| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Bernardini, L Mattii, F Bianchi, I Da Prato, A Dolf. TGF-alpha mRNA expression in renal organogenesis: a study in rat and human embryos. Experimental nephrology. vol 9. issue 2. 2001-03-01. PMID:11150857. |
transforming growth factor-alpha (tgf alpha), a member of this family, is thought to be the fetal ligand of the egf receptor. |
2001-03-01 |
2023-08-12 |
human |
| Y Shen, L Xu, D A Foste. Role for phospholipase D in receptor-mediated endocytosis. Molecular and cellular biology. vol 21. issue 2. 2001-02-02. PMID:11134345. |
we report here that egf receptor endocytosis is dependent upon pld and the pld1 regulators, protein kinase c alpha and rala. |
2001-02-02 |
2023-08-12 |
Not clear |
| L del Carmen Medina, J Vázquez-Prado, J A García-Sáin. Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors. The Biochemical journal. vol 350 Pt 2. 2001-02-01. PMID:10947955. |
the effect of epidermal growth factor (egf) and platelet-derived growth factor (pdgf) on the phosphorylation and function of alpha(1b)-adrenoceptors transfected into rat-1 fibroblasts was studied. |
2001-02-01 |
2023-08-12 |
Not clear |
| L del Carmen Medina, J Vázquez-Prado, J A García-Sáin. Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors. The Biochemical journal. vol 350 Pt 2. 2001-02-01. PMID:10947955. |
wortmannin, an inhibitor of phosphoinositide 3-kinase, blocked the alpha(1b)-adrenoceptor phosphorylation induced by egf but not that induced by pdgf. |
2001-02-01 |
2023-08-12 |
Not clear |
| L del Carmen Medina, J Vázquez-Prado, J A García-Sáin. Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors. The Biochemical journal. vol 350 Pt 2. 2001-02-01. PMID:10947955. |
our data indicate that: (i) activation of egf and pdgf receptors induces phosphorylation of alpha(1b)-adrenoceptors, (ii) phosphatidylinositol 3-kinase is involved in the egf response, but does not seem to play a major role in the action of pdgf, (iii) protein kinase c mediates this action of both growth factors and (iv) the phosphorylation of alpha(1b)-adrenoceptors induced by egf and pdgf is associated with adrenoceptor desensitization. |
2001-02-01 |
2023-08-12 |
Not clear |
| A De Luca, C Arra, A D'Antonio, A Casamassimi, S Losito, P Ferraro, F Ciardiello, D S Salomon, N Normann. Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts. Oncogene. vol 19. issue 51. 2000-12-28. PMID:11127817. |
a majority of human colon carcinomas coexpress the epidermal growth factor (egf)-related peptides transforming growth factor alpha (tgfalpha), amphiregulin (ar) and cripto-1 (cr). |
2000-12-28 |
2023-08-12 |
mouse |
| J Sarosiek, R W McCallu. Mechanisms of oesophageal mucosal defence. Bailliere's best practice & research. Clinical gastroenterology. vol 14. issue 5. 2000-11-21. PMID:11003804. |
it has been recently demonstrated that human oesophageal submucosal glands elaborate mucous secretion rich in bicarbonate and non-bicarbonate buffers, mucin, prostaglandin e(2), epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha). |
2000-11-21 |
2023-08-12 |
human |
| J Hayashi, H Aoki, K Kajino, M Moriyama, Y Arakawa, O Hin. Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. Hepatology (Baltimore, Md.). vol 32. issue 5. 2000-11-21. PMID:11050045. |
interestingly, elk-1 activities were further enhanced by the tumor promoter, 12-o-tetradecanoyl phorbol 13-acetate (tpa), but not by hepatocyte mitogens (epidermal growth factor [egf] and transforming growth factor alpha [tgf-alpha]) in nih3t3 cells and hepg2 cells expressing hcv core protein. |
2000-11-21 |
2023-08-12 |
human |
| D Dixon, H He, J K Hasema. Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium. Environmental health perspectives. vol 108 Suppl 5. 2000-11-16. PMID:11035985. |
immunolocalization of transforming growth factor alpha (tgf-alpha), epidermal growth factor (egf), insulinlike growth factor (igf)-i, vascular endothelial growth factor (vegf(165,189,121)), basic fibroblast growth factor (fgf)-2, egf receptor (r), igf-irbeta, and fgfr-1 was studied in uterine leiomyomas and matched myometrial samples taken from seven women (42-47 years of age) in the proliferative phase of the menstrual cycle. |
2000-11-16 |
2023-08-12 |
Not clear |
| S R Ojeda, Y J Ma, B J Lee, V Prevo. Glia-to-neuron signaling and the neuroendocrine control of female puberty. Recent progress in hormone research. vol 55. 2000-11-13. PMID:11036938. |
two members of the epidermal growth factor (egf) family--transforming growth factor alpha (tgfalpha) and the neuregulins (nrgs)-are produced in hypothalamic astrocytes and elicit lhrh secretion indirectly, via activation of receptor complexes formed by three members of the egf receptor family, also located on astrocytes. |
2000-11-13 |
2023-08-12 |
human |
| M P Junie. What role(s) for TGFalpha in the central nervous system? Progress in neurobiology. vol 62. issue 5. 2000-11-07. PMID:10869779. |
transforming growth factor alpha (tgfalpha) is a member of the epidermal growth factor (egf) family with which it shares the same receptor, the egf receptor (egfr or erbb1). |
2000-11-07 |
2023-08-12 |
Not clear |
| J W Xu, J Ma, T F Li, E Waris, A Alberty, S Santavirta, Y T Konttine. Expression of epidermal growth factor and transforming growth factor alpha in interfacial membranes retrieved at revision total hip arthroplasty. Annals of the rheumatic diseases. vol 59. issue 10. 2000-11-06. PMID:11005785. |
both epidermal growth factor (egf) and transforming growth factor alpha (tgfalpha) have similar biological functions. |
2000-11-06 |
2023-08-12 |
Not clear |
| T Yamaoka, M Itakur. Development of pancreatic islets (review). International journal of molecular medicine. vol 3. issue 3. 2000-10-13. PMID:10028048. |
in this review, factors regulating islet development including differentiation factors (shh, activin, follistatin, and tgf alpha), transcriptional factors (pdx1, isl1, pax4, pax6, nkx2.2, nkx6.1, beta2, and hnf), growth factors (the egf family, hgf, igf-i, igf-ii, reg, ingap, pdgf, fgf, vegf, and ngf), hormones (insulin, the gh family, pthrp, trh, and gastrin), and cell adhesion molecules (n-cam and cadherins) are described after a short introduction and an outline of pancreatic development. |
2000-10-13 |
2023-08-12 |
Not clear |
| S Smida Rezgui, S Honore, J B Rognoni, P M Martin, C Pene. Up-regulation of alpha 2 beta 1 integrin cell-surface expression protects A431 cells from epidermal growth factor-induced apoptosis. International journal of cancer. vol 87. issue 3. 2000-09-28. PMID:10897040. |
from a panel of integrins tested, only alpha 2 beta 1 integrin cell-surface expression was up-regulated after high apoptotic egf treatment, and this up-regulation was not observed under a growth-stimulatory egf concentration (10(-11) m). |
2000-09-28 |
2023-08-12 |
Not clear |
| S Smida Rezgui, S Honore, J B Rognoni, P M Martin, C Pene. Up-regulation of alpha 2 beta 1 integrin cell-surface expression protects A431 cells from epidermal growth factor-induced apoptosis. International journal of cancer. vol 87. issue 3. 2000-09-28. PMID:10897040. |
double-labeling analysis (alpha 2 beta 1/dna) implicated alpha 2 beta 1 integrin in the resistance process since 99% of cells that up-regulated alpha 2 beta 1 integrin survived a high dose of egf. |
2000-09-28 |
2023-08-12 |
Not clear |
| S Chevalier, N Macdonald, R Tonge, S Rayner, R Rowlinson, J Shaw, J Young, M Davison, R A Robert. Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin. European journal of biochemistry. vol 267. issue 15. 2000-09-28. PMID:10903494. |
proteomic analysis of differential protein expression in primary hepatocytes induced by egf, tumour necrosis factor alpha or the peroxisome proliferator nafenopin. |
2000-09-28 |
2023-08-12 |
rat |
| S Chevalier, N Macdonald, R Tonge, S Rayner, R Rowlinson, J Shaw, J Young, M Davison, R A Robert. Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin. European journal of biochemistry. vol 267. issue 15. 2000-09-28. PMID:10903494. |
however, both egf and nafenopin require tumour necrosis factor alpha (tnfalpha) signalling to induce dna replication. |
2000-09-28 |
2023-08-12 |
rat |
| G De Crescenzo, S Grothe, R Lortie, M T Debanne, M O'Connor-McCour. Real-time kinetic studies on the interaction of transforming growth factor alpha with the epidermal growth factor receptor extracellular domain reveal a conformational change model. Biochemistry. vol 39. issue 31. 2000-09-07. PMID:10924142. |
transforming growth factor alpha (tgf-alpha), epidermal growth factor (egf), and related factors mediate their biological effects by binding to the extracellular domain of the egf receptor, which leads to activation of the receptor's cytoplasmic tyrosine kinase activity. |
2000-09-07 |
2023-08-12 |
Not clear |
| X Yu, S Miyamoto, E Mekad. Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites. Journal of cell science. vol 113 ( Pt 12). 2000-09-01. PMID:10825287. |
integrin alpha 2 beta 1-dependent egf receptor activation at cell-cell contact sites. |
2000-09-01 |
2023-08-12 |
Not clear |
| A Banan, Y Zhang, J Losurdo, A Keshavarzia. Carbonylation and disassembly of the F-actin cytoskeleton in oxidant induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor alpha in a human colonic cell line. Gut. vol 46. issue 6. 2000-08-01. PMID:10807896. |
growth factors (epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha)) protect gastrointestinal barrier integrity against a variety of noxious agents. |
2000-08-01 |
2023-08-12 |
human |