| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Adam, D R Drummond, N Solic, S J Holt, R P Sharma, S G Chamberlin, D E Davie. Modulation of the receptor binding affinity of amphiregulin by modification of its carboxyl terminal tail. Biochimica et biophysica acta. vol 1266. issue 1. 1995-05-24. PMID:7718625. |
the ar1-90(leu86) construct was found to be 50- to 100-fold more active than wild type ar1-84 consistent with previously reported studies of the role of the equivalent c-terminal leucine in egf or tgf alpha. |
1995-05-24 |
2023-08-12 |
Not clear |
| K Adachi, H Kurachi, H Homma, H Adachi, T Imai, M Sakata, O Higashiguchi, M Yamaguchi, K Morishige, Y Sakoyam. Estrogen induces epidermal growth factor (EGF) receptor and its ligands in human fallopian tube: involvement of EGF but not transforming growth factor-alpha in estrogen-induced tubal cell growth in vitro. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720660. |
we studied whether egf and/or tgf alpha is involved in the estrogen-induced tubal cell growth in vitro. |
1995-05-23 |
2023-08-12 |
human |
| K Adachi, H Kurachi, H Homma, H Adachi, T Imai, M Sakata, O Higashiguchi, M Yamaguchi, K Morishige, Y Sakoyam. Estrogen induces epidermal growth factor (EGF) receptor and its ligands in human fallopian tube: involvement of EGF but not transforming growth factor-alpha in estrogen-induced tubal cell growth in vitro. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720660. |
if the egf and/or tgf alpha is involved in the cell growth, then the estrogen-induced cell growth should be suppressed by blocking the action of egf and/or tgf alpha. |
1995-05-23 |
2023-08-12 |
human |
| K Adachi, H Kurachi, H Homma, H Adachi, T Imai, M Sakata, O Higashiguchi, M Yamaguchi, K Morishige, Y Sakoyam. Estrogen induces epidermal growth factor (EGF) receptor and its ligands in human fallopian tube: involvement of EGF but not transforming growth factor-alpha in estrogen-induced tubal cell growth in vitro. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720660. |
moreover, the growth inhibitory effect by 1 microgram/ml anti-egf was restored by 10(-8) m egf but not by tgf alpha even at 10(-6) m. all these data suggest that estrogen induces egf and tgf alpha/egf receptors in the human fallopian tube and that egf but not tgf alpha may be involved in the estrogen-induced human tubal cell growth in vitro. |
1995-05-23 |
2023-08-12 |
human |
| X Fan, G V Child. Epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acids and their receptors in the rat anterior pituitary: localization and regulation. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720677. |
evidence has shown that epidermal growth factor (egf), transforming growth factor-alpha (tgf alpha) and their receptors (egf receptors) are present in the anterior pituitary, indicating that the growth factors are synthesized in situ and act locally. |
1995-05-23 |
2023-08-12 |
rat |
| X Fan, G V Child. Epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acids and their receptors in the rat anterior pituitary: localization and regulation. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720677. |
studies have demonstrated that egf could stimulate the hypothalamus-pituitary-adrenal (hpa) cortex axis, particularly at the pituitary level in vivo and in vitro, and also stimulate tgf alpha messenger rna (mrna) expression in cultured bovine pituitary cells. |
1995-05-23 |
2023-08-12 |
rat |
| X Fan, G V Child. Epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acids and their receptors in the rat anterior pituitary: localization and regulation. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720677. |
therefore, this study was designed to localize egf and tgf alpha mrna and their receptors as well as to assess the effects of cold stress (cs) on their expression in the subsets of pituitary cells. |
1995-05-23 |
2023-08-12 |
rat |
| X Fan, G V Child. Epidermal growth factor and transforming growth factor-alpha messenger ribonucleic acids and their receptors in the rat anterior pituitary: localization and regulation. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720677. |
in situ hybridization immunocytochemistry coupled with immunocytochemistry and dual immunocytochemistry studies revealed the presence of 1) egf mrna in somatotropes and gonadotropes; 2) tgf alpha mrna in somatotropes, gonadotropes, and lactotropes; and 3) egf receptors in all subsets of pituitary cells. |
1995-05-23 |
2023-08-12 |
rat |
| A Iida, K Hirose, M Arai, A Yamaguchi, G Nakagawar. Relationships among the expression of epidermal growth factor receptor, proliferating cell nuclear antigen labeling index, and lymph node metastasis in gastric cancer. Oncology. vol 52. issue 3. 1995-05-18. PMID:7715902. |
the expression of epidermal growth factor receptor (egfr), epidermal growth factor (egf), transforming growth factor alpha (tgf alpha) and the labeling index of proliferating cell nuclear antigen (pcna li) were examined immunohistochemically in 288 gastric cancer patients, and the relationships between these results and the lymph node metastasis were studied. |
1995-05-18 |
2023-08-12 |
Not clear |
| A Iida, K Hirose, M Arai, A Yamaguchi, G Nakagawar. Relationships among the expression of epidermal growth factor receptor, proliferating cell nuclear antigen labeling index, and lymph node metastasis in gastric cancer. Oncology. vol 52. issue 3. 1995-05-18. PMID:7715902. |
to investigate the relation between the expression of egfr and pcna li, we divided the patients into the following three groups according to the immunohistochemical findings: group a, egfr (+); group b, egfr (-), and egf(+) or tgf alpha(+); group c, egfr(-), egf(-) and tgf alpha(-). |
1995-05-18 |
2023-08-12 |
Not clear |
| M Yamaguchi, L Ogren, H Kurachi, K Hirota, T Imai, F Talamante. Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 7. 1995-05-11. PMID:7535931. |
this study was undertaken to determine whether transforming growth factor alpha (tgf-alpha) regulates the production of mouse placental lactogen i (mpl-i) and mpl-ii in a manner that is similar to that of epidermal growth factor (egf), which was previously shown to stimulate mpl-i secretion and inhibit mpl-ii secretion. |
1995-05-11 |
2023-08-12 |
mouse |
| C D Woodworth, E McMullin, M Iglesias, G D Plowma. Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 7. 1995-05-11. PMID:7708734. |
growth stimulation by il-1 alpha or tnf-alpha was accompanied by a 6- to 10-fold increase in rna encoding amphiregulin, an epidermal growth factor (egf) receptor ligand. |
1995-05-11 |
2023-08-12 |
human |
| C D Woodworth, E McMullin, M Iglesias, G D Plowma. Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 7. 1995-05-11. PMID:7708734. |
monoclonal antibodies that blocked signal transduction by the egf receptor or that neutralized amphiregulin activity prevented mitogenic stimulation by il-1 alpha or tnf-alpha. |
1995-05-11 |
2023-08-12 |
human |
| C D Woodworth, E McMullin, M Iglesias, G D Plowma. Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 7. 1995-05-11. PMID:7708734. |
these studies indicate that il-1 alpha and tnf-alpha stimulate proliferation of immortal and malignant cervical epithelial cells by an egf receptor-dependent pathway requiring autocrine stimulation by amphiregulin. |
1995-05-11 |
2023-08-12 |
human |
| A A Dlugosz, C Cheng, M F Denning, P J Dempsey, R J Coffey, S H Yusp. Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 5. issue 12. 1995-05-03. PMID:7535082. |
in addition to being potent mitogens for murine epidermal keratinocytes in vitro, transforming growth factor alpha (tgf alpha) and egf elicit distinctive changes in keratin expression: ca(2+)-mediated induction of the differentiation-specific keratins k1 and k10 is blocked, while simple epithelial keratins k8 and k18 are expressed aberrantly (c. cheng et al., cell growth, & differ., 4: 317-327, 1993). |
1995-05-03 |
2023-08-12 |
mouse |
| S E Wilson, Y G He, J Weng, J D Zieske, J V Jester, G S Schult. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells. Experimental eye research. vol 59. issue 6. 1995-05-03. PMID:7698260. |
we sought to determine the effects of exogenous epidermal growth factor (egf), heparin-binding egf (hb-egf), transforming growth factor alpha (tgf-alpha), single-chain precursor hepatocyte growth factor (sc-hgf), double-chain mature hgf (dc-hgf), and keratinocyte growth factor (kgf) on proliferation, motility, and differentiation of first passage cultures of human corneal epithelial cells in serum-free chemically defined medium. |
1995-05-03 |
2023-08-12 |
human |
| S E Wilson, Y G He, J Weng, J D Zieske, J V Jester, G S Schult. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells. Experimental eye research. vol 59. issue 6. 1995-05-03. PMID:7698260. |
egf, hb-egf, tgf alpha or dc-hgf inhibited expression of the differentiation-related marker keratin k3 in epithelial cells, both at the edge and at the center of the islands. |
1995-05-03 |
2023-08-12 |
human |
| I Ono, H Gunji, K Suda, K Iwatsuki, F Kanek. Evaluation of cytokines in donor site wound fluids. Scandinavian journal of plastic and reconstructive surgery and hand surgery. vol 28. issue 4. 1995-04-21. PMID:7899836. |
the fluid was snap frozen and stored immediately at -70 degrees c. the fluid was examined for epidermal growth factor (egf), basic fibroblast growth factor (bfgf), transforming growth factor (tgf) alpha, tgf beta, interleukin (il)-1 alpha and il-1 beta. |
1995-04-21 |
2023-08-12 |
Not clear |
| I Ono, H Gunji, K Suda, K Iwatsuki, F Kanek. Evaluation of cytokines in donor site wound fluids. Scandinavian journal of plastic and reconstructive surgery and hand surgery. vol 28. issue 4. 1995-04-21. PMID:7899836. |
the fluid was rich in tgf alpha but contained no egf or bfgf, which indicates that tgf alpha plays a major part for promoting local wound healing. |
1995-04-21 |
2023-08-12 |
Not clear |
| H Modjtahedi, S A Eccles, G Box, J Styles, C J Dea. Antitumor activity of combinations of antibodies directed against different epitopes on the extracellular domain of the human EGF receptor. Cell biophysics. vol 22. issue 1-3. 1995-04-20. PMID:7534211. |
the receptor (egfr) for epidermal growth factor (egf) and transforming growth alpha (tgf alpha) is often overexpressed in certain types of human malignancy and high levels of expression of the receptor and/or coexpression of growth factors. |
1995-04-20 |
2023-08-12 |
human |