Endocrinology. vol 136. issue 3. 1995-03-29. PMID:7867595. |
the present study was designed to determine if egf and tgf alpha messenger rna (mrna) are expressed in the rat anterior pituitary and hypothalamus and how stress conditions such as cold, ether, or restraint affect their local expression. |
1995-03-29 |
2023-08-12 |
rat |
| X Fan, G T Nagle, T J Collins, G V Child. Differential regulation of epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acid in the rat anterior pituitary and hypothalamus induced by stresses. Endocrinology. vol 136. issue 3. 1995-03-29. PMID:7867595. |
a sensitive mrna detection method, the ribonuclease protection assay, detected both egf and tgf alpha mrna in the rat anterior pituitary and hypothalamus. |
1995-03-29 |
2023-08-12 |
rat |
| X Fan, G T Nagle, T J Collins, G V Child. Differential regulation of epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acid in the rat anterior pituitary and hypothalamus induced by stresses. Endocrinology. vol 136. issue 3. 1995-03-29. PMID:7867595. |
reverse transcription-polymerase chain reaction (rt-pcr) further showed the presence of egf and tgf alpha mrna in these two areas and several other rat tissues (submandibular gland, liver, kidney, lung cerebral cortex, and testis). |
1995-03-29 |
2023-08-12 |
rat |
| X Fan, G T Nagle, T J Collins, G V Child. Differential regulation of epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acid in the rat anterior pituitary and hypothalamus induced by stresses. Endocrinology. vol 136. issue 3. 1995-03-29. PMID:7867595. |
in contrast, tgf alpha mrna in the anterior pituitary and hypothalamus and hypothalamic egf mrna did not show significant changes in response to either acute stresses (cs, es, rs, ts, ns) or longer cs (1c, 3c). |
1995-03-29 |
2023-08-12 |
rat |
| X Fan, G T Nagle, T J Collins, G V Child. Differential regulation of epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acid in the rat anterior pituitary and hypothalamus induced by stresses. Endocrinology. vol 136. issue 3. 1995-03-29. PMID:7867595. |
our results suggest that 1) egf, is up-regulated after some stresses; 2) increased pituitary egf mrna in response to stresses varies with the type of stress; and 3) pituitary tgf alpha and hypothalamic egf and tgf alpha may be not involved in the stress response. |
1995-03-29 |
2023-08-12 |
rat |