| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Qu, J Chen, T Li. [Gene expression of EGFR, EGF and TGF alpha in human colonic carcinoma cell lines]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 16. issue 4. 1995-03-28. PMID:7867092. |
[gene expression of egfr, egf and tgf alpha in human colonic carcinoma cell lines]. |
1995-03-28 |
2023-08-12 |
human |
| X Qu, J Chen, T Li. [Gene expression of EGFR, EGF and TGF alpha in human colonic carcinoma cell lines]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 16. issue 4. 1995-03-28. PMID:7867092. |
gene expression of epidermal growth factor receptor (egfr), epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) in human colonic carcinoma cell lines (ht10, lst174 and lovo) was studied by using northern blot technique. |
1995-03-28 |
2023-08-12 |
human |
| X Qu, J Chen, T Li. [Gene expression of EGFR, EGF and TGF alpha in human colonic carcinoma cell lines]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 16. issue 4. 1995-03-28. PMID:7867092. |
total rnas were isolated from these cell lines, separated by 1% agarose gel electrophoresis, transferred onto a membrane and hybridized with egfr, egf and tgf alpha probes. |
1995-03-28 |
2023-08-12 |
human |
| X Qu, J Chen, T Li. [Gene expression of EGFR, EGF and TGF alpha in human colonic carcinoma cell lines]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 16. issue 4. 1995-03-28. PMID:7867092. |
egf and egfr mrnas were found in all three cell lines, and tgf alpha mrna was seen in lst174 and ht10 cell lines but not in lovo. |
1995-03-28 |
2023-08-12 |
human |
| T Hölting, A E Siperstein, O H Clark, Q Y Du. Epidermal growth factor (EGF)- and transforming growth factor alpha-stimulated invasion and growth of follicular thyroid cancer cells can be blocked by antagonism to the EGF receptor and tyrosine kinase in vitro. European journal of endocrinology. vol 132. issue 2. 1995-03-21. PMID:7858744. |
the present study analyzed the effects of transforming growth factor alpha (tgf-alpha) on invasion and growth of a follicular thyroid cancer cell line (ftc133) and whether blocking the egf receptor by a monoclonal antibody (mab528) or blocking the tyrosine kinase of the receptor by genistein abolished the egf- and tfg-alpha-mediated effects. |
1995-03-21 |
2023-08-12 |
Not clear |
| M Arai, T Tsushima, O Isozaki, H Demura, K Shizume, N Emoto, M Miyakawa, Y Nozoe, H Murakami, E Ohmur. Effects of transforming growth factor alpha (TGF-alpha) on DNA synthesis and thyrotropin-induced iodine metabolism in cultured porcine thyroid cells. European journal of endocrinology. vol 132. issue 2. 1995-03-21. PMID:7858746. |
transforming growth factor alpha (tgf-alpha) is a potent mitogen that is similar structurally to epidermal growth factor (egf). |
1995-03-21 |
2023-08-12 |
mouse |
| S Gronthos, P J Simmon. The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood. vol 85. issue 4. 1995-03-16. PMID:7849315. |
fluorescence-activated cell sorting (facs) of bmmnc using moabs to the alpha chain of the pdgf receptor and to the egf receptor in combination with the moab stro-1 demonstrated constitutive expression of both receptors by greater than 90% on cfu-f. receptors for insulin-like growth factor-1 (igf-1) and nerve growth factor (ngf) were also detected on stro-1+ cfu-f, but in vitro both igf-1 and ngf did not support colony growth. |
1995-03-16 |
2023-08-12 |
human |
| H Modjtahedi, C Dea. The binding of HB-EGF to tumour cells is blocked by mAbs which act as EGF and TGF alpha antagonists. Biochemical and biophysical research communications. vol 207. issue 1. 1995-03-14. PMID:7857293. |
the binding of hb-egf to tumour cells is blocked by mabs which act as egf and tgf alpha antagonists. |
1995-03-14 |
2023-08-12 |
Not clear |
| H Modjtahedi, C Dea. The binding of HB-EGF to tumour cells is blocked by mAbs which act as EGF and TGF alpha antagonists. Biochemical and biophysical research communications. vol 207. issue 1. 1995-03-14. PMID:7857293. |
here, we show that the binding of hb-egf to the egfr is inhibited by mabs which prevent the interaction of egf and tgf alpha with the receptor. |
1995-03-14 |
2023-08-12 |
Not clear |
| H Modjtahedi, C Dea. The binding of HB-EGF to tumour cells is blocked by mAbs which act as EGF and TGF alpha antagonists. Biochemical and biophysical research communications. vol 207. issue 1. 1995-03-14. PMID:7857293. |
we conclude that mabs which act as egf and tgf alpha antagonists should also be effective therapeutic agents for blocking the growth of egfr overexpressing tumours induced by hb-egf. |
1995-03-14 |
2023-08-12 |
Not clear |
| S E Wilson, G S Schultz, N Chegini, J Weng, Y G H. Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Experimental eye research. vol 59. issue 1. 1995-03-01. PMID:7530663. |
the purpose of this study was to determine whether epidermal growth factor (egf), egf receptor, transforming growth factor alpha (tgf-alpha), transforming growth factor beta (tgf-beta), acidic fibroblast growth factor (acidic-fgf), basic fibroblast growth factor (basic-fgf), and interleukin-1-alpha (il-1-alpha) proteins were present in cultures of human corneal cells and/or in sections of human corneal tissue. |
1995-03-01 |
2023-08-12 |
human |
| A Richter, D R Drummond, J MacGarvie, S M Puddicombe, S G Chamberlin, D E Davie. Contribution of the transforming growth factor alpha B-loop beta-sheet to binding and activation of the epidermal growth factor receptor. The Journal of biological chemistry. vol 270. issue 4. 1995-02-22. PMID:7829492. |
we have exploited the differences in binding affinities of the chicken epidermal growth factor (egf) receptor for egf and transforming growth factor alpha (tgf alpha) to study the role of the b-loop beta-sheet of these ligands in receptor recognition and activation. |
1995-02-22 |
2023-08-12 |
human |
| A Richter, D R Drummond, J MacGarvie, S M Puddicombe, S G Chamberlin, D E Davie. Contribution of the transforming growth factor alpha B-loop beta-sheet to binding and activation of the epidermal growth factor receptor. The Journal of biological chemistry. vol 270. issue 4. 1995-02-22. PMID:7829492. |
although egf and tgf alpha share similar secondary and tertiary structures imposed by three highly conserved intramolecular disulfide bonds, they have only 30-40% overall sequence identity. |
1995-02-22 |
2023-08-12 |
human |
| A Richter, D R Drummond, J MacGarvie, S M Puddicombe, S G Chamberlin, D E Davie. Contribution of the transforming growth factor alpha B-loop beta-sheet to binding and activation of the epidermal growth factor receptor. The Journal of biological chemistry. vol 270. issue 4. 1995-02-22. PMID:7829492. |
to investigate its role in receptor binding, we constructed two chimeric growth factors (megf/htgf alpha 21-30 and megf/htgf alpha 21-32) composed of the murine egf (megf) amino acid sequence with residues 21-30 of the b-loop beta-sheet replaced by the equivalent residues of human tgf alpha (htgf alpha); in chimera megf/htgf alpha 21-32, asparagine 32, which lies at the boundary of the amino and carboxyl domains of megf, was also replaced by its htgf alpha counterpart (valine). |
1995-02-22 |
2023-08-12 |
human |
| A Richter, D R Drummond, J MacGarvie, S M Puddicombe, S G Chamberlin, D E Davie. Contribution of the transforming growth factor alpha B-loop beta-sheet to binding and activation of the epidermal growth factor receptor. The Journal of biological chemistry. vol 270. issue 4. 1995-02-22. PMID:7829492. |
in initial studies using unpurified medium, it was found that the recombinant growth factors exhibited differing mitogenic potencies (megf/htgf alpha 21-32 > megf/htgf alpha 21-30 > megf) when assayed on chicken fibroblasts, even though they were equivalent in mitogenesis assays using cells expressing the human egf receptor. |
1995-02-22 |
2023-08-12 |
human |
| A Richter, D R Drummond, J MacGarvie, S M Puddicombe, S G Chamberlin, D E Davie. Contribution of the transforming growth factor alpha B-loop beta-sheet to binding and activation of the epidermal growth factor receptor. The Journal of biological chemistry. vol 270. issue 4. 1995-02-22. PMID:7829492. |
after purification, megf/htgf alpha 21-32 was found to be 50 times more potent than megf in the chick fibroblast mitogenesis assay and exhibited a 10-fold increase in relative affinity for the chicken egf receptor; both growth factors still exhibited equivalent mitogenic and receptor binding activity when tested on cells expressing human egf receptors. |
1995-02-22 |
2023-08-12 |
human |
| A Richter, D R Drummond, J MacGarvie, S M Puddicombe, S G Chamberlin, D E Davie. Contribution of the transforming growth factor alpha B-loop beta-sheet to binding and activation of the epidermal growth factor receptor. The Journal of biological chemistry. vol 270. issue 4. 1995-02-22. PMID:7829492. |
we conclude that the b-loop beta-sheet of htgf alpha is an important determinant of egf receptor binding affinity and biological activity. |
1995-02-22 |
2023-08-12 |
human |
| M Tahara, K Tasaka, N Masumoto, K Adachi, H Adachi, Y Ikebuchi, H Kurachi, A Miyak. Expression of messenger ribonucleic acid for epidermal growth factor (EGF), transforming growth factor-alpha (TGF alpha), and EGF receptor in human amnion cells: possible role of TGF alpha in prostaglandin E2 synthesis and cell proliferation. The Journal of clinical endocrinology and metabolism. vol 80. issue 1. 1995-02-17. PMID:7829602. |
expression of messenger ribonucleic acid for epidermal growth factor (egf), transforming growth factor-alpha (tgf alpha), and egf receptor in human amnion cells: possible role of tgf alpha in prostaglandin e2 synthesis and cell proliferation. |
1995-02-17 |
2023-08-12 |
human |
| M Tahara, K Tasaka, N Masumoto, K Adachi, H Adachi, Y Ikebuchi, H Kurachi, A Miyak. Expression of messenger ribonucleic acid for epidermal growth factor (EGF), transforming growth factor-alpha (TGF alpha), and EGF receptor in human amnion cells: possible role of TGF alpha in prostaglandin E2 synthesis and cell proliferation. The Journal of clinical endocrinology and metabolism. vol 80. issue 1. 1995-02-17. PMID:7829602. |
in this study, we showed the expression of egf, transforming growth factor-alpha (tgf alpha), and egf receptor protein and messenger ribonucleic acid in amnion cells, using an immunofluorescence technique and the reverse transcription-polymerase chain reaction. |
1995-02-17 |
2023-08-12 |
human |
| T Dalton, K Kover, S K Dey, G K Andrew. Analysis of the expression of growth factor, interleukin-1, and lactoferrin genes and the distribution of inflammatory leukocytes in the preimplantation mouse oviduct. Biology of reproduction. vol 51. issue 4. 1995-02-13. PMID:7819439. |
northern blot analysis and/or immunohistochemistry were employed to examine the expression or cellular distribution, respectively, of the growth factors heparin-binding epidermal-like growth factor (hb-egf), transforming growth factor (tgf) alpha, epidermal growth factor (egf), insulin-like growth factor-i (igf-i), tgf beta 1, tgf beta 2, and tgf beta 3; of estrogen-regulated lactoferrin (lf); and of the cytokines interleukin (il)-1 alpha and il-1 beta in the mouse oviduct during the preimplantation period (days 1-4 [day 1 = vaginal plug]) and 7 days after ovariectomy. |
1995-02-13 |
2023-08-12 |
mouse |