| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Casamassimi, A De Luca, S Agrawal, K Stromberg, D S Salomon, N Normann. EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells. Annals of oncology : official journal of the European Society for Medical Oncology. vol 11. issue 3. 2000-07-27. PMID:10811499. |
the epidermal growth factor (egf)-like peptides cripto (cr), amphiregulin (ar) and transforming growth factor alpha (tgfalpha) are expressed in human ovarian carcinomas. |
2000-07-27 |
2023-08-12 |
human |
| R W Wong, R W Kwan, P H Mak, K K Mak, M H Sham, S Y Cha. Overexpression of epidermal growth factor induced hypospermatogenesis in transgenic mice. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10748057. |
egf and transforming growth factor alpha (tgfalpha) bind with equal affinity to the egf receptor, a transmembrane tyrosine kinase, to trigger various biological responses. |
2000-07-20 |
2023-08-12 |
mouse |
| O Melien, D Sandnes, E J Johansen, T Christofferse. Effects of pertussis toxin on extracellular signal-regulated kinase activation in hepatocytes by hormones and receptor-independent agents: evidence suggesting a stimulatory role of G(i) proteins at a level distal to receptor coupling. Journal of cellular physiology. vol 184. issue 1. 2000-07-03. PMID:10825231. |
the present work shows that erk1/2 is activated in a ptx-sensitive way not only by vasopressin, angiotensin ii, prostaglandin (pg) f(2alpha), alpha(1)-adrenergic stimulation, and egf but also by agents whose actions bypass receptors and stimulate protein kinase c (pkc) and/or elevate intracellular ca(2+), such as 12-o-tetradecanoyl phorbol-13-acetate (tpa), exogenous phosphatidylcholine-specific phospholipase c (pc-plc, from bacillus cereus), thapsigargin, and the ca(2+) ionophore a23187. |
2000-07-03 |
2023-08-12 |
Not clear |
| H Messai, A M Khatib, G Lebrun, P Aubin, M Florina, F Jean, D R Mitrovi. Endothelin-1 in monolayer cultures of articular chondrocytes from young and old rats: regulation by growth factors and cytokines. Mechanisms of ageing and development. vol 114. issue 1. 2000-06-26. PMID:10731580. |
first passage cells were starved in dulbecco's modified eagle's medium (dmem) containing 0.2% fcs serum for 24 h and then incubated for 48 h in the same fresh medium with each of the following factors: fetal calf serum (fcs), transforming growth factor-beta (tgf-beta), platelet-derived growth factor (pdgf), epidermal growth factor (egf), insulin-like growth factor-1 (igf-1), interleukin-1 beta (il-1beta), tumor necrosis factor alpha (tnf-alpha), lipopolysaccharide (lps), and no donor, sodium nitroprusside (snp). |
2000-06-26 |
2023-08-12 |
rat |
| M S Roberson, M Ban, T Zhang, J M Mulvane. Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin. Molecular and cellular biology. vol 20. issue 10. 2000-05-18. PMID:10779323. |
the aim of these studies was to elucidate a role for epidermal growth factor (egf) signaling in the transcriptional regulation of the glycoprotein hormone alpha subunit gene, a subunit of chorionic gonadotropin. |
2000-05-18 |
2023-08-12 |
human |
| M S Roberson, M Ban, T Zhang, J M Mulvane. Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin. Molecular and cellular biology. vol 20. issue 10. 2000-05-18. PMID:10779323. |
studies examined the effects of egf and the adenylate cyclase activator forskolin on the expression of a transfected alpha subunit reporter gene in a human choriocarcinoma cell line (jeg3). |
2000-05-18 |
2023-08-12 |
human |
| M S Roberson, M Ban, T Zhang, J M Mulvane. Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin. Molecular and cellular biology. vol 20. issue 10. 2000-05-18. PMID:10779323. |
at maximal doses, administration of egf resulted in a 50% increase in a subunit reporter activity; forskolin administration induced a fivefold activation; the combined actions of egf and forskolin resulted in synergistic activation (greater than eightfold) of the alpha subunit reporter. |
2000-05-18 |
2023-08-12 |
human |
| M S Roberson, M Ban, T Zhang, J M Mulvane. Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin. Molecular and cellular biology. vol 20. issue 10. 2000-05-18. PMID:10779323. |
however, overexpression of c-jun n-terminal kinase (jnk)-interacting protein 1 as a dominant interfering molecule abolished the synergistic effects of egf and forskolin on the alpha subunit reporter. |
2000-05-18 |
2023-08-12 |
human |
| b' N T\\xc3\\xb8rring, P E J\\xc3\\xb8rgensen, B S S\\xc3\\xb8rensen, E Nex\\xc3\\xb. Increased expression of heparin binding EGF (HB-EGF), amphiregulin, TGF alpha and epiregulin in androgen-independent prostate cancer cell lines. Anticancer research. vol 20. issue 1A. 2000-05-11. PMID:10769639.' |
increased expression of heparin binding egf (hb-egf), amphiregulin, tgf alpha and epiregulin in androgen-independent prostate cancer cell lines. |
2000-05-11 |
2023-08-12 |
Not clear |
| Y Iwai-Liao, S Kumabe, M Takeuchi, Y Higash. Immunohistochemical localisation of epidermal growth factor, transforming growth factor alpha and EGF receptor during organogenesis of the murine hypophysis in vivo. Okajimas folia anatomica Japonica. vol 76. issue 6. 2000-05-11. PMID:10774227. |
immunohistochemical localisation of epidermal growth factor, transforming growth factor alpha and egf receptor during organogenesis of the murine hypophysis in vivo. |
2000-05-11 |
2023-08-12 |
mouse |
| Y Iwai-Liao, S Kumabe, M Takeuchi, Y Higash. Immunohistochemical localisation of epidermal growth factor, transforming growth factor alpha and EGF receptor during organogenesis of the murine hypophysis in vivo. Okajimas folia anatomica Japonica. vol 76. issue 6. 2000-05-11. PMID:10774227. |
light and confocal laser scanning microscopy indicated diffuse expression of both tgf alpha and egf in the hypophysis at different foetal stages. |
2000-05-11 |
2023-08-12 |
mouse |
| Y Iwai-Liao, S Kumabe, M Takeuchi, Y Higash. Immunohistochemical localisation of epidermal growth factor, transforming growth factor alpha and EGF receptor during organogenesis of the murine hypophysis in vivo. Okajimas folia anatomica Japonica. vol 76. issue 6. 2000-05-11. PMID:10774227. |
while no findings indicative for temporary changes of tgf alpha and egf patterns were found in the foetal hypophysis, a temporary increment of egf molecules was distinct in the diencephalic mesenchyme at stages iii and iv. |
2000-05-11 |
2023-08-12 |
mouse |
| Y M Yoon, C D Oh, D Y Kim, Y S Lee, J W Park, T L Huh, S S Kang, J S Chu. Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways. The Journal of biological chemistry. vol 275. issue 16. 2000-05-10. PMID:10766877. |
stimulation of the egf receptor blocked precartilage condensation and altered the expression of cell adhesion molecules such as n-cadherin and integrins alpha(5) and beta(1). |
2000-05-10 |
2023-08-12 |
chicken |
| F Wang, R Duan, J Chirgwin, S H Saf. Transcriptional activation of cathepsin D gene expression by growth factors. Journal of molecular endocrinology. vol 24. issue 2. 2000-05-08. PMID:10750020. |
insulin-like growth factor-i (igf-i), transforming growth factor alpha (tgfalpha) and epidermal growth factor (egf) induced cathepsin d gene expression and reporter gene activity in mcf-7 human breast cancer cells transiently transfected with a construct (pcd1) containing a -2576 to -124 cathepsin d gene promoter insert. |
2000-05-08 |
2023-08-12 |
human |
| M Caraglia, P Tagliaferri, A Budillon, A Abbruzzes. Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy. Advances in experimental medicine and biology. vol 472. 2000-04-27. PMID:10736626. |
we have found that ifn alpha increased epidermal growth factor receptor (egf-r) expression, but reduced s phase and proliferative marker expression in human epidermoid kb cells and that this effect was antagonised by epidermal growth factor (egf). |
2000-04-27 |
2023-08-12 |
human |
| M Caraglia, P Tagliaferri, A Budillon, A Abbruzzes. Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy. Advances in experimental medicine and biology. vol 472. 2000-04-27. PMID:10736626. |
growth inhibition induced by ifn alpha was paralleled by decreased hypusine synthesis and, when egf counteracted anti-proliferative effects, a reconstitution of hypusine levels was recorded. |
2000-04-27 |
2023-08-12 |
human |
| S Chevalier, N Macdonald, R A Robert. Induction of DNA replication by peroxisome proliferators is independent of both tumour necrosis factor (alpha) priming and EGF-receptor tyrosine kinase activity. Journal of cell science. vol 112 ( Pt 24). 2000-04-24. PMID:10574725. |
tumour necrosis factor (alpha) (tnf(alpha)) and epidermal growth factor (egf) have been implicated in mediating this growth response since these factors induce a threefold and 17.2-fold increase, respectively, in dna synthesis in rat primary hepatocyte cultures. |
2000-04-24 |
2023-08-12 |
rat |
| S Chevalier, N Macdonald, R A Robert. Induction of DNA replication by peroxisome proliferators is independent of both tumour necrosis factor (alpha) priming and EGF-receptor tyrosine kinase activity. Journal of cell science. vol 112 ( Pt 24). 2000-04-24. PMID:10574725. |
indeed, here we show that costimulation with tnf(alpha) and a suboptimal (4-20% of optimal) concentration of egf permits an 11.7-fold increase in dna synthesis in rat primary hepatocyte cultures. |
2000-04-24 |
2023-08-12 |
rat |
| S Chevalier, N Macdonald, R A Robert. Induction of DNA replication by peroxisome proliferators is independent of both tumour necrosis factor (alpha) priming and EGF-receptor tyrosine kinase activity. Journal of cell science. vol 112 ( Pt 24). 2000-04-24. PMID:10574725. |
3-fold increase in dna synthesis but there was no further increase upon co-administration of either tnf(alpha) or a suboptimal concentration of egf. |
2000-04-24 |
2023-08-12 |
rat |
| S Chevalier, N Macdonald, R A Robert. Induction of DNA replication by peroxisome proliferators is independent of both tumour necrosis factor (alpha) priming and EGF-receptor tyrosine kinase activity. Journal of cell science. vol 112 ( Pt 24). 2000-04-24. PMID:10574725. |
the egfr-tki also prevented progression into s phase upon stimulation with tnf(alpha), but dna synthesis was not reduced to control levels, indicating that tnf(alpha) has a mitogenic activity in the absence of egf signalling. |
2000-04-24 |
2023-08-12 |
rat |