| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Wessely, A Bauer, C T Quang, E M Deiner, M von Lindern, G Mellitzer, P Steinlein, J Ghysdael, H Beu. A novel way to induce erythroid progenitor self renewal: cooperation of c-Kit with the erythropoietin receptor. Biological chemistry. vol 380. issue 2. 1999-06-03. PMID:10195426. |
avian erythroid progenitors expressing the egf receptor/c-erbb (scf/tgfalpha progenitors) can be induced to long-term proliferation by the c-erbb ligand transforming growth factor alpha and the steroids estradiol and dexamethasone. |
1999-06-03 |
2023-08-12 |
Not clear |
| R Romand, S Chardi. Effects of growth factors on the hair cells after ototoxic treatment of the neonatal mammalian cochlea in vitro. Brain research. vol 825. issue 1-2. 1999-05-26. PMID:10216172. |
the aim of this study was to test the possible regenerative potential of several molecules and growth factors such as retinoic acid (ra), insulin, epidermal growth factor (egf) and transforming growth factors alpha (tgfalpha) and beta (tgfbeta) on the neonatal cochlea in vitro after neomycin intoxication. |
1999-05-26 |
2023-08-12 |
rat |
| O Bögler, M Nagane, J Gillis, H J Huang, W K Cavene. Malignant transformation of p53-deficient astrocytes is modulated by environmental cues in vitro. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 10. issue 2. 1999-05-21. PMID:10074901. |
under two conditions (10% fcs and 0.5% fcs plus 20 ng/ml egf), cells acquired the ability to form colonies in soft agarose and tumors in nude mice, and this was accompanied by the expression of genes, including epidermal growth factor receptor, platelet-derived growth factor receptor alpha and beta, protein kinase cdelta, and vascular endothelial growth factor, which are known to be aberrantly regulated in human astrocytomas. |
1999-05-21 |
2023-08-12 |
mouse |
| K Takeyama, K Dabbagh, H M Lee, C Agustí, J A Lausier, I F Ueki, K M Grattan, J A Nade. Epidermal growth factor system regulates mucin production in airways. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 6. 1999-05-20. PMID:10077640. |
here we show that stimulation of epidermal growth factor receptors (egf-r) by its ligands, egf and transforming growth factor alpha (tgfalpha), causes muc5ac expression in airway epithelial cells both in in vitro and in vivo. |
1999-05-20 |
2023-08-12 |
rat |
| A Misajon, P Hutchinson, N Lolatgis, A O Trounson, G Almahbob. The mechanism of action of epidermal growth factor and transforming growth factor alpha on aromatase activity in granulosa cells from polycystic ovaries. Molecular human reproduction. vol 5. issue 2. 1999-05-04. PMID:10065863. |
we investigated aromatization and the mechanism of action of epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha) on oestradiol biosynthesis in freshly prepared granulosa cells from polycystic ovaries. |
1999-05-04 |
2023-08-12 |
Not clear |
| N M Thielens, K Enrie, M Lacroix, M Jaquinod, J F Hernandez, A F Esser, G J Arlau. The N-terminal CUB-epidermal growth factor module pair of human complement protease C1r binds Ca2+ with high affinity and mediates Ca2+-dependent interaction with C1s. The Journal of biological chemistry. vol 274. issue 14. 1999-04-27. PMID:10092586. |
the ca2+-dependent interaction between complement serine proteases c1r and c1s is mediated by their alpha regions, encompassing the major part of their n-terminal cub-egf-cub (where egf is epidermal growth factor) module array. |
1999-04-27 |
2023-08-12 |
human |
| P L Beck, D K Podolsk. Growth factors in inflammatory bowel disease. Inflammatory bowel diseases. vol 5. issue 1. 1999-04-22. PMID:10028449. |
several families of growth factors may play an important role in ibd including: epidermal growth factor family (egf) [transforming growth factor alpha (tgf alpha), egf itself, and others], the transforming growth factor beta (tgf beta) super family, insulin-like growth factors (igf), fibroblast growth factors (fgf), hepatocyte growth factor (hgf), trefoil factors, platelet-derived growth factor (pdgf), vascular endothelial growth factor (vegf) and others. |
1999-04-22 |
2023-08-12 |
Not clear |
| C C Reddy, A Wells, D A Lauffenburge. Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Medical & biological engineering & computing. vol 36. issue 4. 1999-04-19. PMID:10198537. |
comparative mitogenic potencies of egf and tgf alpha and their dependence on receptor-limitation versus ligand-limitation. |
1999-04-19 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Medical & biological engineering & computing. vol 36. issue 4. 1999-04-19. PMID:10198537. |
transforming growth factor alpha (tgf alpha) has been reported to be a more potent agonist when compared to epidermal growth factor (egf) in several systems while acting via their common receptor, the epidermal growth factor receptor (egfr). |
1999-04-19 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Medical & biological engineering & computing. vol 36. issue 4. 1999-04-19. PMID:10198537. |
it has been postulated that this increased potency is mediated by the increased recycling of egfr upon activation by tgf alpha as against receptor activation by egf. |
1999-04-19 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Medical & biological engineering & computing. vol 36. issue 4. 1999-04-19. PMID:10198537. |
the data demonstrates that increased receptor recycling due to endosomal dissociation of tgf alpha can indeed realise an increased mitogenic potency relative to egf under appropriate cellular and experimental conditions (i.e. |
1999-04-19 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Medical & biological engineering & computing. vol 36. issue 4. 1999-04-19. PMID:10198537. |
however, this difference in receptor trafficking does not uniquely determine the relative potencies of these ligands since tgf alpha is a less potent mitogen compared to egf when experimental conditions are dominated by the effects of ligand trafficking on growth factor availability. |
1999-04-19 |
2023-08-12 |
mouse |
| C C Reddy, A Wells, D A Lauffenburge. Comparative mitogenic potencies of EGF and TGF alpha and their dependence on receptor-limitation versus ligand-limitation. Medical & biological engineering & computing. vol 36. issue 4. 1999-04-19. PMID:10198537. |
these results are consistent with a suggested model of hormone responsiveness which favours dissociative ligands (such as tgf alpha) in receptor-limited situations and non-dissociative ligands (such as egf) in the case of ligand limitation. |
1999-04-19 |
2023-08-12 |
mouse |
| E Tremblay, J R Basque, N Rivard, D Ménar. Epidermal growth factor and transforming growth factor alpha down-regulate human gastric lipase gene expression. Gastroenterology. vol 116. issue 4. 1999-04-14. PMID:10092305. |
the aims of this study were to establish the cellular localization of hgl, to assess the correlation between hgl messenger rna (mrna) and protein levels, and to establish the molecular mechanism of action of egf and its homologue transforming growth factor alpha (tgf-alpha) on hgl expression. |
1999-04-14 |
2023-08-12 |
human |
| X D Yang, X C Jia, J R Corvalan, P Wang, C G Davis, A Jakobovit. Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer research. vol 59. issue 6. 1999-04-13. PMID:10096554. |
the e7.6.3 mab exhibits high affinity (kd = 5 x 10(-11) m) to the receptor, blocks completely the binding of both egf and transforming growth factor alpha (tgf-a) to various egfr-expressing human carcinoma cell lines, and abolishes egf-dependent cell activation, including egfr tyrosine phosphorylation, increased extracellular acidification rate, and cell proliferation. |
1999-04-13 |
2023-08-12 |
mouse |
| L E Johannessen, S L Knardal, I H Madshu. Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein. The Biochemical journal. vol 337 ( Pt 3). 1999-03-30. PMID:9895307. |
nuclear run-on assays demonstrated only marginal stimulation of transcription by 10 or 1 nm egf, or by 10 ng/ml tumour necrosis factor alpha. |
1999-03-30 |
2023-08-12 |
Not clear |
| M K Jones, M Tomikawa, B Mohajer, A S Tarnawsk. Gastrointestinal mucosal regeneration: role of growth factors. Frontiers in bioscience : a journal and virtual library. vol 4. 1999-03-24. PMID:10077540. |
in gastric mucosa, transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf) by activating their common receptor, control cell proliferation. |
1999-03-24 |
2023-08-12 |
Not clear |
| O M Onagbesan, M J Peddi. The expression of transforming growth factor alpha receptor protein and its activation in chicken ovarian granulosa cells of maturing follicles. The Histochemical journal. vol 30. issue 9. 1999-03-22. PMID:9870765. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) are structurally related growth factors that exert their biological actions by binding to the same cell-surface receptor, egf receptor. |
1999-03-22 |
2023-08-12 |
human |
| C F Singer, E Marbaix, P Lemoine, P J Courtoy, Y Eeckhou. Local cytokines induce differential expression of matrix metalloproteinases but not their tissue inhibitors in human endometrial fibroblasts. European journal of biochemistry. vol 259. issue 1-2. 1999-03-05. PMID:9914473. |
three categories of gene expression were identified: (a) mmp-13, -15 and -16 mrnas were not detected despite stimulation by various cytokines; (b) mmp-2 and -14 as well as timp-1, -2 and -3 mrnas were constitutively expressed but not markedly affected by the six cytokines tested; (c) mrnas for mmp-1, -9 and -11 were selectively induced by specific cytokines: insulin-like growth factor-ii, epidermal growth factor (egf), platelet derived growth factor (pdgf)-bb and interleukin (il)-6 stimulated mmp-11 expression; mmp-1 was induced by egf, pdgf-bb, tumour necrosis factor (tnf)alpha and il-1alpha, which also exerted additive effects. |
1999-03-05 |
2023-08-12 |
human |
| A Yamane, P Bringas, M L Mayo, O Amano, K Takahashi, H Vo, L Shum, H C Slavki. Transforming growth factor alpha up-regulates desmin expression during embryonic mouse tongue myogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. vol 213. issue 1. 1999-02-16. PMID:9733102. |
during embryonic mouse tongue formation, transforming growth factor alpha (tgf alpha), epidermal growth factor (egf), and their cognate receptor (egfr) are co-expressed spatially and temporally with desmin, a muscle-specific structural protein. |
1999-02-16 |
2023-08-12 |
mouse |