| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuya Maeda, Yukio Kato, Yuichi Sugiyam. pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes. Journal of controlled release : official journal of the Controlled Release Society. vol 82. issue 1. 2002-10-25. PMID:12106978. |
both epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) bind to egf receptors and tgf alpha has been reported to be more potent than egf as far as many biological effects are concerned. |
2002-10-25 |
2023-08-12 |
mouse |
| Kazuya Maeda, Yukio Kato, Yuichi Sugiyam. pH-dependent receptor/ligand dissociation as a determining factor for intracellular sorting of ligands for epidermal growth factor receptors in rat hepatocytes. Journal of controlled release : official journal of the Controlled Release Society. vol 82. issue 1. 2002-10-25. PMID:12106978. |
first, (125)i-human egf (hegf), mouse egf (megf), or human tgf alpha (htgf alpha) was prebound to cell-surface receptors or intracellularly preloaded, followed by further incubation at 37 degrees c in primary cultured rat hepatocytes. |
2002-10-25 |
2023-08-12 |
mouse |
| Vladimir Zachar, Trine Fink, Uffe Koppelhus, Peter Ebbese. Role of placental cytokines in transcriptional modulation of HIV type 1 in the isolated villous trophoblast. AIDS research and human retroviruses. vol 18. issue 12. 2002-10-24. PMID:12201906. |
four cytokines, epidermal growth factor (egf), granulocyte-macrophage colony-stimulating factor (gm-csf), interleukin 1 beta (il-1 beta), and tumor necrosis factor alpha (tnf-alpha), were found to stimulate promoters of both viruses, whereas interferon alpha (ifn-alpha) and ifn-beta were found to suppress the transcription driven from both promoters. |
2002-10-24 |
2023-08-12 |
Not clear |
| Michaël Perrais, Pascal Pigny, Marie-Christine Copin, Jean-Pierre Aubert, Isabelle Van Seuninge. Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. The Journal of biological chemistry. vol 277. issue 35. 2002-10-17. PMID:12077147. |
cell treatment with epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha), or tumor necrosis factor alpha (tnf-alpha) resulted in a dramatic increase of muc2 and muc5ac mrnas levels, promoter activity, and apomucin expression, whereas those of muc5b and muc6 were unchanged. |
2002-10-17 |
2023-08-12 |
Not clear |
| Catelijne Stortelers, Christelle Souriau, Ellis van Liempt, Monique L M van de Poll, Everardus J J van Zoele. Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display. Biochemistry. vol 41. issue 27. 2002-08-21. PMID:12093292. |
epidermal growth factor (egf) binds with high affinity to the egf receptor, also known as erbb-1, but upon replacement of the n-terminal linear region by neuregulin (nrg) 1 or transforming growth factor (tgf) alpha sequences it gains in addition high affinity for erbb-2/erbb-3 heterodimers. |
2002-08-21 |
2023-08-12 |
Not clear |
| Karl Maly, Kukka Strese, Sonja Kampfer, Florian Ueberall, Gottfried Baier, Nassim Ghaffari-Tabrizi, Hans H Grunicke, Michael Leitge. Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1. FEBS letters. vol 521. issue 1-3. 2002-08-01. PMID:12067706. |
expression of pkc isotype-specific dominant negative and constitutively active mutants or downregulation of pkc by isotype-specific antisense oligonucleotides revealed that stimulation by epidermal growth factor (egf) or phorbol ester of the nhe in nih3t3 cells is a pkc(alpha)-specific effect. |
2002-08-01 |
2023-08-12 |
Not clear |
| Karl Maly, Kukka Strese, Sonja Kampfer, Florian Ueberall, Gottfried Baier, Nassim Ghaffari-Tabrizi, Hans H Grunicke, Michael Leitge. Critical role of protein kinase C alpha and calcium in growth factor induced activation of the Na(+)/H(+) exchanger NHE1. FEBS letters. vol 521. issue 1-3. 2002-08-01. PMID:12067706. |
it is concluded that in nih3t3 cells overexpressing the egf receptor (egfr6 cells), egf requires cpkc(alpha) for the activation of the nhe, while calcium/calmodulin-dependent kinases are essential in thapsigargin induced stimulation of the nhe. |
2002-08-01 |
2023-08-12 |
Not clear |
| Liang-Tung Yang, Konstantina Alexandropoulos, Jan Sa. c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation. The Journal of biological chemistry. vol 277. issue 20. 2002-07-16. PMID:11867627. |
we report that epidermal growth factor (egf) can be converted from a non-neuritogenic into a neuritogenic factor through moderate activation of endogenous src by receptor-protein-tyrosine phosphatase alpha (a physiological src activator). |
2002-07-16 |
2023-08-12 |
Not clear |
| Fabienne Desmots, Mary Rissel, David Gilot, Dominique Lagadic-Gossmann, Fabrice Morel, Christiane Guguen-Guillouzo, André Guillouzo, Pascal Loye. Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes. The Journal of biological chemistry. vol 277. issue 20. 2002-07-16. PMID:11884396. |
in addition, mgsta4 was induced in vivo and in cultured hepatocytes by tumor necrosis factor alpha (tnfalpha), interleukin-6 (il-6), and epidermal growth factor (egf), factors that play crucial roles in hepatocyte survival and proliferation during liver regeneration. |
2002-07-16 |
2023-08-12 |
mouse |
| Quincey A Justman, Gail M Clinto. Herstatin, an autoinhibitor of the human epidermal growth factor receptor 2 tyrosine kinase, modulates epidermal growth factor signaling pathways resulting in growth arrest. The Journal of biological chemistry. vol 277. issue 23. 2002-07-12. PMID:11934884. |
in this study, we characterized several early steps in egfr activation and investigated downstream signaling events induced by epidermal growth factor (egf) and by transforming growth factor alpha (tgf-alpha) in nih3t3 cell lines expressing egfr with and without herstatin. |
2002-07-12 |
2023-08-12 |
human |
| Uwe Schiemann, Jan Konturek, Ronald Assert, Kazimierz Rembiasz, Wolfram Domschke, Stanisław Konturek, Aadreas Pfeiffe. mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication. Medical science monitor : international medical journal of experimental and clinical research. vol 8. issue 2. 2002-06-24. PMID:11859273. |
epidermal growth factor (egf) receptor ligands (egfrl) including transforming growth factor alpha (tgf-alpha), amphiregulin, and heparin binding-egf (hb-egf) are involved in gastric mucosal repair in chronic gastritis. |
2002-06-24 |
2023-08-12 |
Not clear |
| Bruce A Lesse. Implantation defects in infertile women with endometriosis. Annals of the New York Academy of Sciences. vol 955. 2002-05-02. PMID:11949954. |
while alpha(v)beta3 expression appears to be stimulated by egf or heparin-binding egf, osteopontin is stimulated by progesterone. |
2002-05-02 |
2023-08-12 |
Not clear |
| A Kasza, M Kowanetz, K Poślednik, B Witek, T Kordula, A Ko. Epidermal growth factor and pro-inflammatory cytokines regulate the expression of components of plasminogen activation system in U373-MG astrocytoma cells. Cytokine. vol 16. issue 5. 2002-04-30. PMID:11814314. |
we have examined expression of the components of the plasminogen activation system in human astrocytoma u373-mg cells and found that interleukin 1beta (il-1beta), tumour necrosis factor alpha tnf-alpha), interferon gamma (inf-gamma) and epidermal growth factor (egf) specifically regulate the expression of tissue-type plasminogen activator (t-pa), urokinase-type plasminogen activator (u-pa), plasminogen activator inhibitor type 1 (pai-1) and protease nexin-1 (pn-1). |
2002-04-30 |
2023-08-12 |
human |
| K B C Apparao, Laurie P Lovely, Yaoting Gui, Ruth A Lininger, Bruce A Lesse. Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome. Biology of reproduction. vol 66. issue 2. 2002-04-23. PMID:11804942. |
on the other hand, egf significantly induced the expression of alpha(v)beta3, whereas estrogen and androgen treatment inhibited its expression. |
2002-04-23 |
2023-08-12 |
human |
| Karianne E Longva, Froydis D Blystad, Espen Stang, Astrid M Larsen, Lene E Johannessen, Inger H Madshu. Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies. The Journal of cell biology. vol 156. issue 5. 2002-04-08. PMID:11864992. |
we show that egfr was initially polyubiquitinated to the same extent upon incubation with egf and tgf alpha, whereas the ubiquitination was more sustained by incubation with egf than with tgf alpha. |
2002-04-08 |
2023-08-12 |
Not clear |
| Karianne E Longva, Froydis D Blystad, Espen Stang, Astrid M Larsen, Lene E Johannessen, Inger H Madshu. Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies. The Journal of cell biology. vol 156. issue 5. 2002-04-08. PMID:11864992. |
egf remains bound to the egfr upon endocytosis, whereas tgf alpha dissociates from the egfr. |
2002-04-08 |
2023-08-12 |
Not clear |
| Wilbur A Franklin, Robert Veve, Fred R Hirsch, Barbara A Helfrich, Paul A Bun. Epidermal growth factor receptor family in lung cancer and premalignancy. Seminars in oncology. vol 29. issue 1 Suppl 4. 2002-04-02. PMID:11894009. |
the efgr family is a group of four structurally similar tyrosine kinases (egfr, her2/neu, erbb-3, and erbb-4) that dimerize on binding with a number of ligands, including egf and transforming growth factor alpha. |
2002-04-02 |
2023-08-12 |
Not clear |
| P V Gordon, W A Price, A D Stiles, J C Rutledg. Early postnatal dexamethasone diminishes transforming growth factor alpha localization within the ileal muscularis propria of newborn mice and extremely low-birth-weight infants. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 6. 2002-03-21. PMID:11826358. |
immunolocalization was performed for three related growth factors (epidermal growth factor [egf], heparin-binding egf [h-egf], and transforming growth factor alpha [tgf-alpha]) and their common receptor. |
2002-03-21 |
2023-08-12 |
mouse |
| J A Morales González, J Gutiérrez Salinas, J Paz Avila, L F Sauceda González, J L Montes Baldera. [Transforming growth factor alpha (TGF-alpha) and epidermoid growth factor (EGF) in polycystic ovary syndrome: potential role in the decrease of apoptosis mechanisms in the follicle]. Ginecologia y obstetricia de Mexico. vol 69. 2002-03-01. PMID:11552458. |
[transforming growth factor alpha (tgf-alpha) and epidermoid growth factor (egf) in polycystic ovary syndrome: potential role in the decrease of apoptosis mechanisms in the follicle]. |
2002-03-01 |
2023-08-12 |
Not clear |
| P Balaram, M John, S Enose, P K Symaladev. Demonstration of TGF-alpha-EGFR and EGF-EGFR autocrine loops and their relation to proliferation in complete hydatidiform moles (CHM). International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 11. issue 5. 2002-02-01. PMID:11737472. |
in this study, we have immunohistochemically evaluated the expression of epidermal growth factor (egf) and transforming growth factor alpha (tgf-alpha) along with their receptor, epidermal growth factor receptor (egfr), and we have related them to the proliferative activity in normal placenta and chm using the expression of proliferating cell nuclear antigen (pcna) as the marker of proliferation. |
2002-02-01 |
2023-08-12 |
Not clear |