| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Müller, W Saeger, L Wellhausen, K M Derwahl, C Hamacher, D K Lüdeck. Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study. Pathology, research and practice. vol 195. issue 9. 1999-10-28. PMID:10507079. |
our results imply that the growth factors (egf, tgf alpha, igf-1), the cell signalling protein gs alpha and the mdrm are expressed by both types of pituitary adenomas in a similar pattern. |
1999-10-28 |
2023-08-12 |
Not clear |
| D K Tsang, D L Crow. The mitogen activated protein kinase pathway is required for proliferation but not invasion of human squamous cell carcinoma lines. International journal of oncology. vol 15. issue 3. 1999-10-14. PMID:10427134. |
in stratified squamous epithelial cells, these receptors include epidermal growth factor receptor (egfr) that binds both egf and transforming growth factor alpha (tgfalpha), and c-met whose ligand is hepatocyte growth factor/scatter factor (hgf/sf). |
1999-10-14 |
2023-08-12 |
human |
| B J Mounho, B D Thral. The extracellular signal-regulated kinase pathway contributes to mitogenic and antiapoptotic effects of peroxisome proliferators in vitro. Toxicology and applied pharmacology. vol 159. issue 2. 1999-10-14. PMID:10495776. |
previous studies suggest mitogenic growth factors that act through the extracellular signal-regulated kinase (erk) pathway, including insulin and epidermal growth factor (egf), modulate peroxisome proliferator-activated receptor alpha activation as well as the mitogenic activity of peroxisome proliferators. |
1999-10-14 |
2023-08-12 |
mouse |
| B K Campbel. The modulation of gonadotrophic hormone action on the ovary by paracrine and autocrine factors. Anatomia, histologia, embryologia. vol 28. issue 4. 1999-10-12. PMID:10488630. |
the putative local factors tested included insulin-like growth factor-i (igf-i lr3 analogue), transforming growth factor alpha (tgf alpha) or epidermal growth factor (egf) and inhibin a. igf-i stimulated both cellular proliferation and hormone production by both granulosa and theca cells in vitro and similarly stimulated ovarian follicle development and ovarian androgen and oestradiol secretion in vivo. |
1999-10-12 |
2023-08-12 |
Not clear |
| B K Campbel. The modulation of gonadotrophic hormone action on the ovary by paracrine and autocrine factors. Anatomia, histologia, embryologia. vol 28. issue 4. 1999-10-12. PMID:10488630. |
both tgf alpha and egf stimulated granulosa and thecal cell proliferation in vitro in a dose-responsive manner and concomitantly inhibited hormone production, whereas intra-arterial infusion of tgf alpha in vivo resulted in induction of atresia in large antral follicles and an acute fall in ovarian hormone secretion. |
1999-10-12 |
2023-08-12 |
Not clear |
| R R Mohan, S E Wilso. Ex vivo human corneal epithelial cells express membrane-bound precursor and mature soluble epidermal growth factor (EGF) and transforming growth factor (TGF) alpha proteins. Experimental eye research. vol 68. issue 1. 1999-09-23. PMID:9986750. |
ex vivo human corneal epithelial cells express membrane-bound precursor and mature soluble epidermal growth factor (egf) and transforming growth factor (tgf) alpha proteins. |
1999-09-23 |
2023-08-12 |
human |
| Y Wang, J Ripperger, G H Fey, D Samols, T Kordula, M Wetzler, R A Van Etten, H Bauman. Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells. Hepatology (Baltimore, Md.). vol 30. issue 3. 1999-09-16. PMID:10462375. |
although egf less effectively engages stat proteins in these cells, it reduces expression of fibrinogen and haptoglobin, but stimulates production of alpha(1)-antichymotrypsin and induces transcription through the alpha(1)-antichymotrypsin and c-reactive protein promoter. |
1999-09-16 |
2023-08-12 |
mouse |
| b' P E J\\xc3\\xb8rgensen, L Eskildsen, E Nex\\xc3\\xb. Adsorption of EGF receptor ligands to test tubes--a factor with implications for studies on the potency of these peptides. Scandinavian journal of clinical and laboratory investigation. vol 59. issue 3. 1999-09-03. PMID:10400163.' |
the aim of this study was to examine the adsorption of four epidermal growth factor (egf) receptor ligands, egf, transforming growth factor alpha (tgf-alpha), heparin binding-egf (hb-egf) and betacellulin, to commonly used test tubes of polyethylene, polystyrene and glass, respectively. |
1999-09-03 |
2023-08-12 |
human |
| S Ho, B Winkler-Lowen, D W Morrish, J Dakour, H Li, L J Guilber. The role of Bcl-2 expression in EGF inhibition of TNF-alpha/IFN-gamma-induced villous trophoblast apoptosis. Placenta. vol 20. issue 5-6. 1999-08-20. PMID:10419807. |
the inflammatory cytokines tumour necrosis factor alpha (tnf-alpha) and immune interferon gamma (ifn-gamma) stimulate villous cytotrophoblast apoptosis while epidermal growth factor (egf) protects. |
1999-08-20 |
2023-08-12 |
Not clear |
| A Adomeit, A Graness, S Gross, K Seedorf, R Wetzker, C Liebman. Bradykinin B(2) receptor-mediated mitogen-activated protein kinase activation in COS-7 cells requires dual signaling via both protein kinase C pathway and epidermal growth factor receptor transactivation. Molecular and cellular biology. vol 19. issue 8. 1999-08-19. PMID:10409720. |
we conclude that in cos-7 cells, bk activates mapk via a permanent dual signaling pathway involving the independent activation of the pkc isoforms alpha and epsilon and transactivation of the egf receptor. |
1999-08-19 |
2023-08-12 |
human |
| L Vinter-Jense. Pharmacological effects of epidermal growth factor (EGF) with focus on the urinary and gastrointestinal tracts. APMIS. Supplementum. vol 93. 1999-08-10. PMID:10424202. |
these findings match the knowledge obtained from animals overexpressing the egf agonist, transforming growth factor alpha (tgf alpha), and the mice with a knock out of the gene encoding for the egf receptor. |
1999-08-10 |
2023-08-12 |
mouse |
| L Vinter-Jense. Pharmacological effects of epidermal growth factor (EGF) with focus on the urinary and gastrointestinal tracts. APMIS. Supplementum. vol 93. 1999-08-10. PMID:10424202. |
egf receptor hyperstimulation (tgf alpha overexpression) in the context of the whole animal leads to epithelial proliferations whereas hypostimulation (egf receptor knock out) leads to epithelial immaturities. |
1999-08-10 |
2023-08-12 |
mouse |
| A Well. EGF receptor. The international journal of biochemistry & cell biology. vol 31. issue 6. 1999-08-05. PMID:10404636. |
upon activation by at least five genetically distinct ligands (including egf, transforming growth factor-alpha (tgf alpha) and heparin-binding egf (hb-egf)), the intrinsic kinase is activated and egfr tyrosyl-phosphorylates itself and numerous intermediary effector molecules, including closely-related c-erbb receptor family members. |
1999-08-05 |
2023-08-12 |
Not clear |
| V A Lavrovsky, A S Chagin, T N Subkhankulov. Internalization of growth factor-receptor complexes under the influence of antibodies initiates cell apoptosis in vitro. European journal of cell biology. vol 78. issue 3. 1999-07-29. PMID:10219569. |
antibodies against growth factors like igf1, igf2, afgf, bfgf and, to a certain extent, tgf alpha and egf were shown to cause apoptosis of normal and tumorigenic cells while apoptotic cell death could be prevented neither by single growth factors nor by serum. |
1999-07-29 |
2023-08-12 |
Not clear |
| J Plendl, B Stierstorfer, F Sinowat. Growth factors and their receptors in the olfactory system. Anatomia, histologia, embryologia. vol 28. issue 2. 1999-07-23. PMID:10385999. |
the potential role of the following factors and their receptors in different species are reviewed: nerve growth factor (ngf); insulin-like growth factors (igfs); fibroblast growth factors (fgfs); epidermal growth factor (egf); transforming growth factor alpha (tgf alpha); amphiregulin (ar) and transforming growth factors beta (tgfs beta). |
1999-07-23 |
2023-08-12 |
Not clear |
| M E Plumb, J J Scibek, T D Barber, R J Dunlap, P L Platteborze, J M Sodet. Chimeric and truncated forms of human complement protein C8 alpha reveal binding sites for C8 beta and C8 gamma within the membrane attack complex/perforin region. Biochemistry. vol 38. issue 26. 1999-07-22. PMID:10387094. |
c8 alpha and c8 beta are homologous and both contain a pair of tandemly arranged n-terminal modules [thrombospondin type 1 (tsp1) + low-density lipoprotein receptor class a (ldlra)], an extended middle segment referred to as the membrane attack complex/perforin region (macpf), and a pair of c-terminal modules [epidermal growth factor (egf) + tsp1]. |
1999-07-22 |
2023-08-12 |
human |
| F Ciardiello, R Bianco, V Damiano, S De Lorenzo, S Pepe, S De Placido, Z Fan, J Mendelsohn, A R Bianco, G Tortor. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 5. issue 4. 1999-07-15. PMID:10213228. |
epidermal growth factor (egf)-related proteins such as transforming growth factor alpha (tgf-alpha) control cancer cell growth through autocrine and paracrine pathways. |
1999-07-15 |
2023-08-12 |
mouse |
| G C Kaiser, F Yan, D B Pol. Conversion of TNF alpha from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase. Experimental cell research. vol 249. issue 2. 1999-07-02. PMID:10366434. |
the goal of this study was to investigate the regulation of map kinase by tumor necrosis factor alpha (tnfalpha) and epidermal growth factor (egf) in intestinal epithelial cells. |
1999-07-02 |
2023-08-12 |
mouse |
| C J Xian, X F Zho. Neuronal-glial differential expression of TGF-alpha and its receptor in the dorsal root ganglia in response to sciatic nerve lesion. Experimental neurology. vol 157. issue 2. 1999-06-29. PMID:10364443. |
to investigate potential roles of transforming growth factor alpha (tgf-alpha) in these plastic changes in the drg following a sciatic nerve transection, here we examined the expression in drgs of tgf-alpha and its receptor (egf receptor), molecules known to be mitogenic to glia and schwann cells and to be neurotrophic for some differentiated neurons. |
1999-06-29 |
2023-08-12 |
Not clear |
| D Seth, K Shaw, J Jazayeri, P J Leedma. Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells. British journal of cancer. vol 80. issue 5-6. 1999-06-23. PMID:10360641. |
with progression, prostate cancer cells switch from epidermal growth factor (egf) to transforming growth factor alpha (tgf-alpha) synthesis, which contributes to autocrine growth and unrestrained proliferation. |
1999-06-23 |
2023-08-12 |
human |