| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Chudek, D Schullerus, M Wilhelm, G Kovac. Lack of interleukin 6 (IL-6) and transforming growth factor alpha (TGF-alpha) expression in chromophobe renal cell carcinomas. British journal of cancer. vol 78. issue 9. 1998-12-01. PMID:9820173. |
we demonstrate the constitutive expression of interleukin 6 (il-6), il-8, granulocyte-macrophage colony-stimulating factor (gm-csf), epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha) and epidermal growth factor receptor (egfr) in normal kidney cells, and in the majority of renal oncocytomas, papillary and non-papillary renal cell carcinomas (rccs) by reverse transcriptase polymerase chain reaction (rt-pcr) technique. |
1998-12-01 |
2023-08-12 |
Not clear |
| M Hamilton, A Wolfma. Oncogenic Ha-Ras-dependent mitogen-activated protein kinase activity requires signaling through the epidermal growth factor receptor. The Journal of biological chemistry. vol 273. issue 43. 1998-11-12. PMID:9774435. |
immunodepletion of conditioned medium with antibodies to transforming growth factor alpha and egf significantly inhibited its ability to stimulate mapk activity. |
1998-11-12 |
2023-08-12 |
Not clear |
| S A Acra, N Bulus, G Bogatcheva, R J Coffey, J A Barnar. Increased intestinal epithelial proliferation in metallothioneine-transforming growth factor alpha transgenic mice. Regulatory peptides. vol 74. issue 2-3. 1998-11-06. PMID:9712170. |
in the intestinal epithelium, transforming growth factor alpha (tgfalpha) appears to be the most physiological ligand for the egf receptor. |
1998-11-06 |
2023-08-12 |
mouse |
| L G Sheffiel. Hormonal regulation of epidermal growth factor receptor content and signaling in bovine mammary tissue. Endocrinology. vol 139. issue 11. 1998-11-06. PMID:9794467. |
mammary tissue from midpregnant heifers was cultured with epidermal growth factor (egf) or transforming growth factor alpha for 1-3 days. |
1998-11-06 |
2023-08-12 |
mouse |
| L G Sheffiel. Hormonal regulation of epidermal growth factor receptor content and signaling in bovine mammary tissue. Endocrinology. vol 139. issue 11. 1998-11-06. PMID:9794467. |
after 1 day, 10 nm egf or transforming growth factor alpha doubled dna synthesis, whereas lower concentrations (0.1 or 1 nm) increased dna synthesis 2- to 3-fold after 2-3 days in culture. |
1998-11-06 |
2023-08-12 |
mouse |
| E Malecka-Panas, J Tureaud, A P Majumda. Enhanced ligand-induced activation of EGF-receptor and overall tyrosine kinase and phospholipase C in colonocytes isolated from azoxymethane-treated rats. Hepato-gastroenterology. vol 45. issue 21. 1998-11-05. PMID:9684124. |
in order to evaluate the role of epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) in colorectal cancer, the present investigation examines changes in egf and tgf-alpha-mediated activation of overall and egf receptor (egf-r) associated tyrosine kinase activity in isolated rat colonocytes after administration of the colonic carcinogen azoxymethane. |
1998-11-05 |
2023-08-12 |
rat |
| P V Pogrebnoy, A I Hobta, M A Soldatkina, L V Garmanchouk, N V Markeeva, T Eremenk. A protein kinase inhibitor from A431 subline overexpressing TGF alpha possesses antimicrobial activity. The new microbiologica. vol 21. issue 3. 1998-10-22. PMID:9699208. |
we report the production of a human peptide antibiotic that was previously characterized as an egf receptor tyrosine kinase inhibitor in epidermoid carcinoma a431/1522 cell subline overexpressing tgf alpha. |
1998-10-22 |
2023-08-12 |
human |
| N Kociok, H Heppekausen, U Schraermeyer, P Esser, G Thumann, S Grisanti, K Heiman. The mRNA expression of cytokines and their receptors in cultured iris pigment epithelial cells: a comparison with retinal pigment epithelial cells. Experimental eye research. vol 67. issue 2. 1998-10-14. PMID:9733590. |
included in our assay were cytokines with known expression in rpe to get a broad basis for comparing ipe cells: basic fibroblast growth factor (bfgf or fgf-2), and one of its receptor (fgfr-1), epidermal growth factor (egf), and its receptor egf-r, transforming growth factor beta(tgfbeta), and its type iii receptor tgfbeta-r3, the platelet-derived growth factors and receptors (pdgf a, pdgf b, pdgf-ralpha, pdgf-rbeta), tumor necrosis factor alpha(tnfalpha), and two receptors tnf-r1 and tnf-r2, insulin (ins) with receptor ins-r, insulin-like growth factors (igf1, igf2), and receptors (igf1-r, igf2-r), vascular endothelial growth factor (vegf), and two receptors (vegf-r1 or flt-1 and vegf-r2 or flk-1), the receptor for vegf-c: vegf-r3 or flk-4, interleukin 6 (il6), and its receptor (il6-r), nerve growth factor (ngf), interleukin 1alpha(il1alpha), and a receptor (il1-r). |
1998-10-14 |
2023-08-12 |
human |
| M R Pillai, P G Jayaprakash, M K Nai. Tumour-proliferative fraction and growth factor expression as markers of tumour response to radiotherapy in cancer of the uterine cervix. Journal of cancer research and clinical oncology. vol 124. issue 8. 1998-10-09. PMID:9750023. |
growth factor analysis was done by analysing for expression of epidermal growth factor (egf), epidermal growth factor receptor (egf-r) and transforming growth factors alpha and beta (tgfalpha, tgfbeta). |
1998-10-09 |
2023-08-12 |
Not clear |
| K K Volentine, H H Yao, J M Bah. Epidermal growth factor in the germinal disc and its potential role in follicular development in the chicken. Biology of reproduction. vol 59. issue 3. 1998-10-05. PMID:9716549. |
these findings prompted us to investigate two questions: 1) is epidermal growth factor (egf) or transforming growth factor alpha (tgfalpha), which binds to the egf receptor, present in the gdr? |
1998-10-05 |
2023-08-12 |
chicken |
| E Enan, D Y Dunlap, F Matsumur. Use of c-Src and c-Fos knockout mice for the studies on the role of c-Src kinase signaling in the expression of toxicity of TCDD. Journal of biochemical and molecular toxicology. vol 12. issue 5. 1998-09-24. PMID:9664232. |
however, other tcdd responses noticeable in c-fos-deficient mice; downregulation of receptors for epidermal growth factor (egf), tumor necrosis factor (tnf alpha), and retinoic acid; and up-regulation of the t3 receptor. |
1998-09-24 |
2023-08-12 |
mouse |
| E Skarpen, L E Johannessen, K Bjerk, H Fasteng, T K Guren, B Lindeman, G H Thoresen, T Christoffersen, E Stang, H S Huitfeldt, I H Madshu. Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1. Experimental cell research. vol 243. issue 1. 1998-09-24. PMID:9716460. |
transforming growth factor alpha (tgfalpha) and egf both induced tyrosine phosphorylation, induction of p21/cip1, and thereby inhibition of dna synthesis. |
1998-09-24 |
2023-08-12 |
Not clear |
| S J Nass, R B Dickso. Epidermal growth factor-dependent cell cycle progression is altered in mammary epithelial cells that overexpress c-myc. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 4. issue 7. 1998-09-16. PMID:9676860. |
components of the epidermal growth factor (egf) receptor signaling pathway are also often overexpressed and/or activated in human breast tumors, and transgenic mouse models have demonstrated that c-myc and transforming growth factor alpha (a member of the egf family) strongly synergize to induce mammary tumors. |
1998-09-16 |
2023-08-12 |
mouse |
| H Lilja, P Blanc, A A Demetriou, J Rozg. Response of cultured fetal and adult rat hepatocytes to growth factors and cyclosporine. Cell transplantation. vol 7. issue 3. 1998-09-01. PMID:9647435. |
when epidermal growth factor (egf) was added, maximal dna synthesis in fetal hepatocytes was seen at 48 h, whereas in adult hepatocytes at 72 h. for adult hepatocytes, the average increase compared to untreated cells was x13.8 with egf, x18.5 with transforming growth factor alpha (tgf-alpha), and x7.6 with hepatocyte growth factor (hgf). |
1998-09-01 |
2023-08-12 |
rat |
| S Kitano, T W Fawcett, Y Yo, G S Rot. Molecular mechanisms of impaired stimulation of DNA synthesis in cultured hepatocytes of aged rats. The American journal of physiology. vol 275. issue 1. 1998-08-25. PMID:9688845. |
we examined epidermal growth factor (egf)- and epinephrine-stimulated mitogen-activated protein kinase kinase (mek) 1 and mek2 activities, dna polymerase alpha activity, and egf-stimulated e2f dna binding activity in primary cultured hepatocytes from 6- and 24-mo-old rats. |
1998-08-25 |
2023-08-12 |
rat |
| C C Reddy, S K Niyogi, A Wells, H S Wiley, D A Lauffenburge. Engineering epidermal growth factor for enhanced mitogenic potency. Nature biotechnology. vol 14. issue 13. 1998-08-14. PMID:9634854. |
specifically, a recombinant epidermal growth factor (egf) mutant with reduced receptor binding affinity is a more potent mitogenic stimulus for fibroblasts than natural egf or transforming growth factor alpha because of its altered trafficking properties. |
1998-08-14 |
2023-08-12 |
Not clear |
| C Messa, F Russo, M G Caruso, A Di Le. EGF, TGF-alpha, and EGF-R in human colorectal adenocarcinoma. Acta oncologica (Stockholm, Sweden). vol 37. issue 3. 1998-08-04. PMID:9677101. |
the over-expression of epidermal growth factor receptor (egf-r), egf and transforming growth factor alpha (tgfalpha) could be a mechanism for colorectal tumor cells to escape normal growth controls. |
1998-08-04 |
2023-08-12 |
human |
| A E Lenferink, R Pinkas-Kramarski, M L van de Poll, M J van Vugt, L N Klapper, E Tzahar, H Waterman, M Sela, E J van Zoelen, Y Yarde. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. The EMBO journal. vol 17. issue 12. 1998-07-30. PMID:9628875. |
we addressed the mechanism underlying these two features of signal tuning by using three ligands: egf; transforming growth factor alpha (tgfalpha); and their chimera, denoted e4t, which act on cells singly expressing erbb-1 as a weak, a strong, and a very strong agonist, respectively. |
1998-07-30 |
2023-08-12 |
human |
| P Qin, M A Kurpaku. The role of laminin-5 in TGF alpha/EGF-mediated corneal epithelial cell motility. Experimental eye research. vol 66. issue 5. 1998-07-24. PMID:9628804. |
transforming growth factor alpha (tgf alpha) and epidermal growth factor (egf) stimulate corneal epithelial cell wound closure. |
1998-07-24 |
2023-08-12 |
human |
| P Qin, M A Kurpaku. The role of laminin-5 in TGF alpha/EGF-mediated corneal epithelial cell motility. Experimental eye research. vol 66. issue 5. 1998-07-24. PMID:9628804. |
in primary culture, a population of corneal epithelial cells are stimulated by tgf alpha or egf to become highly motile. |
1998-07-24 |
2023-08-12 |
human |