| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Kumar, S A Bustin, I A McKa. Transforming growth factor alpha. Cell biology international. vol 19. issue 5. 1995-09-21. PMID:7640654. |
transforming growth factor alpha (tgf alpha) is a close relative of epidermal growth factor (egf), the first polypeptide mitogen discovered in 1962 (cohen, 1962). |
1995-09-21 |
2023-08-12 |
Not clear |
| M R Chicoine, C L Madsen, D L Silbergel. Modification of human glioma locomotion in vitro by cytokines EGF, bFGF, PDGFbb, NGF, and TNF alpha. Neurosurgery. vol 36. issue 6. 1995-09-21. PMID:7643998. |
modification of human glioma locomotion in vitro by cytokines egf, bfgf, pdgfbb, ngf, and tnf alpha. |
1995-09-21 |
2023-08-12 |
human |
| J C Cendan, W W Souba, E M Copeland, D S Lin. Characterization and growth factor stimulation of L-arginine transport in a human colon cancer cell line. Annals of surgical oncology. vol 2. issue 3. 1995-09-18. PMID:7641023. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) are potent mitogens that contribute to abnormal growth regulation in colon cancer. |
1995-09-18 |
2023-08-12 |
human |
| M Strazzabosco, C Poci, C Spirlì, A Zsembery, A Granato, M L Massimino, G Crepald. Intracellular pH regulation in Hep G2 cells: effects of epidermal growth factor, transforming growth factor-alpha, and insulinlike growth factor-II on Na+/H+ exchange activity. Hepatology (Baltimore, Md.). vol 22. issue 2. 1995-09-08. PMID:7635429. |
to investigate intracellular acid/base homeostasis in hepatoma cells and the effects of putative liver growth factors on na+/h+ exchange activity, we have studied intracellular ph (phi) regulation in hep g2 cells, a well-differentiated hepatoma cell line, both in resting conditions and after administration of epidermal growth factor (egf), transforming growth factor-alpha (tgf alpha), and insulinlike growth factor-ii (igf-ii). |
1995-09-08 |
2023-08-12 |
Not clear |
| F Huang, S Sauma, Z Yan, E Friedma. Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate. Experimental cell research. vol 219. issue 1. 1995-09-01. PMID:7628553. |
in addition, tgf alpha activated the egf receptor in each line by increasing its tyrosine phosphorylation. |
1995-09-01 |
2023-08-12 |
Not clear |
| F Huang, S Sauma, Z Yan, E Friedma. Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate. Experimental cell research. vol 219. issue 1. 1995-09-01. PMID:7628553. |
no relationship was found in these four lines between response to tgf alpha and level of expression of either the egf receptor or two egf receptor ligands, tgf alpha and amphiregulin. |
1995-09-01 |
2023-08-12 |
Not clear |
| F Huang, S Sauma, Z Yan, E Friedma. Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate. Experimental cell research. vol 219. issue 1. 1995-09-01. PMID:7628553. |
activated egf receptors initiate both growth-inhibitory and mitogenic signals in these cells since blocking some of the egf receptors on tgf alpha-growth-inhibited u4h cells and tgf alpha-unresponsive u9 cells overrode the inhibitory signals and made both u9 and u4h cells sensitive to mitogenesis by added tgf alpha. |
1995-09-01 |
2023-08-12 |
Not clear |
| F Huang, S Sauma, Z Yan, E Friedma. Colon absorptive epithelial cells lose proliferative response to TGF alpha as they differentiate. Experimental cell research. vol 219. issue 1. 1995-09-01. PMID:7628553. |
these data imply that upon reaching stages of greater maturation, colon enterocytes lose proliferative response to tgf alpha because of changes in signaling by their egf receptors. |
1995-09-01 |
2023-08-12 |
Not clear |
| G Serrero, N M Lepa. Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. Biochemical and biophysical research communications. vol 212. issue 3. 1995-08-25. PMID:7626101. |
prostaglandin f2 alpha (pgf2 alpha) and epidermal growth factor (egf) are potent differentiation inhibitors of adipocyte precursors in primary culture. |
1995-08-25 |
2023-08-12 |
Not clear |
| G Serrero, N M Lepa. Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. Biochemical and biophysical research communications. vol 212. issue 3. 1995-08-25. PMID:7626101. |
we show here that pgf2 alpha specifically inhibited egf binding to adipocyte precursors in a dose dependent fashion. |
1995-08-25 |
2023-08-12 |
Not clear |
| G Serrero, N M Lepa. Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. Biochemical and biophysical research communications. vol 212. issue 3. 1995-08-25. PMID:7626101. |
scatchard analysis indicates that pgf2 alpha causes a 50% decrease in the number of available egf cell surface receptors without change in receptor affinity. |
1995-08-25 |
2023-08-12 |
Not clear |
| G Serrero, N M Lepa. Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. Biochemical and biophysical research communications. vol 212. issue 3. 1995-08-25. PMID:7626101. |
comparison of egf binding at different temperatures and on fixed cells indicates that pgf2 alpha increases internalization of egf-receptor complexes in adipocyte precursors. |
1995-08-25 |
2023-08-12 |
Not clear |
| G Serrero, N M Lepa. Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. Biochemical and biophysical research communications. vol 212. issue 3. 1995-08-25. PMID:7626101. |
pgf2 alpha effect was abolished in cells exposed to prolonged treatment with pma indicating that pgf2 alpha effect on egf binding is mediated by protein kinase c. these results would suggest that in adipocyte precursors pgf2 alpha may be the physiological mediator of phorbol ester effect on egf receptor properties. |
1995-08-25 |
2023-08-12 |
Not clear |
| C S Potten, G Owen, D Hewitt, C A Chadwick, H Hendry, B I Lord, L B Woolfor. Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors. Gut. vol 36. issue 6. 1995-08-24. PMID:7615275. |
the effects of epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), insulin-like growth factor (igf) i and ii, acidic fibroblast growth factor (fgf), tumour necrosis factor alpha (tnf alpha), macrophage inhibitory protein 1 alpha (mip-1 alpha) (ld78), and tgf beta-1 on cell proliferation in the crypts of the small intestine of mice were investigated. |
1995-08-24 |
2023-08-12 |
mouse |
| C S Potten, G Owen, D Hewitt, C A Chadwick, H Hendry, B I Lord, L B Woolfor. Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors. Gut. vol 36. issue 6. 1995-08-24. PMID:7615275. |
little effect was seen after treatment with acidic fgf, tnf alpha, or mip-1 alpha but egf, igf-i and ii, and tgf alpha can all be seen to exert some stimulatory effects on labelling or mitosis. |
1995-08-24 |
2023-08-12 |
mouse |
| C S Potten, G Owen, D Hewitt, C A Chadwick, H Hendry, B I Lord, L B Woolfor. Stimulation and inhibition of proliferation in the small intestinal crypts of the mouse after in vivo administration of growth factors. Gut. vol 36. issue 6. 1995-08-24. PMID:7615275. |
egf and igf-i stimulate both unirradiated mice and 96 hour recipients, while tgf alpha had a greater effect on the 96 hour animals. |
1995-08-24 |
2023-08-12 |
mouse |
| A L Brass, J Barnard, B L Patai, D Salvi, D B Rukstali. Androgen up-regulates epidermal growth factor receptor expression and binding affinity in PC3 cell lines expressing the human androgen receptor. Cancer research. vol 55. issue 14. 1995-08-17. PMID:7606741. |
however, no enhancement of transforming growth factor alpha or egf expression was detected because dht did not affect the levels of these cytokines in the pc3-har cell lysate or conditioned media. |
1995-08-17 |
2023-08-12 |
human |
| D A Fishe. Epidermal growth factor in the developing mammal. Mead Johnson Symposium on Perinatal and Developmental Medicine. issue 32. 1995-08-10. PMID:2485437. |
however, egf mrna has not been shown in the fetus, and it seems likely that the related peptide, alpha tgf, subserves a developmental role in the fetus. |
1995-08-10 |
2023-08-11 |
Not clear |
| D A Fishe. Epidermal growth factor in the developing mammal. Mead Johnson Symposium on Perinatal and Developmental Medicine. issue 32. 1995-08-10. PMID:2485437. |
the mrna for alpha tgf has been demonstrated in the fetus [22] and alpha tgf acts via egf receptors. |
1995-08-10 |
2023-08-11 |
Not clear |
| L W Reneker, D W Silversides, K Patel, P A Overbee. TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes. Development (Cambridge, England). vol 121. issue 6. 1995-08-10. PMID:7600984. |
transforming growth factor alpha (tgf alpha), a member of the epidermal growth factor (egf) superfamily, is a small polypeptide growth factor. |
1995-08-10 |
2023-08-12 |
mouse |