| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Akarasereenont, Y S Bakhle, C Thiemermann, J R Van. Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide. British journal of pharmacology. vol 115. issue 3. 1995-11-27. PMID:7582449. |
in experiments designed to measure 'cox activity', 6-oxo-pgf1 alpha generated by baec activated with recombinant human il-1 beta, tnf-alpha, egf or pdgf for 12 h was measured after incubation of washed cells with exogenous arachidonic acid (30 microm for 15 min). |
1995-11-27 |
2023-08-12 |
human |
| B L Oliver, R I Sha'afi, J J Hajja. Transforming growth factor-alpha and epidermal growth factor activate mitogen-activated protein kinase and its substrates in intestinal epithelial cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 210. issue 2. 1995-11-21. PMID:7568287. |
we report here a possible signaling pathway of two closely related agonists, transforming growth factor-alpha (tgf alpha) and epidermal growth factor (egf). |
1995-11-21 |
2023-08-12 |
Not clear |
| B L Oliver, R I Sha'afi, J J Hajja. Transforming growth factor-alpha and epidermal growth factor activate mitogen-activated protein kinase and its substrates in intestinal epithelial cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 210. issue 2. 1995-11-21. PMID:7568287. |
the addition of either tgf alpha or egf to iec-6 cells also stimulates the activities of the two forms of mitogen-activated protein kinase, p42erk2 mapk and p44erk1 mapk, as evidenced by increased incorporation of radiolabeled phosphate in myelin basic protein. |
1995-11-21 |
2023-08-12 |
Not clear |
| B L Oliver, R I Sha'afi, J J Hajja. Transforming growth factor-alpha and epidermal growth factor activate mitogen-activated protein kinase and its substrates in intestinal epithelial cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 210. issue 2. 1995-11-21. PMID:7568287. |
the activity of the 90-kda ribosomal s6 kinase, a downstream substrate for activated mapk, is also enhanced as evidenced by increased incorporation of radiolabeled phosphate in the rsk kinase substrate peptide in iec-6 cells following stimulation with either tgf alpha or egf. |
1995-11-21 |
2023-08-12 |
Not clear |
| B L Oliver, R I Sha'afi, J J Hajja. Transforming growth factor-alpha and epidermal growth factor activate mitogen-activated protein kinase and its substrates in intestinal epithelial cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 210. issue 2. 1995-11-21. PMID:7568287. |
the increase in iec-6 cell proliferation in response to tgf alpha and egf stimulation may then be due, in part, to an increase in immediate early gene expression as a direct result of mapk and rsk activation. |
1995-11-21 |
2023-08-12 |
Not clear |
| I Ono, H Gunji, J Z Zhang, K Maruyama, F Kanek. A study of cytokines in burn blister fluid related to wound healing. Burns : journal of the International Society for Burn Injuries. vol 21. issue 5. 1995-11-20. PMID:7546257. |
although epidermal growth factor (egf) and basic fibroblast growth factor (bfgf) levels were low, relatively large amounts of cytokines including platelet derived growth factor (pdgf), interleukin (il-6) and transforming growth factor (tgf) alpha were present and these exercised stimulatory effects on wound healing. |
1995-11-20 |
2023-08-12 |
Not clear |
| M Pan, B R Steven. Protein kinase C-dependent regulation of L-arginine transport activity in Caco-2 intestinal cells. Biochimica et biophysica acta. vol 1239. issue 1. 1995-11-07. PMID:7548140. |
treatment of cells with serum-free media containing epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), or the protein kinase c (pkc) activator 12-o-tetradecanoylphorbol 13-acetate (tpa), stimulated system y+ arginine transport activity in caco-2 cells. |
1995-11-07 |
2023-08-12 |
human |
| M T Harte, L E Gentr. Mutations within subdomain II of the extracellular region of epidermal growth factor receptor selectively alter TGF alpha binding. Archives of biochemistry and biophysics. vol 322. issue 2. 1995-11-06. PMID:7574711. |
the interactions of epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) with the epidermal growth factor receptor (egfr) were examined by insertion mutagenesis of the receptor. |
1995-11-06 |
2023-08-12 |
Not clear |
| M T Harte, L E Gentr. Mutations within subdomain II of the extracellular region of epidermal growth factor receptor selectively alter TGF alpha binding. Archives of biochemistry and biophysics. vol 322. issue 2. 1995-11-06. PMID:7574711. |
two receptors with insertions at positions 291 and 474, which border subdomain iii, have significantly decreased binding to both egf and tgf alpha relative to wild type. |
1995-11-06 |
2023-08-12 |
Not clear |
| M T Harte, L E Gentr. Mutations within subdomain II of the extracellular region of epidermal growth factor receptor selectively alter TGF alpha binding. Archives of biochemistry and biophysics. vol 322. issue 2. 1995-11-06. PMID:7574711. |
this confirms previous work demonstrating that subdomain iii forms the primary binding site for egf and tgf alpha. |
1995-11-06 |
2023-08-12 |
Not clear |
| M T Harte, L E Gentr. Mutations within subdomain II of the extracellular region of epidermal growth factor receptor selectively alter TGF alpha binding. Archives of biochemistry and biophysics. vol 322. issue 2. 1995-11-06. PMID:7574711. |
four of the mutants within subdomain ii had a decreased binding to tgf alpha relative to wild type, but had wild type binding to egf. |
1995-11-06 |
2023-08-12 |
Not clear |
| N Normanno, M P Selvam, C Bianco, V Damiano, E de Angelis, M Grassi, G Magliulo, G Tortora, D S Salomon, F Ciardiell. Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line. International journal of cancer. vol 62. issue 6. 1995-11-03. PMID:7558427. |
amphiregulin (ar) is a secreted heparin-binding growth factor that is structurally and functionally related to epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha). |
1995-11-03 |
2023-08-12 |
human |
| J Aubrecht, K I Hirsch-Ernst, V Becker-Rabbenstein, G F Kahl, H Taniguchi, M W Höhn. Induction of cytochrome P-4502B1-related mouse cytochrome P-450 and regulation of its expression by epidermal growth factor/transforming growth factor alpha in primary hepatocyte culture. Biochemical pharmacology. vol 50. issue 6. 1995-10-31. PMID:7575638. |
ligands of the egf receptor, epidermal growth factor, and transforming growth factor alpha inhibited induction on the basis of protein expression and cyp2b-associated 7-pentoxyresorufin-o-depentylase activity. |
1995-10-31 |
2023-08-12 |
mouse |
| B Rohde-Schulz, R B Lichtne. EGF enhances attachment of metastatic rat mammary adenocarcinoma cell clone MTLn3 to fibronectin and collagen. Invasion & metastasis. vol 15. issue 1-2. 1995-10-17. PMID:7672928. |
when egf or tgf alpha were added at 0.3 to 10 ng/ml for 30 min, a dose-dependent increase in adhesion to both matrix proteins was observed. |
1995-10-17 |
2023-08-12 |
rat |
| B Rohde-Schulz, R B Lichtne. EGF enhances attachment of metastatic rat mammary adenocarcinoma cell clone MTLn3 to fibronectin and collagen. Invasion & metastasis. vol 15. issue 1-2. 1995-10-17. PMID:7672928. |
however, egf was more potent at lower concentrations (0.3-3 ng/ml) than tgf alpha. |
1995-10-17 |
2023-08-12 |
rat |
| M L van de Poll, A E Lenferink, M J van Vugt, J J Jacobs, J W Janssen, M Joldersma, E J van Zoele. A single amino acid exchange, Arg-45 to Ala, generates an epidermal growth factor (EGF) mutant with high affinity for the chicken EGF receptor. The Journal of biological chemistry. vol 270. issue 38. 1995-10-17. PMID:7673217. |
the finding that human epidermal growth factor (hegf) and human transforming growth factor (htgf) alpha bind with similar affinity to the human egf receptor but differ in their affinity for the chicken egf receptor was used as a model system to study ligand-receptor interaction of egf receptor agonists. |
1995-10-17 |
2023-08-12 |
human |
| M L van de Poll, A E Lenferink, M J van Vugt, J J Jacobs, J W Janssen, M Joldersma, E J van Zoele. A single amino acid exchange, Arg-45 to Ala, generates an epidermal growth factor (EGF) mutant with high affinity for the chicken EGF receptor. The Journal of biological chemistry. vol 270. issue 38. 1995-10-17. PMID:7673217. |
we previously constructed domain-exchange mutants of hegf and htgf alpha and found that the region cooh-terminal of the sixth cysteine residue in htgf alpha is important for high affinity binding to the chicken egf receptor (kramer, r. h., lenferink, a. e. g., lammerts van bueren-koornneef, i., van der meer, a., van de poll, m. l. m., and van zoelen, e. j. j. |
1995-10-17 |
2023-08-12 |
human |
| M L van de Poll, A E Lenferink, M J van Vugt, J J Jacobs, J W Janssen, M Joldersma, E J van Zoele. A single amino acid exchange, Arg-45 to Ala, generates an epidermal growth factor (EGF) mutant with high affinity for the chicken EGF receptor. The Journal of biological chemistry. vol 270. issue 38. 1995-10-17. PMID:7673217. |
a mutant in which the latter region in hegf was replaced by htgf alpha (designated e6et) showed intermediate binding affinity, whereas replacement of the former region in hegf by htgf alpha was sufficient to generate a mutant (designated e6te) with a similar high affinity for the chicken egf receptor as wild type htgf alpha. |
1995-10-17 |
2023-08-12 |
human |
| B M Bany, T G Kenned. Interleukin-1 alpha regulates prostaglandin production and cyclooxygenase activity in sensitized rat endometrial stromal cells in vitro. Biology of reproduction. vol 53. issue 1. 1995-10-13. PMID:7669843. |
the combined effects of il-1 alpha and egf on pge2 accumulation and cox activity were additive. |
1995-10-13 |
2023-08-12 |
rat |
| M Tateishi, S Kaneko, Y Fukuyama, M Hamatake, S Kohdono, T Mitsudomi, T Ishida, K Sugimach. The close relationship between growth factors and the nucleolar organizer regions in adenocarcinoma of the lung. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. vol 21. issue 4. 1995-10-06. PMID:7664907. |
we examined immunohistochemically 111 cases of primary adenocarcinoma of the lung, for transforming growth factor alpha (tgf alpha) or epidermal growth factor (egf), and argyrophilic nucleolar organizer regions (agnors). |
1995-10-06 |
2023-08-12 |
Not clear |