| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G D Block, J Locker, W C Bowen, B E Petersen, S Katyal, S C Strom, T Riley, T A Howard, G K Michalopoulo. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. The Journal of cell biology. vol 132. issue 6. 1996-05-09. PMID:8601590. |
mature adult parenchymal hepatocytes, typically of restricted capacity to proliferate in culture, can now enter into clonal growth under the influence of hepatocyte growth factor (scatter factor) (hgf/sf), epidermal growth factor (egf), and transforming growth factor alpha (tgfalpha) in the presence of a new chemically defined medium (hgm). |
1996-05-09 |
2023-08-12 |
Not clear |
| C C Reddy, A Wells, D A Lauffenburge. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. Journal of cellular physiology. vol 166. issue 3. 1996-05-02. PMID:8600155. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) elicit quantitatively different cell proliferation responses even though they act via a common receptor, the epidermal growth factor receptor (egfr). |
1996-05-02 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. Journal of cellular physiology. vol 166. issue 3. 1996-05-02. PMID:8600155. |
we hypothesized that differential cellular trafficking of available ligand is responsible for the different mitogenic responses elicited by egf and tgf alpha. |
1996-05-02 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. Journal of cellular physiology. vol 166. issue 3. 1996-05-02. PMID:8600155. |
for a given initial amount of growth factor, tgf alpha is a weaker stimulus than egf in cells expressing either form of the egfr. |
1996-05-02 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. Journal of cellular physiology. vol 166. issue 3. 1996-05-02. PMID:8600155. |
when this difference in ligand depletion is accounted for, or minimized, egf and tgf alpha elicit quantitatively similar growth responses. |
1996-05-02 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. Journal of cellular physiology. vol 166. issue 3. 1996-05-02. PMID:8600155. |
therefore, the relative mitogenic potencies of egf and tgf alpha depend on ligand availability, as determined by the cellular trafficking of these ligands in conjunction with environmental circumstances. |
1996-05-02 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. Journal of cellular physiology. vol 166. issue 3. 1996-05-02. PMID:8600155. |
interestingly, our data demonstrate that tgf alpha can be a less potent mitogenic stimulus than egf under conditions where ligand availability is limited. |
1996-05-02 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. Journal of cellular physiology. vol 166. issue 3. 1996-05-02. PMID:8600155. |
our results suggest a model of regulation of hormone responsiveness which favors dissociative ligands (such as tgf alpha) in receptor-limited situations and non-dissociative ligands (such as egf) in the face of high receptor levels. |
1996-05-02 |
2023-08-12 |
mouse |
| F Gilles, M B Raes, D Stéhelin, B Vandenbunder, V Fafeu. The c-ets-1 proto-oncogene is a new early-response gene differentially regulated by cytokines and growth factors in human fibroblasts. Experimental cell research. vol 222. issue 2. 1996-04-19. PMID:8598225. |
in contrast, bfgf, egf, and pdgf were mainly delayed stimulators, with maximal stimulation being detected by 19 h. in addition, these growth factors potentiated the rapid induction of c-ets-1 by tnf alpha. |
1996-04-19 |
2023-08-12 |
human |
| D M Ignar-Trowbridge, M Pimentel, C T Teng, K S Korach, J A McLachla. Cross talk between peptide growth factor and estrogen receptor signaling systems. Environmental health perspectives. vol 103 Suppl 7. 1996-04-09. PMID:8593872. |
egf and tgf alpha induced transcriptional activation of a consensus estrogen response element (ere) in an er-dependent manner in both cell types. |
1996-04-09 |
2023-08-12 |
mouse |
| N J Kenney, R P Huang, G R Johnson, J X Wu, D Okamura, W Matheny, E Kordon, W J Gullick, G Plowman, G H Smit. Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland. Molecular reproduction and development. vol 41. issue 3. 1996-03-25. PMID:8588926. |
these results imply that together with egf and transforming growth factor alpha (tgf alpha), ar and cr-1 may play salient roles as modifiers in the morphogenesis and differentiation of the mammary gland. |
1996-03-25 |
2023-08-12 |
mouse |
| J B Eggesbø, I Hjermann, G B Joø, R Ovstebø, P Kierul. LPS-induced release of EGF, GM-CSF, GRO alpha, LIF, MIP-1 alpha and PDGF-AB in PBMC from persons with high or low levels of HDL lipoprotein. Cytokine. vol 7. issue 6. 1996-03-21. PMID:8580373. |
lps-induced release of egf, gm-csf, gro alpha, lif, mip-1 alpha and pdgf-ab in pbmc from persons with high or low levels of hdl lipoprotein. |
1996-03-21 |
2023-08-12 |
Not clear |
| J B Eggesbø, I Hjermann, G B Joø, R Ovstebø, P Kierul. LPS-induced release of EGF, GM-CSF, GRO alpha, LIF, MIP-1 alpha and PDGF-AB in PBMC from persons with high or low levels of HDL lipoprotein. Cytokine. vol 7. issue 6. 1996-03-21. PMID:8580373. |
we have examined basal and lipopolysaccharide (lps)-induced release of epidermal growth factor (egf), granulocyte-macrophage colony-stimulating factor (gm-csf), growth-regulated peptide alpha (gro alpha), leukaemia inhibitory factor (lif), macrophage inflammatory protein-1a (mip-1 alpha) and platelet-derived growth factor-ab (pdgf-ab) in peripheral blood mononuclear cells (pbmc) from 20 persons with either high (n = 10) or low (n = 10) levels of high-density lipoprotein (hdl). |
1996-03-21 |
2023-08-12 |
Not clear |
| E R Sherwood, C Le. Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate. World journal of urology. vol 13. issue 5. 1996-03-20. PMID:8581000. |
epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (egfr) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. |
1996-03-20 |
2023-08-12 |
human |
| E R Sherwood, C Le. Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate. World journal of urology. vol 13. issue 5. 1996-03-20. PMID:8581000. |
evidence indicates that egf and tgf alpha are important for maintainence of the structural and functional integrity of the benign prostatic epithelium. |
1996-03-20 |
2023-08-12 |
human |
| M Tamura, H Sasano, T Suzuki, T Fukaya, Y Funayama, K Takayama, R Takaya, A Yajim. Expression of epidermal growth factors and epidermal growth factor receptor in normal cycling human ovaries. Human reproduction (Oxford, England). vol 10. issue 7. 1996-03-19. PMID:8583007. |
immunolocalization of transforming growth factor-alpha (tgf alpha), epidermal growth factor (egf), cripto-1, amphiregulin and epidermal growth factor receptor (egfr) was studied in 51 premenopausal human ovaries at various phases of the menstrual cycle. |
1996-03-19 |
2023-08-12 |
human |
| M Tamura, H Sasano, T Suzuki, T Fukaya, Y Funayama, K Takayama, R Takaya, A Yajim. Expression of epidermal growth factors and epidermal growth factor receptor in normal cycling human ovaries. Human reproduction (Oxford, England). vol 10. issue 7. 1996-03-19. PMID:8583007. |
localization of mrna for tgf alpha and egf was also studied by in-situ hybridization. |
1996-03-19 |
2023-08-12 |
human |
| J M Bartlett, S P Langdon, B J Simpson, M Stewart, D Katsaros, P Sismondi, S Love, W N Scott, A R Williams, A M Lessells, K G Macleod, J F Smyth, W R Mille. The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancer. British journal of cancer. vol 73. issue 3. 1996-03-05. PMID:8562334. |
the expression of mrna for the epidermal growth factor (egf) receptor, egf and transforming growth factor alpha (tgf-alpha) was determined in 76 malignant, six borderline and 15 benign primary ovarian tumours using the reverse transcriptase-polymerase chain reaction and related to clinical and pathological parameters. |
1996-03-05 |
2023-08-12 |
Not clear |
| G Almahbobi, A Nagodavithane, A O Trounso. Effects of epidermal growth factor, transforming growth factor alpha and androstenedione on follicular growth and aromatization in culture. Human reproduction (Oxford, England). vol 10. issue 10. 1996-03-01. PMID:8567811. |
the effects of epidermal growth factor (egf), transforming growth factor alpha (tgf alpha) and androstenedione on follicular growth and oestradiol production were studied in cultured mouse preantral follicles. |
1996-03-01 |
2023-08-12 |
mouse |
| G Almahbobi, A Nagodavithane, A O Trounso. Effects of epidermal growth factor, transforming growth factor alpha and androstenedione on follicular growth and aromatization in culture. Human reproduction (Oxford, England). vol 10. issue 10. 1996-03-01. PMID:8567811. |
increasing concentrations of egf and tgf alpha decreased the number of follicles reaching the large antral stage at day 4 of culture. |
1996-03-01 |
2023-08-12 |
mouse |